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AMPK Signaling

Brain Insulin
Leptin Receptor
Low Glucose,
-Adrenergic Histamine Hypoxia, Ischemia, [AICAR]
Receptor Thrombin Heat Shock Metformin
Glucose Adiponectin Insulin
Exercise
GLUT4

PLC Gq
[cAMP]

STRAD
[AMP] [ATP]
MO25
LKB1
[Ca2+]
PI3K
Sestrin [ATP]
[Phosphocreatine]
GLUT4 CaMKK PKA
Translocation
Akt

Raptor

etabolism
GLUT4 mTOR GL
TSC1/2
vesicle
AMPK PI3 Kinase 4E-BP1
p70

Protein M
GEF Class III
S6K
GLUT4 eEF2K
Gene Expression
MEF ACC Protein Synthesis

GS p53 HuR
TORC2 eEF2
Glycogen

osis
Synthesis PFK2 SREBP-1

opt
Malonyl p21
Ca

CoA Cyclin A

Ap
rb

PGC-1 HSL
oh

d
an
Glycolysis
y

HNF-4 Cyclin B1
dra

SirT1 th
row
eNOS
te

Fatty Acid
HMG-CoA
Me

Gluconeogenesis Synthase
ll G

Reductase
ta

Expression of
Ce
bo

Mitochondrial CPT1
Cardiovascular
lis
m

Genes in Muscle Homeostasis i

ng

Ag
d
Aging r an
Sterol/Isoprenoid ula
Hepatic Fatty asc
Synthesis Lipolysis v
Fatty Acid Acid and r dio
Oxidation VLDL Synthesis Ca

Lipid Metabolism

2006 2010 Cell Signaling Technology, Inc. AMPK Signaling created April 2006 revised November 2010
 www.cellsignal.com

Signaling Pathways Key

Direct Stimulatory Modification

Kinase
Direct Inhibitory Modification
Phosphatase
Multistep Stimulatory Modification
Transcription Factor
Multistep Inhibitory Modification
Caspase
Tentative Stimulatory Modification

Receptor Tentative Inhibitory Modification

Enzyme Transcriptional Stimulation

Transcriptional Inhibition
Cyclin, pro-apoptotic
Translocation
pro-survival
Separation of Subunits or Cleavage Products
GAP / GEF
Joining of Subunits
GTPase

G-protein, ribosomal subunit

Acetylase

Deacetylase

2003 - 2010 Cell Signaling Technology, Inc.