Clinical effect of curcumin from Curcuma longa

on blood lipid profiles: a systematic review and

meta-analysis of randomized controlled trials

Siranee Panyamanarong1, Chidabha Pinage1, Tarattakorn

Sawatdeewongsakun1, Sitthipong Pinchai1
Surasak Saokaew1-4
1
School of Pharmaceutical Sciences, University of Phayao, Phayao,
Thailand
2
Center of Health Outcomes Research and Therapeutic Safety (COHORTS),
School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand
3
Center of Pharmaceutical Outcomes Research (CPOR), Faculty of
Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
4
School of Pharmacy, Monash University Malaysia, Bandar Sunway,
Selangor Darul Ehsan, Malaysia

Abstract
This study aimed to elevate the efficacy of
curcumin from Curcuma longa on blood lipid profiles.
We systematically searched on the following databases:
PubMed, Scopus, EMBASE, Cochrane Central Register of
Clinical Trials, AMED and Google Scholar, from inception
until February 2016. Quality of study assessed by
JADAD score and risk of bias. Random effects model
was used to pool the weighted mean difference (WMD).
Q-statistic test and I2 were used to assess the
heterogeneity. From systematic searching found 10
appropriated studies. Result shown that, in non-DM
group had significantly increased HDL-C level when
compared with placebo [WMD= 2.21 (95%CI 1.45,
2.96), I2 = 0.0%, Q-statistic p= 0.650]. In curcumin
group, which received dose of curcumin less than 1,000
mg can significantly increase HDL-C level when
compared with placebo [WMD= 2.31 (95%CI 1.57, 3.05)
I2 = 0.0%, Q-statistic p= 0.650]. Duration of curcumin
usage appropriated less than 3 months [WMD= 2.22
(95%CI 1.46, 2.98) I2 = 0.0%, Q-statistic p= 0.423].
From this result found that in curcumin group who
received curcumin dose less than 1,000 mg/day and
less than 3 months can significantly increase HDL-C
level in non-DM patients.

curcumin

1, 1, 1,
1, 1-4
1

2


3

curcumin
PubMed, Scopus, EMBASE, Cochrane Central
Register of Clinical Trials, AMED Google Scholar
 .. 2559
JADAD score risk
of bias weighted mean
difference (WMD)
Q-statistic test I-square
test (I2)
10
curcumin
HDL-C [WMD= 2.21
(95%CI 1.45, 2.96), I2 = 0.0%, Q-statistic p= 0.650]
curcumin 1,000
HDL-C
[WMD= 2.31 (95%CI 1.57, 3.05) I2 = 0.0%, Q-statistic
p= 0.650] curcumin
3 HDL-C
[WMD= 2.22 (95%CI 1.46, 2.98) I2 =
0.0%, Q-statistic p= 0.423]

curcumin (<1,000 / )
3 HDL-C