Mannos

? FREQUENTLY ASKED QUESTIONS S SCIENCE

Q: How doe The graph below shows how a concentrated portion of

A: Aloe vera gel can be separated into different parts
based on weight. A ~5 million dalton fraction (a dalton
is a weight measurement frequently used by scientists)
was found in in vitro studies to boost immune cells
activity by stimulating the production of messenger
molecules like IL-1 and TNF-. This activity of
Mannos helps to bolster the immune system.
Q:
that mean?
aloe vera is just as effective at eliciting an immune
response as bacterial lipopolysaccharide. Basically, this
means that the elevated response your immune cells
would have to a bacterial invasion, is the same elevated
2
response they would have to this aloe fraction. Contrast
this to regular aloe juice (Crude Aloe Juice) which is not
nearly as effective at eliciting an immune response as
concentrated aloe fractions.

A: Antioxidants are molecules that are able to protect

our bodys cells by deactivating free radicals.

Q: What are free radicals?

A: Free radicals are molecules like reactive oxygen

species (ROS), hydroxyls, etc. that have an unpaired
electron in their outer shell. These highly reactive
molecules are able to react with other molecules in the
cell and damage DNA, cell membranes, and more.

Q:

A: We recommend that two capsules be taken daily;

however, more can be taken if needed as no adverse
effects at higher levels have been found other than
loose stools. Fig. 1. Evaluation and comparison of AVMP and Manapol with crude aloe
vera fractions. AVMP and Manapol cause weak activation of NF-kappa B
Q: directed luciferase expression in THP-1 cells at 200 ug/mL. In contrast,
the high molecular weight fraction (>500,000 daltons) from crude aloe
A: Mannos is derived from Aloe vera.
vera juice exhibits potent immunostimulatory activity at 50 ug/mL that is
Q: What is Aloe vera? equivalent to levels achieved by maximal concentrations of LPS (10
ug/mL).2
A: Aloe vera is a succulent plant that grows in hot, dry
climates and has a green, waxy outer portion, and soft,
gel-like inner portion. Aloe veras use can be traced
back 6,000 years to early Egypt, where the plant was
R
depicted on stone carvings.
REFERENCES

I13:1599-1616.
Hamman J. Composition and applications of aloe vera leaf gel. Molecules. 2008.

Pugh N, et al. Characterization of aloeride, a new high-molecular weight

polysaccharide from aloe vera with potent immunostimulatory activity. J. Agr.
Food Chem. 2001, 49, 1030-1034.

Im, et al. Identification of optimal molecular size of modified aloe

polysaccharides with maximum immunomodulatory activity. Int Immpharm
2005. 5:271-279.

Vinson J, et al. Effect of aloe vera preparations on the human bioavailability of

vitamins C and E. Phtyomedicine. 2005. 12:760-765.

Mannos
Immunity ; Antioxidant ; Bioavailability

Mannos helps boost the immune system, slow the

effects of aging, and increase vitamin bioavailability.*
Item: 24631
Quantity: 60 Capsules

N NUTRITIONAL CONTENT of ALOE VERA P PRODUCT DEFINITION

Mannos is a purified extract from the aloe vera plant. The

P

Anthraquinones
Aloe-emodin aloe vera plant has been used for centuries to help promote
Aloetic-Acid healing, soothe burns, and improve skin health.* The plant is
Anthranol
Aloin A and B composed of two main parts; the outer, fibrous cell wall and
a soft gel encased by the cell wall.
Minerals
Calcium Mannos is derived from a concentrated and purified portion
Manganese
Sodium of the soft gel. This concentrated portion has been found in
Copper research studies to have the strongest immune modulating
Magnesium
Potassium effects.* Mannos is a capsule taken once daily to promote
Zinc health.
Chromium
Iron

Vitamins
Vitamins B1, B2, B6
Vitamin C
-Carotene
-Tocopherol
Choline F FEATURES & BENEFITS
Folic Acid
P
Other Mannos helps boost the immune system via a highly
P concentrated aloe extract ingredient that increases the production
Mannans
Arabinogalactan 2,3
of cytokines*
Chromones Mannos contains antioxidants that help counteract free radicals
Arachidonic Acid 1
Gibberillin and may slow the effects of aging*
Salicylic Acid Mannos increases the bioavailability of vitamins by improving
Mannose their gastrointestinal absorption*
4

Lectins