Drug Reference and Route of Main Clinical Contraindications

(Generic or page number Administrati Use/Classification (Complications with

trade name) on (ex. Direct-acting disease or other
cholinergics) drugs)

Acetaminophen Pg. 6-7 Plumbs PO Analgesic Antipyretic Do not give to cats! Ferrets
(Tylenol, APAP, Treatment of chronic pain, may also be sensitive.
Paracetamol) especially dogs who have Dose dogs carefully and
renal dysfunction. Also dont overdose as it is
treats moderate pain toxic.
when combined with
products containing
codeine, hydrocodone or
tramadol.

Acetazolamide Pg. 8-9 Plumbs PO Carbonic Anhydrase Dont use in patients with
(Diamox, Inhibitor Diuretic significant hepatic, renal,
Dazamide) Treatment for glaucoma pulmonary obstruction or
on the aqueous humor, adrenocortical
metabolic alkalosis and insufficiency,
diuretics. Adjunctive hyponatremia,
treatment for hypokalemia,
hyperkalemic periodic hyperchloremic acidosis or
Acetylcysteine Pg. 12 Plumbs Nebulization or Mucolytic -- May cause nausea or
(Mucomyst, N- topical Break down thick vomiting when given
acetylcysteine, ophthalmic. respiratory secretions and orally. Dont use with
NAC) treat acetaminophen patients who have
Administer by toxicity. Also treatment pulmonary indications or
gastric tube for for acetaminophen who are hypersensitive to
acetaminophen toxicity or hepatotoxic it. Monitor patients who
poisoning. conditions have bronchospastic
disease as it may cause
 Drug Reference and Route of Main Clinical Contraindications
(Generic or page number Administrati Use/Classification (Complications with
trade name) on (ex. Direct-acting disease or other
cholinergics) drugs)

Acetylsalicylic Pg. 10-11 Plumbs PO GI acidifier/NSAID Do not use if potential

Acid Treatment of non-protein lactic acidosis (grain
(Aspirin) nitrogen induced overload, rumen acidosis)
ammonia toxicosis in is possible. Can thin blood
ruminants (secondary so be careful with anemic
urea poisoning) or patients.
enterolith prevention in
horses by reducing
colonic pH. Also treats

Drug Reference Route of Classification/Main Contraindications(Compl

(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Activated Pg. 399 PO Antidiarrheal absorb certain Beware that the stool will
Charcoal Wanamaker drugs or toxins to prevent or turn black. It isnt used for
(Toxiban) reduce their systemic heavy metals and do not
adsorption from the upper GI administer any oral agents
tract within 3 hours after charcoal
therapy
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Adaptil https://valleyv Diffuser Pheromone natural odor Do not spray directly on the
et.naccvp.com caused by lactating females body of the patient, only on
/product/view/ to alleviate fear, stress, and bedding or diffused
basic/1328002 unwanted behavior in throughout the environment.
? canines Only works for canines not
u=country&p felines
=msds

Adequan https://valleyv IM Polysulfated Do not use in dogs that are

et.naccvp.com glycosaminoglycan Control sensitive to PSGAG, have a
/product/view/ of signs associated with non- bleeding disorder or with
basic/1039000 infectious degenerative renal/hepatic impairment.
? and/or traumatic arthritis of May cause pain at the
u=country&p canine synovial joints injection site.
=msds

Afoxolaner https://www.va PO Antiparasitic Treatment to Do not give to dogs less than

(NexGard) lleyvet.com/ct prevent ticks and fleas for 8 weeks of age. Use in
_detail.html? one month caution with dogs who
pgguid=4fadb experience seizures
f4d-1da4-
4bc1-8b73-
2b3c4a9cb667
&gas=Afoxola
ner
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Albuterol Pg. 24 Plumbs PO or inhaled Beta-Adrenergic Use with caution in patients

(Proventil, dosing (sympathomimetic) agent that have cardiac
Salbutamol, Used mainly in dogs and cats dysrhythmias or dysfunction,
Ventolin) as a bronchodilation to seizure disorders, diabetes,
alleviate bronchospasms or hypertension or
cough. Also can be used in hyperthyroidism. If used
horses. during the late stages of
pregnancy it could inhibit
uterine contractions.

Allopurinol Pg. 31 Plumbs PO Xanthine oxidase inhibitor Dosage adjustment may be

(Zyloprim) Uric acid reducer in dogs needed and use with caution
(especially calcium oxalate in patients with renal or
uroliths in Dalmatians), cats, hepatic dysfunction. Red-
reptiles and birds. Its an tailed hawks and raptors in
alternative treatment for general should be cautious
Leishmaniasis and when using this.
Trypanosomiasis in dogs. Hypersensitivity and hepatic
and renal effects can occur.

Aluminum Pg. 36-37 PO Antacid/Phosphate binder If chronic usage it may lead

hydroxide gel Plumbs Treats hyperphosphatemia in to electrolyte abnormalities
(Amphogel) small animal patients and and possible aluminum
sometimes as gastric antacid toxicity. May inhibit gastric
for ulcers emptying so use cautiously in
patients with gastric outlet
obstruction.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Altrenogest Pg. 35 Plumbs PO Progestin Used in horses to Very sensitive to light.

(Regu-Mate, suppress estrus or maintain Pregnancy is a manufacturer
Matrix) pregnancy when progestin contraindication but it is used
deficient. Can be used in clinically for this. Horses
swine to synchronize estrus intended for food purposes
or dogs for luteal deficiency should not be administered
as well as prevent premature this drug.
delivery.

Amikacin Pg. 39-40 Intrauterine Aminoglycoside antibiotic Risk for toxicity include:
(Amikin, Plumbs infusion in mares used to treat serious gram- preexisiting renal disease,
Amiglyde-V) and IA injection negative infections in most age, fever, sepsis and
in foals with species. dehydration. Cats may also
Gram negative be more sensitive to these
septic arthritis toxic effects. Rare, but could
cause 8th cranial nerve
toxicity in fetuses if it crosses
the placenta.

Aminopentamid Pg. 44 Plumbs IM, SC or PO Indirect-acting Do not use in patients with

e cholinergic/Antispasmodic glaucoma, heart diseases or
(Centrine) Controls vomiting and GI obstruction. Could cause
diarrhea in dogs and cats tachycardia
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Aminophylline Pg. 45-46 PO or IV Bronchodilator/Phosphodieste Dont used in patients

Plumbs rase inhibitor Used for hypersensitive to xanthines
bronchospasms and or caffeine, as well as those
cardiogenic pulmonary with cardiac disease, seizure
edema disorders, gastric ulcers,
hyperthyroidism, renal or
hepatic disease, severe
hypoxia or severe
hypertension. Causes intense
pain if administered IM.

Amitraz Pg. 292 PO or collar form Insecticide Treatment for Do not use if hypothermic, if
(Mitaban Dip) Wanamaker fleas and ticks. Used to treat diabetic or if the patient has
Demodectic Mange seizures

Amitriptyline Pg. 51 Plumbs PO Antipruitic/Behavior and Pain Dont use with monoamine
(Elavil) modifier Antidepressant oxidase inhibitors. Also use
used for behavior disorders with very high caution in
like anxiety and neuropathic patients with seizure and
pain or pruritus in small thyroid disorders
animals. Can reduce seizure
thresholds in epileptic
animals and be used as an
adjunctive treatment of lower
urinary tract disease in cats.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Amoxicillin Pg. 57-58 PO or Parenteral Aminopenicillin Treatment Patients with a history of

trihydrate Plumbs of abscesses in cats and sensitivity to penicillins. Do
(Amoxil, Amoxi- penicillin-sensitive bacteria. not administer to rabbits,
Tabs) Also treats many strains of guinea pigs, chinchillas or
gram-negative aerobes hamsters. Can cause
reactions if used with
Chloramphenicol or
Tetracyclines. Make sure to
give parenteral dose to
patients with septicemia,
shock or grave illnesses due
to delayed GI tract absorption

Aldosterone Drugs.com SQ Hormone Sodium May cause high blood

conservation of the kidneys pressure
and mineralcorticoid to treat
Addisons

Atipamezole Pg. 89 Plumbs IV or IM Adrenergic blocking agent No recommended in pregnant

(Antisedan) (sympatholytic) reversal or lactating patients and
agent for Dexmedetomidine caution when using in elderly
and Medetomidine. May also patients. Do not give IV to
reverse Xylazine retiles because hypotension
can occur
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Benazepril HCl Pg. 108-109 PO Angiotensin Converting Be cautious in patients with

(Fortekor, Plumbs Enzyme (ACE) Inhibitor
Lotensin) Treatment of heart failure by
vasodilation, hypertension,
proteinuria, chronic renal
failure and protein losing
glomerulonephropathies in
dogs and cats.
hyponatremia, coronary or
cerebrovascular insufficiency,
SLE, hematologic disorders.
Monitor patients at the
beginning of therapy if they
have severe CHF

Bismuth Pg. 115 PO Antidiarrheal Treatment of Use cautiously in patients

subsalicylate Plumbs diarrhea and is a triple with bleeding disorders and
(BSS, Pepto- therapy for Helicobacter GI when used in cats. This drug
Bismol) infections is radiopaque so it may
interfere with GI tract
radiologic exams

Buprenorphine Pg. 125-126 IM, IV, SC Opiate partial agonist Use cautiously in patients
(Buprenex, Plumbs Treatment of mild to with hyperthyroidism, severe
Subutex) moderate pain in most renal insufficiency,
species and has the best adrenocortical insufficiency
effect when administered (Addisons), head trauma,
orally in cats for post-op pain and geriatric or debilitated
patients. Rare but may cause
respiratory depression
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Buspirone Pg. 128-129 PO Anxiolytic Treatment of Use cautiously in patients

(BuSpar) Plumbs behavior disorders in dogs with renal or hepatic disease.
and cats especially in Also caution use of this drug
fear/phobia due to social in aggressive animals and
interactions. May also help in working dogs
urine spraying and motion
sickness in cats

Butorphanol Pg. 131-133 IV, IM, SQ and Opioid agent Antitussive,
(Torbutrol, Plumbs PO analgesic and preanesthetic
Torbugesic, in dogs and cats, can provide
Stadol) pain relief for horses with
colic. Also used for chronic,
nonproductive cough in dogs.
Reversal agent for CNS and
respiratory depressant
effects of mu-agonists
Use with caution in patients
with hyperthyroidism, severe
renal insufficiency,
adrenocortical insufficiency
(Addisons), geriatric
patients, head trauma, and
increased CSF pressure. A
higher sedation may occur in
dogs with MDR1 mutations,
and use with caution in
heartworm positive dogs or
those with liver disease. May
cause respiratory depression
in turtles and tortoises.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Captopril Pg. 145-146 PO or injection Vasodilator/ Ace inhibitor -- Concurrent use of NSAIDS
(Capoten) Plumbs form Treatment of heart failure may reduce the
and hypertension effectiveness. Use cautiously
in patients who are
hypersensitive to ACE
inhibitors, those with renal
insufficiency, hyponatremia,
sodium depletion, coronary or
cerebrovascular insufficiency

Carprofen Pg. 154-155 PO NSAID Relieves pain and Do not use in dogs with
(Rimadyl) Plumbs inflammation in dogs with bleeding disorders (Von
degenerative joint disease or Willebrands) or those whove
post op pain had serious reactions to anti-
inflammatories. Use with
caution in geriatric patients
and those with preexisiting
chronic diseases

Cefazolin Pg. 162-163 IV 1st Generation Cephalosporin Can cause pain at injection
sodium (Ancef, Plumbs Used for surgical site if given IM and can cause
Kefzol, Zolicef) prophylaxis and systemic hypersensitivity. Use
infections caused by cautiously in patients
susceptible bacteria hypersensitive to penicillins,
cefamycins, carbapenems,
etc.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Cefovicin Pg. 171-172 SQ Long-acting Cephalosporin Do not use in animals with a

(Convenia) Plumbs Treatment of skin infections known allergy to this drug or
caused by Staph and Strep in other beta-lactam antibiotics.
dogs and Pasteurella in cats Anaphylaxis has been
reported and use with caution
in patients with renal
dysfunction

Cefpodoxime Pg. 174-175 PO 3rd Generation Cephalosporin Do not use in patients who
proxetil Plumbs -- Treatment of skin infections are hypersensitive to this
(Simplicef, caused by Staph, Strep, and drug and use cautiously in
Vantin) Pasteurella in dogs patients with seizure
disorders. The dosage may
need to be adjusted for
patients with diminished
renal function due to
excretion of the drug by the
kidneys
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Ceftiofur Pg. 240 IM or SQ Antibiotic Used in swine for Do not use in animals used
(Naxcel) Wanamaker respiratory disease and cattle for human consumption and
for bovine respiratory make sure to follow
disease, shipping fever and withdrawal times.
pneumonia. Dairy cattle it
can treat subclinical mastitis.
Sheep, goats and horses for
pneumonia and dogs for
urinary tract infections.

Cephalexin Pg. 188-189 PO 1st generation Cephalosporin Do not use in patients who
(Keflex) Plumbs Used in dogs, cats, horses, are hypersensitive to this
rabbits, ferrets and birds for drug or beta-lactam
susceptible Staphylococcus antibiotics and do not use
infections orally in patients with
septicemia, shock or other
grave illnesses.

Charcoal, Pg. 193-194 PO Oral adsorbent Used to Do not use for mineral acids,
activated Plumbs adsorb drugs or GI toxins to caustic alkalies, ethanol,
(Toxiban) prevent or reduce their methanol or iron salts
systemic adsorption because it cant absorb these
and will obscure GI lesions
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Chlorambucil Pg. 195-196 PO Immunosuppressant/ Do not use this drug in

(Leukeran) Plumbs Antineoplastic Used in patients who are
neoplastic diseases like hypersensitive to it and use
lymphocytic leukemia. Can with caution in patients with
also be used in adjunctive preexisting bone marrow
therapy for immune- depression or infection
mediated conditions or as
routine treatment for severe
feline eosinophilic granuloma
complex

Chloramphenico Pg. 198-199
l (Chloromycetin, Plumbs
Duricol, Viceton)
PO, IM, SC, IV Broad-spectrum antibacterial Can not be used in animals
used to treat a variety of that will be used in food
infections in small animals production due to FDA bans.
and horses Do not use in patients with
hematologic abnormalities,
hepatic failure, or neonatal
animals

Chlorothiazide Pg. 203-204 PO Thiazide diuretic General Do not use in pregnant

(Diruil) Plumbs diuretic or edema treatment females, severe renal disease
as well as systemic or preexisting electrolyte or
hypertension, nephrogenic water balance abnormalities,
diabetes insipidus and to impaired hepatic function,
prevent recurrence of hyperuricemia, lupus, or
calcium oxalate uroliths in diabetes mellitus.
dogs
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Chlorphenerami Pg. 205-206 PO Antihistamine Help reduce Do not use in patients

ne maleate Plumbs or prevent histamine hypersensitive to it and use
(Chlor-Trimetron) mediated adverse effects and with caution in patients with
especially in cats for pruritus. angle closure glaucoma,
Also can be a mild sedative in prostatic hypertrophy,
small animals because of its pyloroduodenal or bladder
CNS depressant effects neck obstruction, COPD,
hyperthyroidism,
cardiovascular disease or
hypertension
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Chlorpromazine Pg. 207-208 IV, IM or SC Phenothiazine Inhibits emetic effects of

(Thorazine) Plumbs sedative/antiemetic Can be morphine in the dog and will
use as a preoperative cause severe muscle
medication and tranquilizer. discomfort if injected IM in
Also is a antiemetic or a rabbits. Do not use in horses
treatment for motion or inject into arteries. Dont
sickness in cats. use in patients with
hypovolemia or shock. Use
cautiously in patients with
hepatic dysfunction, cardiac
disease or general
debilitation. Make sure to be
cautious using this as a
restraining agent in
aggressive dogs due to its
effects of making the animal
more jumpy to noise or
sensory inputs.

Ciprofloxacin Pg. 217-218 PO or IV Fluoroquinolone antibiotic Do not use in small or

(Cipro) Plumbs Use as an alternative to medium dogs between 2-8
enrofloxacin if large doses months old because of
are needed and treats cartilage abnormalities. Make
against gram-negative sure to keep the patient
bacteria hydrated during use or it may
cause crystalluria
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Cisplatin Pg. 221-222 IV (dogs) or Antineoplastic mainly used Do not use in cats because of
(Platinol-AQ) Plumbs Intralesional in dogs to treat neoplastic pulmonary toxicity or in
injection diseases (carcinomas and patients with renal
(horses) sarcomas) and neoplastic impairments,
pulmonary effusions as well myelosuppression or
as skin tumors in horses hypersensitivity to this drug.
Use with caution in patients
with CHF

Clavamox Pg. 243 PO or Drops Antibiotic Treatment of Allergic reactions and GI

(Amoxicillin- Wanamaker urinary tract, skin and soft upset can occur. Do not use
clavulanic acid) tissue ifnections in dogs and in rabbits or guinea pigs
cats as well as canine
peridodontal disease,
bacterial cystitis in female
dogs

Clemastine Pg. 227-228 PO Antihistamine Treatment for Dont use if patient is

(Tavist) Plumbs histamine related allergic hypersensitive to this drug.
conditions Use with caution in patients
with prostatic hypertrophy,
bladder neck obstruction,
severe cardiac failure, angle-
closure glaucoma or
pyeloduodenal obstruction
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Clindamycin Pg. 230-231 PO, IV, IM, SC Lincosamide antibiotic Used Do not use in rabbits,
(Antirobe, Cleocin) Plumbs in dogs and cats for wounds, hamsters or chinchillas,
abscesses and osteomyelitis guinea pigs, horses or
caused by Staph or protozoal ruminants because of GI
infections. effects, as well as those who
are hypersensitive to this
drug. Make sure patient
doesnt have corneal ulcer.
Could cause esophageal
strictures in small animals
and do not dry pill animals.
Caution if patient has renal or
haptic disease or is neonatal.

Clomipramine Pg. 235-236 PO Tricyclic antidepressant Do not use if sensitive to this

(Clomicalm, Plumbs used in dogs and cats for
Anafranil) obsessive compulsive
disorders or behavioral
disorders. Also can treat
feather picking in birds or decreased GI motility, urinary
urine spraying specifically in
cats.
drug or if also using
monoamine oxidase
inhibitors. Use cautiously if
patient has seizure disorders,
retention, cardiac rhythm
disturbances, increased
intraocular pressure,
hyperthyroidism or those
using thyroid medication.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Corticotropin Pg. 251-252 IM Hormonal diagnostic agent Do not administer the gel
(ACTH) Plumbs Used in dogs, cats and cattle form IV or use the gel form in
for stimulation of the adrenal patients hypersensitive to
(Acthar) cortex to release cortisol porcine proteins
when there is deficiency of
ACTH. Can be used to
diagnose
hypoadrenocorticism and
Cushings syndrome

Cosequin CVP PO Joint Supplement Maintains Do not feed to cattle or other

the structure of the cartilage ruminants
and helps support joints and
mobility in canines, felines
and equines

Cosyntropin Pg. 255 IV or IM Hormonal diagnostic agent Do not use if patient is

(Cortrosyn, Plumbs Used as an alternative to hypersensitive to this drug or
Synacthen) ACTH to test for who have shown sensitivity
adrenocortical insufficient or to ACTH before
hyperadrenocorticism

Cyanocobalamin Pg. 257-258 SC Vitamin Used to treat Very safe drug; only use as
(Vitamin B12) Plumbs deficiencies of vitamin B12 an injection
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Cyclophospha- Pg. 259-260 PO Immunosuppressive/ Do not use in patients with

mide Plumbs Antineoplastic Used in dogs
(Cytoxan, Neosar) and cats as an antineoplastic
or immunosuppressant as
well as to treat immune-
mediated hemolytic anemia.
Can also be used as a
chemical shearing agent in
sheep
prior anaphylaxis. Use
caution in patients with
leukopenia,
thrombocytopenia, previous
radiotherapy, impaired
hepatic or renal function or
severe immunosuppression

Cyclosporine Pg. 262-264 PO Immunosuppressive Used Do not use in patients

(Atopica, Neoral, Plumbs as a suppressor for immune hypersensitive to this drug or
Sandimmune) mediated diseases and to dogs with malignant
help reduce rejection of neoplasia history. Use
allografts in transplant cautiously in patients with
medicine in dogs and cats. hepatic or renal disease.
Increases tear production and Check cats FeLV and FIP
eliminates dryness in KCS status before use.

Cystorelin CVP IV or IM Hormone Treatment of Do not use in humans

(Gonadorelin ovarian follicular cysts in
diacetate dairy cattle.
tetrahydrate)
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Cyproheptadine Pg. 266-267 PO Antihistamine Used as an Do not use in patients

(Periactin) Plumbs appetite stimulant in cats
and an
antipruritic/antihistamine in
dogs and cats. Can be used
in horses for photic head
shaking or Cushings. May
treat serotonin-syndrome in
small animals
hypersensitive to this drug.
Use with caution in patients
with prostatic hypertrophy,
bladder neck obstruction,
severe CHF, angle-closure
glaucoma or pyeloduodenal
obstruction

Deracoxib Pg. 283-285 PO NSAID Treat post-operative Do not use in patients

(Deramaxx) Plumbs pain in dogs and pain and hypersensitive to this drug.
inflammation associated with Use with caution in patients
osteoarthritis. with GI ulcerative diseases,
renal or hepatic dysfunction,
patients in hypoproteinemic
states or conditions that will
predispose them to
hypercoagulability

Dormosedan https://valleyv Sublingual Alpha 2 agonist Used for Do not allow the horse to
(Detomidine et.naccvp.com sedation and restraint in swallow the gel and make
hydrochloride) /product/view/ horses sure there is no feed in the
basic/3690256 patients mouth. Dont use if
? patient has AV or SA block,
u=country&p respiratory disease or chronic
=msds renal failure.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Desoxycortico- Pg. 290 IM or SC Mineralocorticoid Parenteral Do not use in dogs with CHF,
sterone pivalate Plumbs treatment of Addisons in severe renal disease or
(Percorten-V) dogs and can be used extra edema. Do not administer IV
label in cats because acute collapse and
shock may occur

Dexamethasone Pg. 293-295 IV, IM, PO or Glucocorticoid Used to Do not use alone to treat
(Dexamethasone Plumbs ophthalmic replace glucocorticoid adrenal insufficiency and
sodium activity in patients with dont administer rapidly IV.
phosphate) adrenal insufficiency, anti- May cause GI complications
inflammatory agent and and bleeding in dogs and
(Azium, immunosuppressive for many dont use on fungal
Dexasone) different diseases and infections. Use cautiously in
disorders cats at risk for diabetes
mellitus or with
cardiovascular disease due to
the potent hyperglycemic
effect.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Dexmedetomidi Pg. 298-299 IV or IM Tranquilizer/Alpha 2 May be painful at the

ne Plumbs adrenergic antagonist injection site and Atropine is
(Dexdomitor) sedation and analgesia in not recommended due to
dogs and cats, good for potential for more serious
minor procedures and arrhythmias. Do not use if
outpatient appointments. patient has cardiac disease,
liver or kidney disease,
shock, severe debilitation or
high stress. Caution when use
on patients with seizure,
respiratory, renal or kidney
disorders.

Diazepam Pg. 304-305 Rectally, IV or Tranquilizer (Benzodiazepine) Do not use if hypersensitive

(Valium, Vazepam, Plumbs PO Sedation, relief of anxiety to benzodiazepines or
Diastat) and behavioral disorders, cats with significant
treatment of seizures, liver disease. Inject IV
appetite stimulant and slowly and use with
injectable anesthetic (in caution in cats and
combination with Ketamine) patients with hepatic or
renal disease,
aggressive behavior,
Dichlorophen Pubchem Topical Dewormer Used to treat Can produce colic and nausea
(Daranide) tapeworm infections
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Diethystilbestro Pg. 317-318
l Plumbs
(DES)
PO Hormonal agent Used in Do not use in food production
estrogen responsive animals (FDA banned). Use
incontinence in spayed with extreme caution in
female dogs and treatment patients with anemia or
for benign prostatic leukopenia. Do not use in
hypertrophy in male dogs. females with estrogen-
Can prevent pregnancy after sensitive neoplasms or
mismating female dogs and pregnant females.
cats

Digoxin Pg. 320-322 PO or IV Cardiac glycoside used to Do not use in cats with
(Lanoxin, Plumbs treat CHF, atrial fibrillation hypertrophic cardiomyopathy
Cardoxin) and supraventricular or patients with ventricular
tachycardias fibrillation or digitalis
intoxication. Use with caution
in patients with IHSS or
severe pulmonary diseases
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Diltiazem Pg. 326-327 PO or IV Antiarrhythmic drug/Calcium Do not use in patients with

(Cardizem, Dilacor Plumbs channel blocker Class IV severe hypotension, sick
XR) Channel blocker that permits sinus syndrome, AV block,
entry of calcium ions. acute MI, radiographically
Treatment of hypertension, documented pulmonary
atrial fibrillation and congestion or if they are
supraventricular tachycardias hypersensitive to it. Use with
as well as feline hypertrophic caution in geriatric patients
cardiomyopathy and other with heart failure.
Administer over 2 min if
given IV.

Dioctyl calcium Veterinary PO Surfactant Stool softener in Do not use if any GI

Sulfosuccinate Pharmacology animals complications
(Docusate
calcium)

Dobutamine Pg. 346-347 IV Beta Adrenergic Inotropic Dont use in patients

(Dobutrex) Plumbs (sympathomimetic) agents/ hypersensitive to the drug or
Catecholamine Short-term with idiopathic hypertrophic
Veterinary treatment of heart failure. sub aortic stenosis (IHSS).
Pharmacology Also used in shock patients Use with extreme caution in
when fluid therapy hasnt patients with ventricular
restored acceptable arterial tachyarrythmias or atrial
blood pressure, cardiac fibrillation.
output or tissue perfusion
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Dopamine Pg. 352-353 IV Adrenergic Do not use in patients with

(Intropin) Plumbs (sympathomimetic) agent
Dose-dependent, used to
treat shock and congestive
heart failure and to increase
renal perfusion
Catecholamine
pheochromocytoma,
ventricular fibrillation or
uncorrected
tachyarrhythmias. Use with
caution in patients with
ischemic heart disease or
occlusive vascular disease.
Discontinue the drug if
arrhythmias occur.

Doxorubicin Pg. 359-361 IV Antineoplastic Treatment of Do not use in patients with

(Adriamycin, Plumbs lymphomas, carcinomas, myelosuppression impaired
Doxil) leukemia and sarcomas in cardiac function or cats with
dogs and cats renal insufficiency. Use with
caution in patients with
hyperuricemia or impaired
hepatic function.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Doxycycline Pg. 362-364 PO Tetracycline antibiotic Do not use in patients

(Vibramycin) Plumbs Treatment of a variety of hypersensitive to this drug
infections such as Lyme and make sure to only use
Disease, Heartworm disease, during the second half of
Borrelia, Leptospira, pregnancy when benefits
Rickettsiae, Chlamydia, outweigh fetal risk. Do not
Mycoplasma, Bartonella and administer parenteral in
Bordetella horses. Permanent staining of
the teeth will occur if patient
does not have permanent
teeth or is a pregnant female.

Enalapril Pg. 371-372 PO or injection Vasodilator/ Ace inhibitor -- Do not use in patients who
(Enacard, Plumbs form Treatment of heart failure by are hypersensitive to ACE
Vasotec) vasodilation. May also help in inhibitors and use with
treatment of valvular disease caution in patients with renal
insufficiency

Enrofloxacin Pg. 375-276 PO or IV Fluoroquinolone/antibiotic Can not use in food animals

(Baytril) Plumbs Treats a variety of pathogens and do not use in young,
but is not effective against growing animals. Caution use
anaerobes. in patients with hepatic or
renal insufficiency or
dehydration. Do not give
rapidly if IV injection in
horses
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Ephedrine Pg. 379-380 PO or IV Adrenergic Do not use in patients with

(Vatronol) Plumbs (sympathomimetic) agent severe cardiovascular
bronchodilation and can also disease, especially
treat shock or anesthesia arrhythmias. Use cautiously if
related hypotension. Used to patient has glaucoma,
treat urethral sphincter prostatic hypertrophy,
hypotonus hyperthyroidism, diabetes
mellitus, or hypertension.

Epinephrine Pg. 381-382 IC, intratracheal, Adrenergic Do not use in patients with
(Adrenalin) Plumbs IV, SC (sympathomimetic)/ narrow-angle glaucoma,
Vasopressor- Increases heart hypersensitivity to this drug,
rate and cardiac output, shock, anesthesia with
constriction of the blood halogenated hydrorcarbons,
vessels in skin, dilation of the during labor, cardiac dilation
blood vessels in muscle, or coronary insufficiency. Use
dilation of bronchioles and an with extreme caution in
increase in metabolic rate. patients with prefibrillatory
Catecholamine cardiac rhythm

Eprinomectin Pg. 386-387 Topical Antiparasitic agent Do not give orally or IV

(Ivomec, Eprinex) Plumbs treatment in cattle for a
variety of GI roundworms,
lice, mites, and lungworms as
well as mange in horses and
ear mites in rabbits
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Erythropoietin Pet Place IV or SQ Hematinics/Hormone Allergic reactions can occur

Treatment of anemia because of this being a
(Epogen, associated with chronic renal human coded protein
Procrit) failure in dogs and cats

Epsiprantel Pg. 387 PO Cestocidal antiparasitic agent To not use in puppies or

(Cestex) Plumbs Treatment of Dipylidium kittens that are less than 7
caninum and Taenia weeks old
pisiformis in dogs and
Dipylidium caninum and
Taenia taeniaeformis in cats

Erythromycin Pg. 390-392 PO or IM Macrolide antibiotic Do not use in rabbits, gerbils,

(Gallimycin) Plumbs Treatment of infections by guinea pigs and hamsters.
susceptible organsisms in Use in caution with horses
swine,s heep and cattle. greater than 4 months old.
Usually used if patient is
hypersensitive to penicillin.
Can be used as a prokinetic
agent to increase gastric
emptying in dogs and cats

Estradiol Pg. 395-396 IM Hormonal agent (Estrogen) Can not use in food producing
cypionate Plumbs Used to induce estrus or treat animals due to FDA bans. Do
(ECP) estrogen responsive not use in during pregnancy
incontinence or treat estrogen
incontinence in small
animals. Do not use in ferrets
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Etodolac Pg. 401-402 PO NSAID Used to manage pain Do not use in patients
(EtoGesic, Lodine) Plumbs and inflammation due to hypersensitive to this drug
arthritis in dogs and use with caution in dogs
with occult GI, hepatic,
cardiovascular or
hematologic abnormalities.

Famotidine Pg. 407-408 PO, SC, IM, IV H2-receptor antagonist
(Pepcid) Plumbs Treatment of gastric,
abomasal and duodenal
ulcers, uremic gastritis,
stress related or drug
induced erosive gastritis,
esophagitis, duodenal gastric
reflux and esophageal reflux
Do not use in patients
hypersensitive to H2 blockers
and use with caution in
geriatric patients or those
with impaired hepatic, renal
function, or cardiac disease

Feliway CVP Diffuser Pheromone Provides a Do not place under furniture

calming effect for felines and or plug in with wet hands
eases anxiety
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Fenbendazole Pg. 414-415 PO Antiparasitic agent Used as Not allowed to use on horses
(Panacur, Safe- Plumbs a removal of parasites in meant for food production
Guard) dogs suck as hookworms,
whipworms and tapeworms.
Also can remove parasites in
cattle, horses, swine, cats,
sheep, goats, pet birds and
llamas

Fentanyl Pg. 417-418 IV or Opioid agent 100 times the Do not use in patients
(Sublimaze, Plumbs transdermal analgesic properties of hypersensitive to it and use
Duragesic) patch morphine. Transdermal cautiously with other CNS
patches available for post depressants. Be cautious with
operative pain and control of geriatric, very ill, debilitated
severe and chronic pain or respiratory problem
patients

Firocoxib Pg. 425-427 PO Cox-2 inhibitor NSAID Used Do not use in patients
(Previcox, Plumbs to control pain and hypersensitive to it or other
Equioxx) inflammation due to NSAIDs. Use with caution in
osteoarthritis in dogs and patients with renal, hepatic or
cats as well as post op pain cardiovascular dysfunction or
and inflammation in dogs if they are dehydrated,
hypovolemic, hypotensive or
on concomitant diuretic
therapy. Do not use in dogs
with GI ulcerations or
bleeding disorders
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Fluazuron/ Novartis PO Anti-parasitic Insect Growth Wear gloves when

Ivermectin Regulator that inhibits the administering and follow
(Acatak tick life cycle and controls withdrawal times
Duostar) ticks on cattle. Can also treat
roundworms, lungworms, lice
and mites

Fluconazole Pg. 430-431 IV or PO Antifungal Treatment of Do not use in patients

(Diflucan) Plumbs systemic mycoses, CNS hypersensitive to this drug or
infections or fungal urinary those with hepatic
tract infections impairments. Do not use in
budgerigars

Flunixin Pg. 438-440 IV, SC, or IM NSAID Used to alleviate Do not use in animals
meglumine Plumbs inflammation in horses due hypersensitive to this drug
(Banamine) to musculoskeletal disorders and dont administer IM to
and colic. Controls pyrexia in cattle unless IV route is not
cattle and swine. Used for accessible.
visceral pain in ruminants
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

5-Fluorouracil Pg. 441-442 IV Antineoplastic agent Do not use in any form on

(Adrucil) Plumbs Chemotherapeutic agent cats patients that are
used for canine mammary hypersensitive to it, are in a
carcinoma, dermal squamous poor nutritional state or have
cell carcinoma in GI tract depressed bone marrow or
tumors. Can be used with infections
epinephrine for skin
neoplasms in horses

Fluoxetine Pg. 443-444 PO Selective serotonin-reuptake Do not use in patients

(Prozac, Plumbs inhibitor (SSRI) Used in hypersensitive to it or those
Reconcile) dogs and cats for aggression taking MAOIs. Dont use in
or aforementioned behaviors. patients with diabetes
Also used for canine mellitus or seizure disorders.
separation anxiety

Furosemide Pg. 454-456 PO, IV, or IM Loop Diuretic -- Do not use in patients with
(Lasix) Plumbs Works rapidly to reduce anuria, those with depleted
pulmonary edema and other electrolytes or patients
signs of CHF (ascites and hypersensitive to the drug.
coughing). Animals will Use caution in patients with
urinate within 20-30 minutes. pre-existing electrolyte or
Used in racehorses to water balance abnormalities,
prevent or reduce EIPH impaired hepatic function and
diabetes mellitus
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Gabapentin Pg. 457-458 PO Anticonvulsant/neuropathic Use with caution in patients

(Neurontin) Plumbs pain analgesic Used in dogs with diminished renal
and cats as adjunctive function or those
therapy for refractory or hypersensitive to it
complex partial seizures and
chronic pain

Gamithromycin Zactran.com SQ Antibiotic Used to treat Dairy cattle can have growth,
(Zactran) Bovine Respiratory Disease in fertility and milk problems for
cattle life

Gentamicin Pg. 462-464 IV, SC, IM Aminoglycoside antibiotic Do not use in rabbits or
(Gentocin, Plumbs Treatment for gram-negative patients hypersensitive to it
Garamycin) infections and use cautiously in patients
with preexisting renal
disease, working dogs, or
those with neuromuscular
disorders. May cause muscle
irritation if given IM in horses
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Glipizide Pg. 467-468 PO Sulfonylurea antidiabetic Do not use PO if the patient

(Glucotrol) Plumbs agent Treatment for cats has severe burns, trauma,
with Type II diabetes infection, diabetic coma,
major surgery, ketosis, or
ketoacidosis. May become
ineffective after weeks or
months of use and insulin will
be needed

Glucosamine Pg. 473-474 PO Nutritional supplement Do not use in animals that

chondroitin Plumbs Used to treat osteoarthritis or are hypersensitive to this
sulfate other painful conditions in drug
(Cosequin) horses, cats and dogs. Could
be useful in cats with FLUTD

Glycopyrrolate Pg. 479-480 IV, IM, SC Cholinergic blocking agent Do not use in pregnant
(Robinul-V) Plumbs (anticholinergic) used as a animals or those
preanesthetic and has similar hypersensitive to this drug.
action to atropine but lasts Use with caution in patients
longer. Also used to treat with GI infections or those
sinus bradycardia, sinoatrial with autonomic neuropathy,
arrest and incomplete AV CHF, hepatic or renal disease
block
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Griseofulvin Pg. 486-487 PO Antifungal agent Used in Do not use in patients

(Fulvicin) Plumbs dogs and cats to treat hypersensitive to it or with
dermatophytic fungal hepatocellular failure. Also
infections of skin, hair and can not be used animals
claws as well as ringworm in intended for food or pregnant
horses. animals.

Hemoglobin Pg. 492-493 IV Semi-synthetic hemoglobin Do not use in dogs with

glutamer Plumbs replacer/Colloid Used to advanced cardiac disease,
(HG-200, HBOC- treat dogs with anemia or renal impairment, DIC,
301, Oxyglobin) used extra label in cats or thrombocytopenia,
foals for neonatal hemoglobinemia,
isoerythrolysis hemoglobinuria or
autoagglutination. Do not
volume overload cats

Hetastarch FDA IV Colloid Plasma volume Do not use in critically ill

(Hydroxyethyl) expander to provide adult patients or those with
electrolytes during loss renal problems
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Hydralazine Pg. 498-500 PO or IV Vasodilator -- Do not use in patients who

(Apresoline) Plumbs Reduces afterload especially are hypersensitive to this
caused by mitral valve drug or those with
insufficiency and helps hypovolemia, coronary artery
hypertension disease or preexisting
hypotension. Use cautiously
in patients with renal disease
or those with intracerebral
bleeding

Hydrocortisone Pg. 505-506 IV Glucocorticoid Used to Do not use if patient has

(Cortef, Solu- Plumbs replace glucocorticoid
Cortef) activity with adrenal
insufficiency, anti-
inflammatory agent and
immunosuppressive
systemic fungal infections or
in patients hypersensitive to
this drug

Hydroxyzine Pg. 516-517 PO or IM Antihistamine used as an Do not use in patients

(Atarax, Vistaril) Plumbs antihistamine, antipruritic, hypersensitive to it and use
and sedative/tranquilization with caution inpatients with
prostatic hypertrophy,
bladder neck obstruction,
severe cardiac failure, angle-
closure glaucoma or
pyeloduodenal obstruction
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Ibuprofen Pg. 305 PO NSAID -- Used in dogs for Do not use in dogs unless
(Motrin, Advil) Wanamaker analgesia, reduce swelling recommended by
and lower fever. Also treats veterinarian. Phenobarbital
arthritis and musculoskeletal may reduce the drugs half
pain life. Do not use in cats!

Imidacloprid/ Pg. 287-288 Topical Antiparasitic Flea control Dot not use on kittens
Flumethrin Wanamaker and kills the adult fleas for up younger than 8 weeks or
to 4 weeks puppies under 7 weeks. Do
not use in pregnancy animals

Imipramine Pg. 525-526 PO Tricyclic antidepressant Do not use with monoamine

(Tofranil) Plumbs Used to treat cataplexy and oxidase inhibitors or patients
urinary incontinence. Can who are hypersensitive to it
treat narcolepsy and
ejaculatory dysfunction in
horses

Indoxacarb https://valleyv Topical Antiparasitic Monthly flea Do not use on puppies under
(Activyl) et.naccvp.com and tick treatment for 8 weeks of age. Do not use
/product/view/ canines on cats or allow pet to ingest
basic/1047499
?
u=country&p
=msds
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Insulin,regular Pg. 530-531 IV, IM, SC Hormone Adjunctive Do not use if hypoglycemic or
Plumbs treatment of diabetic hypersensitivity develops and
ketoacidosis (DKA), diabetes dont inject in the same spot
mellitus and hyperkalemia. every single day
Used in dogs and cats mainly
to regulate diabetes

Insulin, NPH, https://valleyv SQ Porcine Insulin Zinc Do not use in animals allergic
Ultralente, or et.naccvp.com Suspension Reduces to pork products or during
PZI /product/view/ hyperglycemia in dogs and hypoglycemia. Consult vet
(Vetsulin) basic/1047430 cats with diabetes mellitus before using in puppies or
? kittens
u=country&p
=msds

Interferon Pg. 536-537 PO, SC Immunomodulator Only use if the risks are less
(Roferon-A, Intron- Plumbs Treatment of a variety of than the benefits if injected
A) virus-induced diseases in parenterally in autoimmune
cats. Sometimes used in disease, severe cardiac or
dogs as an adjunctive pulmonary disease, CNS
treatment for neoplastic disorders or diabetes patients
diseases

Ipecac syrup Notes PO Emetic induces vomiting Cardiotoxic in dogs at high

within 10-30 minutes and can doses and use with caution in
be used in dogs and cats animals with a preexisting
heart condition
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Iron Pg. 545-546 IM Hematinic Used to treat Do not use in patients

Plumbs prophylaxis of iron deficiency hypersensitive to this drug ot
anemias in neonatal food those with anemia, acute
producing animals renal infections or if used
with an oral iron supplement.
If used IM in pigs after 4
weeks old it may cause
muscle tissue staining

Isoflurane Pg. 549-550 Inhaled General anesthetic primary Do not use in patients with
(Isoflo, Iso-Thesia) Plumbs inhalant anesthetic that can malignant hyperthermia or
safely be used in patients those with increased CSF or
with hepatic or renal disease head injury. Not
recommended in mask
induction

Isoproterenol Pg. 552-553 IV Catecholamine/ Adrenergic Do not use in patients with

(Isuprel) Plumbs agonist Atropine resistant tachycardia, AV block, or
bradycardia and can be used ventricular arrhythmias. Use
to treat cardiac disease and cautiously in patients with
acute bronchial constriction coronary insufficiency,
hyperthyroidism, renal
disease, hypertension or
diabetes
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Itraconazole Pg. 558-560 PO Antifungal Treatment of Do not use in patients

(Sporanox) Plumbs systemic mycoses and hypersensitive to it or other
specifically sporotrichosis in azole antifungal agents. Use
horses with caution in patients with
reduced cardiac function and
those with hepatic
impairment

Ivermectin Pg. 562-564 PO Antiparasitic Prevents
(Heartgard, Plumbs heartworms in dogs and cats.
Ivomec) Used in horses to control
strongyles, pinworms,
ascardis, hairworms, stomach
worms, lungworms, etc.
Treatment of GI roundworms,
lungworms, sucking lice and
mites, etc. in cattle and
swine.
Do not use in foals less than
4 months old, puppies less
than 6 weeks old, chelonian,
snakes and skinks. Not FDA
approved in lactating diary
animals or females of
breeding age

Kaopectate CVP PO Antidiarrheal Used to treat Do not use if GI complications

(Kaolin/Pectin) diarrhea and gastroenteritis are present. Use with caution
in beef and dairy cattle, cats, in dogs receiving aspirin
dogs and horses
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Ketamine HCl Pg. 568-570 IM or IV Dissociative Agent Ophthalmic lubrication

(Ketaset, Vetalar, Plumbs Approved for human use,
Ketalarm Ketaflo) primates, and cats.
Extralabel use in dogs,
horses, etc. Sedation,
restraint and anesthesia.
Class III controlled substance
and commonly combined
with acepromazine, xylazine
and diazepam to increase
muscle relaxation.
needed! Do not use in
patients who are
hypersensitive, animals used
for human consumption,
head trauma patients or in
surgeries involving main
respiratory structures. Could
be harmful to patients with
hypertension, heart failure,
arterial aneurysms, hepatic
or renal insufficiency. Do not
use alone for major surgery

Ketoconazole Pg. 573-575 PO Azole antifungal Treatment Do not use in patients

(Nizoral) Plumbs of fungal infections in dogs, hypersensitive to this drug or
cats and other small species. those with hepatic disease or
Also used to treat thrombocytopenia
hyperadrenocorticism in dogs

Ketoprofen Pg. 578-579 IM, IV, SC, PO NSAID Used in horses and Use only when benefits
(Ketofen, Anafen) Plumbs dogs to alleviate outweigh the risks in patients
inflammation and pain with GI ulceration or bleeding
associated with as well as renal or hepatic
musculoskeletal disorders. impairment
Short term analgesic in cats
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Lactated CVP SQ or IV Crystalloid Used for Do not administer calcium

Ringers electrolyte and fluid containing solutions with
solution replacement or an whole blood. Not for the use
(LRS) alkalinizing agent. Help of Lactic Acidosis
rehydrate patients

Lactulose Pg. 582-583 PO Disaccharide May alter the insulin

(Cephulac) Plumbs laxative/ammonia reducer requirements in diabetic
Used to reduce ammonia patients. Use cautiously in
blood levels in the prevention patients with preexisting fluid
and treatment of hepatic and electrolyte imbalances
encephalopathy in small
animals and pet birds. Also a
laxative in small animals

Levamisole Pg. 591-593 PO Antiparasitic/immune Do not use in lactating

(Levasole, Plumbs stimulant Used to treat animals or renal and hepatic
Tramisol) nematodes in cattle, sheep, impairment patients. Use
goats, swine, poultry cautiously in cattle that are
stressed due to vaccination,
dehorning or castration.
Dont administer IM to birds
or use as a dirofilarial
adulticide
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Levothyroxine Pg. 596-597 PO Thyroid hormone Treatment Do not use in patients with
sodium Plumbs of hypothyroidism in all acute myocardial infarction,
(Soloxine, species thyrotoxicosis or untreated
Synthroid) adrenal insufficiency. Use
cautiously in patients with
hypoadrenocorticism, cardiac
disease, diabetes or geriatric
patients

Lidocaine Pg. 599-600 IV or topical Antiarrhythmic drug/Local Do not use the product
(Xylocaine) Plumbs anesthetic Class IB containing epinephrine IV.
Control of PVCs and Cats are more sensitive to
treatment of ventricular CBS and cardio depressant
tachycardia. Prevents post effects. Dont use in patients
operative ileus and hypersensitive to it or with a
reperfusion injury in horses. severe degree of SA, AV or
Local and topical anesthetic intraventricular heart block

Diphenoxylate Pg. 341-342 PO Opioid agent/anticholinergic Controversial in cats.

(Lomotil) Plumbs antidiarrheal agent usually in Oxymorphone is the reversal.
dogs. Also has antitussive Use with caution in patients
properties with hypothyroidism, severe
renal insufficiency,
adrenocortical insufficiency,
respiratory disease and
geriatric patients
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Loperamide Pg. 609-610 PO Opioid agent antidiarrheal Controversial in cats.

(Imodium) Plumbs agent in small animals Oxymorphone is the reversal.
Use cautiously in patients
with hypothyroidism, severe
renal insufficiency,
adrenocortical insufficiency,
head injuries, respiratory
disease and geriatric patients

Lufenuron Pg. 612-613 PO Chitin synthesis inhibitor Do not use the cat product in
(Program, Plumbs use in dogs and cats 6 weeks dogs or vise versa!
Sentinel) and older for flea and
heartworm prevention,
control of adult hookworms
and removal of adult
roundworms and whipworms

Lufenuron + Pg. 288 PO Antiparasitic Monthly flea Do not use in puppies or

milbemycin Wanamaker control which is absorbed kittens younger than 6
oxime into the bloodstream. Also weeks. Make sure to give
(Sentinel) prevents heartworms and with food
some intestinal parasites in
dogs

L-lysine Pg. 614-615 PO Nutritional amino acid None

Plumbs suppressive for FHV-1
infections in cats
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Lutalyse https://valleyv SQ or IM Prostaglandin Used to Do not use in horses or

(Dinoprost et.naccvp.com synchronize the estrus cycle swine. Women handling this
tromethamine /product/view/ in beef and dairy cattle, drug should be careful
injection) basic/3690512 pyometra in cattle and especially if expecting
? abortion in feedlot pregnancy. Do not administer
u=country&p IV
=msds

Magnesium Pg. 615-616 PO Antacid/laxative adjunctive Do not use in patients with

Hydroxide Plumbs treatment of esophagitis, renal disease, those with
gastric hyperacidity, peptic electrolytes restricted in their
ulcer and gastritis. Laxative diet, or those with gastric
in small animals and outlet obstruction
increases rumen pH in
ruminants

Magnesium Pg. 617-618 IV or PO Electrolyte used in Do not use in patients with

sulfate Plumbs magnesium deficient states myocardial damage or heart
or for adjunctive therapy of block. Use with caution in
malignant hyperthermia and patients with impaired renal
anticonvulsant in swine function
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Mannitol Pg. 620-621 IV Osmotic diuretic Promote
(Osmitrol) Plumbs diuresis in acute oliguria
renal failure, reduce
intraocular and intracerebral
pressures and enhance
urinary excretion of some
toxins
Do not use in patients with
anuria secondary to renal
disease, severe dehydration,
pulmonary congestion or
pulmonary edema. Use
cautiously when treating
ethylene glycol toxicity or in
hypovolemic patients

Marbofloxacin Pg. 623-624 PO Fluoroquinolone Antibiotic Do not use small and medium
(Zeniquin) Plumbs Treats susceptible bacterial breed dogs up to 8 months of
infections in dogs and cats age, large breed up to 12
months and giant breeds up
to 18 months. Do not use in
cats under 12 months of age
of patients hypersensitive to
this drug. Use with caution if
patient has seizure disorders.
Can not use in food producing
animals

Maropitant Pg. 624-625 SC or PO Neurokinin receptor Use with caution in dogs with
(Cerenia) Plumbs antagonist antiemetic hepatic dysfunction, with
Prevention and treatment of other meds that are highly
acute vomiting in dogs or protein bound, and puppies
motion sickness. Used extra- less than 11 weeks old
label in cats
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Meclizine Pg. 629-630 PO Antihistamine/antiemetic Do not use in patients that

(Antivert) Plumbs Used in small animals as an are hypersensitive to it or
antiemetic and prevention of those with prostatic
motion sickness hypertrophy, bladder neck
obstruction, severe cardiac
failure, angle-closure
glaucoma or pyeloduodenal
obstruction

Meclofenamic Wedgewood PO NSAID Used to treat acute Use with caution if renal, liver
acid and chronic inflammation, or GI problems and if using
(Arquel) soft tissue injury and with aspirin or corticosteroids
laminitis in horses

Melarsomine Pg. 640-641 IM Arsenical antiparasitic Do not use in dogs with Class
(Immiticide) Plumbs Treatment of class I, II and III IV heartworm disease or cats.
heartworm disease cause by Do not give IV to SC due to
mature and immature adult toxic tissue damage and have
infections in dogs. Also treats dog cage rest after
ferrets administration

Meloxicam Pg. 643-644 PO, IV, SC NSAID Treatment of Do not use in dogs
(Metacam) Plumbs osteoarthritis in dogs and hypersensitive to it or those
short term control of post op less than 6 months. Caution
pain and inflammation in cats in patients with hepatic,
(orthopedic, OHE and cardiac or renal issues
castrations)
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Meperidine Pg. 648-649 IM, SC Opiate agonist Analgesic in Do not use if patient is
(Demerol, Plumbs many species and sedative hypersensitive to it, narcotic
Pethidine) for post op pain. Can treat analgesics, those receiving
colic in horses MAOIs or if diarrhea due to
toxic ingestion. Do not give IV
and those suffering from
respiratory disease or acute
respiratory dysfunction

Methimazole Pg. 661-662 IV, PO or Antithyroid Treats feline Do not use in patients
(Tapazole) Plumbs transdermal hyperthyroidism and hypersensitive to it or acts
prophylactic prevention of with autoimmune disease,
cisplatin-induced primary liver disease, renal
nephrotoxicity in dogs failure, hematologic
disorders, coagulopathies,
pregnant or lactating queens.
Place kittens on milk replacer
if mother is receiving
medication. Bitter tasting

Methocarbamol Pg. 664-665 IV, PO Muscle relaxant Used in Do not use injectable therapy
(Robaxin) Plumbs dogs, cats and horses for if renal pathology is
acute inflammatory and suspected. Do not use in
traumatic conditions of the patients hypersensitive to it,
skeletal muscle and reduces those used for food
muscular spasms. production, or injected SC
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Methohexital Pg. 666-667 IV Ultra-short acting barbiturate Do not use in patients

(Brevital) Plumbs Short acting anesthetic hypersensitive to
agent in small animals, barbiturates or who dont
especially those who need have veins safe for IV use. Do
anesthesia with a full not use in cattle or seizure
stomach prone, asthma,
cardiovascular disease or
ventricular arrhythmias
patients

Methypredniso- Pg. 673-675 IM, IV, PO Glucocorticoid Treat most Do not use in dogs and cats
lone acetate Plumbs maladies including with tuberculosis, peptic
(Medrol, Depo- replacement of glucocorticoid ulcer, acute psychoses,
Medrol) activity in patients with corneal ulcer, Cushingoid
adrenal insufficiency, anti- syndrome, diabetes,
inflammatory agent and osteoporosis, chronic
immunosuppressive psychotic reactions,
hypertension, CHF, etc.

Metoclopramide Pg. 677-679 PO, SC, IM Direct-acting cholinergic / GI Contraindicated if GI

(Reglan) Plumbs prokinetic agent controls
vomiting and promotes
gastric tract emptying
obstruction is suspected,
seizure disorders or head
trauma are present. Do not
use in dogs with
pseudopregnancy
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Metronidazole Pg. 682-683 PO, IV Antibiotic/ Antiparasitic/ Can not use in food producing
(Flagyl) Plumbs Immunosuppressive animals or those
Treatment of Giardia in dogs hypersensitive to it or
and cats as well some some nitroimidazole derivatives.
other parasites. Treatment of Dont use in debilitated,
anaerobic infections in horses pregnancy, nursing or
animals with hepatic
dysfunction.

Midazolam Pg. 690-691 IV, IM Benzodiazepine Use cautiously in patients

(Versed) Plumbs Premedication for general with hepatic or renal disease
anesthesia; cats may go and geriatric or debilitated
through an excited phase patients. Do not administer to
patients in coma, shock or
with significant respiratory
depression.

Milbemycin Pg. 693-694 PO Macrolide antiparasitic Test for preexisting

oxime/ Plumbs Once a month heartworm heartworm first before
Praziquantel preventative and hookworm, administering to dogs. Dont
(Interceptor, roundworm and whipworm use in puppies less than 4
Sentinel) control weeks or kittens less than 6
weeks of age
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Minocycline Pg. 698-699 PO or IV Tetracycline antibiotic Do not use in patients

(Minocin, Dynacin) Plumbs Treats Brucellosis, Lyme hypersensitive to
disease and nosocomial tetracyclines, pregnant or
infections and adjunctive nursing animals, or those less
therapy for treating than 6 months old
hemangiosarcomas

Morphine Pg. 711-712 IM, SQ, CRI or IV Opioid agent naturally Do not use in patients with
(Duramorph) Plumbs occurring narcotic, pain relief hypothyroidism, severe renal
in dogs, cats, horses, swine, insufficiency, adrenocortical
sheep and goats, sometimes insufficiency or
as an anesthetic in swine geriatric/debilitated patients.
(cesarean section in dogs). Do not give to patients also
Also antitussive, antidiarrheal receiving MAOIs or those with
and adjunctive therapy in diarrhea from toxic ingestion
cardiac disease of dogs.
Class II substance
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Moxidectin Pg. 715-716 Topical Antiparasitic Once a month Do not use in animals
(Cydectin, Plumbs preventative for heartworm, hypersensitive to it or
ProHeart, fleas, ear mites (Cats) and patients that are sick,
Advantage Multi) treatment of hookworms, debilitated, underweight or
roundworm, whipworms those with food, flea or
(dogs) in dogs and cats. allergy disease. Dont use in
Treats internal and external female cattle of breeding
parasites in cattle, sheep and age, horses used for food
horses production or foals less than
4 months old

Naloxone Pg. 722-723 IM, IV, or SC Opioid antagonist preferred Do not use in patients
(Naloxone HCL Plumbs antagonist for oxymorphone hypersensitive to this drug
injection, Narcan) and be cautious if they have
preexisting cardiac
abnormalities

Nitenpyram Pg. 738 PO Insecticide Flea adulticide Do not use in animals under
(Capstar, Plumbs in dogs and cats 4 weeks old
Program)

Nitroglycerin Pg. 740-741 Topical Vasodilator Improves Do not use in patients with
Ointment Plumbs cardiac output and severe anemia or if they are
(NTG, Nitro-bid, associated pulmonary hypersensitive to this drug.
Minitran) edema. Also used as a leg Use caution if patient has
sweat to reduce swelling and cerebral hemorrhage or head
treat laminitis trauma, diuretic-induced
hypovolemia or hypotension
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Oclacitinib Clinicians PO Dermatology -- Treat allergy Not labeled for use in cats.
(Apoquel) Brief and atopic dermatitis in dogs Do not use in dogs with
neoplasia, serious infection or
breeding animals

Omeprazole Pg. 750-751 PO Proton pump inhibitor Do not use in patients

(Gastrogard, Plumbs Treats gastroduodenal ulcer hypersensitive to this drug or
Prilosec) disease and prevents gastric those with hepatic or renal
erosions caused by disease
ulcerogenic drugs. Treatment
and prevention of reoccurring
gastric ulcers in horses

Ondansetron Pg. 752-753 IV or PO 5-HT3 Receptor Antagonist Contraindicated in cats and

(Zofran) Plumbs Used for vomiting, nausea, patients hypersensitive to
motion sickness or sickness this drug. Use cautiously in
due to chemotherapy patients with hepatic
dysfunction

Orbifloxacin Pg. 754-755 PO Fluoroquinolone antibiotic Do not use in dogs during the
(Orbax) Plumbs Treatment in dogs and cats rapid growth phase or those
for bacterial infections and hypersensitive to this drug.
gram0negative infections in Do not use in animals with
horses CNS disorders
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Orbifloxacin/ Pg. 252-253 PO Quinolones Used in dogs May cause GI upset, do not
Mometasone/ Wanamaker and cats for bacterial use if obstruction is present
Posaconazole infections and can treat
(Posatex) gram-negative infections in
horses

Oxazepam Pg. 759-760 PO Benzodiazepine Appetite Do not use in patients

(Serax) Plumbs stimulant in cats and dogs or hypersensitive to this drug or
adjunctive therapy of have acute narrow angle
behavior related disorders glaucoma. Controversial use
in felines with liver
dysfunction

Oxymorphone Pg. 764-765 IM, IV, SC Opiod Used as a sedative,
(Numorphan) Plumbs restraining agent, analgesic
and pre anesthetic in dogs
and cats. Analgesic and
anesthesia induction agent in
horses and swine, as well as
rodents when combined with
ketamine/xylazine
Do not use in patients with
hypothyroidism, severe renal
insufficiency, adrenocortical
insufficiency, head injuries,
geriatric or debilitated
patients, hypersensitivity to
narcotic analgesics or those
receiving MAOIs or diarrhea
from toxic ingestion
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Oxytocin Pg. 771-772 SC, IM, IV Hormonal agent Induction
(Pitocin) Plumbs or enhancement of uterine
contractions at parturition,
treatment of postpartum
retained placenta and
metritis, uterine involution
after manual correction of
prolapsed uterus in dogs
Do not use in animas with
dystocia or those
hypersensitive to it. Treat
hypoglycemia or
hypocalcemia if present
before use

Oxytetracycline https://valleyv Topical Tetracycline broad Permanent staining of the

(Terramycin) et.naccvp.com spectrum antibiotic including teeth will occur if patient
/product/view/ bacterial enteritis, respiratory does not have permanent
basic/3690179 tract infection, some UTIs, teeth or is a pregnant female.
? corneal ulcers Has a long withdrawal time,
u=country&p do not use in lactating dairy
=msds or poultry. Do not take with
food.

Panalog https://valleyv Topical Antifungal Treat acute and If used with corticosteroids
(Nystatin) et.naccvp.com chronic otitis and interdigital congenital defects can occur.
/product/view/ cysts in dogs and cats. Also If used in the ear canal make
basic/1094042 manages dermatitis sure the tympanic membrane
? is not ruptured. Do not ingest
u=country&p
=msds
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Pancrealipase Pg. 776-777 PO Pancreatic enzymes Treats DO not use in animals

(Vlokase, Plumbs patients with exocrine hypersensitive to pork
Pancreatic pancreatic enzyme proteins, dont inhale the
Enzymes, insufficiency (EPI) or tests for powder, and avoid contact
Lipase/Protease/ pancreatic insufficiency with mucous membranes or
Amylase) secondary to chronic skin
pancreatitis

Paroxetine Pg. 784-785 PO Selective Serotonin Reuptake Do not use in patients

(Paxil) Plumbs Inhibitor (SSRI) hypersensitive to it or those
antidepressant Treatment of receiving MAOIs. Use
canine aggression and cautiously in patients with
obsessive compulsive seizure disorder, severe
behaviors. Sometimes used cardiac, hepatic or renal
in cats disease

Penicillin-G Pg. 789-790 IM, SC, PO Penicillin antibiotic Do not give IV, it burns during
(Bicillin L-A, Plumbs Treatment of a variety of injection! Do not use in
Permapen) bacterial infections (Ex. patients who are
Upper respiratory tract, hypersensitive to this drug or
equine strangles, UTI, those with septicemia, shock
infected wounds, pneumonia) or other grave illnesses. Use
with caution in patients
sensitive to beta-lactam
antibiotics. Follow withdrawal
times.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Pentobarbital Pg. 797-798 IV, PO Barbiturates short acting
sodium Plumbs (45 minutes 1.5 hours) used
(Nembutal) as routine general anesthesia
in dogs in the past. Today is
used primarily to control
seizures in progress (not the
1st choice) and as a
euthanasia agent
Use cautiously in patients
who are hypovolemic,
anemia, have borderline
hypoadrenal function, or
cardiac or respiratory
disease. Do not use in
patients with severe liver
disease or in a cesarean
section and give IV slowly

Phenobarbital Pg. 805-808 PO or IV Barbiturates long acting (8- Use with caution in patients
(Phenobarbitone) Plumbs 12 hour) anticonvulsant to
prevent epileptic seizures in
dogs and cats and controls
excessive vocalization in cars
for cats. Can speed up
detoxification of insecticide
poisoning in cattle. Class IV
controlled substance
that are hypovolemic,
anemic, borderline
hypoadrenal function, and
cardiac or respiratory
disease. DO not use large
doses in patients with
nephritis or severe
respiratory or liver
dysfunction
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Phenylbutazone Pg. 811-812 PO or IV NSAID Relief of Do not use in patients with

(Butazolidin,Bute Plumbs inflammatory conditions preexisting hematologic or
) associated with the bone marrow abnormalities,
musculoskeletal system in GI ulcers or in food producing
dogs and horses as well as or lactating dairy cattle. Do
lameness in horses. not administer IM or SC
Occasionally because of irritation and use
analgesic/antipyretic in dogs, caution in foals
cattle and swine

Phenylpropanol- Pg. 815-816 PO Adrenergic Use with caution in patients

Amine Plumbs (sympathomimetic) agent with glaucoma, prostatic
(Omade, treats urinary incontinence in hypertrophy,
Prolamine, dogs and cats. May treat hyperthyroidism, diabetes
Dexatrim, PPA) nasal congestion in small mellitus, cardiovascular
animals disorders or hypertension

Pimobendan Pg. 827-828 PO Catecholamine/ Inodilator -- Do not use in cats or dogs

(Vetmedin) Plumbs Treat AV insufficiency, dilated younger than 6 months,
cardiomyopathy, and CHF in diabetes mellitus, those used
dogs for breeding or lactating,
those with hypertrophic
cardiomyopathy, aortic
stenosis or any condition
where cardiac output is not
functional
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Piroxicam Pg. 835-836 PO NSAID / anti-tumor Reduces Do not use in patients

(Feldene) Plumbs pain and inflammation due to hypersensitive to this drug or
degenerative joint disease in those allergic to aspirin or
dogs and adjunctive NSAIDs. Do not use in cats
treatment of bladder
transitional cell carcinoma

Pitressin(ADH) Pet Place IV Hormone Used in dogs and Could cause cardiac
(Vasopressin) cats to diagnose diabetes arrhythmias, heart failure,
insipidus and treat shock in tremor, ataxia, urticaria,
life threatening situations abdominal pain, passage of
gas, anaphylaxis, and
bronchoconstriction.

Ponazuril Pg. 839 PO Antiprotozoal Treatment of Other conditions that can

(Marquis) Plumbs equine protozoal cause ataxia should be ruled
myeloencephalitis (EPM) and out before treatment
other protozoal infections in
dogs, cats, birds, reptiles,
ruminants, etc.
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Polysulfated Pg. 837-838 IM or IA NSAID Treatment of non Do not administer intra-

Glycosaminogly Plumbs infectious joint dysfunction
can and associated lameness of
(Adequan, the carpal joints in horses.
Chondroprotec) Treatment of non
degenerative or traumatic
arthritis in dogs
articular in patients
hypersensitive to it. Do not
use in place of other
therapies in cases where
infection is present or
suspected

Potassium https://valleyv PO Anticonvulsant -- Treatment Use with caution in older

bromide et.naccvp.com of seizure disorders in dogs animals and do not use in
(K-BroVet) /product/view/ cats
basic/1090032
?
u=country&p
=msds

Potassium Pg. 840-841 PO or IV Electrolyte Prevent or treat Do not use in patients with
glucon- Plumbs potassium deficits hyperkalemia, renal failure or
ate severe renal impairment,
(Cal-Dextro K, severe hemolytic reactions,
Tumil-K) untreated Addisons disease
and acute dehydration
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Pralidoxime Pg. 842-843 IM, IV, or SC Antidote / Cholinesterase Do not use in patients
chlor- Plumbs reactivator Treatment of hypersensitive to this drug or
ide (2-PAM) organophosphate poisoning, when there is carbamate
usually used with atropine poisoning. Use with caution in
(Protopam and supportive therapy patients receiving
Chloride) anticholinesterase agent or
those with renal impairment

Praziquantel Pg. 844-845 IM, SC, PO Antiparasitic Used for the Do not use in puppies less
(Droncit) Plumbs treatment of Dipylidium than 4 weeks old or kitten
caninum, Taenia pisiformis less than 6 weeks old
and Echinococcus granulosis
in dogs an Dipylidium
caninum and Taenia
taeniaeformis in cats

Prednisolone Pg. 848-850 PO, IM or IV Steroid Used to replace Do not use in systemic fungal
Plumbs supplementation of infections. Use with caution in
glucocorticoid effects on cats with diabetes mellitus or
hypoadrenocorticism, anti- cardiovascular disease
inflammatory,
immunosuppressive and
antineoplastic agent
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Procainamide Pg. 859-860 IV or PO Antiarrythmiac drug: Class IA Do not use in patients with
(Pronestyl) -- myasthenia gravis, cardiac
Treat premature ventricular glycoside intoxication, or
contractions (PVC) long term, Doberman pinschers and
ventricular tachycardia, and boxers with DCM. Use with
some forms of atrial caution inpatients with
tachycardia hepatic or renal disease or
CHF

Propantheline Pg. 866-867 PO or IV Quaternary antimuscarinic Do not use if patient is

Bromide Plumbs Used for hypersensitive to this drug or
(Pro-Banthine) antispasmodic/antisecretory has GI obstructive disease,
treatment of diarrhea or urge paralytic ileus, sever
incontinence. Reduces ulcerative colitis, obstructive
colonic peristalsis and uropathy or myasthenia
relaxes the rectum for exams gravis. Use with caution if
and surgery in horses there is a GI infection

Propofol Pg. 870-871 IV Anesthetic Induction agent Do not use in patients

(Rapinovet, Plumbs or anesthetic for outpatient hypersensitive to this drug or
PropoFlo, diagnostic or minor where general anesthesia
Diprivan) procedures shouldnt be used. Use with
caution in patients with
hypoproteinemia
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Propanolol Pg. 873-874 IV, PO Antiarrhythmic drug/ Do not discontinue therapy

(Inderal) Plumbs Adrenergic blocker Class II abruptly! Do not use in
Treat hypertrophic patients with overt heart
cardiomyopathy and various failure, hypersensitivity,
arrhythmias greater that 1st degree heart
block or sinus bradycardia

Prostglandin F2 Pg. 178 IM Hormone Lysis of the Pregnant women should not
alpha Wanamaker corpus luteum, contraction of administer and animals with
uterine muscle and asthma should not use this
relaxation of the cervix. drug.

Psyllium Pg. 878-879 PO Bulk forming GI laxative Do not use in cases where
(Metamucil, Equi- Plumbs /Antidiarrheal -- Use to help prompt intestinal evacuation
Psyllium) reduce constipation or is required or intestinal
straining, diarrhea, and to obstruction is present. Do not
treat and prevent sand colic use in rabbits
in horses

Pyrantel Pg. 880-881 PO Antiparasitic Removal of Use with caution in severely

pamoate Plumbs parasites in dogs, cats, debilitated animals
(Strongid T, horses, and swine
Nemex)
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Quinidine Pg. 891-892 PO or IM Antiarrhythmic drug Class Laminitis in horses

(Quinidex) Plumbs IA Do not use in patients whoa
Treatment of atrial fibrilliation re hypersensitive to it or have
(DOC), ventricular complete AV block or
arrhythmias, and ventricular intraventricular conduction
tachycardia defects

Ranitidine Pg. 896-897 PO, IV, IM H2 Receptor Antagonist / Do not use in patients who
(Zantac) Plumbs Prokinetic Treatment of are hypersensitive to tis drug
gastric, abomasal and and use with caution in
duodenal ulcers, uremic patients with diminished
gastritis, stress-related or renal function
drug induced erosive
gastritis, esophagitis,
duodenal gastric reflex and
esophageal reflex. Stimulate
colonic activity in cats

Robenacoxib Pg. 902-903 PO or SC NSAID Used in dogs and Do not use in patients with GI
(Onsior) Plumbs cats as an anti inflammatory ulcers, dogs with hepatic
disease or those that are
hypersensitive to this drug.
Dont use with other
corticosteroids or NSAIDs
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Selamectin Pg. 911-912 Topical Antiparasitic Flea Do not use in sick,

(Revolution) Plumbs infestations, prevention of underweight or debilitated
heartworm disease and ear dogs or cats as well as dogs
mites in dogs and cats as under 6 weeks of age and
well as sarcoptic mange in cats under 8 weeks of age
dogs and tick infestations.
Also for hookworms and
roundworms in cats.

Selegiline Pg. 912-913 PO Monamine oxidase inhibitor Do not use in patients who
(Anipryl, Eldepryl) Plumbs Treatment of Cushings are hypersensitive to this
disease in dogs and Canine drug
Cognitive Dysfunction. Also
treats feline cognitive
dysfunction syndrome

Sevoflurane Pg. 917-918 Inhalant Anesthetic Rapid induction Do not use in patients with
(SevoFlo, Ultane) Plumbs anesthetic used successfully malignant hyperthermia or
in geriatric and debilitated those with increased CSF,
cats head injury or renal
insufficiency. Use caution in
rabbits
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Silymarin Pg. 920-921 PO Nutraceutical hepato- Do not use in patients where

(Marin) Plumbs protectant Treatment of a exogenous estrogens
variety of liver diseases in shouldnt be used
dogs, cats, birds, horses,
rabbits. Also treats chronic
and acute liver disease

Sucralfate Pg. 943 PO Gastroprotectant Treatment Use with caution in animals

(Carafate) Plumbs of oral, esophageal, gastric with decreased intestinal
and duodenal ulcers. Also transit times
prevents drug induced
gastric erosions

Sufadiazine/trim Pg. 253 PO Sulfonamides Used in dogs Do not use in animals with
- Wanamaker and horses to treat infections eye trauma, thyroid issues or
Methoprim caused by susceptible hepatic diseases
(EQUISUL-SDT) organisms. Can treat prostate
infections
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Sulfadimethoxin Pg. 951-952 PO, IV, IM or SC Sulfonamide antimicrobial Do not use in patients that
e Plumbs Used for respiratory, are hypersensitive to this
(Albon) genitourinary, enteric and drug or those with severe
soft tissue infections in cats renal or hepatic impairment
and dogs Treatment of
respiratory infections in
horses and shipping fever
and bacterial pneumonia
complex in cattle. Also used
in poultry

Tiletamine + Zoetis IM Dissociative agent Spastic jerking, convulsions,

Zolazepam combination of ketamine-like
(Telazol) agent and a tranquilizer.
Approved in dogs and cats.
Class III controlled substance.
respiratory depression,
burning at the intramuscular
injection site, drying of the
cornea. Avoid Ketamine with
head trauma and KCS
patients as well as animals
with compromised kidneys.

Tetracycline Pg. 967-968 PO Tetracycline antibiotic Do not use in patients

(Aquadrops, Plumbs Antimicrobial or when hypersensitive to it and only
Panmycin) combined with niacinamide use in the last of
to treat immune mediated pregnancy
skin conditions in dogs
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Theophylline Wedgewood PO Bronchodilator used to Use with caution in animals

relax bronchial muscles in with severe heart disease, GI
dogs and cats making ulceration or kidney and liver
breathing easier and can help disease. Beta blockers,
rid excess fluids through the calcium channel blockers,
kidneys antibiotics, and other drugs
can have reactions

Tobramycin Pg. 990-992 IV, IM or SC Aminoglycoside antibiotic Do not use in patients

(Nebcin, TOBI) Plumbs Treatment of serious gram hypersensitive to it or
negative infections preexisting renal disease.

Toceranib Pg. 993-994 PO Tyrosine kinase inhibitor Do not use in breeding,

phosphate Plumbs antineoplastic Treatment of pregnant or lactating females
(Palladia) Patnaik grade II or III as well or dogs less than 2 years of
as mast cell tumors and age
other
sarcomas/carcinomas/melano
mas in dogs
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Tramadol hydro- Pg. 1002-1003 PO Opioid agonist Treatment of Do not use in patients
Chloride Plumbs post operative pain or cough hypersensitive to it or if
(Ultram) in dogs and horses combined with
acetaminophen meds in cats.
Use caution if using with
drugs that can cause CNS or
respiratory depression

Triamcinolone Pg. 1006-1007 PO Glucocorticoid Treatment of Do not use in systemic fungal

(Vetalog) Plumbs inflammation and related infections and it may induce
disorders in dogs, cats and parturition in large animal
horses. Also manages and species during later stages of
treats acute arthritis, allergic pregnancy
and dermatologic disorders

Triamulin Merck PO Antibacterial Treats gram Do not use in poultry if

positive bacteria, combined with monensin, it is
mycoplasmas, swine toxic
dysentery and mycoplasmal
arthritis
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Trilostane Pg. 1011-1012 PO Adrenal steroid synthesis Do not use in patients

(Vetoryl) Plumbs inhibitor Treatment of hypersensitive to this drug or
pituitary dependent pregnant dogs and use with
hyperadrenocorticism or caution in patients with renal
adrenal dependent or hepatic impairment.
hyperadrenocorticism in
dogs, feline pituitary
dependent
hyperadrenocorticism and
equine hyperadrenocorticism.
Can treat alopecia in
Pomeranians and Alaskan
malamutes

Tulathromycin Pg. 1017-1018 IM Macrolide antibiotic Do not use in patients

(Draxxin) Plumbs Treatment of bovine hypersensitive to this drug or
respiratory disease and cattle and swine used for
bovine foot rot. Can also food production
treat swine respiratory
disease

Ursodiol Pg. 1021-1022 PO Bile acid Used as an Do not use in rabbits or

(Actigall, Plumbs adjunctive therapy for the hindgut fermenters
Ursodeoxycholic management of cholesterol
acid) containing gallstones or
chronic liver disease
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Vasopressin(AD Pg. 1026-1027 IM or IV Antidiuretic Hormone Used Do not use in patients

H) Plumbs as a diagnostic agent and hypersensitive to this drug or
treatment for diabetes with chronic nephritis. Use
(Pitressin) insipidus in small animals with caution in patients with
vascular disease, seizure
disorders, heart failure or
asthma

Vincristine Pg. 1034-1035 IV Antineoplastic Treatment of Use with caution in patients

(Oncovin) Plumbs lymphoid and hematopoietic with hepatic disease,
neoplasms in dogs and cats. leukopenia, infection or
May also treat immune preexisting neuromuscular
mediated thrombocytopenia disease

Vitamin B12 Pg. 344 IM or SQ Vitamin Acts as a coenzyme May cause an allergic
(Cyanocobalamin) Wanamaker in protein synthesis reaction

Vitamin K1 Pg. 403 IM Vitamin Synthesis of blood Anaphylaxis may occur with
(Phytonadione) Wanamaker coagulation factors II, VII, IX IC injections
and X by the liver to treat
anticoagulant rodenticide
poisoning
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Warfarin Pg. 1040-1042 PO Anticoagulant Long term Do not use in patients with
(Coumadin) Plumbs treatment of thrombotic preexistent hemorrhagic
conditions in cats, dogs or tendencies or diseases, eye
horses or CNS surgery, major
regional lumbar block
anesthesia, active bleeding,
aneurysm, acute nephritis,
hypertension or pregnancy

Xylazine Pg. 1043-1044 IV, IM or SC Adrenergic If used in cattle it is 1/10 of

(Rompun, AnaSed, Plumbs (sympathomimetic)
Gemini, Sedazine) agent/Tranquilizer Sedation,
analgesia, short-term
anesthesia (combined with
other agents), induction of
vomiting. Commonly used in
horses for castration and
minor procedures. Yohimbine
is the reversal
the equine dose. Do not use
in patients receiving
epinephrine or with active
ventricular arrhythmias and
dont use during the last
trimester of pregnancy in
cattle. Horses can still kick!

Yohimbine Pg. 1047-1048 IV Adrenergic blocking agent Do not use in patients that
(Yobine, Plumbs (sympatholytic) Used to are hypersensitive to this
Antagonil) reverse the effects of drug and be cautious with
Xylazine in dogs and can be patients with seizure
used prophylactically before disorders
amitraz dips
 Drug Reference Route of Classification/Main Contraindications(Compl
(Generic or and page Administratio Clinical Use ications with disease or
trade name) number n other drugs)

Zylkene https://valleyv PO Behavior modifier Used to Dont give on an empty

et.naccvp.com relieve stress in dogs, cats stomach
/product/view/ and horses and controls
basic/1005106 unwanted behaviors like
? territorial marking
u=country&p
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References

Acatak Duostar (fluazuron, ivermectin) | Novartis Animal Health Inc. (Australia). (n.d.). Retrieved from

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Compendium of Veterinary Products for iPhone

Dichlorophen | C13H10Cl2O2 - PubChem. (n.d.). Retrieved from

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Drugs.com | Prescription Drug Information, Interactions & Side Effects. (n.d.). Retrieved from
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HEXTEND (6% Hetastarch in Lactated Electrolyte Injection). (n.d.). Retrieved from

 http://www.fda.gov/biologicsbloodvaccines/bloodbloodproducts/approvedproducts/newdrugapplicatio

nsndas/uc

m376773.htm

Horse Supplies, Pet Supplies, Farm Supplies, Goat Supplies - Valley Vet Supply. (n.d.). Retrieved from

https://www.valleyvet.com/

Ibuprofen (Motrin, Advil, etc.). (n.d.). Retrieved from http://www.petplace.com/article/drug-

library/library/over-the-

counter/ibuprofen-motrin-advil-etc

Oclacitinib | Clinician's Brief. (n.d.). Retrieved from http://www.cliniciansbrief.com/article/oclacitinib

Plumb, D. C., John Wiley & Sons, Educational Concepts, L.L.C, & Brief Media. (2015). Plumb's veterinary

drug handbook.

(7th ed.).

Riviere, J. E., & Papich, M. G. (2009). Veterinary pharmacology and therapeutics (9th ed.).

THE MERCK VETERINARY MANUAL. (n.d.). Retrieved from http://www.merckvetmanual.com/mvm/index.htm

TELAZOL CIII (TILETAMINE HCL AND ZOLAZEPAM HCL). (n.d.). Retrieved from

https://www.zoetisus.com/_locale-
 assets/mcm-portal-assets/products/pdf/cad_pis/telazol_pi.pdf

Wanamaker, B. P., & Massey, K. L. (2009). Applied pharmacology for veterinary technicians. (5th ed.). St.

Louis, MO:

Saunders/Elsevier.

ZACTRAN (gamithromycin). (n.d.). Retrieved from http://www.zactran.com/index.html