BIOC 450

PROTEIN STRUCTURE AND FUNCTION

TIMETABLE - Fall 2015
Lecturers:
B. Nagar, (Coordinator), Room 464, Bellini Building, Tel: 514-398-7272, bhushan.nagar@mcgill.ca
R. Salavati, Room A-209, Institute of Parasitology, Tel: 514-398-7721, reza.salavati@mcgill.ca
E. Purisima, NRC, Biotech. Research Institute, 6100 Royalmount, Tel: 514-496-6343, enrico.purisima@cnrc-nrc.gc.ca
A. Berghuis, Room 466, Bellini Building, Tel: 514-398-8795, albert.berghuis@mcgill.ca
M. Schmeing, Room 465, Bellini Building, Tel: 514-398-2331, martin.schmeing@mcgill.ca
K. Gehring, Room 469, Bellini Building, Tel: 514-398-7287, kalle.gehring@mcgill.ca
I. Rouiller , Room 115, Strathcona Bldg., Tel: 514-398-3244, isabelle.rouiller@mcgill.ca
J. Young, Room 467, Bellini Building, Tel: 398-2006, jason.young2@mcgill.ca
P. Pawelek, Science Complex Loyola Campus, Rm SP280.27, Concordia, Tel: 848-2424, ppawelek@alcor.concordia.ca
C. von Roretz, Room HS314, 21275 Lakeshore Rd., Tel: 514-457-6610 ext. 5189, christopher.vonroretz@mcgill.ca
Location and Time: McIntyre Medical Sciences Building, Room 521 from 10:35AM-11:25AM
Prerequisites: BIOC 311, BIOC 312 and/or sufficient Organic Chemistry
Date Day Lecture Title Lecture Lecturer
Sept. 04 F Introduction 1 BN
07 M LABOUR DAY NO CLASSES
09 W Primary Structure/Protein Processing 2 EP
11 F Primary Structure/Protein Processing 3 EP
14 M Primary Structure/Protein Processing 4 EP
16 W Primary Structure/Protein Processing 5 EP
18 F Post-translation Modification 6 EP
21 M Secondary Structure 7 BN
23 W Secondary/Tertiary Structure 8 BN
25 F Tertiary Structure 9 BN
28 M Tertiary/Quaternary Structure 10 BN
30 W Protein Folding 11 BN
Oct. 02 F Protein Folding/ Pymol 12 BN
05 M Project Session/Pymol 13 BN
07 W MIDTERM EXAM NO LECTURE - 6:30 PM-8:30PM (Stewart Biology, S1/4 )
09 F Enzyme Kinetics 14 RS
12 M THANKSGIVING NO CLASSES
14 W Enzyme Kinetics 15 RS
16 F Enzyme Kinetics 16 RS
19 M Enzyme Kinetics 17 RS
21 W Enzyme Kinetics - Ribozymes 18 CVR
23 F Project Session 19 RS/CVR
26 M Enzyme Mechanism 20 AB
28 W Enzyme Mechanism 21 AB
30 F Enzyme Mechanism 22 AB
Nov. 02 M Enzyme Mechanism 23 AB
04 W Enzyme Mechanism 24 AB
06 F Special Topic Antibiotic Resistance and Structural Biology 25 AB
09 M Project Session 26 AB/CVR
11 W MIDTERM EXAM NO LECTURE - 6:30PM-8:30PM ( Stewart Biology, S1/4)
13 F Poster Presentations (~4) 27 BN
16 M Poster Presentations (~5) 28 BN
18 W Poster Presentations (~4) 29 BN
20 F Poster Presentations (~5) 30 BN
23 M Special Topic TBA 31 CVR
25 W Special Topic Gaia, Life-Force and Other Nonsense 32 KG
27 F Special Topic Cytosolic Chaperones 33 JY
30 M Special Topic Nonribosomal Peptide Synthetases 34 MS
Dec. 02 W Special Topic Elucidating Protein-Ligand Interactions through Computer Stimulation 35 EP
04 F Special Topic Study of Molecular Machines by cryo-EM 36 IR
07 M Special Topic Protein-Protein Interactions Required for Bacterial Iron Uptake 37 PP
MARKING SYSTEM: Mid-terms 25% or 15%; Final Examination 40%
 Suggested reading:

A. REFERENCES

1. R.B. Silverman, The Organic Chemistry of Enzyme-Catalyzed Reactions 2000. Academic Press, San
Diego, CA
2. N.C. Price and L. Stevens, Fundamentals of Enzymology The Cell and Molecular Biology of Catalytic
Proteins, 3rd Edition. 1999. Oxford University Press, Oxford, U.K.
3. J. Kyte "Mechanism in Protein Chemistry". 1995. Garland Publishing Inc.
4. J. Kyte "Structure in Protein Chemistry". 1995. Garland Publishing Inc.
5. C. Branden and J. Tooze, "Introduction to Protein Structure" 1991. Garland Publishing Inc.
6. L. Stryer, "Biochemistry, 3rd. Edition" Chapters 1-3, 7-11. 1988 Freeman and Co.
7. J. Bell and E. Bell, "Proteins and Enzymes". 1988. Prentice Hall Inc.
8. A. Fersht, "Enzyme Structure and Mechanism" 1985. Freeman and Co., San Francisco.
9. T.E. Creighton, "Proteins" Structures and Molecular Properties. 1984. Freeman and Co., N.Y.
10. G.G. Hammes, "Enzyme Catalysis and Regulation" 1982. Academic Press, N.Y.

B. REFERENCE SERIES

1. H. Neurath and R.L. Hill, eds. "The Proteins", 3rd. ed. Academic Press. N.Y.
2. P.D. Boyer, ed. "The Enzymes", 3rd. ed. Academic Press, N.Y.
3. S.P. Colowick and N.O. Kaplan, eds. "Methods in Enzymology", Academic Press, N.Y.
4. "Annual Reviews of Biochemistry", Annual Reviews Inc. Palo Alto, CA.

MARKING SCHEME
BIOC 450

First Midterm - Enrico Purisima ~50%

(25% or 15%) - Bhushan Nagar ~50%

Second Midterm - Albert Berghuis ~50%

(25% or 15%) - Reza Salavati ~40%
- Chris Von Roretz ~10%

Final Exam - Enrico Purisima ~17%

(40%) - Bhushan Nagar ~18%
- Albert Berguis ~22%
- Reza Salavati ~18%
- Chris Von Roretz ~4%
- Special Topics ~21%

Team Project (Groups of ~4)

(20%)

Of the first two midterm exams, the one in which you receive the higher grade will count for 25% and the other for 15%.
The exams will consist of short written answers.

If you miss writing one of the midterm exams, you MUST BRING a doctors note to the Student Affairs
Coordinator (Maria Dimas Office 905, McIntyre Building) within 2 WEEKS of the exam date. The doctors note will only
be accepted if it is DATED THE DAY OF THE EXAM. In this case, the remaining midterm will be worth 25% and the
final exam worth 55%. In the unlikely event that both midterms are missed, the final exam will be worth 80%. If legitimate
doctors notes are not provided, you will receive a zero on the midterms and the final exam will be worth 55%.

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