A

PROJECT REPORT
ON

"INSTRUMENTATION AND CHEMICAL

ANALYSIS OF PANTAPIL AND TROMANIL
PLUS TABLETS"
Submitted in the partial fulfillment of the requirement of degree in

MASTER OF SCIENCE

IN

BIOTECHNOLOGY

SESSION : 2017-2018

Submitted to: Submitted by:

Mrs. Ritika Saxena Rakhi Shrav-15111026
Assistant Professor Rashmi Sharma-15111027
Shaheena Jamshed-15111029
M.Sc. B.T. IV-Sem.

IFTM UNIVERSITY, MORADABAD

 CERTIFICATE

This is to certify that the project entitled "INSTRUMENTATION AND

CHEMICAL ANALYSIS OF PANTAPIL AND TROMANIL PLUS

TABLETS" submitted by "Rakhi Shrav-15111026, Rashmi Sharma-

15111027 & Shaheena Jamshed-15111029" in the partial fulfillment of the

requirement for the degree of "Master of Science" has carried out the work

presented in this report under my supervision. The dissertation work embodies

result of original work and studies carried out by students themselves.

MRS. RITIKA SAXENA

Assistant Professor
 ACKNOWLEDGEMENT

I express my deepest sense of gratitude towards my guide Dr. Tanjeel

Ahmad (Head of Department), and Mrs. Ritika Saxena (Assistant Professor)
IFTM, Moradabad for his/her patience, inspiration, guidance, constant
encouragement, moral support, keen interest, and valuable suggestions during
preparation of this project.

My heartfelt gratitude goes to all faculty members of school of science

department, who with their encouraging and caring words and most valuable
suggestions has contributed, directly or indirectly in a significant way toward
completion of this seminar report.

I am indebted to all my classmates for taking interest in discussing my

problem and encouraging me.

I our a dept of gratitude to my father and mother for their consistent

support, sacrifice, candid views, and meaningful suggestion given to me at
different stages of this work.

Last but not the least I am thankful to the almighty who gave me the
strength and health for completing my reports.

RAKHI SHRAV-15111026
RASHMI SHARMA-15111027
SHAHEENA JAMSHED-15111029
 ABSTRACT
Drugs can be delivered to patients by more than one route and by more than one
type of dosage form. Even though dosage form and drug delivery system
are used interchangeably, drug delivery system implies that a technology has
been used to deliver a drug to the desired body site for drug release with a
predetermined rate. Among various drug delivery systems, oral extended release
(ER) formulation is the most commonly used. In the present project based on
different drug release mechanisms, to formulate extended release tablets
different technologies have been used, where gliclazide was investigated.
 CONTENTS

Page No.
CHAPTER-1 INTRODUCTION 1-5
1.1 PANTAPIL 1
1.2 NIMESULIDE 1
1.3 COMPANY PROFILE: 3
CHAPTER-2 REVIEW LITERATURE 6-11
CHAPTER-3 MATERIALS & METHOD 12-32
3.1 Uv Spectrophotometer: 12
3.1.1 Appratus: 13
3.1.2 Application: 14
3.2 Disintegration Apparatus: 14
3.3 Dissolution Appratus: 15
3.3.1 Appratus: 15
3.3.2 Procedure: 16
3.4 Fribilator: 16
3.4.1 Appratus: 16
3.4.2 Calculation: 17
3.5 Sonicator 17
3.5.1 Principle: 17
3.6 Hardness Tester 18
3.7 Ph METER 19
3.7.1 Principle: 19
3.8 High Performance Liquid Chromatography(Hplc) 19
3.9 Karl Fischer Titrator 21
3.9.1 Reagents: 22
3.9.2 Chemical Reactions: 22
3.9.3 Procedure: 21
3.10 Tablets 21
3.10.1 Uncoated Tablets: 22
3.10.2 Coated Tablets: 25
3.10.3 For Film-Coated Tablets: 25
3.10.4 Dispersible Tablets: 25
3.10.5 Effervescent Tablets: 26
3.10.6 Modified-Release Tablets: 26
3.10.7 Soluble Tablets: 26
3.10.8 Tablets For Use In The Mouth: 26
3.10.9 Enteric-Coated Tablets: 26
3.11 Standard Testing Process Of Pantapil 40 Tablet 27
3.12 Testing Process Of Pantapil 40 Tablet 28
CHAPTER-4 RESULT AND DISCUSSION 33-41
4.1 Result Of Pantapil 40 Tablet 33
4.2 Standard Testing Process Of Tromanil Plus Tablet 35
4.3 Result Of Tromanil Plus Tablets 40
CHAPTER-5 CONCLUSION 41
CHAPTER-6 REFERENCES 42-46
 LIST OF FIGURES

Fig. No. Title Page No.

1 Company Profile 3
2 UV Spectrophotometer 13
3 Disintegration Apparatus 14
4 Dissolution Appratus 15
5 Fribilator 16
6 Sonicator 17
7 Hardness Tester 18
8 ph Meter 19
9 HPLC 20
10 Karl Fischer Titrator 21