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art & science continence focus

Assessment and treatment of older


patients with constipation
Kyle G (2006) Assessment and treatment of older patients with constipation. Nursing Standard. 21, 8,
41-46. Date of acceptance: February 14 2006.

Summary Case study


This article examines the experiences of an older patient with Day one Mary, a healthy and active 83-year-old,
constipation to illustrate the importance of thorough assessment. had a fall at her great-grandsons third birthday.
The interaction between another medical condition and constipation As a consequence of the fall Mary experienced
is discussed, and indications for laxative use are outlined. The pain in her back, however, she was still able to
current evidence base for bowel care is limited. Tools for risk mobilise independently. Her family took Mary
assessment are required and further research is needed to improve home because she was adamant that she would be
patient care in this area. best equipped to cope there.
Author Day two Mary had difficulties overnight with
pain in her back and was taken to her local
Gaye Kyle is senior lecturer, Faculty of Health and Human Science, accident and emergency department in the
Thames Valley University, Slough, Berkshire. Email: gaye.kyle@tvu.ac.uk morning. Mary was diagnosed with a crush
Keywords fracture of the second lumbar vertebra, caused by
the trauma of her fall, and osteoporosis which
Bowel management; Constipation; Suppositories was previously undiagnosed.
These keywords are based on the subject headings from the British She was commenced on two tablets of
Nursing Index. This article has been subject to double-blind review. co-dydramol four times a day, which she agreed
For related articles and author guidelines visit our online archive at to take because of the considerable pain she was
www.nursing-standard.co.uk and search using the keywords. experiencing. Mary was also given calcium
supplements and prescribed alendronic acid
(as sodium alendronate) 70mg once weekly for
CONSTIPATION IS a problem that can affect osteoporosis.
any person at any time in life. Those who are ill, in Her mobility became greatly diminished and
hospital or in an institution are particularly at risk her appetite was poor because of the pain. She
of developing constipation. It is rarely asked a neighbour to purchase some senna at the
life-threatening, but the distress it causes can lead local chemist, because Mary worries if she does
to reduced patient comfort and diminished not open her bowels daily.
quality of life (Sweeney 1997). Day three Mary was in great distress because of
Constipation affects the patients physical, severe back pain. She contacted the GP who
psychological and social wellbeing, yet there prescribed an opioid analgesic, tramadol, 50mg
is a reluctance by patients and healthcare three times a day, and advised her to discontinue
professionals to discuss bowel function until it taking co-dydramol.
has become a significant problem. Successful Day four Mary was unable to move and sat all day
treatment of constipation depends on defining the with a heat pad behind her back. She continued to
patients symptoms following careful assessment. take tramadol and was also taking two senna
The case study described in this article enables tablets each night. She informed her family that
the examination of variables that resulted in the her stomach was swollen and bloated, and that
patients distressing situation. The contributing she had not opened her bowels since the day
factors are identified and discussed. A short before her fall.
interview with the patient and a review of her Lack of exercise, inability to prepare food
medical and nursing notes supplied the details for and abdominal discomfort resulting from
the article. Permission has been given to publish constipation contributed to Marys poor food
this case study and a pseudonym is used to intake. However, Mary made every effort to keep
maintain confidentiality (Nursing and Midwifery her fluid intake as usual. She knew from past
Council 2004). experience when she was on holiday that any

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art & science continence focus glycerine suppositories were administered.
Mary tried to keep the suppositories in her
rectum, but after one hour she had to urinate
and, to use Marys words, the suppositories just
reduction in her usual fluid intake could result blew out.
in constipation, and she was anxious to prevent Day seven Marys stomach was now distended
this reoccurring. and hard, her mobility was greatly reduced and
Day five Mary contacted the surgery to say that her feeling of nausea was increasing. Despite the
her pain was no better and that she was finding fracture in her back, Mary was now primarily
it difficult to get out of bed. When the GP concerned about her worsening constipation,
visited, Mary mentioned that she had not which made her feel isolated and low in mood.
opened her bowels since before her fall, despite She was no longer trying to mobilise, which is
taking two senna every night. She was given a important in the initial stage of rehabilitation for
prescription changing her analgesia to patients with back fractures. She also
tramadol-modified release 100mg twice daily. experienced fullness in her rectum and a feeling
She was also given a prescription for lactulose that faeces was pushing against her anus.
15ml at night. Mary tried to take the lactulose Mary contacted the surgery again. Another
but the sweetness of the medication exacerbated GP visited and undertook an abdominal
her feelings of nausea. examination revealing a constipated sigmoid
Day six Mary telephoned the surgery and asked colon. A full digital rectal examination was not
to speak to the district nurse. Mary requested conducted because the GP observed that
an enema because it was seven days since her last Mary had a gaping anus full of impacted faeces.
bowel action. Mary was told that there were no Mary was prescribed Movicol and an
enemas available at the surgery but that the anti-emetic. She was initially prescribed four
district nurse or community staff nurse would sachets of Movicol to take immediately, and a
visit her. further four sachets to take that evening.
The district nurse visited Mary but no Day eight Mary had a successful bowel
physical examination was undertaken. Two evacuation. She felt much relieved and started
to rehabilitate successfully. Her appetite returned
FIGURE 1 and she began preparing her own food again.
The Bristol Stool Form Scale She continued to take one sachet of Movicol
twice a day until her bowels were consistently
Separate hard lumps between types 3 and 4 on the Bristol Stool Form
Type 1 Scale (Figure 1). She now takes one sachet of
like nuts (hard to pass)
Movicol if she goes more than one day without
opening her bowels.
Type 2 Sausage-shaped but lumpy
Discussion
Constipation can be influenced by physical,
Type 3 Like a sausage but with psychological, physiological, emotional and
cracks on its surface environmental factors. It is largely a subjective
sensation and has many interrelated causes.
Constipation can be clinically classified into
Like a sausage or
Type 4 three categories, and may result from one or
snake, smooth and soft
more of these:
Primary.
Type 5 Soft blobs with clear-cut
edges (passed easily) Secondary.
Iatrogenic.
Type 6 Fluffy pieces with ragged Primary constipation, also referred to as simple
edges, a mushy stool or idiopathic, is associated mainly with lifestyle
changes and where there is no underlying
pathophysiology causing the constipation.
Type 7 Watery, no solid pieces, Secondary constipation results from
entirely liquid physiological diseases or conditions that affect
bowel function. Iatrogenic-induced
Reproduced by kind permission of Dr KW Heaton, reader in medicine at the
University of Bristol. 2000 Norgine Ltd
constipation results from medication or
treatment (Box 1).

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There continues to be much debate in the


BOX 2
literature as to what constitutes a clear definition
of constipation (Richmond 2003). The British Rome II criteria for definition of constipation
National Formulary (BNF) (2006) states that For definition of constipation, two or more of the
constipation is: the passage of hard stools less following symptoms should be present for at least
frequently than the patients own normal 12 weeks out of the preceding 12 months.
pattern. This definition is open to great variation
Straining at defecation for at least a quarter of
in bowel habits. Most definitions now include
the time.
symptoms such as frequency of defecation,
hardness of stools, abdominal fullness or Lumpy and or hard stools for at least a quarter
bloating and feelings of incomplete evacuation, of the time.
although patients tend to emphasise symptoms A sensation of incomplete evacuation for at least
such as pain and straining rather than frequency a quarter of the time.
(Romero et al 1996). Three or fewer bowel movements per week.
The Rome II criteria (Box 2) are frequently
used to define constipation (Thompson et al (Thompson et al 1999)

1999). However, they are mainly used as


inclusion criteria for research purposes and have constitutes constipation did not affect Marys
limited use in practice, as demonstrated in the outcome. Initially, Mary tried to treat herself by
case study where they could not be applied. asking a neighbour to purchase over-the-counter
The American College of Gastroenterology laxatives for her. Harari et al (1996) state that
Chronic Constipation Task Force (2005) states constipation is common in older people and is
that the widespread use of Rome II criteria is often treated with numerous prescriptions and
impractical because observation studies indicate over-the-counter laxatives.
that most patients who report constipation do Management Prodigy Guidance (2005) advises
not fulfil these criteria. Nevertheless, a a stepped approach to the management of
definition in terms of bowel frequency alone is constipation. After excluding any underlying
imprecise, because bowel habits vary from one medical conditions, the first step is dietary advice
individual to another. This lack of clarity of and the second is the use of laxatives. The
what constitutes constipation could limit National Prescribing Centre (NPC) (2004)
treatment strategies. reviewed trials on the effectiveness of laxatives in
In the case study, Mary knew she was adults. They concluded that there is insufficient
constipated, so any confusion about what clinical evidence to assess objectively the relative
effectiveness and tolerability of laxatives
(Petticrew 1997, Tramonte et al 1997, Petticrew
BOX 1
et al 2001, Jones et al 2002). However, there are
Drugs that commonly cause constipation seven indications for when laxatives should be
Antacids (containing aluminium hydroxide or used (Prodigy Guidance 2005):
calcium carbonate). No response to adequate non-drug treatment
Amiodarone. (after one month of dietary advice).
Anticholinergics (tricyclic antidepressants, Faecal impaction.
antihistamines and antipsychotics).
Constipation or painful defecation associated
Antidiarrhoeal agents. with illness, surgery or pregnancy.
Antiparkinsonian agents.
Older age and poor diet.
Calcium-channel blockers.
Drug-induced (iatrogenic) constipation.
Calcium supplements.
Medical conditions in which bowel strain is
Clonidine. undesirable, for example, haemorrhoids or
Disopyramide. rectal prolapse.
Diuretics. Preparation for an operation or investigation.
Iron preparations. Mary fulfilled four of these criteria: faecal
Lithium. impaction, constipation associated with illness,
poor diet because of nausea and immobility, and
Non-steroidal anti-inflammatory drugs.
drug-induced constipation from opioids and
Opioids, analgesics and cough suppressants calcium supplements. Laxatives are the obvious
(Prodigy Guidance 2005) treatment when these criteria are present.
However, it is important to adopt a proactive

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art & science continence focus possibility of constipation, especially as her usual
level of mobility was greatly reduced.
Immobility is a primary risk factor in
constipation (Harari 2004). Marys diminished
approach when assessing older patients with mobility resulted in reduced colonic motor
constipation. A prompt and comprehensive activity and eventual weakening of the
patient assessment would have resulted in earlier abdominal wall muscles. This led to difficulty in
identification and treatment of the risk factors raising intra-abdominal pressure sufficiently for
involved, thereby relieving Marys constipation defecation which would have been exacerbated
sooner and minimising any distress and by Marys back pain.
discomfort. The decision to prescribe lactulose 15ml at
Numerous studies support the benefit of a night to an older patient who is already
high fibre diet to prevent constipation (NPC constipated and feeling nauseous may not have
2004). Therefore, the first step of giving dietary been the best treatment option because lactulose
advice to address constipation would have been may take up to two to three days to have an effect
appropriate for Mary if given concurrently with and is not suitable for rapid relief of constipation
laxative advice (Prodigy Guidance 2005). (NPC 2004). It should not be regarded as first-
Constipation is a common side effect of opioid choice therapy in the management of patients
analgesia. Even compound analgesic with constipation (Prodigy Guidance 2005).
preparations, such as co-dydramol, contain Macrogols, such as Movicol and Idrolax,
sufficient opioid to cause constipation are inert polymers of ethylene glycol. There is
(BNF 2006). This raises the question of why the limited evidence from several trials that
healthcare team did not advise Mary about the polyethylene glycol is a safe and effective
alternative to lactulose in the management of
BOX 3 patients with constipation (Attar et al 1999,
Assessment of bowel function Corazziari et al 2000).
Movicol is the only laxative recommended
When assessing a patients bowel habits, a careful history should be taken in the treatment of faecal impaction, so it was an
and the following points noted: appropriate laxative for Mary when it was
Description of problem, sensation, wind, feelings of discomfort or prescribed (BNF 2006). However, when Mary
incomplete evacuation. first consulted the GP she may not have been
impacted, although this was not confirmed
Frequency of normal and current bowel movement.
because a comprehensive bowel assessment was
Description of normal diet and fluid intake. not undertaken.
Any changes to normal diet or fluid intake. Assessment Assessment is important for the
effective management of any distressing
Any change in mobility.
symptom. Mary should have received an initial
Whether the patient is able to prepare food, and whether the patient is assessment to ascertain the possible causes of her
reliant on others for shopping and preparation of food. constipation, for example, medication, poor diet
Check condition of tongue and breath for signs of dehydration. and reduced mobility. Accurate assessment of the
cause of constipation is the first crucial stage in
Check for poorly fitting dentures or decayed teeth.
developing a treatment plan (Koch and Hudson
Check medication. Bowel habit may change as a result of taking 2000). Points to consider during assessment have
medication for the alleviation or prevention of another been outlined by Norton and Chelvanayagam
pathophysiological condition. Five or more medications are a particular (2000) and adapted in Box 3.
risk for constipation (Potter et al 2002).
There is no conclusive evidence that one laxative
Description of stool: colour, mucous, consistency (use Bristol Stool Form is more effective than another in treating older
Scale, Figure 1). patients (Petticrew et al 1999). The appropriate
Any unusually offensive odour to stool (may be due to diet or laxative should be chosen according to the
malabsorption). individual patients needs and circumstances.
Glycerine suppositories act as a rectal
Pain or bleeding on defecation (may suggest local injury, for example,
stimulant because of the mildly irritant action of
haemorrhoids, anal fissure or underlying pathology such as colorectal
cancer). glycerol (BNF 2006). A stimulant laxative is a
suitable choice for short-term use to allow usual
Unexplained change in bowel habit (may suggest underlying pathology bowel function to be restored (NPC 2004).
such as colorectal cancer).
Despite a lack of assessment, the use of
Ask the patient how he or she usually copes with the problem. It may be suppositories appears to have been appropriate
that the patient uses digital rectal stimulation. for Mary. However, as the suppositories remained
(Adapted from Norton and Chelvanayagam 2000) intact after one hour in the rectum, they may not
have been appropriately administered.

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Glycerine suppositories should be moistened Koch and Hudson (2000) found no evidence that
before insertion and then placed alongside the a change in bowel motility is an inevitable
bowel wall. Suppositories need body heat to consequence of ageing. Nevertheless, the rate
dissolve so that the glycerol can act as a bowel of regular laxative use among older people is
irritant. If suppositories are placed in the middle reported to be between 7 and 10 per cent (Harari
of faecal matter they remain intact and serve no et al 1994, Pahor et al 1995). This rate rises to
purpose. There are conflicting between 50 and 75 per cent in nursing homes
recommendations about the administration of (Harari et al 1994, 1995).
suppositories. Baxter et al (2004) advocate The apparent reduction in bowel movement
insertion of the blunt end of suppositories first, frequency observed in older people appears to be
using previous research to substantiate this related to contributory factors associated with
viewpoint (Abd-el-Maeboud et al 1991). ageing, such as reduced mobility, polypharmacy,
However, Abd-el-Maeboud et al (1991) make chronic disease and poor diet, rather than ageing
no reference to the insertion of suppositories for itself (Harari 2004).
bowel care, so their research could be Risk assessment data are not yet available
interpreted for systemic or local action of to assist healthcare professionals with
suppositories or both. interpretation of contributing factors to
The application of research that is reported in constipation (Richmond and Wright 2004).
clinical textbooks, such as The Royal Marsden The use of such data or a risk assessment tool
Hospital Manual of Clinical Nursing Procedures may have prevented the exacerbation of
(Dougherty and Lister 2004), can be problematic Marys constipation. If Marys constipation
if the research has used simple descriptive had persisted or continued to be inappropriately
statistics. The findings of Abd-el-Maeboud et al managed, certain complications could
(1991) suggest that although the apex foremost have ensued, including haemorrhoids,
mode of insertion is common sense, base urinary incontinence, urinary tract infection,
foremost insertion is preferable for administering rectal bleeding and possible hospitalisation.
rectal suppositories (Abd-el-Maeboud 1992). Any of these complications would have
This conflicting advice can mean that healthcare adversely affected Marys quality of life and
professionals are unsure about what constitutes would have had cost implications for the NHS.
best practice in the administration of It is estimated that 10 per cent of district
suppositories. nursing time is spent on bowel management
It is often assumed that constipation is an (Poulton and Thomas 1999). In 2001, more than
inevitable consequence of older age. However, 12 million prescriptions for laxatives were

References
Abd-el-Maeboud K (1992) The (2004) Elimination: bowel care. In NHS Plan: A Plan for Investment, Journal of the American Geriatrics
best way to insert rectal Dougherty L, Lister SE (Eds) The A Plan for Reform. The Stationery Society. 42, 9, 947-952.
suppositories. Nursing Times. 88, Royal Marsden Hospital Manual of Office, London.
Harari D, Gurwitz JH, Avorn J,
10, 50. Clinical Nursing Procedures. Sixth
Department of Health (2001) Choodnovskiy I, Minaker KL
edition. Blackwell Publishing,
Abd-el-Maeboud KH, el-Naggar T, Prescription Cost Analysis. The (1995) Correlates of regular laxative
Oxford, 285-303.
el-Hawi EM, Mahmoud SA, Stationery Office, London. use by frail elderly persons. American
Abd-el-Hay S (1991) Rectal Bayliss V, Cherry M, Locke R, Department of Health (2003) Journal of Medicine. 99, 5, 513-518.
suppository: commonsense and Salter L (2000) Pathways for Essence of Care: Patient-focused Harari D, Gurwitz JH, Avorn J,
mode of insertion. The Lancet. 338, continence care: background and Benchmarks for Clinical Governance. Bohn R, Minaker KL (1996) Bowel
8770, 798-800. audit. British Journal of Nursing. The Stationery Office, London. habit in relation to age and gender.
9, 9, 590-596.
American College of Dougherty L, Lister SE (Eds) Findings from the National Health
Gastroenterology Chronic British National Formulary (2004) The Royal Marsden Hospital Interview Survey and clinical
Constipation Task Force (2005) (2006) British National Formulary Manual of Clinical Nursing implications. Archives of Internal
An evidence-based approach to No 51. British Medical Association Procedures. Sixth edition. Blackwell Medicine. 156, 3, 315-320.
the management of chronic and the Royal Pharmaceutical Publishing, Oxford. Jones MP, Talley NJ, Nuyts G,
constipation in North America. Society of Great Britain, London.
Harari D (2004) Bowel care in old Dubois D (2002) Lack of objective
American Journal of
Corazziari E, Badiali D, age. In Norton C, Chelvanayagam S evidence of efficacy of laxatives in
Gastroenterology. 100, Suppl 1, S1-4.
Bazzocchi G et al (2000) Long (Eds) Bowel Continence Nursing. chronic constipation. Digestive
Attar A, Lemann M, Ferguson A term efficacy, safety, and tolerability Beaconsfield Publishers, Diseases and Sciences. 47, 10,
et al (1999) Comparison of a low of low daily doses of isosmotic Beaconsfield, 132-149. 2222-2230.
dose polyethylene glycol electrolyte polyethylene glycol electrolyte
Harari D, Gurwitz JH, Avorn J, Koch T, Hudson S (2000) Older
solution with lactulose for balanced solution (PMF-100) in the
Choodnovskiy I, Minaker KL people and laxative use: literature
treatment of chronic constipation. treatment of functional chronic
(1994) Constipation: assessment review and pilot study report.
Gut. 44, 2, 226-230. constipation. Gut. 46, 4, 522-526.
and management in an Journal of Clinical Nursing. 9, 4,
Baxter A, Regan F, Watts C Department of Health (2000) The institutionalized elderly population. 516-525.

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art & science continence focus until it has become a significant problem for the
patient (Ross 1998). The problems associated
with a reactive approach to constipation are
compounded by ongoing reference to
written in England in general practice management of constipation, rather than
(Department of Health (DH) 2001). prevention, in the literature (Harari et al 1994,
Powell and Rigby 2000, NPC 2004). The case
Conclusion study demonstrates that, despite Marys
awareness of her constipation, healthcare
Discussion of the issues raised in the case study professionals did not respond effectively until
highlights the lack of agreement on what Marys constipation was affecting her general
constitutes a working definition of constipation. wellbeing and quality of life.
Poor understanding of the use of laxatives and Evidence-based health care is an NHS priority
limited assessment protocols indicate the need (DH 2000). There is increasing emphasis on
for a national consensus on bowel management. supporting all clinical practices with quality
The introduction of bowel assessment pathways evidence. However, the common nursing
will provide healthcare professionals with a clear procedure of inserting rectal suppositories for
structure for assessing patients with constipation bowel care is not supported by quality evidence.
(Bayliss et al 2000). This highlights the need for more rigorous bowel
The response of NHS trusts to the Essence care research.
of Care document (DH 2003) will help to ensure An emerging theme from much of the nursing
the development of benchmarks on bowel literature is the importance of assessing patients
management that are based on best patient- to identify those at risk of constipation
focused practice. Continual improvement of (Richmond 2003, Richmond and Wright 2004).
these benchmarks will be maintained by Assessment strategies are necessary to prevent
comparison and sharing of knowledge and the development of this distressing condition.
expertise from similar clinical areas. Risk assessment tools have been described as the
Digital rectal examination courses are now backbone of prevention (Thompson 2005),
run throughout the UK. They provide an ideal therefore a prerequisite for the prevention of
forum for enhancing education on all aspects constipation is the development of such a tool.
of bowel management. However, bowel To date no such risk assessment tool exists. Once
management remains an underfunded and healthcare professionals can easily identify
under-researched area of health care (Kyle patients at risk, they can institute preventive
2005). Constipation rarely receives attention measures to meet each patients needs NS

References continued
Kyle G (2005) Steps to best Petticrew M (1997) Treatment of Management of bowel dysfunction: and control in an acute hospital
practice in bowel care. Nursing constipation in older people. Nursing evacuation difficulties. Nursing setting. British Journal of Nursing.
Times. 101, 2, 47. Times. 93, 48, 55-56. Standard. 14, 47, 47-51. 7, 15, 907-913.

National Prescribing Centre Petticrew M, Watt I, Brand M Prodigy Guidance (2005) Sweeney M (1997) Constipation.
(2004) The management of (1999) Whats the best buy for Constipation. www.prodigy.nhs.uk/ Diagnosis and treatment. Home
constipation. MeReC Bulletin. 14, 6. treatment of constipation? Results of constipation (Last accessed: Care Provider. 2, 5, 250-255.
a systematic review of the October 18 2006.) Thompson D (2005) An
Norton C, Chelvanayagam S
efficacy and comparative efficacy of evaluation of the Waterlow
(2000) A nursing assessment Richmond J (2003) Prevention
laxatives in the elderly. British Journal pressure ulcer risk-assessment tool.
tool for adults with fecal of constipation through risk
of General Practice. 49, 442, 387-393. British Journal of Nursing. 14, 8,
incontinence. Journal of Wound, management. Nursing Standard.
Petticrew M, Rodgers M, Booth A 17, 16, 39-46. 455-459.
Ostomy, and Continence Nursing. 27,
5, 279-291. (2001) Effectiveness of laxatives in Thompson WG, Longstreth GF,
Richmond JP, Wright ME (2004)
adults. Quality in Health Care. 10, 4, Drossman DA, Heaton KW,
Nursing and Midwifery Council Review of the literature on
268-273. Irvine EJ, Muller-Lissner SA
(2004) The NMC Code of constipation to enable development
Potter JM, Norton C, Cottenden A of a constipation risk assessment (1999) Functional bowel disorders
Professional Conduct: Standards for and functional abdominal pain. Gut.
Conduct, Performance and Ethics. (Eds) (2002) Bowel Care in Older scale. Clinical Effectiveness in
People: Research and Practice. Nursing. 8, 1, 11-25. 45, Suppl 2, II43-II47.
NMC, London.
Royal College of Physicians, London. Tramonte SM, Brand MB,
Pahor M, Mugelli A, Guralnik JM Romero Y, Evans JM, Fleming KC,
Mulrow CD, Amato MG,
Poulton B, Thomas S (1999) The Phillips SF (1996) Constipation and
et al (1995) Age and laxative use in OKeefe ME, Ramirez G (1997)
nursing cost of constipation: clinical fecal incontinence in the elderly
hospitalized patients. A report of the The treatment of chronic
update. Primary Health Care. 9, 9, population. Mayo Clinic Proceedings.
Gruppo Italiano di Farmacovigilanza constipation in adults. A systematic
17-22. 71, 1, 81-92.
nellAnziano GIFA. Aging (Milan). review. Journal of General Internal
7, 2, 128-135. Powell M, Rigby D (2000) Ross H (1998) Constipation: cause Medicine. 12, 1, 15-24.

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