Professional Documents
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OVERVIEW
The original definitions of sepsis and related conditions (SIRS, severe sepsis and
septic shock) are now more than 20 years old (Sepsis- 1 originated from the
ACCP/SCCM consensus meeting in 1991 and Sepsis 2 from 2001)
SEPSIS 3 DEFINITIONS
1. T >38 C or <36 C
2. P >90/min
3. RR >20/min or PaCO2 <32 mmHg
4. WCC >12 or >10% immature band forms
Sepsis
mortality: 10-15%
Severe Sepsis
o SBP <90 mmHg or MAP < 65 mmHg or lactate > 2.0 mmol/L (after
initial fluid challenge)
Septic Shock
mortality: 43-54%
APACHE and SOFA are scoring systems that are commonly used in intensive care
APACHE = Acute Physiology, Age and Chronic Health Evaluation (I-IV)
SOFA = Sequential Organ Failure Assessment