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ANTIBACTERIAL
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Abstract
Modification hydroxyapatitre (HA) with zinc oxide (ZnO) via sol-gel method has been
successfully carried out. The analysis of X-Ray Diffraction (XRD) showed hexagonal
crystal system and the addition of zinc can increase the intensity and crystallinity of the
sample. The spectrum of Fourier Transform Infrared (FTIR) showed the presence of
functional groups suitable for the identification of HA in wave numbers 3000-3600 cm-1,
1000-1045 cm-1 and 1300-1490 cm-1 indicating the presence of the O-H, P-O and C-O,
respectively. Antibacterial test has been done using disc diffusion method and resulted
that the capability of HA as antibacterial increasing with the increase of ZnO
concentrations. HA/ZnO 1:1 with a concentration of 1000 ppm has inhibitory activity
with a maximum diameter of 8 millimeters.
keywords: Modifikation, Hydroxyapatite, ZnO, Sol gel, Antibacterial
.
2. C.S.Ciobanu, 2012,Antibacterial
Figure 3. Clear zone around the growth of
activity of silver-doped HA
E. coli that has been given an antibacterial
HA and HA/ZnO3(at a concentration of 500 nanoparticles against gram-positive
ppm and 1000 ppm). and gram-negative bacteria,
Nanoscale Research Letters, No.1,
The ability of increasing inhibition, Vol.7, p. 324.
comparable with the addition of Zn to
the HA. The positive charge of the Zn2+ 3. Vasconcelos,M.C.2011,Barreto,
ion and a negative charge on the Tailoring the Microstructure of Sol
bacterial cell membrane will cause Gel Derived Hydroxyapatite/Zirconia
attraction between Zn2+ ions and Nanocrystallin Composites,
negatively charged areas on the Nanoscale Research Letters, 2011,
bacterial cell wall to form an No.6, p. 20.
electrostatic bond. This will form an
electrostatic bond stress leads to 4. Angraini, D.,2013,Sintesis
damage the cell wall permeability, Zn(II)/Silika dengan Method Sol-Gel
reducing the normal intake of nutrients sebagai Material Antibakteri
to sustain life, causes cells to become terhadap Escherichia coli dan
dead.4 Thus, a growing number of Zn2+ Staphylococeus aureus. Thesis,
in the sample, the greater the ability to FMIPA,program pasca sarjana, UGM,
inhibit the growth of E. coli bacteria. Yogyakarta.
V. Acknowledgements
Acknowledgements profusely, the two
counselors, who have provided
comments and suggestions in the
smooth conduct of research and in the
preparation of the journal.