Drugs:

Week 1 2
Cytoxan Alkylating agents
Benzo[a]pyrene Adduct former in cigarette smoke
Cis platin Crosslinking agents
Etoposide Type II topoisomerase inhibitor (which induces double strand breaks)
Rifampin (tb) Binds to beta subunit of prok RNA pol
Dactinomycin (actinomycin D) Binds to DNA template and interferes w/ RNA pol progression (also used in tumor therapy)
NtRTIs Nucleotide reverse transcriptase inhibitors; Major class of drugs against retroviruses.
Tetracycline Bacterial ribosome A site.
Streptomycin Bacterial 30S sub-unit
Erythromycin Bacterial 50S sub-unit
Chloramphenicol Bacterial peptidyl transferase
Puromycin Premature termination
Cyclohexamide Eukaryotic 80S ribosome
Mevinolin (statin) Hypercholesterolemia; HMG-CoA reductase; competitive
5-Fluorouracil Cancer; thymidylate synthase; suicide
Methotrexate Cancer; dihydrofolate reductase; competitive
Allopurinol Gout; xanthine oxidase; suicide
Coumadin Anticoagulant; -Glutamylcarboxylase; competitive
Aspirin Anti-inflammatory; cyclooxygenase; suicide
Captopril High BP; Angiotensin-converting enzyme; competitive
Isoniazid Tx for tuberculosis, but it can induce B6 deficiency
Antimalarial primaquine Stimulate H2O2 synthesis and can produce a hemolytic crisis
Sulfonamides Stimulate H2O2 synthesis and can produce a hemolytic crisis
Acetanilid Stimulate H2O2 synthesis and can produce a hemolytic crisis
Analgesic
Nalidixic Stimulate H2O2 synthesis and can produce a hemolytic crisis
Antimicrobial
Nitrofurantoin Stimulate H2O2 synthesis and can produce a hemolytic crisis
Urinary antiseptic
Coumpound in fava beans Stimulate H2O2 synthesis and can produce a hemolytic crisis
Favism (often life-threatening attack of hemolysis w/ black urine)
Week 3 4
Aspirin, indomethacin, Inhibit cyclooxygenase
phenylbutazone
Mevinolin, lovastatin, Zocor Drugs that inhibit cholesterol synthesis
Thiazides, cyclosporine, tegretol
Statins [SEE LIPID LOWERING DRUG CHART FOR STATINS, FIBRATES, OMEGA 3, NIACIN, BILE ACID BINDING RESINS,
Atorvastatin (Lipitor), Rosuvastatin EZETIMIBE]
(Crestor), Lovastatin (generic),
Fluvastatin (Lescol), Pitavastatin
(Livalo), Simvastatin (generic) and
Pravastatin (generic)
Fibrates
Gemfibrozil (Lopid), fenofibrate
(generic)
Warfarin and statins Significant drug interactions with fibrates
Omega 3 Fatty acids (Lovasa)
Niacin (Vit B3, Nicotinic acid)
Bile acid binding resins:
Cholestyramine (Prevalite),
Colestipol, Colesevelam
Ezetimibe (Zetia)
Thioureas Antithyroid drugs; inhibit oxidation of iodine (but no effect on its uptake)
Allopurinol [Also listed above] Treats gout; inhibits xanthine oxidase (oxidizes hypoxanthine to uric acid, the end product of purine
degradation)
Week 5 6
Imatinib (Gleevec)
Nilotinib (Tasigna)
Genedicine
Glybera (Alipogene tiparvovec)
Taxol (Paclitaxel)
Vinca alkaloids (vainblastine and
vincristine):
Week 7 8
Alprazolam (Xanax)
Beta-carboline
Cetuximab (Erbitux)
Trastuzumab (Herceptin)
Protein tyrosine kinase inhibitor (used in CML)
Alternative to imatinib
Adenoviral mediated p53-based therapy used in China for tx of head and neck cancer
AAV to treat lipoprotein lipase deficiency (LPLD) which can result in severe pancreatitis
Spindle poison; Lung, ovarian, breast, head and neck cancer
Hyperstabilizes MTs by binding to beta-tubulin and preventing dynamic instability
Leukemia and lymphoma
Binds to tubulin dimers to inhibit their assembly
Benzodiazepine. Agonist at the GABA receptor anxiolytic effects
Inverse agonist anxiety
EGFR inhibitor. Metastatic colon cancer pts w/ RAS mutations dont respond to this.
HER2 Amplified tumors may be treated w/ this.