Early Diagnosis of

AMI
can be
Challenging
AMI: Acute Myocardial Infarction
Early Diagnosis of AMI
can be Challenging

AMI: Acute Myocardial Infarction

 Early detection of MI is crucial to preserve the cardiac function1

Key challenges leading to Cardiac markers are powerful

delayed diagnosis include2 tools for the diagnosis of AMI2

Chest Pain is highly non-specific Guidelines recommend cardiac biomarkers should

be measured at presentation in patients with
Early Diagnosis is challenging in the absence of suspected MI3,4,5,6
history of heart diseases
Creatinine kinase - MB considered as reference
Compromised sensitivity of ECG: standard for MI, but is highly non specific3,4,5,6
30-50% patients initially present with
normal or non-diagnostic ECG Cardiac Troponin is the only biomarker that is
recommended to be used for the diagnosis of
AMI due to its superior accuracy. 3,4,5,6

Ref. 1. Daubert MA, Jeremias A. The utility of troponin measurement to detect myocardial infarction: review of the current findings. Vascular health and risk management. 2010 Sep 7;6(1):691-9.
2. Al-Hadi HA, Fox KA. Cardiac markers in the early diagnosis and management of patients with acute coronary syndrome. Sultan Qaboos University medical journal. 2009 Dec;9(3):231.
3. Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Ganiats TG, Holmes DR, Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes. Circulation. 2014 Jan 1:CIR-0000000000000134.
4. OGara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK, De Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction. Circulation. 2013 Jan 29;127(4):e362-425.
5. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzlez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failureThe Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European heart journal. 2016 Jul 14;37(27):2129-200.
6. American College of Emergency Physicians. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology. 2013 Jan 29;61(4):e78.
AMI: Acute Myocardial Infarction ECG: Electro Cardiogram
 Bridging the Gap : for faster & accurate diagnosis of Acute Myocardial Infarction

Introducing

Ez
Dx TROPONIN I *
Rapid cTni Detection Test

A rapid semi-quantitative, chromatography
immunoassay for the detection of
Cardiac Troponin I in human
serum, plasma or whole
blood specimens
Highly Sensitive
and Specific Cardiac Biomarker
A positive result indicates myocardial damage
Aids in the diagnosis of myocardial infarction
Rules-in AMI even if characteristic ECG changes
are missing

*cTni - Cardiac troponin I

AMI: Acute Myocardial Infarction
ECG: Electro Cardiogram
 Bridging the Gap for faster & accurate diagnosis of Acute Myocardial Infarction

Introducing

Ez
Dx
TROPONIN I Rapid cTni Detection Test *

Detects the damage that other markers cTni* is Highly Specific to the
can miss myocardium unlike Cardiac Troponin T (cTnT)
Up to 80% of patients with AMI will have an
cTnT may be expressed in patients with diseased
elevated troponin level within 2-3 hours of
skeletal muscles and in regenerating skeletal muscles9
emergency department arrival, versus 6-9 hours
or more with Creatinine kinase - MB
cTnT is also elevated in patients with chronic renal
& other cardiac markers7
insufficiency
Superior efficacy as compared to other Cardiac Biomarkers8
Comparative Efficacy of Cardiac Biomarkers
Markers Sensitivity Specificity
Total CK $ 73.5% 84.6%
CK-MB # 88.2% 93.2%
Troponin I 100% 96.3%
Ref.
7. http://emedicine.medscape.com/article/811905-overview#a1
8. Falahati A. Sharkey SW. Christensen et al. Implementation of serum cardiac troponin I as marker for detection of acute myocardial infarction. Am Heart J.1999 Feb;137(2):332-7
9. Cummins B, Auckland ML, Cummins P. cardiac specific troponin I radioimmunoassay in the diagnosis of acute myocardial infarction. Am Heart J 1987; 113:1333-44
AMI: Acute Myocardial Infarction *cTni - Cardiac troponin I $ CK - Creatinine kinase #CK-MB - Creatinine kinase - MB
 Bridging the Gap for faster & accurate diagnosis of Acute Myocardial Infarction

Introducing

Ez
Dx
TROPONIN I *
Rapid cTni Detection Test

Highly Versatile Point of Quick Diagnosis

Care Diagnosis for AMI
- Useful for detection in emergency room,
clinical and ambulance set up
- Can be stored at 4-30C
- Reliable results available in 15 mins
- On the spot rule in for Myocardial Infarction
Easy to Use

Cost Effective
- Simple strip based bed side test
- Shelf life of 24 months (2 years)
- Simple bed side test kit
- Requires only four (80L) drops of blood
- Does not require any additional equipment or
reagents
- Does not require any special training
*cTni - Cardiac troponin I
AMI: Acute Myocardial Infarction
 Bridging the Gap for faster & accurate diagnosis of Acute Myocardial Infarction

Introducing

Ez
Dx
TROPONIN I *
Rapid cTni Detection Test

How to use

Negative Positive Invalid

s

(60L) 3 drop of serum/plasma

1. Remove the test device from the sealed pouch

2. Allow the test kit to attain room temperature
3. Using a micropipette/ Sample Dropper, add 4 drops (80L) of whole blood or 3 drops (60L)
of serum/plasma specimen into the sample well (S)
4. Read the result at the end of 15 minutes
Important: Do not read the test after 20 minutes, since it may give incorrect results.
*cTni - Cardiac troponin I
 Bridging the Gap for faster & accurate diagnosis of
Acute Myocardial Infarction

Introducing

Ez
Dx
TROPONIN IRapid cTni* Detection Test

A rapid semi-quantitative, chromatography immunoassay for

the detection of Cardiac Troponin I in human serum,
plasma or whole blood specimens

Detection limit:
0.6ng/ml of cTni*
Storage conditions :
To be stored at 4C 30C

*cTni - Cardiac troponin I