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Dr. Jonathan Wright
explains bioidentical
hormone replacement
for women
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Rather than merely suppressing hot flushes using any patent med-
Getting the Most icine or pseudo-hormone that seems to work, the primary goal
of BHRT is to restore a hormonal environment as close to the
natural, premenopausal state as possible.
Out of BHRT BHRT requires that we follow the hormonal recipe Mother Nature
has worked out over millions of years of evolution in the hu-
By Jonathan Wright, M.D. man female. The closer that recipe is followed, the happier and
healthier you will be. If symptoms are caused by an imbalance in a
complex, integrated physiologic system, like the one that controls
Its Simple Really: Just Follow Mother sex steroid secretion and activity, rather than ignoring and/or over-
riding that control as conventional treatments almost always do
Natures Hormone Recipe natural medicine aims to restore the natural balance of hormones
to which the body is accustomed.
Many doctors and patients think they are using genuine BHRT just
by taking pills containing bio-identical estradiol and progesterone. Since menopausal complaints and symptoms are largely a result
Although estradiol is the primary estrogen produced by the pre- of a hormone deficiency, once that deficiency is resolved by
menopausal ovary, normal metabolic processes eventually result in replacing the deficient hormones with bio-identical copies, the
three primary circulating estrogens: estriol, estradiol, and estrone. complaints and symptoms generally go away of their own accord.
There is no need to suppress them artificially. This may seem like
Estradiol is the most potent and most carcinogenic of these and a subtle distinction, but when it comes to the overall health of
also comprises less than 10% of the total circulating estrogen. women using hormone replacement, it makes all the difference in
When women replace deficient ovarian hormones with 100% the world.
estradiol, they can distort the natural balance of circulating
estrogens, and theres no guarantee that their natural metabolic Maximizing the value of BHRT requires that doctors have a real
processes will produce sufficient estriol to counteract the inherent appreciation of the way these hormones are metabolized and how
carcinogenicity of estradiol and the estrone, which the body does much the body actually needs and can safely handle at any one
form from estradiol. time. Using too little may yield unsatisfactory results, while using
too much may carry unacceptable risks. In this regard, what often
In true BHRT, potentially carcinogenic estradiol in its natural gets lost in the translation from conventional HRT to BHRT is any
physiologic proportions (10% or less) is balanced by relatively serious attention to the dose, timing, route of administration, and
high doses of the more benign, anti-carcinogenic estriol, which metabolic processing of the replacement hormones.
You can take bio-identical hormones via one of several routes: Hormones, carefully measured and formulated in an appropriate
cream or gel, need only be rubbed once or twice a day into the
Oral capsules. Nothing unusual here. Like most patented med- skin, or preferably, mucous (epithelial) membranes, especially
icines and nutritional supplements, just swallow compounded those that line the labia or vagina. The hormones diffuse through
bio-identical hormone capsules and the body does the rest, although the skin or epithelial tissue and pass easily and directly into the
as we shall see, not always for the best. Oral administration of ster- bloodstream. With no destructive detours through the GI tract and
oid hormones has distinct disadvantages, as discussed below. liver, bio-identical estrogens and progesterone applied topically
enter the blood stream metabolically unchanged. When you apply
Creams or gels. You can rub hormone-containing creams or gels estrogen, progesterone, and testosterone topically it is estrogen,
into your skin (transdermal), or preferably your vaginal mucosa or progesterone, and testosterone that go into your blood stream.
labia (transmucosal or transvaginal). Based on more than 25 years Admittedly, this may take a little more effort than popping a pill in
of personal experience at the Tahoma Clinic, we have found these the morning, but the advantages are substantial!
topical methods (especially transmucosal) to be the preferred ways
of using bio-identical hormones, especially if they are personally
formulated by a compounding pharmacist. Intravaginal Dosing Avoids Dermal
Suppositories. You insert the hormone, formed into a suppository Absorption Fatigue
by a compounding pharmacist, either in the vagina or the rectum
for rapid transmucosal absorption. Experience has shown us that intravaginal application offers
more than merely theoretical advantages. At the Tahoma Clinic,
Lozenges (troches). You allow the hormone-containing lozenge we monitor the 24-hour urinary hormone levels of women using
to dissolve in your mouth, but try not to swallow, so that a large BHRT at regular intervals to make certain their levels are within
portion of the hormones get absorbed directly into your blood their individual physiologic target range. Over several years, this
stream through the mucous membranes that line your mouth. This monitoring has shown us that, in many women using transdermal
method, which is technically considered to be a transmucosal estrogen preparations, urinary estrogen levels begin to decline
method of administration, is designed to avoid having the hor- progressively, suggesting that they are absorbing less and less
mones pass through the gastrointestinal (GI) tract. The problem is estrogen through their skin as time goes by.
that, due to normal saliva formation, it can be hard not to swallow
and usually 50% or more of the hormone winds up getting into However, we have found that when we switch the route of admin-
your GI tract anyway. istration from transdermal to transvaginal without altering the
dose their urinary levels rise right back up to their target range,
Sublingual (under-the-tongue) drops. The same logic as lozenges. and any symptoms of low estrogen they might have been experi-
encing quickly disappear.
Oral administration works reasonably well for some drugs and
nutritional supplements, but for replacement of sex steroids, oral We attribute this loss of effect of transdermal administration to a
administration can seriously detract from their optimal use. In fact, factor we term dermal absorption fatigue: repeated transdermal
oral administration of steroid hormones is Exhibit A when it comes applications over many months seem to cause the skin to lose
to demonstrating how profitability trumps safety and efficacy. To some of its ability to transport the hormones into the blood stream.
prove our point that taking sex steroids by mouth may not be the Why this happens remains a mystery, but we know it does, and we
best idea, all we have to do is look again at the way the human know that switching to intravaginal dosing avoids it.
body is designed.
In this interview, the Founder and Chairman of TA Sciences, Mr. Noel Thomas Patton
discusses the role of telomeres, health, longevity and TA-65 with Phil Micans
PM: Thank you Noel for taking time out of your NTP: Sure, telomeres are the protective end caps
busy schedule to talk a bit about telomeres and of your chromosomes. Telomeres are made of re-
your unique product TA-65. Now I dont want petitive sequences of DNA and act like the protec-
to start with a controversial question! But a lot tive plastic tips at the ends of a shoelace. But with
of people in the industry know that you paid a each cell division, telomeres get shorter and dam-
considerable amount of money to get the rights aged until eventually they get too short and the
for the TA-65 ingredient/ function from Califor- cell either dies or becomes senescent. So telomere
nia biotech company Geron Corp; what was it length directly correlates to the age of our cells,
that excited you about the product to do that? they are the ticking clocks of cellular aging.
NTP: I originally got interested when I realized I
was aging and I wanted to do something about it!
I had learned about telomeres being the ticking
clock in our cells and that an enzyme called tel-
omerase can lengthen short telomeres. So when
I heard that Geron had discovered something
proven to extend telomeres, I went after it with a
passion. To be quite honest, at first I just wanted to
save my own aging derriere.
PM: It is a scientific fact telomeres shorten
PM: Perhaps we should just backtrack for our
with age and are associated with most diseases
readers; could I ask you to describe what tel-
of aging. So what do we know now about
omeres are?
the types of improvements we can expect if
TA65 30
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If you look five years out, most of these meetings will be about
[natural] therapies. Mario Sznol, M.D.
Recently, Dr. Ruger M. Perlmutter, head of research patients with harmful drugs that indiscriminately
and development at Merck & Co. Inc. said, I think attack both healthy and sick cells and cause serious
all of you will recognize this is a special moment [in side effects. This strategy uses a short protein chain
medical research]. He made this dramatic statement of 6 to 9 amino acids in length that trigger the bodys
to a standing room only audience at a traditional key receptor sites.
pharmaceutical meeting in New York.
One such site is located in the melanocyte cells of
What inspired the esteemed Dr. Perlmutter was a our skin. These cells cause our skin to naturally tan.
recently uncovered strategy to conquer diseases and This is an all-natural process because melanocyte
aging that cannot be achieved by traditional drugs. cells also cause natural pigmenting in brown- and
This new strategy seeks to stimulate a bodys bio- dark-skinned people with and without sunlight.
logic systems. It is significantly superior to treating
Directions: Apply one spray to one nostril only once Precautions: Keep this and all other medicines out
daily (each spray is 10 IU). The maximum daily al- of the reach of children. This product is not intended
lowance for adults is 50 IU. The maximum dosage to for use by pregnant or lactating women. This infor-
be given at one time is 20 IU. Check blood pressure. mation does not replace your physicians advice,
always seek and follow your physicians advice.
Caution: Although the hypertensive action of MSH
is minimal when applied intra-nasally and in nor-
mal doses, it should be administered with caution if I used MSH2-Pro only once or
increased blood pressure is to be avoided. In cases of twice weekly, and I experienced a
hypertension, advanced arteriosclerosis and epilepsy,
this product should be administered with caution. lovely tan all over my body without
Contraindications: Coronary insufficiency; halo-
the need for sunbathing.
thane or cyclopropane anesthetic.
www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com 15
NO SUNLIGHT,
NO PROBLEM
MSH2-Pro Gives You An All Over Tan
Just one or two sprays daily help produce a natural all
over tan - without the need to expose the skin
to direct sunlight or to have injections.
MSH2 Also:
Reduces appetite and increases libido
Works synergistically with the other hormones
to rejuvenate cells and organs
Dear Dr. Dean... as intracellular garbage, and may in some way impair
Q. In the last few years my skin has developed liver cellular function. Fortunately, there are a number of
spots. Additionally, I have a diagnosis of Hepatitis C substances that can eliminate these pigmentsand
or B. Apparently there are often false positives in the you can watch your skin changes as an indicator of
testing. While my liver enzymes are slightly elevated the degree of their removal. Centrophenoxine, DMAE,
they are not in the range of someone with the hepatitis and Hydergine, have all been demonstrated to reduce
C virus. The enzyme levels decrease with major lipofuscin deposits in experimental animals1. I know
autohemotherapy (using ozone). I have had several several patients who have used these substances to rid
glutathione IVs, and I regularly do a gall bladder flush. themselves of their age spots, over 3-6 months
What other therapies are available for liver health?
Im puzzled that you have a diagnosis of hepatitis A or
Thanks a lot, J.M., United States
B. With tests available today, very specific, accurate
A: Dear J.M., diagnoses can be made. If you really do have hepatitis,
Firstly, liver spots dont have anything to do with the type of hepatitis can accurately be madeand if you
liver disease. They are also known as age spots, have hepatitis C, a viral load (using PCR) will provide
and are due to the deposition of aging pigment an indication of the severity of the disease. Liver enzyme
(lipofuscin). Lipofuscin is a fluorescent, highly cross- tests are an indicator of liver abnormalities, but may be
linked lipoprotein pigment resulting from the inefficient caused by other factors such as statins, acetaminophen
metabolism of polyunsaturated fatty acids. Lipofuscin (Tylenol) or other drugs. Id ask your physician to re-
accumulates in our cells with age, and liver spots in the check, or find another doctor.
skin are thought to be an indicator of the concentration Nevertheless, to answer your specific question regarding
of lipofuscin elsewhere in the body. Dr. Kalidas Nandy, substances that you can add to your liver support
of the Department of Anatomy and Neurology, Boston program, I suggest vitamin B-12, N-Acetyl Cysteine
University School of Medicine, stated that; One of the (NAC), glutathione, carnitine, taurine and methionine,
most consistent cytological changes in aging mammals, is and the herbs milk thistle and turmeric.
the deposition of lipofuscin (age pigment).1 Researchers
Metformin, which is now recognized as the treatment
in Italy emphasize that; lipofuscin pigments are well
of choice for Type 2 diabetes, and which I have long-
known biomarkers of the aging process.2
recommended as a premier antiaging substance, has also
I believe that liver spots are an indicator of the degree recently been reported to be of benefit for those with
of lipofuscin accumulation in other parts of the body hepatitis C and diabetes. In a study of 100 diabetics with
(brain, heart, muscles). Although there is no evidence that hepatitis C, 26 of whom were treated with metformin,
lipofuscin is in any way harmful, it can be considered it was found that metformin use resulted in an 81%
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energy reserves and reduced aging at the cellular level. treatment with BEC5 Curaderm. A typical treatment
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The eggplant cancer cure by Bill Cham Basal cell carcinomas (BCC)
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Squamous cell carcinomas (SCC)
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Keratoses
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For example, one open study with 72 patients had 100% healed Age spots
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BEC5 Curaderm is a topical preparation which is safe and UPDATE: To achieve the best possible results in the quickest
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cancer care. Dermatologists at the Royal London Hospital
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Finally, for those who want to get metals out of their skin, use I am so grateful for the development
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Can-C eye-drops be a genuine breakthrough.
Richard Lippman, Ph.D.
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41
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Allergies
Bio-EnR-Gy C, Joint-Pro, pregnenolone, Thym-
Uvocal, Wobenzym
44
ARMD (see eyesight) Cognitive (also see memory & senile dementias)
Alertness: Adrafinil, modafinil
Aromatase inhibitors Creativity: Aniracetam, piracetam, pramiracetam
Arimidex, Beyond HRT, DIM-Pro2, progesterone Concentration: Phosphatidylserine
Focus: Deprenyl, desmopressin, vasopressin
Arterial (See heart, arterial & blood) Energy: ATP-Boost, centrophenoxine, picamilone
General support: Gerovital-H3, vinpocetine
Arthritis (rheumatoid & osteo) Intelligence: Hydergine
Gerovital-H3, Hy-Col, Joint-Pro, krill, pregnenolone, Work load: Hydergine, thyroid
pyritinol, SAMe, Thym-Uvocal, Wobenzym
Compulsive disorder treatment (also see
Asthma (see Allergies) alcoholism)
5HTP, Gamalate-B6, L-tryptophan, picamilone
Autism (also see chelation agents)
Oxytocin, piracetam Cortisol alteration (also see stress)
Aldosterone, fludrocortisone, GABOB, Gamalate B6,
At-home test kits (also see health diagnostics) hydrocortisone, Peptide Bioregulator - Glandokort,
Bio-CUFF, Bio-CLIP, Nitric Oxide saliva strips, Gerovital-H3, phenytoin
PulmoLife, vitamin C urine strips
Cross linking (see advanced glycated end products)
Back Problems (see spine)
Deep vein thrombosis (see frequent fliers)
Bells palsy
Beyond B12 Dental (see teeth & gums)
Beta blockers Depression (also see well-being & anti-depressants)
Propranolol 5HTP, aniracetam, ATP Boost, ATP-Boost,
CurcuminSR , D3-Pro, deprenyl, Gerovital-H3,
Blood disorders (see heart, arterial & blood) Lithium-Pro, L-tryptophan, milnacipran, Geront,
picamilone, piracetam, pramiracetam, pregnenolone,
Blood pressure SAMe, Thym-Uvocal, thyroid, Vigor-Pro
Neo40, Nitric-Pro, oxytocin, propranolol, vinpocetine
Detox (also see chelation agents)
Bone problems (also see joints & arthritis) Artemisinin, Bio-En-R-Gy C, Beyond Clean, Beyond
Andro-Pro, Bone-Pro, Esnatri, Hy-Col, Fiber, DIM-Pro 2, Detox-Pro, Dr. Gordons organic
progesterone, SAMe, thyroid greens, zeolite
Chronic fatigue syndrome (see mental stimulants Dr. Wrights recommend products
& physical energy improvement) Esnatri, cobalt chloride, progesterone
Influenzas (also see anti-biotics, infections & immune Migraines (also see pain relief)
system improvement) Beyond B12, nicergoline, memantine, picamilone,
1st Line, Relenza Quinton
Insulin & glucose control (see diabetes) Minerals (including trace- also see vitamins)
Beyond Chelation Improved, Cardio-Pro, Quinton
Intestinal flora (see probiotics)
Mitochondrial support
Joints (also see bones & arthritis) ATP-Boost, CoQ10, deprenyl, glutathione, hydergine,
Boluoke, Hy-Col, Joint-Pro, krill, Peptide idebenone, PQQ, pregnenolone, SAMe
Bioregulator- cartilage (Sigumir), pregnenolone, SAMe,
Thym-Uvocal, Wobenzym Multiple Sclerosis (also see mitochondrial support)
Melatonin, naltrexone, TRH
Kidney disorders (also see infections)
Aminoguanidine, Peptide Bioregulator- Pielotak, SAMe, Nail condition
TRH Gerovital-H3, krill
Learning (also see memory & mental stimulants) Narcolepsy (sleeping in the daytime)
Aniracetam, desmopressin, hydergine, piracetam, Adrafinil, melatonin, modafinil, picamilone
pramiracetam, vasopressin
Nitric Oxide release
Libido (see sex) Nitric-Pro, Neo40, Nitric Oxide saliva test strips
Lipids (see blood disorders) Oral health care (see teeth & gums)
Liver disorders (also see infections) Osteoporosis (see bone problems)
Idebenone, Peptide Bioregulator- liver (Svetinorm),
pregnenolone, SAMe, silver protein Pain relief
ATP-Boost, Gerovital-H3, memantine, milnacipran,
Longevity enhancement (significant increases seen nicergoline, oxytocin, Wobenzym
in animal studies)
Centrophenoxine, deprenyl, Desmopressin, melatonin Parasites (see infections)
Parkinson (see senile dementia)
Lou Gehrig (ALS)
Naltrexone, TRH Peptides
Adrenals = Glandokort, Blood vessels = Ventfort,
Lungs Brain (CNS) = Cerluten, Cartilage = Sigumir, Kidney
ACF228 Breathe-Easy, Centrophenoxine, Nitric-Pro, = Pielotak, Liver = Svetinorm, Pancreas = Suprefort,
PulmoLife Pineal = Endoluten, Prostate = Libidon, Retina =
Visoluten, Testes = Testoluten, Thymus = Vladonix,
Lupus Thyroid = Thyreogen
Milnacipran, naltrexone
Pets (see Animal use)
Lymes
1st Line, silver protein Photoaging (see radiation & skin problems)
Macular degeneration (see ARMD & eyesight) Ph balance (rebalancing)
Active H-minus, Dr. Gordons organic greens,
Malaria (also see anti-biotics) Quinton
Artemisinin
Physical energy improvement
Menopause (see HRT) Active H-minus, ATP-Boost, Beyond B12, CoQ10,
idebenone, L-carnosine, maca, PQQ, pregnenolone, SAMe,
Mental stimulants yohimbine
Adrafinil, aniracetam, centrophenoxine, deprenyl,
Senile dementia (also see cognitive & memory) Telomeres (also see DNA support)
Alzheimers: Centrophenoxine, CurcuminSR, Krill, L-carnosine, TA65
galantamine, hydergine, memantine
General support: Anacervix, aniracetam, piracetam, Testosterone & testes (also see fertility and prostate)
pramiracetam, vinpocetine, Wobenzym Andro-Pro, Arimidex, Beyond B12, Beyond GHS,
Parkinsons: bromocriptine, cabergoline, deprenyl, DIM-Pro 2, melatonin, oxytocin, Peptide Bioregulator -
rasagiline Testoluten, TRH, Vigor-Pro
Smoking cessation
5HTP
Spine Issues
Peptide Bioregulator- cartilage (Sigumir)
Take control of your New Years resolutions for a longer, healthier life.
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*Offer valid from January 11th until January 31st 2014
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Unique Supplements
Designed by Dr Garry Gordon
Move toxins through
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30 Sachets: 504 grams Powder:
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Restrictions may apply in some countries. All information is educational and does not replace your physicians and is subject to IAS terms and conditions which may change without notice.