IntroductionTelomeres protected chromosomes from degeneration, allowing
cells to divide without losing genes. Once telomeres are shortened to a critical length, cells are triggered into replicative senescence, which is associated with aging. The high rate of morbidity due to type 2 diabetes is a global issue and aging is a major risk factor for Type 2 diabetes, thus writer hypothesizes that telomere shortening might increase the risk of developing type 2 diabetes. This would help future endeavor in developing preventive intervention for type 2 diabetes. MethodsSystematic journal review from the Internet, both laboratory and clinical studies regarding the association between shortened telomere length with type 2 diabetes. ResultsA study on mice shows that shortened telomere length would impair the replicative potential of pancreatic beta cell and several prospective clinical studies had proven that longer length of telomere would reduce the risk of developing type 2 diabetes ( = 2.78; hazard ratio [HR] 0.06 [95% CI 0.010.42]. ConclusionsShortened telomere length is highly associated with the risk of developing type 2 diabetes and it might be a casual mediator for other risk factors of type 2 diabetes. To prove this, further prospective studies are needed.
Advances in Secondary Prevention Mechanisms of Macrovascular Complications in Type 2 Diabetes Mellitus Patients_ a Comprehensive Review. - Documento - Gale OneFile_ Nursing and Allied Health