Introduction to EMBL-EBI

EMBO Computational structural biology

Tom Hancocks
Training Team
tom@ebi.ac.uk
www.ebi.ac.uk
What is EMBL-EBI?

European Molecular Biology Laboratory

European Bioinformatics Institute

Non-profit research institute

Europes hub for biological data

Services and research

 European Molecular Biology Laboratory

Heidelberg Hamburg Hinxton

Basic research Structural biology Bioinformatics

EMBL staff Grenoble Monterotondo

1500 people
5 locations
60+ nationalities
Structural biology Mouse biology
What is EMBL?

20 member states
World-leading research institute
European life science flagship

Mission
Basic research in molecular biology
Train scientists, students and visitors
New instruments and methods
Services to scientists
Technology transfer
EMBL-EBIs mission

Services
Research
Training
Industry
Coordination
 Research at EMBL-EBI Neurons in
Parkinsons disease
Molecular basis of
ageing
Protein targets for
new drugs

Stem cell DNA data storage

differentiation

Cancer
genome
structure
7
Train Online
EMBL-EBI resources
 Bioinformatics underpins research
Genomes Literature

Nucleotide sequence
Protein sequence
Gene expression
Protein structure
Protein features

Protein interactions Chemical entities

Pathways Systems
 Where does the data come from?

11
 You submit data
and we

A
Provide tools
virtuous Archive it
circle
Analyse it Classify it

Share it
Who does this?

Range of staff at EMBL-EBI who all play a role in providing

the data service

Bioinformaticians / computational biologists

Curators
Software engineers / programmers
Web developers
User Experience analysts
Trainers
EMBL-EBI biological data

200GB in 1996 238TB in 2006 16PB in 2012

40 DVDs US Library of 1 year of data at

Congress LHC!
 TB of data

0
2000
4000
6000
8000
10000
12000
14000
16000
18000

1996

1997

1998

1999

2000

2001
EBI biological data

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012
EMBL-EBI users: a snapshot
Resources
DNA & RNA Systems
genes, genomes & variation reactions, interactions & pathways

Gene expression Chemical biology

RNA, protein & metabolite expression chemogenomics & metabolomics

Proteins Ontologies
sequences, families & motifs taxonomies & controlled vocabularies

Structures Literature
molecular & cellular structures Scientific publications & patents

Other software
cross-domain tools & resources
Accessing the data

The data we hold is publically accessible

It is there to be used by you!

Accessed by a whole range of individuals from bench

scientists to bio-informaticians to clinicians

Increase in clinical data

New considerations for data access and use
With thanks to our funders

EMBL member states: Austria, Belgium, Croatia, Denmark,

Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy,
Luxembourg, the Netherlands, Norway, Portugal, Spain,
Sweden, Switzerland, United Kingdom.
Associate member state: Australia

Other major funders: the European Commission,

UK Research Councils, the US National Institutes of Health
and the Wellcome Trust
Thank you!

www.ebi.ac.uk
Twitter: @emblebi
Facebook: EMBLEBI