ABSTRACT

THE RASIONALITY OF ORAL ANTIDIABETIC USE IN DIABETES

MELITUS TYPE 2 PATIENTS AT RSUP DR. MOHAMMAD HOESIN
PALEMBANG FROM 1 JANUARY 2014 UNTIL 31 DECEMBER 2014

(Hana Yuniko Gandasari, Faculty of Medicine, University of Sriwijaya, 66 pages)

Background. Diabetes melitus (DM) is a chronic disease happens because the
body can not produce insulin. Oral antidiabetic therapy given to diabetes mellitus
type 2 patients should be indicated rationally. This study is conducted to find out
more about the rationality of oral antidiabetic uses to diabetes melitus type 2
patients at RSUP Dr. Mohammad Hoesin Palembang from 1 January 2014 until
31 December 2015
Method. This statistic descriptive study of drug utilization was conducted in
RSUP Dr. Mohammad Hoesin Palembang. The number of patients from 1 January
2014 until 31 December 2015 was 317 patients, but only 80 patients that can be
examined based on inclusion criteria.
Results. There were 3 types of the drug used, namely the alpha glucosidase
inhibitors (4,1%), sulfonylurea (65,3%) and biguanid (30,6%). Dose for alpha
glucosidase inhibitors more often used 50 mg as many 2 (50%) patients. The dose
for biguanid more often used 500 mg as many as 63 (98,5%) patients. A dose of 5
mg glibenklamid granting as many as 3 (100%) patients, gliklazid 80 mg as many
as 10 (100%) patients, glimipiride 2 mg as many as 5 (71,4%) patients, glikuidon
30 mg as many as 9 (100%) patients. The frequency of the used of the alpha
glucosidase inhibitor and biguanid were more often used three times a day (75%).
The frequency of glibenklamid all used once a day (100%), gliklazid more often
used twice a day (60%), glimpiride all used once a day (100%) and glikuidon
more often used once a day (55,5%). Oral antidiabetic used which were given 14
days were alpha glucosidase inhibitors (50%), bigunaid (68,8%), sulfonylurea
(83,3%). An oral antidiabetic drug interactions with other medications as many as
120 interactions, 17 (14,16%) were synergistic, 50,79 (61%) were potential
action, 11 (9,16%) were antagonistic and 31 (25,83%) interactions that were not
yet known.
Conclusions. There was still an irrasionality used of oral antidiabetika and need
to be fixed so that the use of oral antidiabetika more rational and achieve effective
therapy with minimal side effects.

Keywords. Oral antidabetic (ADO), Drug Utilization Study

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