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Penicillin
Cefazolin
Vancomycin
Gentamycin
Erythromycin
Tetracycline
Slfamethoxazole-trimethropin (SMZ-TMP)
PENICILLIN
Drgs that Weakens the bacterial cell wall: PENICILLINS
Active against broad variety of bact and have low toxicity.
AEs typically allergic rxns
Have a beta-lactam ring – beta-lactam antibiotics inclde: cephalosporins,
aztreonam, imipenem, meropenem and ertapenem
All these disrpt the bacterial cell wall
PD: penicillins weaken cell wall by binding to penicillin-binding proteins:
(1). Inhibition of transpeptidases and (2). Activation of atolysins.
Transpeptidases – enz for c wall cynthesis; atolysins – cleave bonds in c
wall to allow growth
Penicillins
First Antibiotic in WW II
Four Grops
o –Natural
o –Penicillinase resistant
o –Amino-Penicillin
o –Extended Spectrm Penicillin