Feeding-Regulatory Peptides See other side for NEW!

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Controlling Energy Balance Feeding Regulatory

Peptides Series
Energy balance plays an important role in regulating CODE PRODUCT QTY
weight, and loss of balance can contribute to obesity and
other eating disorders. Melanin-concentrating hormone Melanin-Concentrating Hormone Peptides
(MCH), an orexigenic signal that increases food intake, PMC-3881-PI Ac-Arg-[Cys-Met-Ava-Arg-Val-Tyr-Ava- 1 mg
and melanocortin or melanocyte-stimulating hormone Cys]-NH2 5 mg
(MSH), an anorexigenic signal that decreases food Disulfide bond between Cys2 and Cys9
Ava = Aminovaleric acid
intake, are participants in this balancing act. Therefore, Melanin Concentrating Hormone Receptor
much effort has been focused on developing MCH 1 Antagonist
and MSH agonists and antagonists as research tools PMC-3886-PI Ac-D-Arg-[Cys-Met-Leu-Asn-Arg-Val-Tyr- 1 mg
and potential therapy for eating disorders. Peptides Arg-Pro-Cys]-NH2 5 mg
International now offers both a selective agonist Ac-D- Disulfide bond between Cys2 and Cys11
Melanin Concentrating Hormone Receptor
Arg-[Cys-Met-Leu-Asn-Arg-Val-Tyr-Arg-Pro-Cys]-NH2 1 Agonist
(PMC-3886-PI)1 and antagonist Ac-Arg-[Cys-Met-Ava- PMC-4369-v Melanin-Concentrating Hormone 0.5 mg
Arg-Val-Tyr-Ava-Cys]-NH2 (PMC-3881-PI)2 for the MCH-1 (Human) vial
receptor. Appetite Boosting Peptide

For those interested in studying anorexigenic Melanotropin Peptides

signaling, Peptides International offers 3 new PMC-3669-PI [Nle4, D-Phe7]--MSH-Amide 1 mg
melanocortin receptor agonists, Ac-Nle-cyclo Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg- 5 mg
Trp-Gly-Lys-Pro-Val-NH2
[Asp-His- D -Phe-Arg-Trp-Lys]-NH 2 ( PMC-3683- Melanocyte Stimulating Hormone Agonist
PI), [Nle4, D-Phe7]--MSH-Amide (PMC-3669-PI), / Melanocortin 1, 3, 4 and 5 Receptor
and Ac-Tyr-Val-Nle-Gly-His-D-Phe-Arg-Trp-Asp-Arg- Agonist
Phe-Gly-NH2 (PMC-3685-PI).3-6 The former, also known PMC-3683-PI Ac-Nle-cyclo [Asp-His-D-Phe-Arg-Trp- 1 mg
as melanotan II, is a popular choice due to its stability Lys]-NH2 5 mg
and ability to cross the blood-brain barrier and has Melanotan II, MT-II
Potent Melanocortin 1, 3, 4 and 5
been shown to inhibit food intake in mice.7 In addition, Receptor Agonist
a selective melanocortin receptor 4 antagonist (PMC- PMC-3685-PI Ac-Tyr-Val-Nle-Gly-His-D-Phe-Arg-Trp- 1 mg
3887-PI)8 is now available and should prove useful Asp-Arg-Phe-Gly-NH2 5 mg
for understanding the physiological role of the Melanocortin 1, 3, 4 and 5 Receptor
melanocortin receptor system in energy homeostasis Agonist
and related diseases. PMC-3887-PI cyclo [CO-(CH2)2-CO-D-Nal(2)-Arg-Trp- 1 mg
Lys]-NH2 5 mg
1. M.A. Bednarek, C. Tan, D.L. Hreniuk, O.C. Palyha, D.J. MacNeil, Melanocortin 4 Receptor Antagonist
L.H.Y. Van der Ploeg, A.D. Howard, and S.D. Feighner, J. Biol. Chem.,
277, 13821 (2002). Ghrelin Peptides
2. M.A. Bednarek, D.L. Hreniuk, C. Tan, O.C. Palyha, D.J. MacNeil,
L.H. Y. Van der Ploeg, A.D. Howard, and S.D. Feighner, Biochemistry, PGH-3694-PI H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 1 mg
41, 6383 (2002). Growth Hormone Releasing Peptide 6 5 mg
3. F. Al-Obeidi, V.J. Hruby, A.M. Castrucci, and M.E. Hadley, J. Med. Chem.,
32, 174 (1989). PGH-3681-PI [Dap3]-Ghrelin (Human, Rat, 1-5) 1 mg
4. F. Al-Obeidi, V.J. Hruby, A.M. Castrucci, and M.E. Hadley, J. Med. Chem., Ghrelin Analog Active Fragment* 5 mg
32, 2555 (1989).
PGH-3680-PI [Dap3]-Ghrelin (Rat) 0.5 mg
5. M. Cai, A.V. Mayorov, C. Cabello, KM. Stankova, D. Trivedi, and V.J. Hruby,
Ghrelin Analog* vial
J. Med. Chem., 48, 1839 (2005).
6. T.K. Sawyer, P.J. Sanfilippo, V.J. Hruby, M.H. Engel, ClB. Heward, * Ser3 from parent peptide replaced with 2,3-diaminopropionic acid (Dap) to
J.B. Burnett, and M.E. Hadley. Proc. Natl. Acad. Sci., 77, 5754 (1980). enhance stability. M.A. Bednarek et al., J. Med. Chem., 43, 4370 (2000).
7. W. Fan, B.A. Boston, R.A. Kesterson, V.J. Hruby, and R.D. Cone, Nature,
385, 165 (1997).
8. M.A. Bednarek, T. MacNeil, R.N. Kalyani, R. Tang, L.H.Y. Van der Ploeg,
and D.H. Weinberg, J. Med. Chem., 44, 3665 (2001).

Peptides International,
Peptides International, Inc.Inc. P.O. Box 99703 Phone: 502-266-8787 1-800-777-4779
Louisville, KY 40269-0703 USA Fax: 502-267-1329 E-mail: peptides@pepnet.com
 Feeding-Regulatory Peptides
Feeding Regulatory
Peptides Series

CODE PRODUCT QTY CODE PRODUCT QTY

Increase Food Intake PCR-4111-s CRF (Ovine) 0.1 mg vial
PCR-4111-v CRF (Ovine) 0.5 mg vial
PAR-4366-s Agouti-Related Protein (Human, 86-132) 0.1 mg vial
PGL-4344-v Glucagon-like Peptide 1 (Human, 7-36 Amide) 0.5 mg vial
PDY-4108-v Dynorphin A (Human) 0.5 mg vial
PGL-3723-PI Glucagon-like Peptide 1 1 mg
PEN-4060-v -Endorphin (Human) 0.5 mg vial
(Human, 7-36)-Lys(Biotinyl)-Amide 5 mg
PGA-4245-v Galanin (Human) 0.5 mg vial
PGL-3722-PI Glucagon-like Peptide 1 1 mg
PGA-4244-v Galanin (Rat) 0.5 mg vial (Human, 9-36 Amide) 5 mg
PGL-4391-s Galanin-like Peptide (Human, 1-60) 0.1 mg vial
PGL-4376-v Glucagon-like Peptide 2 (Human) 0.5 mg vial
PGH-4372-s Ghrelin (Human) 0.1 mg vial
PGH-3792-PI GO-CoA-Tat (Rat, Mouse) 0.5 mg vial
PGH-3741-PI 1 & 5 mg
1 mg
PGH-4373-s Ghrelin (Rat) 0.1 mg vial PMR-4057-v -MSH 0.5 mg vial
PGR-4127-s GRF (Human) 0.1 mg vial NES-3863-PI Nesfatin-1 (Human) 0.5 & 1 mg
PGR-4127-v GRF (Human) 0.5 mg vial vial

PMC-4369-v Melanin-Concentrating Hormone (Human) 0.5 mg vial NES-3865-PI Nesfatin-1 Like Peptide (Mouse) 0.5 & 1 mg
vial
PNP-4158-s NPY (Human, Rat) 0.1 mg vial
PNM-4490-v Neuromedin U (Human) NEW! 0.5 mg vial
PNP-4158-v NPY (Human, Rat) 0.5 mg vial
PNM-4491-v Neuromedin U (Mouse) NEW! 0.5 mg vial
PNP-4162-s NPY (Porcine, Bovine) 0.1 mg vial
PNM-4377-v Neuromedin U (Rat) 0.5 mg vial
POR-4346-s Orexin-A (Human) 0.1 mg vial
PNT-4029-v Neurotensin 0.5 mg vial
POR-4348-s Orexin-B (Human) 0.1 mg vial
PYY-4400-v Peptide YY (Human, 3-36) 0.5 mg vial
POR-4347-s Orexin-B (Rat, Mouse) 0.1 mg vial
PST-4387-s Stresscopin (Human) 0.1 mg vial
PRF-4419-s Pyroglutamylated RF amide Peptide (Human) 0.1 mg vial
PST-4388-s Stresscopin-Related Peptide (Human) 0.1 mg vial
Decrease Food Intake
PTR-4011-v TRH 0.5 mg vial
PAD-4421-s Adrenomedullin 2 (Human) 0.1 mg vial PUC-4328-s Urocortin (Human) 0.1 mg vial
PAD-4422-s Adrenomedullin 2 (Rat) 0.1 mg vial PUC-4327-s Urocortin (Rat) 0.1 mg vial
PBM-4086-v Bombesin 0.5 mg vial PUC-4383-s Urocortin II (Mouse) 0.1 mg vial
PCL-4051-s Calcitonin (Human) 0.1 mg vial
Others
PCL-4051-v Calcitonin (Human) 0.5 mg vial
PAP-4456-s Adropin (Human, 34-76) 0.1 mg vial
PCA-4350-s CART (Human, 55-102) 0.1 mg vial
PCP-3724-PI [Tyr0]-C-Peptide (Human) 1 & 5 mg
PCA-4351-s CART (Rat, 55-102) 0.1 mg vial
PCP-3725-PI C-peptide (Human) 1 mg
PCK-4100-v CCK-Octapeptide (26-33) (Sulfated Form) 0.5 mg vial
PGR-4178-s GIP (Human) 0.1 mg vial
PCG-4160-s CGRP (Human) 0.1 mg vial
PNP-4459-v Neuropeptide B- 29 (Rat) 0.5 mg vial
PCG-4160-v CGRP (Human) 0.5 mg vial (Non-Brominated Form)
PCG-4163-s CGRP (Rat) 0.1 mg vial
PNP-4403-v Neuropeptide W-30 (Human) 0.5 mg vial
PCG-4163-v CGRP (Rat) NEW! 0.5 mg vial
PNP-4404-v Neuropeptide W-30 (Rat) 0.5 mg vial
PNM-3408-v CPN-116 0.5 mg vial
PYY-3726-PI Peptide YY 1 & 5 mg
PCR-4136-s CRF (Human, Rat) 0.1 mg vial
PSI-4023-v Somatostatin 0.5 mg vial
PCR-4136-v CRF (Human, Rat) 0.5 mg vial
All Peptides International -s and -v products are sold with net peptide weight content.

Peptides
Peptides International,
International, Inc.Inc. P.O. Box 99703 Phone: 502-266-8787 1-800-777-4779
Louisville, KY 40269-0703 USA Fax: 502-267-1329 E-mail: peptides@pepnet.com