MSC Chemistry 2016-2018

THE ASSAM KAZIRANGA UNIVERSITY, JORHAT
SYLLABUS
For
MASTER OF SCIENCE
In
CHEMISTRY
(Batch 2016-18)
SCHOOL OF BASIC SCIENCES

Course Structure:
Master of Science in Chemistry
Total Credit 89
Code Course L T P C Marks
Semester I
BS2201 Conceptual Inorganic Chemistry 3 1 0 4 100
BS2202 Stereochemistry and Principles of 3 1 0 4 100
Organic Synthesis
BS2222 Principles of Physical Chemistry 3 1 0 4 100
BS2211 Quantum and Computational Chemistry 3 1 0 4 100
BS2239 Inorganic Chemistry Laboratory 0 0 12 6 100
Total 12 4 12 22 500
Semester-II
BS2228 Transition Metal Chemistry 3 1 0 4 100
BS2206 Organic Reactions and Mechanism 3 1 0 4 100
BS2207 Chemical Dynamics and 3 1 0 4 100
Electrochemistry
BS2208 Group Theory and Spectroscopy 3 1 0 4 100
BS2229 Organometallic and Bioinorganic 3 0 0 3 100
Chemistry
BS2240 Organic Chemistry Laboratory 0 0 12 6 100
Total 15 4 12 25 600
Semester-III
BS2209 Advanced Topics in Inorganic 3 1 0 4 100
Chemistry
BS2210 Heterocyclic Chemistry 3 1 0 4 100
BS2226 Environmental and Green Chemistry 3 0 0 3 100
BS22* Elective I 3 1 0 4 100
BS22** Elective II 3 1 0 4 100
BS2241 Physical Chemistry Laboratory 0 0 12 6 100
Total 15 4 12 25 600
Semester-IV
BS22*** Elective III 3 1 0 4 100
BS2227 Research Methodology and Analytical 3 0 0 3 100
Techniques
BS2238 Dissertation 0 0 20 10 200
Total 6 1 20 17 400
Total (Overall) 48 13 56 89 2100
Specializations:
a. Organic Chemistry
b. Inorganic Chemistry
c. Physical Chemistry
Students have to choose any one for the Elective I, Elective II and Elective III
according to their choice of specialization.
*Elective I:
a. Natural Product Chemistry (BS2212)
b. Advanced Organometallic Chemistry (BS2213)
c. Polymer Chemistry (BS2230)
**Elective II:
a. Advanced Topics in Organic Chemistry (BS2216)
b. Bioinorganic Chemistry (BS2225)
c. Catalysis and Surface Chemistry(BS2242)
***Elective III:
a. Medicinal Chemistry (BS2219)
b. Industrial Chemistry (BS2224)
c. Chemistry of Materials (BS2221)
SEMESTER I
The Assam Kaziranga University

School of Basic Sciences
M. Sc. (Chemistry)
BS2201: Conceptual Inorganic Chemistry 4 (3-1-0) Semester I
Rationale:
To provide a strong base to students that necessary to study the advanced inorganic chemistry.
Catalog Description:
It covers fundamental topics of inorganic chemistry from atomic structure and bonding to
solution chemistry.
Pre-requisite:
Basicconceptions of atomic structure as well as bonding, and reactivity of inorganic compounds
are essential. Basic conceptions of mathematics and physics will also be needed.
Course Outline:
1. Periodic properties and bonding (24 Lectures)

Periodic properties, Ionic bonding, Valence bond theory, LCAO-MO theory, Orbital symmetry
and overlap, Walsh diagram, Bond energy and covalent radii, Metallic bonding, Band theory,
Hydrogen bonding, Clathrates, VSEPR model and the use of outer d-orbitals,
Electronegativity (Pauling,Mulliken and Allred-Rochow methods); Group electronegativity
and polarity of bonds; Bonding in alloys, Intermetallic compounds.
Stereochemistry and bonding in non-transition element compounds, Phosphonitrilic
compounds.
2. Oxidation and reduction reactions (5 Lectures)

Use of redox potential data, Analysis of redox cycles, Redox stability in water,
Disproportionation, Frost, Latimer and Pourbaix diagrams; Applications in metal extractions.
3. Acids and bases: (5 Lectures)

Generalized acid base concept including HSAB concept.
4. Aspects of d- and f-block elements (14 Lectures)

Elements of first transition series and their comparison with the second and third series,
General periodic trends, Chemistry of various oxidation states of first row transition metals
and their comparison with the second and third row transition metals based on electronic
configuration.Lanthanide contraction, Oxidation states of f-block elements, Complexes of
lanthanides and actinides,
Radioactivity: Nuclear structure and stability, Radioactivity, Principles of fission and fusion,
Natural and artificial radioactivity, Nuclear reactor, Application of radioisotopes.
Text Book(s):
1. Housecroft C.E., Sharpe A.G., Inorganic Chemistry, 4thedn., (Pearson 2012).
2. Huheey J.E., Keiter E. A., Keiter R.L., Medhi O.K., Inorganic Chemistry: Principles of
Structure and Reactivity, 4th edn., (Pearson, 2006).
3. Miessler G., Tarr D.A., Inorganic Chemistry, 3rdedn.,(Pearson, 2008).
Reference Book(s):
1. Atkins P., Overton T., Rourke J., Weller M., Armstrong F., Inorganic Chemistry, 5 thedn.,
(Oxford University Press, 2006).
2. Cotton F.A., Wilkinson G.,Murillo C.A., Bochmann M., Advanced Inorganic Chemistry,
6thedn., (John Wiley, 1999).
3. Douglas B., McDaniel D., Alexander J., Concepts and Models in Inorganic Chemistry, 3 rdedn.,
(John Wiley & Sons, 1994).
4.Porterfield W.W., Inorganic Chemistry A Unified Approach, 2ndedn., (Academic Press, 2009).
5. Arnikar H.J., Essential of Nuclear Chemistry, 4 thedn., (New Age International Publishers Ltd.,
2013).
E-Resources:
Journals and Magazines:
Grading System:
The final grade will be based on the following weight distribution:
- Internal Evaluation (30%)
- End Semester Examination (70%)

M. Sc. (Chemistry)
BS2202: Stereochemistry and Principles of Organic Synthesis4 (3-1- 0) Semester

I
Rationale:
It is important to learn how to draw reasonable mechanism for organic reactions because
mechanisms are the framework that gives sense to organic chemistry. Understanding and
remembering the bewildering array of reactions known to organic chemists would be completely
impossible if it was not possible to organize them into just a few mechanistic types. The ability
to formulate mechanistic hypothesis about how organic reactions proceed is also required for
discovery and optimization of new reaction.
This is a course in organic chemistry which will cover few basic mechanistic type like
substitution by SN1 and SN2, elimination reaction, addition of nucleophiles to carbon- carbon
multiple bond, addition to carbonyl group, pericyclic reaction and free radical reactions.
Principles of Stereo chemistry which is very essential to understand organic reaction
mechanisms are also covered.
Pre-requisite:
Basic idea of structure and bonding,stereochemistry and ways of representing organic structures.
Course Outline:
1. Stereochemistry: (12
Lectures)
Principles of Stereochemistry: Stereoisomerism in organic compounds,Concept of
conformational and configurartional isomerism; Fischer, Newman and Sawhorse
formula; effect of conformation on reactivity. Neighbouring group participation;
Chirality,E-Z isomerism, R-S nomenclature;configurational and conformational isomerism
of simple cyclic and acyclic systems, stereogenicity, stereoselectivity, enantioselectivity,
diastereoselectivity.Racemic modification and optical purity; resolution of
isomers,determination of enantiomeric and diastereomeric excess;
enantiodiscrimination.Newer methods of asymmetric synthesis (including enzymatic and
catalytic nexus),asymmetric induction, methods of asymmetric induction substrate,
reagent and catalytically controlled reaction.Enantio- and Diastereo selective synthesis,
Topicity and prostereoisomerism;
2. Structure and reactivity: (3 Lectures)
Linear free energy relationships, Hammett and Taft equations, and parameters;
Applications of acid-base concept, HSAB theory; Huckel rule, Aromaticity in benzenoid and
non-benzenoid compounds, antiaromaticity and homoaromaticity; n-annulenes,
heteroannulenes, fullerenes, cryptates.
3. Substitutionreactions: (7 Lectures)
Substitution at saturated carbon by SN1 and SN2 elimination addition and SET, substitution at
carbonyl, alkenyl and aryl Carbon, Parameters influencing reaction rates; Neighboring group
participation by and bonds, Anchimeric assistance; Synthetic applications of nucleophilic
substitution involving alcohols, thiols, amines and hydrides; 1,3-dithiane reactivity,
Umpolung effect; Aromatic nucleophilic and electrophilic substitution, aromatic substitution
of aniline.
4. Elimination reactions: (5 Lectures)

Mechanism and stereochemistry of different types of elimination reactions; Effects of
substrate structure, attacking base, leaving group and medium; Competition
betweensubstitution and elimination; Formation of other double bonds (C=N, C=O) and triple
bonds by elimination reactions; Mechanism and orientation in pyrolytic elimination.
5. Addition to carbon-carbon multiple bonds: (5 Lectures)

Mechanistic and stereochemical aspects of addition reactions involving electrophiles,
nucleophiles and free radicals; Regio- and chemo-selectivity; Orientation and reactivity;
Addition to cyclopropane and carbon-heteroatom multiple bonds; 1,2 and 1,4- addition
reaction, Hydroboration, alkylation, epoxidation and hydroxylation; Addition of halogen polar
reagents to alkenes.
6. Carbonyl and related groups: (6 Lectures)

Homologation and de-homologation of carbonyl compounds; Nucleophilic addition of hetero-
atoms (N,O,S);Acylation of carbonyl carbon; Carbonyl cyclizations and cleavages;
Carboxylic acids and derivatives, decarboxylation reactions.
7. Photochemical reaction: (4 Lectures)

Photochemical reaction of alkenes and carbonyl compounds; Photooxygenation;
Photochemistry of aromatic compounds; Photochemical isomerisation, addition and
substitution;Photo-Fries rearrangement of ethers and anilides; Barton reaction, Hoffmann-
Loefller-Freytag reaction, di--methane rearrangement; Singlet molecular oxygen reactions;
Photo-cleavages.
8. Pericyclicreactions: (6 Lectures)
Main features of pericyclic reactions; Woodward-Hoffman rules, correlation diagram and
FMO approaches; Electrocyclic reactions: conrotatory and disrotatory motions for 4n and
4n+2 systems;Cycloadditionsantarafacial and suprafacial additions, [2+2] and [4+2]
reactions (hand), 1,3-dipolar cycloadditions and chelotropic reactions; Sigmatropic[i,j]
shifts of C-H and C-C bonds; Sommelet-Hauser, Claisen, thio-Claisen, Cope and aza-Cope
rearrangements.
Text Book(s):
1. DepuyC., Chapman O.L.,Molecular Reactions and Photochemistry, (Prentice-Hall of India,
1975).
2. March J.,Advanced Organic Chemistry: Reactions, Mechanisms and Structure,4thedn.,(John
Wiley & Sons Asia Pvt. Ltd., 2005).
3. NasipuriD.,Stereochemistry of organic compounds: Principles and Application, 4thedn., (New
Academic Science, 2012).
4. Pine S.H.,Organic Chemistry,5thedn.,(McGraw-Hill, 1987).
Reference Book(s):
1. Carey F.A., Sandburg R.J.,Advanced Organic Chemistry: Part A and B, 5thedn., (Springer,
2008 and 2010).
2. FlemingI.,Frontier Orbital Theory and Organic Reactions, (John Wiley & Sons, 1976).
3. Grossman R.B., The Art of Writing Reasonable Organic Reaction Mechanisms, 2 ndedn.,
(Springer, 2010).
4. Harris J.M., Wamser C.C., Fundamentals of Organic Reaction Mechanisms, (Wiley, 1976).
5. MarchandA.P., Lehr R.E., Pericyclic Reactions, (Academic Press, 1977).
6. Woodward R.B., HoffmanR., Conservation of Orbital Symmetry, (Verlag-Chemie/Academic
Press, 1970).
E-Resources:
Grading System:
Academic Council Approval:

M. Sc. (Chemistry)
BS2222: Principles of Physical Chemistry 4 (3-1-0) Semester I
Rationale:The objective is to make the concepts ofthermodynamics, quantum chemistry and

macromolecules clear and interesting to students.
Catalog Description:Integrating coverage of thermodynamics, macromolecules and basic
quantum chemistry into a single course and carefully structured to provide a clear and
consistent resource for beginners. Explores fully the principles of equilibrium, non-
equilibrium and statistical thermodynamics, macromolecules and quantum chemistry.
Pre-requisite:Knowledge of physical principles and mathematics.
`
Course Outline:
1. Equilibrium thermodynamics (12Lectures)

Review of the laws of thermodynamics, free energy, chemical potential and entropies.
Concept and determination of fugacity,activity, activity coefficient, Debye-Hckel theory
for activity coefficient of electrolytic solutions; ionic strength.
Partial molar quantities, Gibbs Duhem equation, thermodynamics of mixing.
Application of phase rule to three component systems: triangular plots, water-acetic acid-
chloroform system.
2. Non-Equilibrium thermodynamics (9Lectures)

Entropy production and entropy flow, relation between forces and fluxes, microscopic
reversibility and Onsagers reciprocity relations, electro-kinetic phenomena, diffusion,
electric conduction, irreversible thermodynamics for biological systems, coupled reactions.
3. Statistical thermodynamics (9Lectures)

Ensembles, Maxwell Boltzmann distribution, partition functions, principles of
equipartition, heat capacity of solids(Einstein model and Debye modification).
4. Macromolecules (9Lectures)
Polymer and polymerization, chain (free radical, cationic, anionic and coordination) and
step polymerization, ring scissonpolymerisation. Molecular masses, determination of
molecular masses, osmometry and viscometry, light scattering, control of molecular mass,
chain configuration of macromolecules- root mean square and radius of gyration, random
flight model and chain stiffness in macromolecules.
5. Bio-physical chemistry (11 Lectures)

Bioenergetics-standard free energy change in biochemical reactions, hydrolysis of ATP,
synthesis of ATP from ADP, Biological oxidation & reduction reactions- electron transfer in
and redox potentials of biologically important half reactions, chemistry involved in oxidative
phosphorylation. Configuration of biological macromolecules; polypeptide and protein
structure-protein folding.
Enzymes-classification and catalysis; enzyme kinetics, mechanism of action; Enzyme
regulators and inhibitors; Enzyme models-host-guest chemistry.
Nucleic acids, structure and functions of DNA-the double helix structure; Genetic code-
replication, transcription, translation of genetic information-chemical basis of heredity.
Text Book(s)
1. Atkins P.W., de PaulaJ.,Physical Chemistry,9thedn.,(W.H. Freeman, 2009).
2. Billemeyer F.,Textbook of Polymer Science 3rdedn.,(John Wiley& Sons, 1984).
3. Castellan G.W.,Physical Chemistry, 3rdedn., (Narosa Publishing House, 2003).
4. Lehninger A.L., Nelson D.L., Cox M.M., Lehninger Principles of Biochemistry, 4 thedn.,
(Palgrave Mcmillan, 2004).
Reference Book(s)
1. Engel T., Reid P., Physical Chemistry, 3rdedn., (Prantice Hall, 2012).
2. Kalidas C., Sanganarayana M. V., Non-Equilibrium Thermodynamics: Principles and
Applications(Macmillan India, 2002).
3. Stumpf P.K., Conn E.E., Bruening G., Roy H.D., Outline of Biochemistry, 5 thedn., (Wiley
India Pvt. Ltd., 2006).
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2211: Quantum and Computational Chemistry 4 (3-1-0)Semester-I
Rationale:
Understanding of the elementary principles of quantum mechanics, electronic structure of
atoms and their periodicity, electronic structure of molecules and chemical bonding will help
to perform quantum-chemical calculations.
Details of quantum mechanics for study of chemical systems.
Pre-requisite:
Knowledge of mathematics and physical principles.
Course Outline:
1. Fundamental principles and applications to simple systems (16Lectures)

Origin of the quantum theory,postulates of quantum mechanics, linear and
Hermitianoperators,commutation of operators and uncertainty principle, postulates,
properties of wave functions, Schrodinger equation, energy eigenvalue equation, equation of
motion and constant of motion,exactly solvable problems,particle in a box, harmonic
oscillator, rigid rotator, step potential and tunneling, hydrogen atom.
2. Atomic structure (28Lectures)

The variation theorem; linear variation principle, perturbation theory, applications of
variational methods and perturbation theory to the helium atom,ordinary angular momentum,
generalized angular momentum, eigenfunctions, and eigenvalues of angular momentum
operator, Ladder operator, addition of angular momenta,spin, antisymmetry, Pauli exclusion
principle, Slatter-determinantal wave functions,term symbol (RS and jj coupling) and
spectroscopic states, term separation energies of pn and dn configurations, magnetic effects:
spin-orbit coupling and Zeeman splitting, Hellmann-Feynmann theorem,antisymmetry
principle and many-electron wave functions,virial theorem, Born-Oppenheimer
approximation, valence bond (VB) and molecular orbital (MO) theory for diatomic molecules
hydrogen molecule ion, hydrogen molecule; excited states of H2: singlet and triplet, non-
crossing rule and correlation diagram, hybridization,Huckel MO treatment for simple and
conjugated polyenes, Hybridisation and valence MOs of H 2O, NH3 and CH4, Introduction to
the SCF.
3. Computational chemistry (6Lectures)

Introduction to internet and computer, historical perspectives of computational chemistry,
computable quantities: structure, potential energy surface, chemical properties.
Text Book(s):
1. Atkins P.W. Friedman R.S., Molecular Quantum Mechanics 3rd Ed., (Oxford Univ. Press,
1997).
2. McQuarrie D.A., Quantum Chemistry, (Viva Books Pvt. Ltd., 2011).
3. PilarF.L., Elementary Quantum Chemistry, 2ndedn., (Dover Publications Inc., NY, 1990).
Reference Book(s):
1. Atkins P.W.,De PaulaJ.,Physical Chemistry,9thedn.,(W.H. Freeman, 2009).
2. Chandra A.K., Introduction to Quantum Chemistry,(Tata McGraw Hill).
3. LevineI.N., Quantum Chemistry, 7thedn., (Prentice Hall India, 2013).
Journals:
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2239: Inorganic Chemistry Laboratory 6 (0-0-12) Semester I
Rationale:
Laboratory work at postgraduate masters level course is essential to produce skilled technicians
for industry and highly competent workers for research laboratories.
This course has included different analytical and synthetic methodologies, which will help
students analytical skill to undertake academic and industrial research work.
Pre-requisite:
Basic experimental skills, conceptions of acids and bases, safety rules in chemical laboratory.
Course Outline:
A. Quantitative analysis
Quantitative estimation involving volumetric, gravimetric and spectrophotometric methods of
constituents in three component mixtures, alloys, ores, minerals etc.
B. Synthesis and characterization of inorganic compounds

Synthesis of inorganic compounds, including those involving new synthetic methodology.
Characterization by using any of the following techniques: elemental analysis, conductance
measurements,and infrared (IR/FTIR), UV-Visible, Thermal Analysis, Cyclic Voltammetry;
Text Book(s):
1. Marr G., RockettB.W., Practical Inorganic Chemistry, (Van Nostrand, 1972).
2. Mendham J.,Danney R.C., BarnesJ.D., ThomasM., Vogels Textbook of Quantitative
Chemical Analysis, (Pearson Education, 2000).
3. PassG., SutcliffeH.,Practical Inorganic Chemistry, 2ndedn.,(Chapman & Hill, 1974).
Reference Book(s):
1. BassetJ., Denney R.C., Jeffery G.H., MendhamJ., Vogels Text Book of Quantitative
Analysis, 4thedn., (English Language Book Society, 1978).
2. Day R.A. Underwood A.L., Quantitative Analysis, 6thedn., (PHI, Delhi, 2013).
E-Resources:
Grading System:

SEMESTER II
M. Sc. (Chemistry)
BS2228:Transition Metal Chemistry 4 (3-1-0)Semester II
Rationale:
To provide a sound knowledge of transition metal chemistry, which will help the students for
further advanced learning in inorganic chemistry.
Detail properties of transition metal chemistry and basics of organometallic chemistry.
Pre-requisite:
Knowledge of periodic table, basic transition metal chemistry and co-ordination chemistry.
Course Outline:
1. Bonding in transition metal complexes (11 Lectures)

Crystal Field Theory, The splitting of d-orbitals in various fields,Adjusted crystal field
theory,Molecular orbital theory of complexes (including complexes with and without
bonding), MO diagrams of octahedral, tetrahedral and square planar complexes, Jahn-Teller
effect, Splitting of f-orbitals in octahedral field, thermodynamic effects: hydration, ligation
and lattice energy..
2. Electronic structure and spectra of transition metal complexes (10Lectures)
Interpretation of electronic spectra, Selection rules, Spectroscopic states, Orgel and Tanabe-
Sugano diagrams, band intensities and band width, Spectrochemical and Nephelauxetic series,
Charge-transfer spectra, Optical properties of lanthanides and actinides.
3. Magnetic properties of transition metal complexes (4 Lectures)
Types of magnetic behaviour: dia-, para-, ferro- and anti-ferromagnetic compounds, Spin-orbit
coupling, Temperature independent paramagnetism, Application of crystal field theory to
explain magnetic properties, Spin- crossover.
Magnetic properties of lanthanides and actinides.
4. ESR and Mossbauer spectra of transition metals (7 Lectures)
ESR spectroscopy: Origin of g-shifts and hyperfine coupling, line shape; ESR of d1and
d9transition metal ions in cubic and tetragonal ligand fields; evaluation of g values and metal
hyperfine coupling constants.
Mossbauer spectroscopy: Principles, isomer shift, quadruple effect of magnetic field,
applications to iron and tin compounds.
5. Metal-ligand equilibria in solution (5 Lectures)
Stepwise and overall formation constants,Trends in stepwise formation
constants,Determination of binary formation constant by spectrophotometry,Factors affecting
stability of metal complexes and chelate effect.
6. Kinetics and mechanism of inorganic reactions (11 Lectures)

Labile and inert complexes,Mechanisms of ligand-replacement reactions,Ligand displacement
reactions in square planar and octahedral complexes,The transeffect,Isomerization and
racemization of tris-chelate complexes,Electron transfer reactions,Stereo-chemicalnonrigidity
and fluxional molecules.
Text Book(s):
1. Housecroft C.E., Sharpe A.G., Inorganic Chemsitry, 4thedn., (Pearson, 2012).
2. Huheey J.E., Keiter E.A., Keiter R.L, Medhi O.K., Principles of Structure and Reactivity,
1stedn., (Pearson Education, 2006).
3. Miessler G., Tarr D.A., Inorganic Chemistry, 3rdedn., (Pearson, 2008).
4. Janes R., Moore E., Metal-Ligand Bonding, The Open University, Royal Society of
Chemistry, 2004.
5. Parish R.V., NMR, NQR, EPR and Mossbauer Spectroscopy in Inorganic Chemistry, (Ellis
Horwood, New York, 1990).
Reference Book(s):
2. Carlin, R.L. Magnetochemistry, (Springer Verlag, 1986).
3. Cotton F.A., Wilkinson G., Murillo C.A., Bochmann M., Advanced Inorganic Chemistry,
4. Dutta, R.L., Syamal, A. Elements of Magnetochemistry, 2ndedn., (East-West Press, 1993).
5. Hay R.W. Reaction Mechanisms of Metal Complexes, (Woodhead Publishing, 2013).
6. Figgis B.N., Hitchman M.A., Ligand Field Theory and Its Applications, (Wiley India,
2000).
7. Drago R.S., Physical Methods in Inorganic Chemistry, Reinhold Publishing Corporation,
New York, 1965.
8. Banwell C.N., McCash E.M., Fundamentals of Molecular Spectroscopy, 4thedn., (Tata
McGraw-Hill, New Delhi, 2006).
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2206: Organic Reactions and Mechanism4(3-1-0) Semester II
Rationale:
Organic functional group interconversion is one of the important areas in synthetic organic
chemistry. Knowledge of reduction, oxidation reaction, and reactive intermediates will give an
insight to plane for different conversions. To design new synthetic routes knowledge of
disconnection approach is necessary.
This is a course in Organic Chemistry is covering the study of oxidation and reduction reactions,
reactive intermediates, and disconnection approach.
Pre-requisite:
Knowledge about oxidation and reduction, free radical, reactive intermediate.
Course Outline:
1. Reduction reactions: (14 Lectures)

(a) Catalytic hydrogenation: Scope and mechanisms for heterogeneous catalytic
hydrogenation of alkenes and other functional groups; Reduction selectivity; Catalyst
poisoning and desulphurization; Homogeneous catalytic hydrogenation with Wilkinson
catalyst; Alkene double bond isomerisation, stereoselectivity, concept and application of
hydrogenoysis.
(b) Dissolving metal reductions: Scope and basic mechanisms; Liquid ammonia reduction
withAlkali metals, Birch reduction of arenes; Acyloin condensation and related reactions.
(c) Metal hydride reductions: Scope, stereochemistry and mechanism of metal Hydride
reductions of carbonyl compounds; Reduction of other functional groups like nitro, nitroso,
azoandoxime groups; MPV reduction; Use of hydroboration in reduction, oxidation and
carbonylation, regioselectivity, stereo-selectivity and synthetic utility of alkyl boranes.
(d) Reduction with hydrazine & derivatives: Reduction of carbonyl group with hydrazine;
tosylhydrazine, diimide and semicarbazide; Use of hydrazine with other reducing agents on
conjugated systems.
2. Oxidation reactions: (14 Lectures)

(a) Cr- and Mn-oxidations: Oxidation of alcohols & aldehydes with Cr (VI) &Mn(VII)
oxidants;
Oxidation of C=C and C-H bonds; Uses of Sarrett reagent, PCC, PDC and Collins reagent.
(b) Peroxyoxidations: Alkene epoxidation by peracids and metal/alkyl hydroperoxides,
Sharpless asymmetric epoxidation.
(c) Other methods of oxidation: DMSO and Swern oxidations; Oppenauer oxidation;
Prevost and Woodward hydroxylation of alkenes; Oxidative cleavage of C-C single and
double bonds; periodates, LTA, oxidation of organic substrates with mercuric acetate and
SeO2, Oxidative rearrangement and cyclization.
3. Reactive intermediates: (14 Lectures)

(a) Carbenes: Stability, structure and spin states of carbenes; Cyclopropanation-spin
dependence and stereochemistry; Carbene insertion to C-H bonds; Rearrangement to alkenes;
Wolff rearrangement of acylcarbenes and its synthetic applications; Carbenoids.
(b) Nitrenes: Stability, structure and spin states of nitrenes; C-H bond insertions and aziridine
formation; Rearrangement of acylnitrenes (Hoffmann, Curtius and Schmidt reactions with
applications in organic synthesis); Nitrenoids.
(c) Free radicals: Stability and fate of organic free radicals; Metal-induced radical reactions;
Radical cyclisation and coupling reactions; Addition to multiple bonds; Aromatic substitution
by radicals; Allylicbromination by NBS and decarboxylativebromination;
4. Disconnection approach: (8 Lectures)

Disconnection approach, Synthonand type of synthons, one group and two group
disconnections, reversal of polarity, chemo selectivity, one group C-C, C-X disconnections,
Domino reactions and multicomponent reaction
Text Book(s):
1. Gilchrist T.L., Rees C.W., Carbenes, Nitrenes and Arynes, (Nelson, London, 1969).
2. KalsiP.S., Organic Synthesis Through Disconnection Approach, 1stedn.,(Medteck, 2014).
3. March J., Advanced Organic Chemistry: Reactions, Mechanisms and Structure, 4thedn.,(Wiley
Student Edition, John Wiley & Sons Asia Pvt. Ltd., 2005).
Reference Book(s):
1. HouseH.O., Modern Synthetic Reactions, (W. A. Benjamin, 1972).
2. WarrenS., WyattP., Organic Synthesis: The Disconnection Approach, 2ndedn.,(Wiley, 2008).
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2207: Chemical Dynamics and Electrochemistry 4 (3-1-0) Semester II
Rationale:If gases do exist as particles then they must be explainable on this basis kinetic
molecular model. This reading is essential for the understanding of advanced learning in
chemical kinetics and advanced electrochemistry.
Catalog Description:This course deals with the experimental and theoretical aspects of
chemical reaction kinetics and electrochemistry.
Pre-requisite:Strong background in chemistry at the degree level. Knowledge of mathematics

is required.
Course Outline:
1. Chemical dynamics
(30Lectures)
Methods of determinations of reaction rates, theories of reaction rates Arrhenius theory,
collision theory, steric factor, activated complex theory, steady state kinetics, treatment of
unimolecular reactions.
Composite reactions including photochemical, chain reactions and oscillatory reactions.
Fast reactions, luminescence and energy transfer, study of fast reactions by flow method,
relaxation method, flash photolysis, Temperature and Pressure jump and nuclear magnetic
resonance method. Reaction dynamics, dynamics of molecular motions, probing the transition
state, dynamics of unimolecular reactions Lindemann-Hinshelwood and RRKM theory.
Electron transfer and proton transfer reactions, reactions in solutions, ionic reactions, kinetic
salteffect, reactions on solid surfaces and solid state reactions.
Homogeneous and heterogeneous catalysis, enzyme catalysis, phase transfer catalysis.
2. Electrochemistry: (20Lectures)
Electrochemical cells, cell reactions, Nernst equation electrode kinetics, electrical double
layer, various models, electrode/electrolyte interface, ion transport, diffusion, over potential,
Butler-Volmer equation, Tafel plot, dynamic electrochemistry, corrosion and its prevention,
batteries, solid state battery, fuel cells, Polarography, half-wave potential.
Text Book(s):
1. Atkins P.W.,De PaulaJ.,Physical Chemistry, 9thedn.,(Oxford University Press, 2009).
2. Laidler K., Chemical Kinetics, (Harper and Row, 1995).
Reference Book(s):
1. BockrisJ.O.M., Reddy A.K.N., Modern Electrochemistry, Volume 1 and 2, (Kluwer Academic,
2000).
2. Pilling M.J.,SeakinsP.W., Reaction Kinetics, (Oxford Press, 1997).
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2208: Group Theory and Spectroscopy 4 (3-1-0) Semester II
Rationale:
The knowledge of group theory and spectroscopy is important to provide a framework to
understand the structure and bonding in molecules.
Catalogue Description:
General principles of group theory and all aspects of spectroscopy and its applications to simple
chemical systems.
Prerequisite:
Fundamentals of chemistry, theoretical knowledge of analytical principles as well as the basic
conceptions of mathematics and physics are essential to understand the topics.
Course Outline:
1. Chemical applications of group theory (16Lectures)

Symmetry elements and symmetry operations; symmetry groups; molecular dissymmetry and
optical activity; symmetry point groups for compounds having co-ordination number 2 to 9,
matrix representation of groups, reducible and irreducible representation, the great
orthogonality theorem, applications of symmetry concepts in vibrational spectroscopy and
molecular orbital description of molecules.
2. Rotational and vibrational spectra (7 Lectures)

Pure rotational, vibrational and vibrational-rotational spectra of diatomic molecules, pure
vibrational spectra of polyatomic molecules: normal coordinate analysis, symmetry of normal
coordinates; group theoretical derivation of selection rules, Fermi resonance, theory of Raman
scattering, rotational, vibrational and vibrational-rotational Raman spectra of molecules;IR
and Raman spectroscopy in structure determination of organic and inorganic compounds.
3. Electronic spectra (5 Lectures)

Frank-Condon principle, electronic spectra of polyatomic molecules, electronic transitions,
change of molecular shape on electronic excitation, selection rule, intensity and oscillator
strengths.
4. Mass spectrometry (6 Lectures)

Basic principles and instrumentation, mass spectral fragmentation of organic compounds,
applications.
5. Nuclear magnetic resonance (NMR) spectroscopy(13 Lectures)

Basic principles, origin of chemical shifts, spin-spin coupling, relaxation processes,
approximate chemical shift values of various chemically non-equivalent protons and
correlation to protons bonded to carbon (aliphatic, olefinic, aldehydic and aromatic); protons
bonded to other nuclei (alcohols, phenols, enols, carboxylic acids, amines, amides, SH);
chemical exchange, effect of deuteration; complex spin-spin interaction between two, three,
four and interacting nuclei (first order spectra); complex interaction, virtual coupling,
stereochemically hindered rotation, karplus curve, variation of coupling constant with dihedral
angle, nuclear magnetic double resonance, simplification of complex spectra using shift
reagents, Fourier transform technique and nuclear Overhauser effect (NOE).
6. 13C NMR spectroscopy (3 Lectures)

Chemical shift (aliphatic, olefinic, alkynes, aromatic, hetero-aromatic, carbonyl carbon);
coupling constants, two-dimensional NMR spectroscopy, NOESY, DEPT and INEPT
terminologies.
Text Book(s):
1. Banwell C.N.,McCashE.M.,Fundamentals of Molecular Spectroscopy, 4thedn., (Tata McGraw-
Hill, New Delhi, 2006).
2. Cotton F.A., Chemical Application of Group Theory, 3rdedn. (John Wiley & Sons, 1999).
3. NakamotoK., Infrared and Raman Spectra of Inorganic and Coordination Compounds, 5 thedn.,
(John Wiley, 1997).
4. Silverstein R.M., BasselerG.C.,MorillT.C.,Spectroscopic Identification of Organic
Compounds, (John Wiley, 1981).
Reference Book(s):
1. DragoR.S.,Physical Methods in Chemistry, (Saunders College Publishers, 1977).
2. Harris D.C., Bertolucci M.D., Symmetry and Spectroscopy: An Introduction to Vibrational
and Electronic Spectroscopy, (Dover Publications Inc., New York, 1989).
3. Kemp W., Organic Spectroscopy, 3rdedn., (McMillan Press Ltd., 1991).
4. Parish R.V., NMR, NQR, EPR and Mossbauer Spectroscopy in Inorganic Chemistry, (Ellis
Horwood, New York, 1990).
5. RamanK.V., Group Theory andIts Applications to Chemistry, (Tata McGraw-Hill Publishing
Company Ltd., New Delhi).
6. Williams D., Fleming I., Spectroscopic Methods in Organic Chemistry, (McGraw Hill, 1989).
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2229: Organometallic and Bioinorganic Chemistry 3 (3-0-0) Semester-II
Rationale:
To provide a sound knowledge of organometallic and bioinorganic chemistry, this will help the
students for further advanced learning in these two important areas of chemistry.
The overall goal of this paper is to coversome basic and advanced level topics of related subjects,
which are essential for master level students.
Pre-requisite:
Knowledge of coordination-chemistry including bonding of polyatomic molecules and transition
metal complexes, basics of biological sciences.
Course Outline:
1. Organometallic chemistry(15 Lectures)

Common type of ligands: bonding and spectroscopy, Types of organometallic reactions, Metal
carbonyls, nitrosyls and dinitrogen complexes, Reactions involving co-ordinated ligands,
Cyclometallation reactions, Bonding, synthesis and reactivity of transition metal complexes
with CO, NO, O2, N2 and tertiary phosphine and arsine ligands.
Synthesis, structure, bonding and reactivity of transition metal complexes with olefins,
cyclopentadienyl, cyclopentadienide, benzenoid, -allyl and enyl systems; Transition metal-
carbon -bond: metal-alkyls, metal-carbenes, metal-carbynes, double and multidecker
sandwich complexes.
2. Homogeneous and heterogeneous catalysis (12 Lectures)

Hapticity of ligands, The 18-electron rule, Catalytic reactions of alkenes isomerisation,
hydrogenation, carbonylation, hydroformylation and polymerization, Fischer-Tropsch process.
3. Bioinorganic chemistry (12 Lectures)

Scope, Inorganic elements in biological systems and their significance; Iron storage and
transport-siderophores, ferritin and transferring, Active transport of cations across membranes,
Na+/K+ pump, Heme-protiens hemoglobin, and myoglobin; Electron transfer proteins-
structure and functions of iron-sulphur proteins, Cytochromes, Plastocyanine; Metal enzymes-
nitrogenases and dioxygen fixation, Vitamin B12;
Toxicity of mercury, cadmium, lead, chromium, beryllium, selenium and arsenic with specific
examples; Inorganic drugs, Chelation therapy, Metals used for diagnosis and chemotherapy.
Text Book(s):
1. Gupta B.D., Elias A.J., Basic Organometallic Chemistry, 2ndedn., (Universities Press, 2013).
2. Housecroft C.E., Sharpe A.G., Inorganic Chemistry, 4thedn., (Pearson 2012).
3. Huheey J.E., Keiter E. A., Keiter R.L., Medhi O.K., Inorganic Chemistry: Principles of
Structure and Reactivity, 4th edn., (Pearson, 2006).
5. Rehder D., Bioinorganic Chemistry, 1stedn., (Oxford University Press, 2014).
Reference Book(s):
2. Cotton F.A., Wilkinson G.,Murillo C.A., Bochmann M., Advanced Inorganic Chemistry,
3. Mehrotra R.C., SinghA., Organometallic Chemistry: A Unified Approach, 2ndedn.,(New Age
International, 2000).
M. Sc. (Chemistry)
BS2240:Organic Chemistry Laboratory 6 (0-0-12)Semester II
Rationale:
This course has included different analytical and synthetic methodologies, which will help
students analytical skill to undertake academic and industrial research work.
Pre-requisite:
Basic experimental skills, basic concept of organic chemistry, safety rules in chemical laboratory.
Course Outline:
A. Preparations of organic compounds using following reactions

1. Aldol condensation
2. Henry reaction
3. Esterification and organic acids and hydrolysis.
4. Reduction involving sodium borohydrate
5. PCC, PDC, Swern oxidation
6. Chan-lam coupling
7. Sujuki, Negishi, Heck and Stille coupling.
8. Buchwald coupling
9. Sandmayer reaction
10. Pegylation of phenolic OH
11. Protection of alcohol,amine and amino acid (Boc protection, tosylation, mesylation,
benzylation)
12. Protection of carbonyl groups.
13. Synthesis of few heterocyclic compounds.
14. Reduction and hydrolysis of nitrile.
15. Nitration of aromatic compounds, Reduction of nitro group
B. Purification of organic compounds using
2. Column chromatography
2. Crystallization technique
3. Steam distillation
4. Sublimation
C. Analysis of organic products using 1H NMR, 13C NMR, LCMS, IR, determination of optical
rotation.
Text Book(s)
1. Furniss B.S., Hannaford A.J., Rogers V., Smith P.W.G., Tatchell A.R., Vogels Textbook of
Practical Organic Chemistry, 4thedn., (ELBS, 1978).
2. Leonard J., Lygo B., Procter G., Advanced Practical Organic Chemistry, 3rdedn., (CRC
Press, 2013).
3. Mann F.G., Saunders B.C., Practical Organic Chemistry, 4thedn., (Longman 1979).
Reference Book(s):
Grading System:

SEMESTER III
M. Sc. (Chemistry)
BS2209: Advanced Topics in Inorganic Chemistry 4 (3-1-0) Semester-III
Rationale:
Inorganic chemistry, a major branch of chemistry is a vast subject. Due to the continuous
development of this subject, it is necessary to include new topics in the curricula. The present
paper is therefore developed to include some topics, which are not possible to cover in the
previous papers due to vast nature of inorganic chemistry.
The overall goal of this paper is to cover some special topics in inorganic chemistry, whichare
not possible to cover in previous papers but the knowledge of these topics are essential for
master level students.
Pre-requisite:
Knowledge of acid- base reactions, chemical kinetics, periodic properties, and basic conception
of analytical chemistry
Course Outline:
1. Cages, clusters, rings (12 Lectures)

Cages, clusters, rings boranes, carboranes, metalloboranes and metallocarboranes, siloxanes,
Hetero-atomic rings,Metal carbonyl hydrides and metal carbonyl clusters: LNCC and HNCC,
Wades rule and the capping rule.
Metal-metal multiple bonds, Major structural types, Quadrupole bonds and One-dimensional
solids.
3. Photochemistry of metal complexes and metalmetal multiple bonds (14 Lectures)

Excited states, Ligand field states, Charge-transfer states and Thexi states; Phosphoresence
and fluorescence; Photochemical reactions: substitution and redox reactions of Cr(III), Ru(II)
and Ru(III) complexes; Applications: synthesis and catalysis, Chemical actinometry and
photochromism.
3. Supramolecular chemistry (6 Lectures)

Definition of supramolecular chemistry, Supramolecular host-guest compounds, Macrocyclic
effect, Nature of supramolecular interactions.
7. Basics of inorganic materials chemistry (12 Lectures)

Importance of inorganic materials chemistry, Synthesis of materials: solid state, solution based
and chemical deposition methods, Defects and ion transport: electrolytes, metal oxides and
nitrides, High temperature superconductor, Layered compounds and intercalation,
Chelcogenidesthermoelectrics, Framework structures, Hydrides, Inorganic pigments,
Fullerides.
5. Nanomaterials (6 Lectures)
General introduction to nanomaterials and emergence of nanotechnology; Properties of nano-
materials; Characterization and fabrication; Thin films: chemical vapor deposition and Atomic
layer deposition techniques; Carbon based nanostructures: fullerenes, graphene and
nanotubes, Bioinorganic nanoparticles, Applications of nanoparticles and nano-materials.
Text Book(s):
1. Atkins P., Overton T., Rourke J., Weller M., Armstrong F., Shriver and Atkins Inorganic
Chemistry, 5thedn., (Oxford University Press, 2010).
3. Huheey, J.E., Keiter, E.A., Keiter, R.L, Medhi, O.K., Principles of Structure and Reactivity,
1stedn., (Pearson Education, 2006).
5. Pradeep T., Nano: The Essentials, (Tata McGraw Hill, 2007).
6. Porterfield W.W., Inorganic Chemistry: A Unified Approach, 2 ndedn., (Academic Press,
1993).
7. Steed J.W., Atwood J.L., Supramolecular Chemistry, 2ndedn., (Wiley 2009).
Reference Book(s):
1. Adamson A.W., FleischauerP.D., Concepts of Inorganic Photochemistry (John Wiley & Sons,
1975).
2. Beer P.D., Gale P.A., Smith D.K., Supramolecular Chemistry, (Oxford University Press,
1999).
3. Cotton F.A., Wilkinson G., Murillo C.A., Bochmann M., Advanced Inorganic Chemistry,
6thedn. (John Wiley, 1999).
4. Moeller T., Inorganic Chemistry: A Modern Approach, (John Wiley, 1982).
5. Ratner M., RatnerD., Nanotechnology: A Gentle Introduction to the Next Big Idea, (Pearson
Education 2003).
6. RoundhillbD.M., Photochemistry and Photophysics of Metal Complexes, (Plenum Press,
1990).
7. Zhong Cao G., Nanostructures and Nanomaterials: Synthesis, Properties and Applications,
(Imperial College Press, 2004).
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2210: Heterocyclic Chemistry 4 (3-1-0) Semester-III
Rationale:
Most of the molecules present in biological system and used as medicine are heterocyclic
compounds. Knowledge of their synthesis and reactivity is essential for advanced studies.
This is a course in organic chemistry which will cover synthesis and different types of reaction
heterocycles molecule will undergo. Different heterocyclic present in the biological system is
also covered
Pre-requisite:
Basic idea of structure of different heterocycles and their nomenclature is required.
Course Outline:
1.Introduction: (4 Lectures)
Hantzsch-Widman nomenclature for monocyclic, fused and bridged heterocycles; General
approaches to heterocyclic synthesis; Aliphatic and aromatic heterocycles; Basicity and
aromaticity of heterocycles.
2. Small ring heterocycles: (5 Lectures)

Syntheses of aziranes, oxiranes&thiiranes; Ring openings and heteroatom extrusion; Synthesis
& reactions of azetidines, oxetanes&thietanes; Strain.
3. Azoles: (5 Lectures)
Structural and chemical properties; Synthesis of pyrazole, isothiazole and isoxazole; Synthesis
of imidazoles, thiazoles&oxazoles; Nucleophilic and electrophilic substitutions; Ring
cleavages; Benzofused analogues.
4. Condensed five-membered rings (1 heteroatom): (5 Lectures)

Synthesis of indole, benzofuran and benzo-thiophene; Nucleophilic, electrophilic and radical
substitutions; Addition reactions; Indole rings in biology.
5. Diazines: (5 Lectures)
Structural & chemical properties; Synthesis of pyridazines, pyrimidines, pyrazines;
Nucleophilic and electrophilic substitutions.
6. Bicyclic heterocycles: (5 lectures)

Synthesis of quinolines, isoquinolines, benzofuseddiazines, acridines, phenothiazines,
carbazoles and pteridines; Substitution reactions.
7. Seven-membered rings: (4 Lectures)

Synthesis & reactions of azepines, oxepines, thiepines&diazepines.
8. Porphyrins:(4 Lectures)
Classification and synthesis of porphin rings; Natural and synthetic metallo- porphyrins;
importance in biology.
9. Biological heterocycles:(5 Lectures)

Chemical and biological properties and total synthesis of thiamine, lysergic acid, reserpine,
nicotine, phenanthrene alkaloids, papaverine, nucleic acids bases.
10. Nucleic acids:(5 Lectures)

Primary, secondary and tertiary structure of DNA; DNA replication and heredity;
Structure and function of mRNA, tRNA and rRNA.
11. Proteins:(3 Lectures)

Acid-base properties of amino acids; polypeptides; primary, secondary, tertiary and quaternary
protein structures; classification of proteins on basis of structure and biological function;
Merrifield peptide synthesis.
Text Book(s):
1. FinarI.L.,Organic Chemistry: Volume2, (ELBS, 1986).
2. Gilchrist T.L.,Heterocyclic Chemistry, (Longman, 1989).
3. LehningerA.L.,Biochemistry, (Kalyani Publishers, 1983).
4. PaquetteL.A.,Modern Heterocyclic Chemistry, (W. A. Benjamin, 1968).
Reference Book(s):
1. Katritzky A.R., ReesC.W.,Comprehensive Heterocyclic Chemistry, Volumes 1-7, (Pergamon
Press, 1984).
Journals:
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2226: Environmental and Green Chemistry 3 (3-0-0) Semester-III
Rationale:
The industrial development has given humankind a unique standard of living and quality of life.
However, this has also exerted a price of environmental degradation. The knowledge of
environmental chemistry is inevitable to make a contribution to the improvement of
environmental quality. The goal of this course is to provide the knowledge of how to do a
chemists share in improving environmental quality.
On the other hand, green chemistry is a recently developed philosophy of chemical research and
engineering that encourages the design of products and processes that minimize the use and
generation of hazardous substances. It is therefore necessary to provide adequate information to
the chemistry student about the principles and applications of green chemistry.
The overall goal of this paper is to gain an understanding of the fundamental chemical processes
that are central to a range of important environmental problems and to utilize this knowledge in
making critical evaluations of these problems. The program is also designed to provide master
level student with a thorough understandingof principles and applications of green chemistry.
The principles and instrumental techniques of someenvironmental analytical procedures
including their applications are also covered in the designed course.
Pre-requisite:
Basic knowledge of units and their conversions, knowledge of recent environmental problems,
basic knowledge of all branches of chemistry i.e. analytical, inorganic, organic and physical
chemistry;
Course Outline:
Part I: Environmental Chemistry

1. Introduction (3 Lectures)
Biotic and abiotic components of environment, macroenvironment and microenvironment, C,
O2, N2, P, S, CO2 etc. cycles, chemical speciation.
2. Pollution and its control (17Lectures)

Air pollution A brief introduction of atmospheric chemistry, types and sources of air
pollutants, industrial and transport related air pollutions, global warming and its effects, local
issues.
Water pollution types and sources, physical and chemical water pollutants, criteria of water
quality.
Soil Pollution - A brief idea of chemistry of soil, Organic and inorganic soil pollutants.
Specific Pollutants- Waste materials, trace elements, pesticides and polynuclear aromatic
hydrocarbons.
Chemical solutions to environmental problems, better biodegradability, kinetics of
decomposition, chemical- and bio-remediation of contaminated area, phytoremediation.
Examples of pollutions including local environmental issues.
3. Environmental analytical chemistry (4 Lectures)

Trace elements and radionuclide analysis, Analytical procedures involved in environmental
monitoring including brief explanation of instrumental methods, Analysis of soil: moisture,
salinity, colloids, cation and anion exchange capacities of soil,Air pollution monitoring: sampling
(collection) of air pollutants-SO2, NO2, NH3, O3 and SPM.
Part II:Green chemistry (15 Lectures)

Principles of green chemistry, atom economy, designing safer chemicals, safer solvents and
auxiliaries, design for energy efficiency, renewable feedstock, real time analysis for pollution
prevention, and inherently safer chemistry for accident prevention, green synthesis:
supercritical solvents, ionic liquids, green catalyst, clean technology.
Text Book(s):
1. Buell P., GirardJ., Chemistry Fundamentals: An Environmental Perspective, 2 ndedn., (Jones &
Bartlett Publishers, 2002).
2. Manahan S.E., Environmental Chemistry, 8thedn., (Lewis Publishers, London, 2004).
3. WillardH.H., Merritt L.L., Dean J.A., Settle F.A., Instrumental Methods of Analysis, 7thedn.,
(Wadsworth Publishing Company, California, 1988).
4. Anastas P.T., Warner J.C., Green Chemistry: Theory and Practice, (Oxford University Press,
2000).
5. Lancaster M., Scott J., Wilson, K., Green Chemistry: An Introductory Text, (RSC Publishing,
2010).
Reference Book(s):
1. Moore J.W., Moore E.A., Environmental Chemistry, (Academic Press, London, 1976).
3. Pulford I., FlowersH., Environmental Chemistry at a Glance, (Blackwell Publishing, 2006).
4. Mendham J., Denney R.C., Barnes J.D., Thomas M., Vogels Textbook of Quantitative
Chemical Analysis (Peterson Education, 2000).
5. MonkP.M.S., Fundamentals of Electro-analytical Chemistry, (John Wiley & Sons, 2001).
6. Cann, M.C., Connelly M.E., Real World Cases in Green Chemistry, (ACS, 2000).
7. Monograph on Green Chemistry Task Force Experiments, (Chemistry Task Force Committee,
DST, New Delhi, 2008).
8. Ahluwalia V.K., Kidwai M.; New Trends in Green Chemistry, (Kluwer Academic Publishers,
2004).
E-Resources:
1. www.sciencedirect.com
2. www.rsc.com
3. www.springer.com
4. www.acs.com
1. Environmental Science and Technology (http://pubs.acs.org/journal/esthag).
2. ACS Sustainable Chemistry & Engineering (http://pubs.acs.org/journal/ascecg).
3. Green Chemistry (http://pubs.rsc.org/en/journals/journalissues/gc).
4. Environmental Pollution (http://www.journals.elsevier.com/environmental-pollution).
5. Journal of Cleaner Production (http://www.journals.elsevier.com/journal-of-cleaner-
production).
6. Environmental Chemistry Letters (link.springer.com/journal/10311).
7. Energy & Environmental Sciences (pubs.rsc.org/en/journals/journalissues/ee).
Grading System:

Elective I
M. Sc. (Chemistry)
BS2212: Natural Product Chemistry 4 (3-1-0) Semester-III
Rationale:
Nature is the source of a large of molecules. Many of them have medicinal values. It is essential
to know the classification, isolation, characterization and structure of natural molecules to do
advanced studies.
This is a course in organic chemistry which will cover the classification, isolation,
characterization and biosynthesis of natural products. Synthetic processes for different class of
natural products are discussed.
Pre-requisite:
Basic idea of nomenclature and organic reaction mechanism is essential.
Course Outline:
1. Natural products and their biosynthetic pathways: (18 Lectures)

General classification of natural products, their isolation and characterization and biosynthesis
of common plant products; Biosynthesis pathways for natural products using co-enzymes and
enzymes; Synthesis of selected natural products based on genetic classification fatty acid
derivatives and related compounds, general biogenesis and synthesis of cis-jasmone, methyl
jasmonate, prostaglandins, exaltone and muscone.
2.Terpenoids and alkaloids: (18 Lectures)

General biosyntheses of mono- and sesquiterpenes, trans-chrysanthemic acid, cyclo-
pentatomonoterpene lactones, Synthesis of -vetinone and total synthesis of -eudesmol;
Synthesis of hirsutene, abietic acid, cisjuvenile hormone; trans annular cyclisation of
caryophyllene, synthesis of caryophyllene and isocaryophyllene; Rearrangements of santonic
acid and thujospene; Synthesis and rearrangement of longifolene; Structure, synthesis and
biosynthesis of common alkaloids: reticuline, yohimbine and tylophorine.
3. Steroids: (14 Lectures)

Biosynthesis of diterpenes, higher terpenes and steroids; Nomenclature of steroids and
synthesis of squalene; Lanosterol and caretonoids; Synthesis of equlenins; Estrogens and total
synthesis of non-aromatic steroids (progesterones); Corticosteroids; Conversion of diosgenin
to progesterone and its synthesis; Miscellaneous transformations of steroid molecules.
Text Book(s):
1.Dewick P.M., Medicinal Natural Products,(John Wiley & Sons Ltd.).
Reference Book(s):
1. NakanashiK.,Natural Products Chemistry, Volumes I and II, (Academic Press, 1974).
E-resources:
2. www.rsc.com
3. www.springer.com
4. www.pubs.acs.com
Journals:
Grading System:

Elective I
M. Sc. (Chemistry)
BS2213:Advanced Organometallic Chemistry 4 (3-1-0) Semester-III
Rationale:
Organometallic chemistry is the study of chemical compounds containing bonds between carbon
and a metal. Thus organometallic chemistry combines aspects of inorganic chemistry and organic
chemistry. By considering the present importance of organometallic chemistry, this course is
developedto provide a sound knowledge of organometallic chemistry, which will help the
students for further advanced learning in organometallic chemistry.
This course contains advanced knowledge and application of organometallic chemistry,Syntheses
of some important organometallic reagents and their applications to organic synthesis and
homogeneous catalysis.
Pre-requisite:
Knowledge of organic chemistry, transition and non-transitional metal chemistry and co-
ordination chemistry is essential.
Course Outline:
1. Main group organometallics (14 Lectures)

Synthesis and reactions of organolithium compounds; Synthesis and reactions of
organomagnesium compounds; Organometallics of zinc and mercury: preparation, structure,
bonding and reactions of aluminum organyls; Thallium(I) organyls (synthesis of TlCp);
Organyls of sodium, synthesis of NaCp; Silicon and tin organyls of coordination number 4.
2. Transition metalcarbon bond (12 Lectures)

(a) Transition MetalCarbon -Bond: Brief review of metal alkyl compounds; transition
metalcarbene and transition metal-carbyne compounds; transition metal vinylidene and
transition metal allenylidene compounds.
(b) Transition Metal-Carbon -Bond: Cyclopropenyl cation (C3R3+) as a ligand; C4R4as a
ligand (R = H, Me, Ph).
3. Syntheses of cyclopentadienyl and arene metal analogues (12 Lectures)

Synthesis and reactions of cyclopentadienyl metal carbonyls, cyclopentadienyl metal
hydrides, cyclopentadienyl metal halides, arene metal carbonyls, 6-arene-chromium
tricarbonyl in organic synthesis.
4. Applications to organic synthesis and homogeneous catalysis (12 Lectures)

(a) In Organic Synthesis: Hydrozirconation of alkenes and alkynes; Carbonylation of
Colmans reagent; 4-diene iron-tricarbonyls in organic synthesis
(b) In Catalysis: Asymmetric hydrogenation; synthesis of acetic acid and glycol (Monsanto
acetic acid process); Arylation/vinylation of olefins (Heck reaction); Wacker process
(olefinoxidation); Asymmetric epoxidation.
Text Book(s):
1. Cotton F.A., WilkinsonG., Murillo C.A., Bochmann M., Advanced Inorganic
Chemistry,5thedn., (Wiley India, 2003).
2. Crabtree R.H., The Organometallic Chemistry of the Transition Metals, 6 thedn., (Wiley,
2014).ElschenbroichC.,Organometallics, 3rdedn., (Wiley-VCH Publication, 2006).
3. Gupta B.D., Elias A.J., Basic Organometallic Chemistry, 2ndedn., (Universities Press, 2013).
5. Mehrotra R.C., SinghA.,Organometallic Chemistry: A Unified Approach, 2ndedn.,(New Age
International Publishers, 2000).
Reference Book(s):
1. BochmannM.,Organometallics-1: Complexes with Transition Metal-Carbon -Bonds, (Oxford
Chemistry Primers, 1994).
2. Bochmann M.,Organometallics-2: Complexes with Transition MetalCarbon -bonds,
(Oxford Chemistry Primers, 1994).
3. Mathey F.,SevinA.,Molecular Chemistry of the Transition Elements, (John Wiley, 1996).
4. YamamotoA., Organotransition Metal Chemistry: Fundamental Concepts and Applications,
(Wiley, 1986).
5. Pearson A.J.,Metallo-Organic Chemistry(John Wiley & Sons, 1985).
E-Resources:
2. www.rsc.com
3. www.springer.com
4. www.pubs.acs.com
5. www.wiley.com
Grading System:
Elective I
M. Sc. (Chemistry)
BS2230: Polymer Chemistry 4 (3-1-0) Semester-III
Rationale:
The knowledge of polymer chemistry is important for its wide application in different
polymer material manufacturing industries and the scope of polymer industry is growing in
the North-Eastern corner ofIndia.
Includes Kinetics and mechanism of polymerization, polymerization techniques and
characterization, thermodynamics of polymer solutions, Applications of polymers.
Prerequisite:General physical chemistry principles.
Course Outline:
1. Introduction
Historical background, basic nature, classification, raw materials for polymers used in gas
cracker, naphtha cracker. Kinetics and mechanism of polymerization: Degree of
polymerization and molecular mass of polymer, kinetics of various types of
polymerization, copolymerization, reactivity ratio, molecular mass distribution, control of
molecular mass.
2. Polymerization Techniques and Polymer Characterization

Special features of polymerization, various polymerization techniques, polymerization
reactions, Determination of molecular mass by GPC, light scattering, and end group
analysis methods. Zimm plot. Viscosity of polymer solutions: thermal, mechanical,
rheological and electrical properties of polymers, polyelectrolytes and ion-exchange resins.
3. Thermodynamics of Polymer Solutions

Chain conformation, molecular dimensions in solution, solubility of polymers,
solubilityparameters, lattice theory, H, S and G of mixing in polymer solution, dilute
polymersolutions, 1and -temperature, phase separation, fractionation.
4. Structure-Property Relationship
Stereochemistry of polymers, cross-linking, polymer architecture, optically active
polymers.
Elasticity, viscoelasticity Newton, Maxwell and Voigt-Kelvin models of viscoelastic
behaviour. Crystal structure of polymers, crystallization and melting, degree of
crystallinity.
5. Natural and Synthetic Polymers and Their Applications

Natural polymers: rubber, natural fibers, silk fibers. Synthetic polymers: HDPE, LDPE, PP,
PS, Nylon, dendrimers etc. Moulding of polymer.Applications and future trends of polymers.
Text Book (s):

1. Gowariker, V.R., Viswanathan, N.V. and Sreedhar, J., Polymer Science, New
AgeInternational (2011).
2. Billmeyer, F.W., Textbook of Polymer Science, Wiley India (2010).
Reference book (s):

1. Misra, G.S., Introduction to Polymer Chemistry, New Age International (2008).
2. Flory, P.J., Principles of Polymer Chemistry, Asian Books.
Journals:
E-Resources:
Grading System:

Elective II
M. Sc. (Chemistry)
BS2216: Advanced Topics in Organic Synthesis 4 (3-1-0) Semester-III
Rationale:
The field of chemical synthesis continues to amaze with its growing andimpressive power to
construct increasingly complex and diverse molecular architectures.Being the precise science
that it is, this discipline often extends not only into the realmsof technology, but also into the
domains of the fine arts, for it engenders unparallelpotential for creativity and imagination in its
practice. Enterprises in chemical synthesisencompass both the discovery and development of
powerful reactions and the inventionof synthetic strategies for the construction of defined target
molecules, natural ordesigned, more or less complex.Strategic Applications of Named Reactions
in Organic Synthesis is destined to become unusually useful, valuable, and influential for
advanced students and researchers in the field.
This is a course in organic chemistry which will cover the discussion of a number of name
reactions, their mechanisms in detail and the strategic application in an advanced level.
Pre-requisite:
Basic idea of organic name reaction and disconnection approach.
Course Outline:
1. Reaction, mechanism and applications (17 Lectures)
(a) Nucleophilic C-C bond formation:Henry reaction, Wittig reaction and Horner-Wordwoth-
Emmons reaction and their selectivities,chemistry of enolates:E,Zgeometry of enolates, kinetic
vs. thermodynamic control of enolates, stereoselectiveenolate reactions, alkylation, aldol
condensation (Zimmerman and Evans models), mukaiyama reaction.
(b) Electrophilic C-C bond formation: Nazarov cyclization, prins reaction, Vilsmeier-Hack
reaction, Pictet-Sprengler reaction, reactions of -allyl palladium complexes, Heck reaction,
Stille coupling, Noyori reaction,Suzuki coupling, Neigishi Coupling, Chan-Lam Coupling
reactions of allylsilane.
(c) Miscellaneous reactions: Biginelli reaction, Hantzsch reaction, Passerini reaction, Ugi
reaction, McMurryolefination, ring closing metathesis (RCM): Grubbs reaction, Mitsonobu
reaction, Nef reaction, Sharpless asymmetric epoxidation and asymmetric dihydroxylation,
Julia olefination.
2. Reagents in organic synthesis (17 Lectures)
Use of following reagents/reactions in organic synthesis and functional group transformations:
K-selecteride and L-selecteride, sodium cyanoborohydride, super hydrides, 9-BBN, IBX,
Dess-Martin periodinane, manganese dioxide, Fetizon reagent, dioxiranes, ceric ammonium
nitrate,Gilmans reagent, lithium disopropylamide, dicyclohexylcarbodimide,
trimethysilyliodide, trin-butyltin hydride, Tebbe reagent, Corey-Nicolaou reagent, Petersons
synthesis, bakers yeast, lipase, Moshers reagent, use of Os, Ru, and Tl reagents and DDQ.
3. Disconnection approach (14 Lectures)
Synthons and synthetic equivalents, disconnection approach, functional group inter-
conversions, importance of order of events in organic synthesis, one group and two group C-X
disconnections,
chemoselectivity, reversal of polarity, cyclisation reactions, amine synthesis, one group C-C
disconnections: alcohols and carbonyl compounds, regioselectiviity, alkene synthesis, use
of acetylenes and aliphatic nitro compounds in organic synthesis, two group C-C
disconnections: Diels-Alder reaction, 1,3-difunctionalised compounds, ,-unsaturated
carbonyl compounds, control in carbonyl condensations, 1,5-difunctionalised compounds,
Michael addition and Robinson annelation,principle of protection of alcohol, amine,
carbonyl and carboxyl groups, Common protecting groups, retrosynthetic analysis,
synthesis of quercetin, pinene, camphor and emetine.
Text Book(s):
1. Carey F.A., Sundberg R.J.,Advanced Organic Chemistry,Part B, (Plenum Press, 2007).
2. KalsiP.S., Organic Synthesis through Disconnection Approach, 1stedn., (Medtec, India, 2014).
3. MarchJ., Advanced Organic Chemistry: Reactions, Mechanism and Structure, 4thedn.,(John
Wiley & Sons, 2005).
4. SmithM.B.,Organic Synthesis, 2ndedn.,(McGraw-Hill Inc., 2001).
5. Warren S., WyattP., Organic Synthesis: The Disconnection Approach, 2 nd edition, (Wiley,
2008).
Reference Book(s):
1. CarruthersW.,Some Modern Methods of Organic Synthesis,4thedn.,(Cambridge University
Press, 2004).
2. TrostB.M., FlemingI.,Comprehensive Organic Synthesis, Volumes. 1-9, (Pergamon, 1991).
E-resources:
2. www.rsc.com
3. www.springer.com
4. www.acs.com
Journals:
Grading System:
Academic Council Approval

Elective II
M. Sc. (Chemistry)
BS2225: Bioinorganic Chemistry 4 (3-1-0) Semester-III
Rationale:
Bioinorganic chemistry is a scientific discipline spanning the field of inorganic
chemistry and biology. Knowledge of bioinorganic chemistry will help students to understand
the role of various inorganic elements on the various bio-chemical processes.
Basic to advanced knowledge of bioinorganic chemistry.
Pre-requisite:
Basic knowledge of cell biology, protein chemistry, nucleic acids chemistry, carbohydrate
chemistry, enzyme kinetics, toxicological chemistry.
Course Outline:
1. Metal Storage Processes (10 Lectures)

Transition-metal storage, transport and bio-mineralization: Biological significance of
transition-metals, chemical properties relative to storage and transport, biological systems of
metal storage, transport and (bio-) mineralization, recent development.
2. Calcium in Biology (10 Lectures)

Calcium in living cells, transport and regulation, molecular aspects of intramolecular
processes, extracellular binding protiens.Role in muscle contraction, blood clotting
mechanism and biological calcification, recent development.
3.Protiens and Enzymes of Transition Elements (16 Lectures)

Hemerythrin, ferritin and transferrins, peroxidase, catalase, cytochrome P-450. Iron sulphur
proteins: rubredoxin and ferredoxins. Cytochrome C oxidase and superoxide dismutase,
ceruloplasmin, Vitamin B12, B12 co-enzymes and cobalamines, carbonic anhydrase, carboxy
peptidase, metallothionins, interchangeability of Zn and Co in enzymes. Structural and
functional models.Biological nitrogen fixation, photosynthesis, Photosystem I and II in
cleavage of water, recent development in these fields.
4. Metals in Medicine(12 Lectures)

Toxicity of mercury, cadmium, lead, chromium, beryllium, selenium and arsenic, biological
defence mechanisms, chelation therapy, metals used for diagnosis and chemotherapy,
platinum complexes as anticancer drugs, complexes of gold, copper, zinc, mercury, arsenic
and antimony as drugs, recent development in these fields.
Text Book(s)
1. Bertini I., Gray H.B., Stiefel E.I., Valentine J.S.,Biological Inorganic Chemistry: Structure
and Reactivity, (University Science Books, US, 2006).
2. Cowan, J. A. Inorganic Biochemistry- An Introduction, (Wiley- VCH, 1997).
3. Hanzlik, R. P. Inorganic Aspects of Biological and Organic Chemistry, (Academic Press,
1976).
Reference Book(s)
1. Rehder D., Bioinorganic Chemistry, (OUP, Oxford, 2014).
2. Lippard, S. J., Berg, J. M. Principles of Bioinorganic Chemistry, (University Science
Book, Mill Valley, 1994).
3. Hay, R. W. Bioinorganic Chemistry, (Ellis Hollwood, 1984).
E-Resources:
Grading System:

Elective II
M. Sc. (Chemistry)
BS2242:Catalysis and Surface Chemistry 4 (3-1-0) Semester-III
Rationale:
The course on catalysis isidentified as not only of appliedimportance in general, but also of
particular relevance to the North-Eastern corner ofIndia, since this region is rich in petroleum
and bio-diversity. Moreover the course on surface phenomena is provided due to its wide scope
in industry and research and development. It brings physicists, chemist, electronics engineers,
and material engineers to the same platform giving a complete interdisciplinary approach
towards a problem and solution.
Includes mechanism of catalysis, catalyst types, characterization, theories involved in catalysis to
its wide industrial applications. This course also covers the surfaces and interfaces, types,
properties, different forces of attractions surfactants and its applications.
Prerequisite: BS2203
Course Outline:
1. Introduction (7Lectures)
Definition, role of catalysts, classification of catalysts,
Surfaces and interfaces, characteristic features of surfactants, general structural features &
behavior of surfactants, hydrophobic/solvophobic interaction,adsorption of surfactants at
interfaces, solid liquid, gas-liquid and liquid-liquid interfaces.
Characterization of catalysts and their surfaces: Methods of surface analysis, surface area,
pore size, void fraction, particle size, mechanical strength, surface chemical composition,
surface acidity and reactivity, environmental aspect.
2. Surfactants and surface phenomena(10 Lectures)

Classification of surfactants, micelles, critical micelle concentration, Kraft point,cloud point,
micellar structure and shape, aggregation number, thermodynamics of micellisation, mixed
micelles, HLB, biological membrane, reversed micelle, self assembly of nanostructures,
micellar catalysis, Interfacial rheology, solubilisation, wetting, foaming, dispersion,
emulsification and applications. Structure of surfaces, thermodynamics of surfaces, dynamics
at surfaces, physico-chemical properties of surfaces, physical processes at interfaces, surface
properties.
3. Homogeneous catalysis (4Lectures)

Mechanism of homogeneous catalysis, acid-base catalysis, enzyme catalysis, micellar
catalysis, phase transfer catalysts, homogeneous catalysis in industry, Zigler-Natta catalysts.
4. Heterogeneous catalysis (15Lectures)

Adsorption and catalysis, mechanism of heterogeneous catalysis, kinetics of heterogeneous
catalytic reactions, volcano principle,
Production and design of industrial catalysts: materials and methods, precipitated catalysts,
impregnated catalysts, skeletal catalysts, fused and molten catalysts, calcination, reduction,
shape formation of catalyst particles, Catalytic reactors.
Examples of heterogeneous catalysts: clays, zeolites, bimetallic, semiconductor and oxide
catalysts, supported catalysts, polymer catalysts, catalytic processes in petroleum industry
reforming, cracking and hydrotreating; hydrogenation, hydrodesulphurization, Fischer-
Tropsch process, etc.
Promotion and promoters, causes and mechanism of deactivation, poisoning, sintering,
prevention of catalyst decay, regeneration of catalysts.
Text Book(s):
1. Bartholomew C.H., Furrauto R.J.,Fundamentals of Industrial Catalytic Processes 2ndedn.,
(Wiley Interscience, 2006).
2. Rosen M.J., Surfactants and Interfacial Phenomena (John Wiley, 2004)
2. Chakrabarty D.K., Viswanathan B.,Heterogeneous Catalysis (New Age Int., 2008).
3. Bond G. C., Heterogeneous Catalysis: Principle and Application; Clarendon Publisher, (1987).
4. Viswanathan B.; Kannan, S.; Deka, R. C., Catalysts and Surfaces Characterization
Techniques, Narosa Publishers (2010).
Reference Book(s):
1. Augustine R.L., Heterogeneous Catalysts for Synthetic Chemists, (Marcel-Dekker, 1996).
2. Gates B.C., Catalytic Chemistry, (John Wiley & Sons, 1992).
3. Wijngaarden R.J., Industrial Catalysis, (Wiley-VCH, 1998).
4. Thomas, J. M.; Thomas, W. J., Principle and Practice of Heterogeneous Catalysis, Wiley VCH
(1996).
Journals:
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2241: Physical Chemistry Laboratory 6 (0-0-12) Semester III
Rationale:
This course has included different analytical methodologies, which will help students analytical
skill to undertake academic and industrial research work.
Pre-requisite:
Basic experimental skills, basic concept of chemistry, safety rules in chemical laboratory.
Course Outline:
(At least 10 experiments to be done)

1. To estimate the concentration of HCl, acetic acid, copper sulphate by conductometric
method.
2. To study the reaction rate of hydrogen peroxide and HI and determine the energy of
activation.
3. To determine the ionization constant of acetic acid by conductometric method
4. To determine the hydrolysis constant of aniline hydrofluoride by conductometric method.
5. To find the stability constant of coordination compound formed between Cu 2+ and 5-sulpho
salycilic acid.
6. To establish the order of the reaction of potassium oxalate and mercuric chloride by ratio
variation method.
7. To determine the stability constant of an indicator(methyl red)
8. To evaluate the formation constant between iodine and pyridine by determining the isobastic
point
9. To estimate the mixture of HCl, NaCl and NH4Cl conductometrically
10. To study the catalytic composition of H2O2.
11. To study the formation constant of FeSCN at ionic strength of one.
12. Determination of viscosity and shear viscosity of polymer solution, microemulsion and gels
by using various types of viscometers.
13. Study of redox reactions, determination of half-wave potential and quantitative determination
of metal ions by polarometry and cyclic voltammetry.
14. Determination of molecular weight by different techniques.
15. Determination of flash point and pour point.
NB: Any other experiments depending upon availability of analytical instruments in the
laboratory.
Text Book(s):
1. Viswanathan B., Raghavan P.S.,Practical Physical Chemistry (Viva Books Pvt. Ltd., 2005).
Reference Book(s):
1. James A.M., Prichard F.E.,Practical Physical Chemistry (Longman, 1974).
2. Levitt B.P.,Findleys Practical Physical Chemistry (Longman, 1973).
E-resources:
2. www.rsc.com
3. www.springer.com
4. www.pubs.acs.com
Journals:
Grading System:

SEMESTER IV
M. Sc. (Chemistry)
BS2227: Research Methodology and Analytical Techniques 3 (3-0-0)Semester IV
Rationale:
To provide a strong base to a students who opt to become a researcher in his field. New add on
which can enhance value, in a global value chain and new generic or specific items(s), which can
be the front end of new knowledge. To enhance the choice of specific subjects, detailed action
plan, milestones, regular review of the current knowledge in the subject.
It covers planning a research program from the available knowledge, the potential for making an
original contribution to the literature in the field,the research implications and construct a
research proposal and present in the form of synopsis and seminar. The theory and applications
of various instrumental methods, used in R&D works are also included.
Pre-requisite:
Knowledge of common laboratory techniques along withbasic conceptions of chemistry,
mathematics and physics.
Course Outline:
1. Research methodology (8 Lectures)
Meaning and objectives of research, nature and significance of research, criteria of good
research, ethics in research, formulating the research problem, literature
survey,understanding scientific papers, preparing the research design, collection of data,
project execution, analysis of data, hypothesis testing using statistical analyses,
generalization and interpretation, plausible research implications.
Publication from research: types of publications, research paper and technical report
preparations,presentation in seminar: oral and poster, application for patent, types of patent.
Computers in research: computers and researchers, online literature collections, Latex,
softwares used in research.
2. Laboratory safety issues (2
Lectures)
Laboratory safety issues: lab, workshop, electrical, health and fire safety, safe disposal of
hazardous materials.
3. Errors in analysis and analytical data treatment (4

Lectures)
Errors, determinant, constant and indeterminate, Accuracy and precision, distribution of
random errors, average and standard deviation, variance and confidence limit, significance
figures and computation rules, least square method, correlation coefficient and its
determination,use of spread sheets for plotting calibration curves, quality assurance and
control charts.
4. Sampling in research (2Lectures)
Sampling techniques: gas, liquid and solid, crushing and grinding, the gross sampling,
preparation of a laboratory sample, moisture in samples-essential and non-essential water,
absorbed and occluded water, determination of water (direct and indirect
methods),decomposition and dissolution, sources of error.
5. Instrumental analysis (20

Lectures)
Applications of instruments in analysis including basic theory and examples: thermal
analysis, X-ray diffraction (XRD) techniques, X-ray fluorescence (XRF), infra-red
(IR)/Fourier transform IR (FTIR) spectroscopic techniques, AAS and ICP analytical
techniques, chromatography, electroanalytical methods, magnetic resonance techniques
(NMR etc.), scanning electron microscopic technique, energy dispersive X-ray analysis,
vacuum techniques, temperature measurement, radiation detectors.
Techniques of analysis of nano-materials: transmission electron microscopy, atomic force
microscopy, impedence spectroscopy, nano scale impedence microscopy (NIM).
Text Book(s):
1. Kothari C.R., Research Methodology, 2nd edition (New Age International (P) Limited
Publishers, 2004).
2. Day R.A., Underwood A.L., Quantitative Analysis, 6thedn., (Prentice Hall, 1991).
3. Khopker S.M., Basic Concepts of Analytical Chemistry, 3rd Edition, (New Age Science,
2008).
Reference Book(s):
1. Hawkins C., Sorgi M.,(edtd.) Research How to Plan, Speak and Write about It, (Narosa
Publishing House, 1993).
2. Manahan S.E., Environmental Chemistry, 9thedn., (CRC Press, 2010).
3. Vogel A.I., A Textbook of Practical Organic Chemistry, (Longman, 1974).
4. Mendham, J.; Danney, R.C.; Barnes, J.D.; Thomas, M. Vogels Textbook of Quantitative
Chemical Analysis, (Peterson Education, 2000).
5. Khopker S.M., Basic Concepts of Analytical Chemistry, 3rd Edition, (New Age Science,
2008).
6. Mermet J.M., Otto M., Kellner R., Analytical Chemistry, (Wiley-VCH, 2004).
7. Skoog D.A., West D.M., Holler F.J., Crouch S.R., Fundamentals of Analytical Chemistry,
8thedn., (Saunders College Publishing, 2007).
8. Kennedy J.H., Analytical Chemistry: Principles, (Saunders College Publishing, 1990).
9. Dick J.G., Analytical Chemistry, (R.E. Krieger Publishing, 1978).
10. Wilson C.L., Wilson D.W., Comprehensive Analytical Chemistry, (Elsevier, 1982).
11. Christian G.D., OReilly J.E., Instrumental Analysis, (Allyn&Bacon, 1986).
12. Pradeep T., Nano: the Essentials, (Tata McGraw Hill, 2007).
13. Kolasinski K.W., Surface Science: Foundations of Catalysis and Nanoscience, 2 nd edn.,
(Wiley, 2009).
E-resources:
2. www.rsc.com
3. www.springer.com
4. www.pubs.acs.com
5. www.wiley.com
Grading System:

Elective III
M. Sc. (Chemistry)
BS2219: Medicinal Chemistry 4 (3-1-0) Semester IV
Rationale:
To provide a background of medicinal chemistry which will help to work in drug discovery
research.
It covers fundamental topics related to drug development .Synthesis and activity of antibiotics
and type I and Type II is discussed.
Pre-requisite:
Basicconcepts of chemical biology is required.
Course Outline:
1. Introduction: (14 Lectures)

Concept of drug, pro-drugs and soft drugs, lead compound and lead modification,structure
activityrelationship (SAR), quantitative structure-activity relationship (QSAR),factors
affecting bioactivity: resonance, inductive effect, isosterism, bio-isosterism,
spatialconsiderations,physicochemical parameters:lipophilicity, partition coefficient,
electronic ionization constants, steric, shelton and surface activity parameters and redox
potentials,concept of drug receptors : elementary treatment of drug-receptor
interactions,theories of drug activity : occupancy theory, rate theory, induced fit theory:
factors affecting modes of drugadministration, absorption, metabolism and elimination.
2. Antibiotics: (12 Lectures)
Cell wall biosynthesis, inhibitors of -lactam rings, antibiotics inhibiting protein synthesis,
isolation, structure elucidation, synthesis, SAR and mode of action of penicillins,synthesis of
penicillin G, penicillin V, ampicillin, amoxicillin and cephalosporin, isolations and structures
elucidation, synthesis, SAR and mode of action of following antibiotics: streptomycin,
tetracyclines and chloroamphanicol.
3.Drug Types I: (12 Lectures)

(a) Antineoplastic drugs: Cancer chemotherapy, role of alkylating agents and antimetabolites
inthe treatment of cancer,carcinolytic antibiotics and mitotic inhibitors, synthesis of
echlorethamine,melphalan, 5-bromouracil and 6-mercaptopurine,anticancer action of cisplatin
andtaxol.
(b) Cardiovascular drug: Classification, synthesis and mode of action of quinidine,
verapamil,methyldopa and buphenine.
(c) Hypnotics and sedatives: SAR and mode of action; Synthesis of diazepam, oxazepam,
chlorazepam,alprazolam, barbiturates, thiopental sodium.
(d) Local anaesthetics: Classification, SAR and mode of action; Synthesis of procaine, -
eucaineand -eucaine, xylocaine, cinchocaine and quinisocaine.
4. Drug Types II : (12 Lectures)

(a) Antiinfective drugs: Mode of action and synthesis of sulphonamides, furazolidone,
ciprofloxacin,norfloxacin, daspone, isoniazide.
(b) Antipyretic Analgesics: Classification and mode of action of antipyretic
analgesics;Synthesis of paracetamol, chincophan, Novalgin and mefenamic acid.
(c) Antihistamines: SAR and mode of action of H1-receptor antagonists; Synthesis
ofbromazine, mepyramine, methapyriline, antazoline, promethazine and phenindamine.
(d) Antimalarial drug: Nitrogen heterocycles as antimalarial agents, their classification
andmode of action, synthesis of chloroquine, pamaquine, primaquine, Mepacrine
andpyrimethamine. Introductory idea on Artemisinin, artemether and arteether.
Text Book(s):
1.Brunton L., Lazo J., Parker K., Goodmans & Gilmans, The Pharmacological Basis of
Therapeutics, (McGraw-Hill, 2005).
2. LednicerD.,Strategies for Organic Drug Synthesis and Design, (John Wiley, 1998).
3. PandeyaS.S.,Dimmock J.R., Introduction to Drug Design, (New Age International, 2000).
4. Patrick G.L., Introduction to Medicinal Chemistry, 3rdedn., (OUP, 2005).
5. Wolff M.E. (ed.), BurgersMedicinal Chemistry and Drug Discovery, Volume-1, (John Wiley,
1994).
Reference Book(s):
E-resources:
2. www.rsc.com
3. www.springer.com
4. www.pubs.acs.com
Journals:
Grading System:
Elective III
M.Sc. (Chemistry)
BS2221: Chemistry of Materials 4 (3-1-0) Semester- IV
Rationale:
The Physics and Chemistry of Materials provides the background information necessary to
assimilate the current academic and patent literature on materials and their applications. The
course focuses on the most technologically important materials being utilized and developed by
scientists and engineers.
It coversstructure of materials, physical properties of materials, including electrical, thermal,
optical, magnetic, and mechanical properties, A section on surfaces, thin films and interfaces.
Prerequisite: None.
Course outline
1. Glasses, ceramics, compositesandnanomaterials (8 Lectures)
Glassystate,glassformers and glass modifiers, applications,Ceramicstructures,mechanical
properties, clay products, refractories,characterization, propertiesandapplications.
Microscopiccomposites, dispersion strengthened andparticle-reinforced,fibre-reinforced
composites, macroscopic composites, nanocrystalline phase, preparation procedures,
specialproperties, applications.
2. Thinfilms and Langmuir-Blodgettfilms (8 Lectures)
Preparationtechniques, evaporation/sputtering, chemical processes, MOCVD, sol-gel,
etc.Langmuir-Blodgett(LB)film, growthtechniques, photolithography, properties and
applications of thinandLBfilms.
3. Liquid c rystals (6 Lectures)
Nomatic, smectic, cholesteric properties and applications.
4. Polymeric materials (6 Lectures)
Molecular shape, structure and configuration, crystallinity, stress-strain behaviour, thermal
behaviour, polymer types and their applications, conducting and ferro-electric properties.
5. Ionicconductors (7 Lectures)
Typesofionicconductors, mechanism ofionicconduction, interstitial
types(Frenkel);vacancymechanism, diffusion superionicconductors; phase transitions and
mechanism of conduction insuper ionic conductors, examples and applications of
ionicconductors.
6. HighTcmaterials (5 Lectures)
Defectperovskites, highTcsuperconductivity incuprates, preparation andcharacterizationof1-
2-3 and 2-1-4 materials, normal state properties; anisotropy; temperature dependence of
electrical resistance, optical phonon modes, superconducting state,heat capacity; coherence
length, elastic constants, position lifetimes, microwave absorption-payingandmulti gap
structure inhigh Tcmaterials, applicationsofhighTcmaterials.
7. Materialsfor solid-state devices (2 Lectures)
Rectifiers, transistors, capacitors IV-V compounds, low-
dimensionalquantumstructures;opticalproperties.
8. Organic solids, fullerenes, molecular devices (2 Lectures)
Conducting organics, organicsuperconductors,magnetisminorganicmaterials,
dopedfullerenesassuperconductors.
9. Molecular devices (3 Lectures)
Molecular rectifiers and transistors, artificial photosynthetic devices, optical storage
memoryandswitches -sensors.
10. Nonlinear opticalmaterials (3 Lectures)
Nonlinearopticaleffects,second a nd third order-molecular hyper
polarizabilityand secondorder electricsusceptibility-materialsforsecondand
t hi rd harmonicgeneration.
Text Book(s):
1. Ashcroft N.W., Mermin N.D., Solid State Physics (Saunders College, 1993).
2. Keer H.V., Principles of the Solid State (Wiley Eastern, 1993).
Reference Book(s):
1. Callister W.D., Material Science and Engineering- An Introduction (Wiley, New York, 1985).
2. Lever K.D., Alexender J.M., Rawlings R.D., Materials Science (J.C. Senderson, ELBS).
3. Marck J.E., Allcock H.R., West R., Inorganic Polymers (Prentice Hall, 1992).
Journals:
E-Resources:
Grading System:
Elective III
M. Sc. (Chemistry)
BS2224:Industrial Chemistry 4 (3-1-0) Semester-IV

Rationale:
Industrial chemistry deals with commercial production of chemicals and related products from
natural raw materials and their derivatives. The goal of studying industrial chemistry at
university is to try and bridge the gap between classical chemistry and chemistry, which is
applied in industry.
The program is designed to provide master level student with a thorough understandingof
industrial materials and processes with special emphasize on those relevant to northeast India;
Pre-requisite:
Basics of chemistry and environmental science, knowledge of ores, minerals and natural
resources of northeast India
Course Outline:
1. Energy Sources (16 Lectures)

Coal and biomass: Renewable and non-renewable fuel sources, origin and classification of
coal, desulphurization, production of coal chemicals, Biomass as energy sources, gasification
of coal, biomass and coal-biomass, thermokinetics.
Petroleum and petrochemicals: Origin and history of petroleum, methods in petroleum
exploration, reservoir conditions, oil field waters, secondary enhanced oil recovery,
instrumental methods used in petroleum explorations, drilling fluid, oil-field chemicals,
transportation of petroleum,refining of petroleum, composition of petroleum, hydro-treating,
cracking of oil, reforming, isomerization, unleaded oil, petrochemicals, cracking of natural
gas, natural gas as a fuel.
Other energy sources: H2 gas and its preparation methods, nuclear energy, fuel cells, hybrid
cells.
2. Silicate industries (4 Lectures)

Cement, glass and ceramics: Chemical and mineral composition of cements, clinkerization
process, various grades of cement, analysis and testing of cement, production and uses of
gypsum, glass: composition and chemistry of glass productions, types of glasses, glass-
ceramics, silicate based ceramic industries: basic raw materials, basic ceramic chemistry and
ceramic products.
3. Inorganic chemical industries (15 Lectures)

Fertilizer: Essential plant nutrients and their functions, raw materials and process,
productions of: super phosphates, phosphoric acids, synthetic ammonia, urea, potassium
nitrate, biofertilizers.
Sulfur and sulfuric acid: Sources of sulfur and mining, sulfur from fuel gases, production of
sulfuric acid by contact process, recovery of used sulfuric acid.
Iron and steel:Various grades of products.
Chloro-alkali industry: Manufacture of soda ash, chlorine and caustic soda, cell types
including fuel cells, bleaching powder, calcium and sodium hypochlorite..
Electrochemical industry: Production of Al, Mg, and Na by elecrochemical process, primary
and secondary cells.
Industrial gases:Manufacturing and industrial uses of H 2, O2, N2, CO2, Cl2 and acetylene
gases, liquefaction of gases, production of low temperature.
Pulp & paper industry: Raw materials, methods of pulping, paper production processes,
cellulosic products: natural fiber production and processing.
4. Organic chemical industries (10 Lectures)

Dyes, detergents and soaps:Raw materials and processing, dyeing, raw materials for
detergents productions, specification and detergency, synthetic glycerin.
Agrochemicals: Production of ethanol and methanol, chemicals for improving production of
crops, chemicals from woods.
Pharmaceutical industry: Chemistry involved in the production of some important
pharmaceuticals.
Fats, waxes and oils: Extraction and processing of oils and fats, fat hardening, types of wax.
Polymers and rubbers:Synthetic and natural rubbers, compounding and fabrication of
rubber, raw materials of polymer, polymer processing and fabrication.
Surface coating industries: Various types of paints, pigments, varnishes.
5. Materials in electronic industries (5Lectures)

Recent trends in sensor technology, types of sensors, applications of sensors, semiconductor
IC technology, high purity silicon, germanium, gallium arsenide (GaAs),indium phosphide
(InP), etc. preparations, crystalgrowth and there use in electronic industry,high temperature
materials, high alumina, alumina, SiC, chromite, zirconia, magnesite etc.,ionic &superionic
conductors, -alumina oxide ion conductors, halide conductors.
Text Book(s):
1. Gesser H.D., Applied Chemistry: A Textbook for Engineers and Technologist, 1 st edition,
(Springer, 2008).
2. Austin G.T., Shreves Chemical Process Industries, 5th edition, (Tata McGraw-Hill, 2012).
3. Heaton A.,The Chemical industry, 2ndedition (Blackie Academic, 1996).
4. Thompson R. (Ed.) Industrial inorganic chemicals: production and uses (Royal Society of
Chemistry, 1995).
Reference Book(s):
1. BhaskaraRao B.K., Modern Petroleum Refining Processes, 5 th edition, (Oxford & IBH
Publishing Co Pvt. Ltd., 2010).
2. Satyanarayana D., Petroleum Geochemistry, 1st edition (Daya Publishing House, 2011).
3. Kent J.A., Handbook of Industrial Chemistry (McGraw-Hill, 2004).
4. Speight J.G., The chemistry and Technology of Petroleum (Dekker, 1999).
5. Dawe R.A., Lucas A.G. (edtd.), Modern Petroleum Technology, Volume 1: Upstream, Volume
2: Downstream (John Wiley, 1990).
6. Patranabis D., Sensors and Transdusers, 2ndedition (Prentice, Hall of India, 2003).
7. BalsubramaniamR.,Callister'sMaterials Science and Engineering, (John Wiley & Sons, 2009).
8. West A.R., Solid State Chemistry and Its Applications, (John Wiley & Sons, 2003).
E-Resources:
Grading System:

M. Sc. (Chemistry)
BS2237:Dissertation10 (0-0-20) Semester IV
Rationale:
To provide a strong base to students to study the advanced chemistry.To enhance the choice of
specific subjects, detailed action plan and execution of planned work, to understand how to
analyze the experimental results and how to prepare dissertation/publications on his/her work.
It covers the experimental planning ofthe proposed research program in chemistry from the
available knowledge, the potential for making an original contribution to the literature in the
field,the research implications and preparing the research outputs, execution of planned
experimental work on his topic and analysis of thus obtained results, dissemination of the results
in the form of a thesis and presentation of his finding in seminar.
Pre-requisite:
Basicconceptions of chemistry, physico-chemical processes involved in reactions, reagents and
knowledge of chemistry laboratory techniques including separation, preparation and isolation of
pure molecules.Conceptions of mathematics and physics will also be needed.
Course Outline:
1. Preparation of research synopsis:

In the final semester, students have to carry out research work at Kaziranga University or
specified organization. The area of the work is to be decided by the advisor. Before starting of
the project work, students have to submit the work-plan in the form of a synopsis followed by
oral presentation in the presence of faculty members and external expert(s).
2. Research project
After preparation and approval of the synopsis, students have to carry out research work at
Kaziranga University or specified organization. The area of the work is to be decided by the
advisor. On completion of the project work, students have to submit the work in the form of a
dissertation followed by oral presentation in the presence of faculty members and external
expert(s).
3. Testing
The student will be tested both in subject matter and the mode of presentation.
The components in the subject matter include
1. Standard of subject and plan
2. Preparation and mastery
3. Originality and logical development
4. Answers to question
5. Summary and references
The components in the mode of presentation include
1. Economy of time
2. Voice as a tool of communication
3. Blackboard use and teaching aids
4. Language and diction
5. Relating to the audience
Text Book(s):
No definite textbooks are available. Representative thesis of different universities may be
consulted.
Reference Book(s):
Text books ofspecialized areas may be referred
E-resources:
2. www.rsc.com
3. www.springer.com
4. www.pubs.acs.com
Journals:
Grading System:
*** ** ***

MSC Chemistry 2016-2018

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THE ASSAM KAZIRANGA UNIVERSITY, JORHAT

SCHOOL OF BASIC SCIENCES

The Assam Kaziranga University

BS2201: Conceptual Inorganic Chemistry 4 (3-1-0) Semester I

1. Periodic properties and bonding (24 Lectures)

2. Oxidation and reduction reactions (5 Lectures)

3. Acids and bases: (5 Lectures)

4. Aspects of d- and f-block elements (14 Lectures)

Journals and Magazines:

The Assam Kaziranga University

BS2202: Stereochemistry and Principles of Organic Synthesis4 (3-1- 0) Semester

4. Elimination reactions: (5 Lectures)

5. Addition to carbon-carbon multiple bonds: (5 Lectures)

6. Carbonyl and related groups: (6 Lectures)

7. Photochemical reaction: (4 Lectures)

Journals and Magazines:

Academic Council Approval:

BS2222: Principles of Physical Chemistry 4 (3-1-0) Semester I

Rationale:The objective is to make the concepts ofthermodynamics, quantum chemistry and

1. Equilibrium thermodynamics (12Lectures)

2. Non-Equilibrium thermodynamics (9Lectures)

3. Statistical thermodynamics (9Lectures)

5. Bio-physical chemistry (11 Lectures)

Journals and Magazines:

Academic Council Approval:

BS2211: Quantum and Computational Chemistry 4 (3-1-0)Semester-I

1. Fundamental principles and applications to simple systems (16Lectures)

2. Atomic structure (28Lectures)

3. Computational chemistry (6Lectures)

Academic Council Approval:

BS2239: Inorganic Chemistry Laboratory 6 (0-0-12) Semester I

B. Synthesis and characterization of inorganic compounds

Academic Council Approval:

1. Bonding in transition metal complexes (11 Lectures)

6. Kinetics and mechanism of inorganic reactions (11 Lectures)

Journals and Magazines:

The Assam Kaziranga University

BS2206: Organic Reactions and Mechanism4(3-1-0) Semester II

1. Reduction reactions: (14 Lectures)

2. Oxidation reactions: (14 Lectures)

3. Reactive intermediates: (14 Lectures)

4. Disconnection approach: (8 Lectures)

Journals and Magazines:

The Assam Kaziranga University

BS2207: Chemical Dynamics and Electrochemistry 4 (3-1-0) Semester II

Pre-requisite:Strong background in chemistry at the degree level. Knowledge of mathematics

Journals and Magazines:

Academic Council Approval:

BS2208: Group Theory and Spectroscopy 4 (3-1-0) Semester II

1. Chemical applications of group theory (16Lectures)

2. Rotational and vibrational spectra (7 Lectures)

3. Electronic spectra (5 Lectures)

4. Mass spectrometry (6 Lectures)

5. Nuclear magnetic resonance (NMR) spectroscopy(13 Lectures)

6. 13C NMR spectroscopy (3 Lectures)

Journals and Magazines:

Academic Council Approval:

BS2229: Organometallic and Bioinorganic Chemistry 3 (3-0-0) Semester-II

1. Organometallic chemistry(15 Lectures)

2. Homogeneous and heterogeneous catalysis (12 Lectures)

3. Bioinorganic chemistry (12 Lectures)

BS2240:Organic Chemistry Laboratory 6 (0-0-12)Semester II

A. Preparations of organic compounds using following reactions