Professional Documents
Culture Documents
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and herbal medicine opens CAM Conference revolutionise for IBS Candida
hand in hand series in March nutrition research update
Parasites
that heal:
what our
old friends
can do
for us
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2016
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cameditors note
cam magazine WELCOME
is published for qualified practitioners of
Breakthroughs?
complementary and alternative medicine
in this issue
JANUARY 2016
Features
16 CAM Conferences
Booking opens for 2016
Nutrigenomics prof Dr Ahmed
El-Sohemy signed for March
18
40
Sushi or ice cream?
Parasites that heal: Blood sugar response
depends on your genes
what our old friends New nutrigenomics study from
can do for us the Weizmann Institute: could
it change the way nutrition
Worms can heal! Naturopath Emma Lane looks research is done?
at the research in gut diseases, multiple sclerosis,
allergies, inflammation and auto-immune disease
showing the benefits of parasites that co-evolved 28 CAM Case study
Sharing a client: how nutrition and
with our immune systems. acupuncture combine to help IBS
22 44
Blinded by science: CAM Hero
practising nutrition as if Personalised nutrition in the
evidence mattered 1960s: Dr William Kelley,
metabolic typing and the
CAM contributing editor Miguel Toribio-Mateas, cancer cure that worked
BANT chairman, sets us up for the New Year
with a look at the professional backlash against
evidence-based scientism, and previews the
Regulars
launch of a new Functional Dietetics curriculum.
5 News
Functional Dietitian: BANT
launches bid to personalise
dietetics
Feeling full up? Its your gut
14
microbes, not you
Food and environment: Faecal transplant in a pill: new
probiotic is getting there
nutritional therapy and herbal
medicine hand in hand
10 CPD Dates
Meet naturopath, nutritionist and herbalist Susse
Wedel, whose practice in Ibiza emphasises the
interactions and relationships between us, our 12 New releases
Methylated B complex breaks
food and our environment. new ground
Alkalise if not now, when?
36 Listings
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@CAMmagUK
avert a growing health catastrophe. researchers observed responsible for this effect, says Barrs.
By detecting differences in small RNA
Presenting her annual report, she
an average of 4,000 expressions (where the function is not yet
structural changes to
was backed by statistics showing that In
determined) and DNA methylation patterns,
England in 2013, 56.4% of women aged the researchers have proven that weight loss
34-44 and 62% of women aged 45-54 were
classified as overweight or obese.
sperm cell DNA can change the epigenetic information men
carry in their spermatozoa. In other words,
She warned that if the food industry Researchers in Prof Romain Barrs what is transmitted in the fathers sperm can
did not do more, it should face a sugar tax. laboratory compared sperm cells from 13 potentially affect the development of a future
She told the BBC: I think it is inevitable lean men and ten obese men and discovered embryo and, ultimately, it can shape the
that manufacturing has to reformulate that the sperm cells in lean and obese men, childs physiology.
and resize, that supermarkets and respectively, possess different epigenetic We did not expect to see such important
others need to stop cheap promotions marks that could alter the next generations changes in epigenetic information due
on unhealthy food and putting unhealthy appetite. (Cell Metabolism 2016 (in press), to environmental pressure, says Barrs.
food at the check-out, and limit advertising doi: 10.1016/j.cmet.2015.11.004.) Discovering that lifestyle and environmental
dramatically. A second major discovery was made as factors, such as a persons nutritional state,
I think were at a tipping point. If researchers followed six men before and can shape the information in our gametes
industry wont deliver, then well have to one year after gastric-bypass surgery (as a and thereby modify the eating behaviour
look at a sugar tax. weight-loss intervention) to find out how the of the next generation is, to my mind, an
surgery affected the epigenetic information important find, he adds.
contained in their sperm cells. The
Obesity
Autism: brains
researchers observed an average of 4,000
structural changes to sperm cell DNA from If we consider it in an obesity context, a
first microbiome drug for ulcerative colitis. immune response. Instead, specific strains of pathogens, such as antibiotic-resistant
CAM contributor Patty Carter of http:// bacteria are introduced that re-balance the bacteria. We are also researching the use
biomeonboardawareness.com reports: billions of different types of bacteria that are of Ecobiotic drugs for the treatment of
Finally, an IBD microbiome drug goes to in the digestive tract, which then increases metabolic diseases, such as non-insulin
clinical trial. immunity and manages the disease. Instead dependent type 2 diabetes, other
Seres Therapeutics began its Phase 1b of being immunosuppressive, this treatment inflammatory diseases, such as Crohns
placebo-controlled clinical trial on Dec 14 targets the root cause of UC which is gut disease, and infections related to antibiotic
for SER-287, which is the first drug aimed at dysbiosis. use, cancer chemotherapy, and immune
the microbiome for a non-infectious, chronic Seres have other microbiome drugs in the suppression.
condition, ulcerative colitis (UC). pipeline. Ecobiotic drugs, they say, Are
This is the first IBD microbiome drug In addition to our CDI product candidates, combinations of selected microbes that may
that actually targets the constituents of the we are developing Ecobiotic drugs to treat catalyse a shift of the microbiome from a state
microbiome. This approach treats chronic inflammatory bowel disease, including that supports disease to a state that supports
disease without suppressing the bodys ulcerative colitis, and various enteric health.
The CAM Awards are hugely successful, but were aware they only reward and recognise a handful of practitioners and clinics each year. Meanwhile, we know that
CAM practitioners are quietly getting on with changing peoples lives, every day and we want to celebrate and share the inspiration. So weve re-vamped our
popular In Practice series. It is coordinated by regular CAM contributor Rebecca Smith, who runs a successful practice of her own, established 20 years ago. Contact
her direct to be part of the feature: rebecca@newportcomplementaryhealthclinic.co.uk, and follow her on Twitter: @NCHealthClinic.
cam 2016
conferences
in collaboration with
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Join us for 2016s most exciting education programme, with cutting-edge
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10 September 5 November
Feeding the brain: Nutrition resolution:
nutrition for bullet-proof breaking the cycle of stress
neuroimmunity and chronic inammation
A
ccording to a Weizmann Institute personalnutrition.org), was conducted by the
of Science study reported in groups of Prof Eran Segal of the Department of
the November 19 issue of the Computer Science and Applied Mathematics
high-impact journal Cell (doi: and Dr Eran Elinav of the Department of
http://dx.doi.org/10.1016/j. Immunology. Prof Segal said: We chose to
cell.2015.11.001), the answer varies from focus on blood sugar because elevated levels
one person to another. The largest study of are a major risk factor for diabetes, obesity
its kind supports the need for personalised and metabolic syndrome. The huge differences
dietary recommendations and might trigger a that we found in the rise of blood sugar
revolution in nutrition research. levels among different people who consumed
The study, which continuously monitored identical meals highlights why personalised
blood sugar levels in 800 people for a week, eating choices are more likely to help people
revealed that the bodily response to all foods stay healthy than universal dietary advice.
was highly individual. Indeed, the scientists found that different
The Personalized Nutrition Project (www. people responded very differently to both
R
esearchers from the University components with no genetic information. that the impact of
of Toronto (U of T) report that Changes in their dietary habits were dietary advice based
personalised dietary advice assessed after three and 12 months. The on diet-related
based on a persons genetic researchers found that subjects who genes with speciic
makeup improves eating habits received DNA-based dietary advice started actionable advice
compared to current one-size-its-all to show improvements to their diets after has been tested.
dietary recommendations. three months and the changes became even Prof Jos M.
We conducted the irst randomised more apparent after 12 months. Ordovs, Director See Prof Ahmed El-Sohemy
at the first CAM Conference
controlled trial to determine the impact Speciically, those who were informed that of Nutrition and of 2016 on March 19.
of disclosing DNA-based dietary advice on they carried a version of a gene linked to salt Genomics at
eating habits, says Ahmed El-Sohemy, an intake and high blood pressure signiicantly Tufts University, who was not involved
associate professor in nutritional sciences reduced their sodium intake, in accordance in the study, says personalised dietary
at U of T and Canada Research Chair in with the recommendation, compared to the information not only increases compliance,
Nutrigenomics. We found that people who group that received the standard advice for but also supports the long-term health of
receive DNA-based advice improve their diet sodium intake. patients. One of the major problems that
to a greater extent than those who receive No effects were observed for the other we have found regarding one-size-its-
the standard dietary advice. Theyre also the components of the diet. However, most all dietary recommendations is peoples
ones who need to change it the most. subjects were already meeting the dietary adherence to them, says Ordovs. This
Prof El-Sohemy will launch the 2016 recommendations for the three other work supports the notion that DNA-based
series of CAM Conferences, having agreed components at the start of the study, and the recommendations can be more beneicial for
to present on March 19 following BANTs researchers believe this might explain why the individual and, in addition, will increase
annual meeting. no signiicant changes were seen in these his or her compliance, which will increase
Prof El-Sohemy and colleagues collected intakes. our ability of preventing chronic diseases
data on the intake of caffeine, sodium, This study addresses some notable using dietary approaches.
vitamin C and sugar from 138 healthy young limitations in previous studies that
adults. The subjects were then randomised attempted to measure the impact of
into two different study groups one was disclosing genetic information on lifestyle
given DNA-based dietary advice for each changes, says El-Sohemy. Previous studies
of the four dietary components of interest, focused on disease risk prediction rather Booking for the 2016 CAM Conferences in
collaboration with BANT is now open. Guarantee
and the other group was given current than metabolic genes that affect speciic your place today by booking online at www.
standard dietary advice for the same dietary components of the diet. This is the irst time camconferences.co.uk or by calling 01279 810080.
I
f you are a social media user, particularly
a Twitter fan, you may have noticed a
growing trend Ive spotted in the last few
months. Increasing numbers of frustrated
healthcare professionals, including
medical doctors and dietitians, have publicly
raised their concerns about a group of very
vocal members of their own professions for
whom science and evidence are the most
valuable part of human learning.
This latter group of serial tweeters are
keen to let the world know that they believe
in the universal applicability of the scientific
method, and that empirical science constitutes
the most authoritative worldview. They take
this to the point where theyre quite happy
to exclude any other viewpoints, particularly
those that cannot be confirmed by large scale
randomised controlled trials which have then
been included in a systematic review.
Any piece of scientific and clinical
knowledge that doesnt make it to the tiny top
of this evidence-based medicine pyramid is
simply not accepted as true, hence the current
conflicts in the interpretation of evidence.
Only last month I had an interesting, mildly
heated Twitter debate on detoxification
with a well-known dietetics professor. He
is quite obviously a highly intelligent man,
but couldnt agree with me that inducing the
activity of detoxification enzymes by means
of nutritional substrates (food, nutritional
supplements etc.) was necessary at all. He
just didnt see the point, nor the clinical
applicability, of engaging in any kind of
induction (or inhibition) of detoxification
enzymes. controlled trial thats long enough and thats
In fact, it took a few tweets for him to even run on enough human participants for it to be
acknowledge the existence of the biological included in a systematic review can easily end
reality that is the enzymatic detoxification up costing a quarter of a million pounds. No
system. That only came about after I provided wonder there are hardly any RCTs on the use
a link to a paper published in the BioMed of food and food supplements as medicines
Central journal BMC Genomics. (See screen for the treatment of various conditions.
shot opposite). Theres no money to be made from foods and
Just taking a look at the evidence-based natural products that cant be patented, so the
medicine pyramid (below), one realises funding for this research is simply not there.
that the model is ill-fitted for any non- But the lack of good evidence according
pharmacological intervention. A randomised to this model does NOT mean the evidence
Personalised vs individualised
A perfect example of how shockingly
confusing their message to the outside world
is comes from the BDA factsheet on Type 2
diabetes. It states this factsheet is for people from the scientific research base. Thats the framework in functional dietetics. This means
with diabetes only, then proceeds to provide evidence published daily in hundreds of that the first Functional Dietitians may be
the reader with information based on the scientific papers from reputable research out practising in a little longer than three
EatWell Plate, ie a one-size-fits-all. Would you centres worldwide; if it doesnt quite make years. BANT will then need to continue the
ask a type 2 diabetic to eat according to the it to the tip of the EBM pyramid, this weight negotiations with the HCPC in order to get
EatWell Plate, with up to 50% refined carbs, of scientific evidence is ignored and/or grandparenting rights for all current BANT/
and even a little slice of cake and a can of classed as irrelevant by those claiming to be CNHC Registered Nutritional Therapists to
coke? Hm. uniquely able to assess it. join the HCPC Register of Dietitians.
It seems science is actually showing that The Functional Dietetics consultation runs Why are we doing this? The general
more and more real evidence supports for three months to 24 February 2016. For public needs and is asking for nutritional
the approach taken by BANT Nutritional two years BANT has collected data, delivered interventions that are individualised and that
Therapists for years. And it also seems that to the BANT council through the efforts of work for them as unique people. They need
growing numbers of healthcare professionals a highly specialised law firm, that debunks the type of interventions that a functional
and the general public alike are realising that myths such as you need to complete a six- medicine model can deliver. Im proud of
this is the case. People need interventions that month placement in the NHS to become a BANT Council for the incredible amount
work and scientists dont want to be seen to dietitian, or you need to complete a degree of work thats gone into producing the
be on the wrong side of science. So as the tide course at a university to be HCPC registered. framework, and look forward to a very exciting
changes, those who now want to say weve Another gem is that the HCPC has confirmed 2016, with potentially life-changing turns for
done personalised nutrition all along are that you dont need to be a member of the the nutritional therapy profession. cam
either going to have to admit they were wrong BDA to be a dietitian. Another myth busted.
to start with, or admit we were right. They The BDA is simply a registrant professional
simply cannot have their cake and eat it, even association for those practising dietetics
About the author
Miguel Toribio-MaTeas is a Registered
if a slice of it is allowed on the EatWell Plate. (which, incidentally, is not a protected title, Nutritional Therapist (BSc Hons Nutritional
Thats why last month BANT launched only Dietitian is). There can be several Medicine) and published author, with a
specialism in healthy ageing. He has a
a full public consultation on its curriculum professional associations in one register, as Fellowship in Anti-Ageing, Regenerative and Functional
framework for Functional Dietetic Practice to is the case for the podiatry and chiropody Medicine with the American Academy of Anti-Aging
Medicine (A4M) and has passed board certification
meet the registration standards of the Health register, where four professional associations exams in metabolic and nutritional medicine in the USA.
and Care Professions Council (HCPC). This happily coexist. Miguel is completing an MSc in Clinical Neuroscience at
Roehampton University, working with neuroimmunologist
is the same HCPC, by the way, who in 2006 The HCPC has clarified (in writing) all of
Dr Francisco Holgado-Molina on the assessment of
wrote to BANT, the Association for Nutrition these statements, and BANT has published the impact of nutrients (CoQ10, serine, vitamin C) and
and the BDA, recommending that we should this and other facts in a FAQ document that signalling molecules (NADH) on mitochondrial activity,
DNA replication and cell fate/apoptosis of murine neural
all work together as a cohesive community is key to the consultation and I recommend stem cells. His background includes more than 15 years
of nutrition health experts. BANT would like everyone interested reads carefully. Its in scientific, technical and medical research publishing,
and postgraduate studies in systems complexity and
us all to work together, but any time weve enlightening. (http://bant.org.uk/wp-content/ international business. Miguel is well-known for his
tried to build bridges weve been dismissed uploads/2015/11/FUNCTIONAL_DIETETICS_ active voluntary role with the British Association for
on the grounds that we lack evidence for CURRICULUM_FRAMEWORK_FAQ.pdf) Applied Nutrition and Nutritional Therapy (BANT). He
is the UK Head of Clinical Nutrition for Cenegenics, the
our approach, the same approach that sees As Chair of BANT I am excited to see a world number one personalised age management clinic.
people lose weight and reverse their type 2 tangible opportunity in front of us the ability Additionally, Miguel has advisory and educational roles
with Vitae Natural Nutrition and keeps developing his own
diabetes on primetime TV, but that apparently for training providers to develop courses age management range. More about Miguel at https://
is dangerous and not based on evidence that build upon the proposed curriculum miguelmateas.com.
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T
he client is a 23-year- abdominal discomfort for roughly
old woman who is eight years since the age of 15,
coming in because of when her parents separated.
fatigue and IBS, with Around this time she also suffered
constipation, pain, a bad cold and cough virus and
wind, bloating and abdominal had never felt well since.
discomfort. She took a food intolerance
As therapists we are taught ELISA test during her teens and The nutritional therapy
the advantages of cross-referring discovered gluten sensitivity: approach was based on the
clients to other practitioners; cutting this out of her diet did functional medicine 4 Rs
however this doesnt always work initially make a considerable clients mind and sympathetic for digestive health: Remove,
out in practice, as patients may difference to both bowel nervous system while improving Replace, Reinoculate and Repair
struggle to afford more than one movements and bloating, but the the flow of stagnated Qi through alongside support for her
therapy simultaneously, or feel benefits were not sustained. her digestive system and liver. nervous system with specific
unable to cope with more than A few months before starting Several ear and body points nutrients and simple deep
one technique at a time. her treatments, the client moved were used to Calm the Shen (ie breathing relaxation techniques.
When collaborative working house; this depleted her energy calm the mind), including Shen Similarities between
does happen, the results can be levels even further and worsened Men, Point Zero, Sympathetic the Western and Eastern
enlightening and empowering for her IBS. She was aware of her and YinTang. This combination of interpretations are visible:
both client and therapists. tendency to hold on to stress in body and auricular acupuncture nutritionally supporting the
Tiziana and I began cross- her stomach, and of not finding had a profound impact on the parasympathetic nervous system
referring clients to each other time for relaxation. Due to low clients parasympathetic nervous and its influence on the gut/brain
several years ago while based energy levels she was no longer system, allowing her to deeply axis equates to Calming the Shen,
at the same multi-disciplinary enjoying regular exercise; this in relax and engage in healing. while reducing inflammation
clinic. We recognised the need for turn was worsening her IBS. The disposition towards stress and enhancing digestion
a team work approach to holistic Her diet was typically very and worry was also reflected in and elimination parallels the
health, with foods, supplements, good, with plenty of home- her pulse and tongue diagnosis acupuncture effects of promoting
energy medicine and physical/ prepared meals, fresh vegetables, which highlighted liver Qi Liver Qi and warming and
manipulative therapies each wholegrains and regular fluid stagnation with heat. Various tonifying the digestive organs.
having their place in supporting a intake of water and herb teas. points such as the 4 Gates were
client on their health journey. used to promote the flow of Functional testing
This case history documents Eastern and Western liver Qi. The client was keen to take
the progress one shared client interpretations of the The clients abdomen often another food intolerance test as
made while following a functional case felt cold to the touch, a sensation she felt new food sensitivities
nutrition plan and receiving From the TCM acupuncture point which tied in with Kid and Sp had developed. The test
Traditional Chinese Medicine of view, the client had a mixture Yang positions on her pulse being highlighted multiple food
(TCM) acupuncture treatments of patterns of disharmony, with fine, deep and deficient. Moxa reactions, the strongest being
for digestive health. stress and chronic tension being and needling were used to warm to cows milk, cranberry, oats,
key contributing factors. Tizianas and tonify Qi and Yang in her core pea and egg white. Other animal
Health history approach was multi-faceted and and digestive organs: the needles milks were also quite strongly
Our client had been experiencing also used her advanced training conducted the warmth from the reactive, alongside several nuts
low energy and IBS symptoms in auricular acupuncture. She moxa, helping it penetrate deeply and grains. The presence of
of constipation, pain, wind and focused primarily on calming the into her system. multiple reactions suggested
Visit www.kinesiology.co.uk OR
call 020 8391 5988 for more info.
cam candida update
Coconut oil
can control
overgrowth
of a fungal
pathogen
in GI tract
A
new inter-disciplinary study it is well-regulated by the immune system. The team, led by microbiologist Prof
led by researchers at Tufts When the immune system is compromised, Carol Kumamoto and nutrition scientist Dr
University has found that coconut however, the fungus can spread beyond Alice Lichtenstein, investigated the effects
oil effectively controlled the the GI tract and cause disease. Systemic of three different dietary fats on the amount
overgrowth of Candida albicans in infections caused by Candida can lead to of Candida in the mouse gut: coconut oil,
mice. In humans, high levels of Candida in the invasive candidiasis, which is one of the most beef tallow and soybean oil. A control group
gastrointestinal tract can lead to bloodstream common blood infections among hospitalised of mice were fed a standard diet for mice.
infections, including invasive candidiasis. patients, cutting a swathe through anyone Coconut oil was selected based on previous
The research, published in mSphere, has immunocompromised, including premature studies that found that the fat had antifungal
given strong backing to the CAM approach of infants and older adults. properties in the laboratory setting.
using dietary approaches as an alternative to Antifungal drugs can be used to decrease Coconut oil even reduced fungal
antifungal drugs in order to tackle Candida and control Candida in the gut and prevent colonisation when mice were switched from
(2015, doi: 10.1128/mSphere.00020-15). it from spreading to the bloodstream, but beef tallow to coconut oil, or when mice were
Although we always tend to think repeated use of antifungal drugs can lead to fed both beef tallow and coconut oil at the
of Candida as a yeast that turns into a drug resistant-strains of fungal pathogens. In same time. These indings suggest that adding
fungal pathogen at the drop of a sugar order to prevent infections caused by Candida, coconut oil to a patients existing diet might
cube, researchers see it as part of the the amount of Candida in the gastrointestinal control the growth of Candida in the gut, and
gastrointestinal tracts normal lora, where tract needs to be reduced. possibly decrease the risk of fungal infections
against Candida but treat shape without any environmental cue usually this
transformation (called filamentation) doesnt happen
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W
hile there is no doubt that showed positive outcomes and suggest that Bacteria and worms from healthy people
parasites can cause serious worms and other organisms, through our and animals have been transplanted to
health problems, it is now evolutionary history, have developed a role in stimulate a healing response in unhealthy
understood that as a result driving our immune systems. organisms especially in regards to
of the hosts protective Wilson and colleagues, in a 2005 study, inflammatory diseases. A study published by
response, some worms can actually help the showed that worms in the gut can keep Duke University in April this year added new
human immune system. The evidence for allergies at bay. They found that mice infected insight into parasites and their potential. (Pi,
this is so strong that over the past few years with the helminth H. polygyrus activated 2015).
a number of studies have tested worms for regulatory T-cells in the gut. These T-reg cells The researchers hypothesised that
clinical benefits. were dispatched to the lungs, where they enhancing biodiversity in laboratory rats,
During the past ten years, studies have dampen the immune response to inhaled including treating the rats with worms,
found that certain helminth infections protect allergens. The study reported significantly would suppress their immune systems. But
against the development of allergic diseases. reduced airway inflammation in the infected the results were the opposite. They found
(A helminth is a parasitic worm.) Several mice (Wilson, 2005). enhanced, rather than suppressed, immune
clinical trials investigated the effects of A 2007 study showed beneficial function and increased biodiversity. The
deliberate exposure to parasites like porcine immunomodulation in humans with multiple findings add to the growing understanding of
whipworm (Trichuris suis) (Summers, 2003, sclerosis when they were infected with the complex environment in the digestive tract
2005) or hookworm (Necator americanus) helminths (Correale, 2007). and its role in maintaining health.
to develop helminth therapies (Feary, Senior author William Parker, PhD, said the
2010). They proved to be a safe option to Effects on IBD study suggests that biome enrichment might
control aberrant inflammation. The goal of In 2010, scientists at the University of serve as an immune trainer to improve
researchers is now to identify the parasite- California, San Francisco published a immune function and overall health: In our
derived immunomodulatory molecules comprehensive cellular and molecular clean environment, rats and by extension
responsible for the protective effects. analysis of changes in the intestinal mucosa humans, are not doing well. We are potentially
One of the earliest insights was from of a patient with irritable bowel disease. seeing a decreased ability to respond to
researcher John Turton, who in 1976 noted Active colitis was associated with T-helper dangerous antigens while, at the same time,
the absence of his own normally pronounced cells producing IL-17 and expression of we respond to things that we shouldnt,
hay fever attacks during two summers in pro-inflammatory genes such as IL-17 and IL- causing allergies and autoimmune problems.
which he was infected with hookworms; 13RA2. However, during parasitic colonisation This work demonstrates we all may really
he wrote a paper for The Lancet describing with the human whipworm T. trichiura, the need better biodiversity introduced back in
his experience. He had deliberately infected colitis remitted and there was a decrease in the system.
himself in order to rear larvae for his own IL-17-producing cells and a dramatic increase The hygiene hypothesis that our over-
research (Turton, 1976). in IL-22-producing cells. They also saw a clean environment is causing allergies has
A University of Nottingham study involving relative reduction in pro-inflammatory gene been expanded. There are now good reasons
parasites (Scrivener et al, 2001) focused expression (Broadhurst, 2010). to think that a whole range of autoimmune
on hookworm and asthma; in America, Researchers are excited that parasites, and disorders are a result of our diminished
scientists have explored whipworms effects their secreted products, could be used to treat exposure to organisms like helminths.
on ulcerative colitis and Crohns disease inflammatory diseases. Consequently, live Prof Graham Rook, from the Centre for
(Summers et al, 2005, 2003). At the University helminths are currently employed in at least Clinical Microbiology, University College
of Cambridge, a study examined how the 15 clinical trials in efforts to alleviate allergic London, developed the old friends version
tropical worm which causes the parasitic and autoimmune disorders. (See the 2013 of the hygiene hypothesis in 2003. He
disease bilharzia could modulate type 1 review by Khan and Fallon in the International said: The rise in allergies and inflammatory
diabetes (Zaccone et al, 2010). All the studies Journal for Parasitology). diseases seems at least partly due to gradually
losing contact with the range of microbes our organism we lived with throughout history. unpleasant consequences but also maybe
immune systems evolved with, way back in (Rook GA. 2010). theres a positive side that we can exploit in
the Stone Age. Only now are we seeing the Scientists are now suggesting that we new therapies for allergies.
consequences of this, doubtless also driven by need constant exposure to a diverse range of In 2014, Prof Bill Gause, Rutgers New Jersey
genetic predisposition and a range of factors old friends, not just speciic microbes. The Medical School, and colleagues showed that
in our modern lifestyle from different diets most likely explanation of this need for daily intestinal helminth infection may indirectly
and pollution to stress and inactivity. It seems exposure to microbes, particularly in early life, affect inlammation by inluencing the
that some people now have inadequately is because they interact with the regulatory composition of the intestinal microbiome.
regulated immune systems that are less able systems which keep our immune systems in Studies suggest that intestinal helminth-
to cope with these other factors. balance. Without this our immune systems induced responses have potent systemic
Rook suggests that the old friends include may overreact, react inappropriately, or fail to effects on the immune system, raising the
commensal organisms (the normal microbiota switch off completely when no longer needed, possibility that whole parasites, or speciic
of the skin, gut and respiratory tract of which is an underlying cause of these diseases. molecules produced by them, may be an
humans) and some potentially pathogenic Prof Jan Bradley, a parasitologist from the important resource for the development
organisms such as helminths (worms), which University of Nottingham, said: If you dissect of future immunotherapies to control
can establish chronic infections. These latter any free-living organism it has worms. Its full inlammatory diseases (Mishra, 2014).
have to be tolerated, because attempts by the of them, in its blood, in its guts, everywhere.
immune system to eliminate infections that it Prof Bradley continues: It is only in the last Cross-talk with the microbiome
cannot remove only leads to pointless tissue- 50 years in Britain that humans have been free While it appears some worms can actually help
damaging inlammation. of worms. In the past we would have eaten the immune system of their hosts, very little
Prof Rook said that it now looks more our own sewage through contaminated water was known about how worms interact with
and more likely that the development of systems or spreading it on crops. Even getting the hosts immune system. However a new
our regulatory immune system depends on bitten a lot by insects would help to keep a study from the Ecole Polytechnique Fdrale
molecules that are encoded not in the genome healthy amount of worms in our system. We de Lausanne (EPFL) shows that these effects go
of the human, but in the genome of some other have evolved to have worms. Worms can have through the guts bacteria (Zaiss M, 2015).
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D
r William Donald addicted. They were replaced also failed by conventional
Kelley, DDS, MD, who with fresh produce, grains and medicine, he started them on
died ten years ago, mostly raw fruits and vegetables. the same diet regime that had Dr William Kelly: pioneered
the enzyme and nutritional
was an American In three months, Kelley was worked for him. One of these was treatment of cancer.
orthodontist who, back at work and he started to his then wife, but she got sicker
with a deep interest in medicine, realise that diet and cancer were on his vegetarian diet; only when Types: three, eight, nine and ten,
had studied in its many areas connected. he put his dogma to one side and who can handle a mix of foods.
since he was a child. Described His new regime made him put her on good quality meat, did Kelley was a fan of Dr Roger
by the late Dr Nicholas Gonzalez healthier, but he still had cancer. she get better. Williams, the scientist who
as an extraordinary brilliant Reading one of Gersons books Kelley was man enough to came up with the concept of
man, Kelley was a pioneer in led him to the research of John realise that he hadnt yet got the biochemical individuality in the
research relating to nutrition and Beard, an early 20th century answer. One diet didnt fit all, 1950s, but where Kelley went
CAM methods to treat cancer, embryologist who had made no matter how many pancreatic with his study of types was far
beginning in the 1960s. the connection between cancer digestive enzymes you threw in. beyond Williams and not only
Through a long process over cells and pancreatic enzymes. More meticulous observation remarkable in its own right, but
many years, Kelley worked He proposed in 1906 that and research followed, out of way ahead of discoveries to do
out the relationship between pancreatic proteolytic digestive which came his realisation that with genes and SNPs.
enzymes, minerals, co-enzymes enzymes represent the bodys people could be categorised For each type, Kelley had not
and proper detoxification main defence against cancer, and into different metabolic types. only worked out what basic
methods. And realised the that enzyme therapy would be This related to their particular diet they needed, but whether
importance of this against cancer. useful as a treatment for all types balance, or imbalance, in the it should be raw or cooked,
Kelley described cancer as of cancer, explained Gonzalez, sympathetic and parasympathetic what nutritional supplements
single disease, caused by a lack who later reviewed Beards work nervous system. they should take and he
of certain enzymes. He had his in the light of modern molecular recommended a lot and what
own research and also used some biology. ( In The Trophoblast Ten types their mental, physical and
of Dr Max Gersons ideas in using and the Origins of Cancer: One In One Answer to Cancer, behavioural characteristics
vitamins, minerals, pancreatic solution to the medical enigma published in 1962, Kelley would be.
enzymes, coffee enemas, prayer of our time, written with Linda proposes ten basic metabolic Kelley wrote: Individuals are
and osteopathic manipulation in Isaacs, MD). types, which could be subdivided classified into ten basic types,
his treatment regimes. To test the research, Kelley into three groups: which are named Metabolic
took heavy doses of pancreatic Group A, which includes the Types One through Ten. By
Pancreatic cancer enzymes. He realised that he was Sympathetic Dominant Metabolic classifying each person into their
In the early 1960s, Kelley killing the cancer cells, but due Types: one, four, and six these own proper type, it is possible
himself faced news from his to the toxins the cancer released are people best suited to a to determine accurately what
own physician that he was soon upon death, he had Herxheimer vegetarian diet; vitamins, minerals, foods and
to die from a fast-spreading (healing crisis) reactions, which Group B, which includes the other supplements would best
pancreatic cancer He was told to made him feel very unwell. He Parasympathetic Dominant support his or her own body
go home and prepare for death. started using coffee enemas as a Metabolic Types: two, five, and chemistry. Equally important,
His mother travelled to live way of detoxing his overworked seven, which Kelley called the it is possible to know what
with him and was said to rescue liver. carnivore types; and supplements and foods they
him by removing all junk food, Kelleys road back to health Group C, which includes should not have. With the
sweets and cookies from his diet, was a long trial and error process. the Balanced Sympathetic/ knowledge of these factors, it
to which he admitted he was When he began to attract people Parasympathetic Metabolic is possible to design a program