8/10/2015 Multi-Drug Interaction Checker

9InteractionFound

PatientRegimen

isosorbidedinitrate
ISDN

fondaparinux
Arixtra

simvastatin

aspirin

clopidogrel

ranitidine

furosemide

insulinaspart

allopurinol

bisoprolol

SeriousUseAlternative

fondaparinux+clopidogrel

fondaparinux,clopidogrel.Eitherincreaseseffectsoftheotherbypharmacodynamicsynergism.High
likelihoodseriousorlifethreateninginteraction.Contraindicatedunlessbenefitsoutweighrisksandno
alternativesavailable.Neverusecombination.Enhancedriskofhemorrhage.

SignificantMonitorClosely

aspirin+bisoprolol

aspirindecreaseseffectsofbisoprololbypharmacodynamicantagonism.Significantinteractionpossible,
monitorclosely.Longterm(>1wk)NSAIDuse.NSAIDsdecreaseprostaglandinsynthesis.

aspirin+clopidogrel

aspirin,clopidogrel.Eitherincreasestoxicityoftheotherbypharmacodynamicsynergism.Significant
interactionpossible,monitorclosely.Theneedforsimultaneoususeoflowdoseaspirinandanticoagulantor
antiplateletagentsarecommonforpatientswithcardiovasculardiseasemonitorclosely.

fondaparinux+aspirin

fondaparinuxandaspirinbothincreaseanticoagulation.Potentialfordangerousinteraction.Usewithcaution
andmonitorclosely.

bisoprolol+aspirin

bisoprololandaspirinbothincreaseserumpotassium.Potentialforinteraction,monitor.

bisoprolol+furosemide

bisoprololincreasesandfurosemidedecreasesserumpotassium.Effectofinteractionisnotclear,use
caution.Potentialforinteraction,monitor.

aspirin+furosemide

aspirinincreasesandfurosemidedecreasesserumpotassium.Effectofinteractionisnotclear,usecaution.
Potentialforinteraction,monitor.

Minor

aspirin+insulinaspart

aspirinincreaseseffectsofinsulinaspartbypharmacodynamicsynergism.Minorornonsignificant
interaction.Largedoseofsalicylate.

aspirin+furosemide

aspirindecreaseseffectsoffurosemidebypharmacodynamicantagonism.Minorornonsignificant

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8/10/2015 Multi-Drug Interaction Checker
interaction.NSAIDsdecreaseprostaglandinsynthesis.

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