SEP

Student Exchange Program

Elose Snac
Toulouse College of Pharmacy

Produc1on Department


 CONTENTS

INTRODUCTION

PRODUCTION DEPARTMENT

WHAT DID I LEARN?

CONCLUSION
 INTRODUCTION

SEP: Student exchange program

Visit of the compagny

ObservaJon
PRODUCTION DEPARTMENT
Mission
 PRODUCTION DEPARTMENT
ORGANISATION
Manager

2 producJon sites
Supervisors

230 workers
Leaders
More than 200 products
Operators
 FLOW PROCESS FOR LIQUID AND SEMI SOLID FORM

WEIGHING

MIXING

Semi solid
Topical liquid
Oral liquid

FILLING: PRIMARY PACKAGING

CREAM TUBE FILLING HANDMADE BOTTLING
SHAMPOO FILLING IN LINE PROCESS

SECONDARY PACKAGING
 FLOW PROCESS FOR SOLID FORM
WEIGHING

Wet
granula1on
Dry
granula1on

Direct
compression

COMPRESSING
 FLOW PROCESS FOR SOLID FORM
WEIGHING
Wet granula1on

Mixing
Granula1on

COMPRESSING
 FLOW PROCESS FOR SOLID FORM
WEIGHING
Wet granula1on
Mixing
GranulaJon

Drying

COMPRESSING
 FLOW PROCESS FOR SOLID FORM
WEIGHING
Wet granula1on
Mixing
GranulaJon

Drying

Milling

COMPRESSING
 FLOW PROCESS FOR SOLID FORM

WEIGHING
Wet granula1on
Mixing
GranulaJon

Drying

Milling

Final mixing

COMPRESSING
 FLOW PROCESS FOR SOLID FORM
WEIGHING
Wet granula1on
Mixing
GranulaJon
Dry
granula1on
Drying

Direct
Milling
compression

Final mixing

COMPRESSING
COMPRESSING MACHINE
 COATING

PRIMARY PACKAGING

SECONDARY PACKAGING
 WHAT DID I LEARN?
Flow process
Technical skills Specic condiJons
Sanitary condiJons
Safety condiJons

Team working on a producJon issue

PharmaceuJcal eld abroad

PharmaceuJcal culture Exchange with students/professionals
 CONCLUSION

Two weeks Too short to realise a reel project

Observa1on and talks InteresJng and helpful

Successful rst step in the producJon eld

TERIMA KASIH!
PT. Guardian Pharmatama
Produc'on Department

Pedro Nuno
Francisco
Pharmaceu'cal Industry
Produc'on Dpt.
Produc'on Department

+/- 200 people in Citereup

184 solid products

 Produc'on Department

+/- 200 people in Citereup

184 solid products

1st week

Solid Produc'on Process Flow

Liquid and Semi-solid Produc'on

Process Flow
2 week
nd
Task
Which a''vi'es may be done to
ensure the operators are doing the
job correctly? (inuence the quality of
the product)
 Wet granula'on

(Staging) (Staging) +Binder solu'on

Star)ng Mixing
Weighing Pre-mixing Drying Milling Final Blendin
materials (granula)on)

(St

Capsule Filling Compression

(Staging) (St
Shipping Secondary Primary
Finished (Coa)ng)
Packaging Packaging
Product
(Staging)
 Wet granula'on

(Staging) (Staging) +Binder solu'on

Star)ng Mixing
Weighing Pre-mixing Drying Milling Final Blendin
materials (granula)on)

(St

Capsule Filling Compression

(Staging) (St
Shipping Secondary Primary
Finished (Coa)ng)
Packaging Packaging
Product
(Staging)
Weighing
Warehouse Department
Weighing
Warehouse Department

Handover
Warehouse Produc'on
Department Department
Staging
O p e r a t o r s c o l l e c t t h e
m a t e r i a l w e i g h e d a T e r
staging
Staging
O p e r a t o r s c o l l e c t t h e
m a t e r i a l w e i g h e d a T e r
staging

Change the material label

Staging
O p e r a t o r s c o l l e c t t h e
m a t e r i a l w e i g h e d a T e r
staging

Change the material label Change/hide one of the star'ng materials

Staging
O p e r a t o r s c o l l e c t t h e
m a t e r i a l w e i g h e d a T e r
staging

Change the material label Change/hide one of the star'ng materials

Do the operators collect the correct material?

Mixing
Operators need to check the cleanliness of the room
Mixing
Operators need to check the cleanliness of the room
Mixing
Operators need to check the cleanliness of the room

Do the operators con'nue with the

procedure?
Mixing
Operators need
Operators need to follow to understand the
the procedure and write procedure
every step
Mixing
Operators need
Operators need to follow to understand the
the procedure and write procedure
every step

Check periodically if the current step corresponds to

the procedure step
Mixing
Operators need
Operators need to follow to understand the
the procedure and write procedure
every step

Check periodically if the current step corresponds to Interview the operator aTer
the procedure step procedure
Drying (Same ac'vity as mixing)
Operators need to check the cleanliness of the room

Do the operators con'nue with the

procedure?
Drying (Same ac'vi'ves as mixing)
Operators need to follow Operators need
the procedure and write to understand the
every step procedure

Check periodically if the current step corresponds to Interview the operator aTer
the procedure step procedure
Drying
Operators need to understand the procedure of IPC (LOD)
Drying
Operators need to understand the procedure of IPC (LOD)

Interview the operator aTer IPC

Milling (Same ac'vity as mixing and drying)
Operators need to check the cleanliness of the room

Do the operators con'nue with the

procedure?
Milling
Operators need to Operators usually use
add lubricant the same mesh type
Milling
Operators need to Operators usually use
add lubricant the same mesh type

Change/hide the material

Milling
Operators need to Operators usually use
add lubricant the same mesh type

Change/hide the material Change the mesh

Final Blending (Same ac'vity as mixing, drying and milli
Operators need to check the cleanliness of the room

Do the operators con'nue with the

procedure?
Final blending
Operators need to add other formula components
Final blending
Operators need to add other formula components

Change/hide the material

Staging
Operators need to register the storage in the logbook
Staging
Operators need to register the storage in the logbook

Interview the operator aTer

storaging
Staging
Operators need to register the storage in the logbook

Interview the operator aTer

Check the logbook
storaging
Conclusion
1st contact of Pharmaceu'cal Industry
Great opportunity to learn and get more
informa'on about pharmaceu'cal industry
BeYer understanding about the produc'on
department
PT. Guardian Pharmatama
Produc'on Department

Thank you all for your Pedro Nuno

aFen)on!! Francisco
Pharmaceu'cal Industry
Student Exchange Programme

PT Guardian Pharmatama
Citeureup plant
Produc4on department

Jules QUIEVRE
 Compression
Change racks labels

Add or remove material in the barrels

Put a wrong punch/die among the ones that will be used

Check cleanliness : place a tablet from another batch

somewhere

Check the logbook

Interview the operators

Filling
Change labels

Add or remove material in the barrel

Check line clearance : Leave other products

Check the logbook

Interview the operators

Coating
Change labels (materials and coa4ng material)

Check the logbook

Interview the operators

Staging
Check the logbook

Interview the operators

Primary packaging
Change the foils during the process

Change the product label

Check cleanliness : place a dosage form from another batch

somewhere

Put some wrong products to see if the last operator of the line
sees them
Secondary packaging
Change leaets

Change package or labels

Put wrong product

Code verica4on : put codeless boxes

Weighing : put empty cardboard boxes

Storage before warehouse
Modify quan4ty of cardboard boxes (remove or add some)
 Suggestions
Sanitary condi,ons

Objects on the oor (punches, notebooks, ) Non prac,cal

Risk of contamina,on



Prac4cality EFFICACY
Specic area
Cleanliness CONTAMINATION


Corridor between the produc4on area and the canteen
Risk of contamina,on

Door between produc4on and boUle cleaning (no airlock)
 Eciency

One cleaning room for two departments Loss of ,me

Always busy



Handmade processes Loss of ,me
Loss of raw material
Sieving
BoUling

Computerise more documents such as batch les

Safety condi,ons

Some operators do not wear their respiratory masks

Conclusion
Chance to see how a produc4on plant is organised and run

Learnt about R&D and produc4on

Observa4ons and explana4ons compelling and benecial

Great rst experience in the pharmaceu4cal industry and in

produc4on

THANK YOU VERY MUCH