Professional Documents
Culture Documents
Politically:
Croatia, Bosnia&Hercegovina,
Serbia, Montenegro, Kosovo,
Albania, Turkey, and Macedonia.
Republic of Macedonia
Population (2006): 2 039 000
Area : 25 713 km
25500 3700
10500000
12500
Europe (exluding Turkey) Macedonia Europe (excluding Turkey) Macedonia
0.25% 30%
Gjoshe Stefkov, Svetlana Kulevanova, Medicinal and aromatic plants in Europe and Macedonia,
Maced. pharm. bul., 49, 150-151, 2003
MAPs of the Republic of Macedonia (2)
The flora of the Republic of Macedonia is quite rich, with a mosaic of diverse
floral elements (Tertiary relicts, Mediterranean, Greek-Anatolian, Ilyric,
Caucasian, Middle-European, Eurasian, arctic-alpine and cosmopolitan) and
large number of endemic species (Macedonian, south Balkan, Balkan etc).
It is represented by:
210 families, 700 MAP
920 genera,
150 most commonly used
3700 species
The most commonly used in folk Medicinal and aromatic plants (MAPs) and
medicine: their parts, are used:
- Hypericum, Vaccinium, Juniperus, medicinally,
Plantago, Matricaria, Crataegus, for cosmetics,
Rosa canina, Urtica, Calendula, as herbal teas,
Sideritis etc. as species,
in liquers and bitters,
as insecticides and fungicides,
and in domestic cleaning products.
Gjoshe Stefkov, Svetlana Kulevanova, Medicinal and aromatic plants in Europe and Macedonia,
Maced. pharm. bul., 49, 150-151, 2003
Import of MAPs in Macedonia
The imports of the MAPs in Macedonia are not significant and represent very
small number (20%) compared to the export value that leaves the country.
However, there are incidental imports which are then re-exported to other
larger importer countries.
The most attractive products for collection that appear on the Macedonian
market are:
Fungi: Boletus, Chanterelles, Lactarius, Morchela etc.
Lichens: Evernia, Cetraria
Berries: Blackberries, Blueberries, Raspberries, Cranberries etc.
Medicinal and aromatic plants: Adonis, Gentiana, Hypericum, Juniper,
Thymus, Veratrum, Ramonda, Salvia etc.
2011:
- 16 milion $ per year
- 60.000 people involved
- the largest part (50% of all):
mashrooms, Italy.
- MAPs in:
EU, Russia, USA, Australia
For cure
Domestic plants:
Hypericum large reputation as medicinal plant.
Valeriana, Achilea, Herniaria, Althaea, Malva, Tilia, Melissa, wild Mentha, Salix,
Arctostaphylos, Gentiana, Plantago, Verbena, Teucrium, Quercus, Origanum,
Satireja, Thymus, Inula, Artemisia, Tussilago, Taraxacum, Centaurea, Urtica, etc.
For refreshment
Hibiscus, Rosa canina, Rubus, Ribes, Vaccinium, Fragaria, Sideritis, Citrus, etc.
Processing of the MAPs and other
WGPs
The processing of WGPs covers few technology cycles that create semi-final
products offered mainly on the export markets. The collected and buy-out
WGPs exported are:
Wild mushrooms: Fresh and Chilled, Frozen, Dried, Brined and Fried
Berries: Fresh and Chilled, Frozen
Lichens: Dried
MAP: Dried parts.
Extracts or other herbal preparations are produced rarely!
There are mainly two lines in the WGP processing industry:
1. Frozen products
2. Dried products
Herbal medicinal
products and herbal and
food supplements are
mainly imported from
European countries, USA,
China, etc.
Research on MAPs
University Ss. Cyril and Methodius, Skopje
1. Faculty of Pharmacy, Institute of Pharmacognosy,
Svetlana Kulevanova, Ph.D., Professor. svku@ff.ukim.edu.mk
Gjoshe Stefkov, Ph.D., Assistant Professor, gstefkov@yahoo.com
Aneta Dimitrovska Ph.D., Professor. andi@ff.ukim.edu.mk
Tatjana Kadifkova Panovska, Ph.D., Assosiate Professor, taka@ff.ukim.edu.mk
Marija Karapandzova, Ph.D. student. Marija_Karapandzova@ff.ukim.edu.mk
Jelena Acevska Ph.D. student. jpetrusevska@yahoo.com
Antioxidant activity of the plant species from Macedonian flora and their possible
use as hepatoprotective agents, Ministry of Science, R. of Macedonia, 2003-2006.
COST action 926: EU Commission, Brussels, 2005-2008. Impact of new
technologies on the health benefits and safety of bioactive plant compounds.
Research on MAPs (4)
Present interest:
Thymus spp. RoM, Kosovo, Albania
Salvia officinalis, Salvia spp.
Origanum vulgare, Origanum spp.
Sideritis scardica and S. raeseri, etc.
2007-2008 SEE-ERA.NET Research Project: EXPLORING THE MOLECULAR BIODIVERSITY
OF MEDICINAL AND AROMATIC PLANTS. (Cooperation with Mediterranean Agronomic
Institute of Chania, Greece, University of Veterinary Medicine, Vienna, Austria). (main sp. Salvia).
2008-2010 SEEDNet Project GENETIC STRUCTURE OF DALMATIAN SAGE (Salvia officinalis
L.) Populations: A Model for a Collaborative Research on MAP Genetic Resouces. Financed by SIDA
(Swedish International Development Agency)
2005-2007 Chemical characterization of wild growing medicinal and aromatic plants of the Lamiaceae
family and evaluation of the possibilities for their cultivation (model plant Sideritis), Macedonian
Bulgarian bilateral project.
2010-2011 Conservation and Characterization of Oregano (Origanum vulgare L.) wild population
in Europe, finance by ECPGR (bioversity), Medicinal and Aromatic Plants working group
2010-2012 SEE-ERA.NET Plus Joint Call: A model approach for the conservation and the
sustainable exploitation of the indigenous Sideritis spp. (Mountain tea) traditionally used in the
SEE, WB countries
2010-2012 SEE-ERA.NET Plus Joint Call ConSage; Conservation and utilization of the diversity of
sage species (Salvia spp.) traditional food preservatives and spices
Research on MAPs (5)
Publications on Sideritis (2006-2011)
Kostadinova E., Alpieva K., Stefova M., Antonova D., Evstatieva Lj., Matevski V., Kulevanova S. Stefkov Gj.,
Bankova V. (2007) Chemical comosition of the essenmtial oils of three Micromeria species growing in Macedonia
and Bulgaria. Maced. J.Chem. Chem. Ing. 26 (1): 3-7.
K. I. Alipieva, E. P. Kostadinova, L. N. Evstatieva, M. Stefova, V. S. Bankova, An iridoid and a flavonoid from
Sideritis lanata L., Fitoterapia, 80, 5153 (2009).
B. Quazimi, M. Karapandzova, G. Stefkov, S. Kulevanova, chemical composition of ultrasonic-assisted n-hexane
extracts of Sideritis scardica Griseb. and S. raeseri Boiss.&Heldr. (Lamiaceae) from Macedonia and Albania, Maced.
Pharm. Bull., 56 (1,2) 45-56, 2010.
K. Alipieva, J. Petreska, . Gil-Izquierdo, M. Stefova, L. Evstatieva, V. Bankova. Influence of the Extraction Method
on the Yield of Flavonoids and Phenolics from Sideritis spp. (Pirin Mountain tea): A Preliminary Study. Nat. Prod.
Communications (2009).
Jasmina Petreskaa, Marina Stefovaa, Federico Ferreresb, Diego. A. Morenob, Francisco. A. Toms-Barbernb, Gjose
Stefkovc, Svetlana Kulevanovac and Angel Gil-Izquierdob (2011) Dietary Burden of Phenolics Per Serving of
Mountain Tea (Sideritis) from Macedonia and Correlation to Antioxidant, Activity, Natural Product
Communication, 6: (9), 1305-1314.
Petreska J., Stefkov G., Kulevanova S., Alpieva K., Bankova V., Stefova M. (2011) Phenolic compounds of Mountain
tea from the Balkans: LC/DAD/ESI/MSn profile and content, Natural Product Communication, 6: 1-10.
Petreska J., Stefova M., Ferreres F., Moreno D.A., Tomas-Barberan F.A., Stefkov G., Kulevanova S., Gil-izquiredo A.
(2011) Potential bioactive phenolics of Macedonian Sideritis species used for medicinal Mountain tea. Food
Chemistry, 125: 13-20.
Jasmina Petreska, Gjoshe Stefkov, Svetlana Kulevanova, Kalina Alipieva, Vassya Bankova, Marina Stefova,
Distribution of bioactive flavonoids in Sideritis species used for medicinal mountain tea in the Balkan countries,
Macedonian Pharmaceutical Bulletin 57 (suppl), 2011.
M. Spaseska, M. Karapandzova, B. Quazimi, G. Stefkov, T. Stafilov, K. Baceva, S. Kulevanova, The Content Of
Minerals In Herbs And Tea-infusions Of Mountain Tea (Sideritis Scardica And Sideritis Raeseri), Macedonian
Pharmaceutical Bulletin 57 (suppl), 2011.
Research on MAPs (6)
2004 - 2011
Teucrium polium anti-diabetic
Teucrium chamaedrys
Teucrium montanum
Centaurium erythrea
Vaccinium myrthilus
Vaccinium vitis-idaea
Arctostaphylos uva-ursi
Stefkov Gj., Jager A., Molgaard P., Josefsen K., Kulevanova S. (2007) In vitro investigation of the insulinotropic
effect of Teucrium polium extracts in INS-1E insulinoma cells, Maced. Pharm. Bull. 53: 306-307.
G. Stefkov, S. Kulevanova, B. Miova, S. Dinevska-Kjovkarovska, P. Molgaard, A. Jager, K. Josefsen, Effects of
Teucrium polium ssp. capitatum flavonoids on the lipid and carbohzdrate metabolism in rats, Pharmaceutical Biology,
2011.
Gjoshe Stefkov, Biljana Miova, Suzana Dinevska-Kjovkarovska, Jasmina Petreska, Marina Stefova, Gordana
Petrusevska, Svetlana Kulevanova, Antidiabetic and Antilipidemic Properties of Centaurim erythrea L.
(Gentianaceae), Macedonian Pharmaceutical Bulletin 57 (suppl), 2011.
Research on MAPs (7)
Pinus peuce national level
Pinus nigra
Pinus silvestrys
Pinus mugo
2010-2012 Characterisation of chemical composition and biological activity of Pinus (Pinaceae) and Juniperus
(Cupressaceae) species from Mascedonian flora and evaluation of the possibilities of their medicinal or
commercial use, Ministry of Science and education of RoM.
M. Karapandzova, G. Stefkov, S. Kulevanova, Essential oil composition of Pinus peuce Griseb. (Pinaceae)
growing on Pelister Mtn, Republic of Macedonia, Maced. Pharm. Bull., 56 (1,2) 13-22, 2010.
Karapandzova M., Stefkov Gj., Trajkovska-Dokic E., Kadifkova Panovska T., Petrovski O., Kulevanova S. (2010)
Chemical composition of essential oil of Pinus peuce (Pinaceae) from Macedonia and its antimicrobial activity.
Planta Med. 76: 1298 (P424).
M Karapandzova, G Stefkov, E Trajkovska Dokik, T Kadifkova Panovska, A Kaftandzieva, S Kulevanova,
Chemical characterization and antimicrobial activity of the needle essential oil of Pinus mugo (Pinaceae) from
Macedonian flora, Planta Med 2011; 77. DOI: 10.1055/s-0031-1282708 M. Karapandzova
M. Karapandzova, G. Stefkov, S. Kulevanova, Essential oils composition of Pinus peuce Griseb. (Pinaceae)
growing on Pelister Mtn., Republic of Macedonia Maced. pharm. bul., 56, 13-22, 2011.
Floresha Sela, Marija Karapandzova, Gjoshe Stefkov, Svetlana Kulevanova, Essential oil composition of
Macedonian juniper (Juniperus communis L., Cupressaceae) Macedonian Pharmaceutical Bulletin 57 (suppl),
2011.
Research on MAPs (8)
Blueberries
Lj. Melovski, S. Hristovski, Gj.Stefkov, A. Jankovski, M.
Janchevska, Assessment of the blueberries production on
Osogovo Mtn. and recommendations for their sustainable use.
MES Report (2010).
Papaver somniferum
2010-2013 first phase ALKMAF: Novel Perspectives of Poppy
utilization in R. Macedonia; Alkaloid AD Skopje & Center for Natural
Products Research Instutute of Pharmacognosy, Faculty of Pharmacy,
UKIM, Skopje.
Research on MAPs (9)
Antioxidant activity
2008-2011 CHROMLAB-ANTIOXIDANT (FP7, 204756) Reinforcement of the WBC Research
Capacities for Food Quality Characterization Prof. M. Stefova Coordinator.
2003-2006 Antioxidant activity of the plant species from Macedonian flora and their possible use as
hepatoprotective agents, Ministry of Science, R. of Macedonia,. COST action 926: EU
Commission, Brussels, 2005-2008. Impact of new technologies on the health benefits and safety of
bioactive plant compounds.
Kadifkova Panovska T., Kulevanova S. (2007) The in vitro effect of Micromria cristata extracts on microsomal lipid
peroxidation, 3rd International Conference on Polyphenols and health, Book of abstracts: P227.
Kulevanova S., Kadifkova Panovska T. (2007) Assesment of Micromeria cristata extracts as new potential sources of
natural antioxidants, 3rd International Conference on Polyphenols and health, Book of abstracts: P009.
Kadifkova Panovska T., Kulevanova S. (2005) Effect of some Teucrium species (Lamiaceae) on lipid peroxydation
in rat liver microsoms. Fresenius Environmental Bulletin 14 (10): 957-959.
Kadifkova Panovska T., Kulevanova S., Stefova M. (2005) In vitro antioxidant activity of some Teucrium species
(Lamiaceae), Acta Pharm. 55: 207-214.
T. Kadifkova-Panovska, S. Kulevanova, I. Gorgoski, M. Bogdanova, G. Petrushevska, Hepatoprotective effect of the
ethyl acetate extract of Teucrium polium, L. against carbontetrachloride-induced hepatic injuri in rats, Acta Pharm.,
57 (2007) 241-248
Recent trends and future prospective
of Pharmacognosy group
A MODEL APPROACH FOR THE CONSERVATION AND THE SUSTAINABLE
EXPLOITATION OF THE INDIGENOUS SIDERITIS SPP. (MOUNTAIN TEA)
TRADITIONALLY USED IN THE SEE, WB COUNTRIES.
SEE-ERA.NET PLUS JOINT CALL - SEEERAPLUS (2011-12)
CONSERVATION AND UTILIZATION OF THE DIVERSITY OF SAGE SPECIES (SALVIA
SPP.) TRADITIONAL FOOD PRESERVATIVES AND SPICES.
SEE-ERA.NET PLUS JOINT CALL SEEERAPLUS (2011-12)
RESOUCE ASSESMENT OF BLUBERRIES ON OSOGOVO MTN
COLABORATION WITH INSTITUTE OF BOTANY AND ECOLOGICAL ASSOCIATION
OF R. Macedonia (2010-2012)
CHARACTERIZATION OF CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY
OF PINUS (PINACEAE) AND JUNIPERUS (CUPRESACEAE) SPECIES FROM
MACEDONIAN FLORA AND EVALUATION OF POSSIBILITIES FOR THEIR
MEDICINAL AND/OR COMMERCIAL USE , MINISTRY OF EDUCATION AND
SCIENCE OF MACEDONIA (2010-2012)
FUTURE PERSPECITVES OF POPPY IN R. MACEDONIA
NATIONAL PROJECT FINANCED BY ALKALOID SKOPJE (2010-2020)
Report of a Working
Group on Medicinal
and Aromatic Plants
23 ECPGR member countries:
Sixteen target species were identified:
1. Gentiana lutea
Second Meeting, 2. Gentiana punctata
2004, Strumica, Macedonia 3. Hypericum perforatum
Third Meeting, 2007,
Olomouc, Czech Republic
4. Origanum vulgare subsp. vulgare
5. Origanum vulgare subsp. hirtum
6. Tanacetum corymbosum
Descriptors for the species 7. Tanacetum cinerariifolium
Genetic conservation programe 8. Tanacetum parthenium
9. Salvia officinalis
10. Sideritis scardica
11. Sideritis raeseri
12. Achillea millefolium agg.
13. Arctostaphylos uva-ursi
14. Helichrysum italicum
15. Helichrysum spicatum
16. Satureja montana
The priority list of species for development of
European MAP conservation strategies was
expanded for:
17. Artemisia absinthium,
18. Carum carvi,
19. Melissa officinalis,
20. Mentha spp.,
21. Thymus spp.