176 EMAS2017 / Maturitas 100 (2017) 93202
and hypertriglyceridemia in PCOS D (30% and 23.9%) was found to
be intermediate between that of PCOS C (24.5% and 18.4%) and PCOS
A (47.3% and 27%). The high prevalence of hypercholesterolemia
(around 50%) was common feature of all groups. In conclusion, in
women with PCOS, the presence of oligomenorrhea was associ-
ated with higher prevalence of metabolic disturbances compared
with the presence of hyperandrogenism in both lean and obese
women with PCOS. Obesity is more prevalent in hyperandrogenic
PCOS phenotypes than in non-hyperandrogenic PCOS phenotype
and controls. In obese controls, asymptomatic PCOM and PCOS
women, the prevalence of cardiometabolic risk factors was much
higher than in their lean counterparts.
http://dx.doi.org/10.1016/j.maturitas.2017.03.194
P095
Clinical condition of hypoleptinemia in patients
with weight loss-related amenorrhea
Hirofumi Kashiwagi , Shunichiro Izumi, Yoshie
Kametani, Takahiro Suzuki, Hitoshi Ishimoto,
Mikio Mikami
Tokai University, School of Medicine Department of
Obstetrics and Gynecology, Isehara, Japan
Objectives: Patients with weight loss-related amenorrhea
have been increasing in our modern society. As leptin is
secreted from adipose cell, low body weight induces decrease
of the secretion. Hypoleptinemia may impair the function of
hypothalamus-pituitary-ovary axis and result in amenorrhea as
well as immunological abnormality. To identify the pathological
mechanism, we tried to analyze immunological and endocrine con-
dition of in the patients of weight loss-related hypoleptinemia.
Methodology: According to the research protocol approved by
IRB, 5 patients with weight loss-related amenorrhea and some nor-
mal menstrual women were recruited. Preliminarily, the endocrine
prole and lymphocyte subsets by ow cytometry were analyzed.
Results: All patients showed the low serum concentration of
leptin, gonadotropin and ovarian hormones, while normal ranges
in control women. The results of LH-RH load test in the patient
showed low reactivity in the patient group, indicating severe grade
of hypothalamic amenorrhea. Whereas, the prole of lymphocyte
subsets (CD4, CD8, and B cells) was within the normal range.
Conclusions: In this study, there was no signicant difference
in constitution of lymphocyte between the two groups. Since a few
previously reported on this disease/condition, we should inten-
sively try to investigate the changes before/after weight recovery
and at the immunological abnormal conditions such as pregnancy,
infection and autoimmune disease.
http://dx.doi.org/10.1016/j.maturitas.2017.03.195
P096
Abeta apolipoprotenaemia as a very rare cause
of secondary amenorrhea
Christina Tzouma 1, , H. Milionis 2 , V.E.
Hatzidakis 1 , M. Syrrou 3 , P. Messaropoulos 4 , M.
Oikonomou 5 , I. Koutoulakis 6 , P. Drakakis 6 , S.
Kalantaridou 1
1 University of Athens, Aretaieio Hospital, Unit of
Primary Ovarian Insufciency, 2nd Department of
Obstetrics and Gynaecology, Athens, Greece
2 University of Ioannina, Department of Internal
Medicine, School of Medicine, Ioannina, Greece
3 Medical School, Laboratory of General Biology,
Ioannina, Greece
4 Tzaneio Hospital, General Hospital of Piraeus,
Athens, Greece
5 Thriassio Hospital, General Hospital of Elefsina,
Athens, Greece
6 University of Athens, Alexandra Maternity
Hospital, 1st Department of Obstetrics and
Gynecology, Athens, Greece
Aim: We report a rare case of secondary amenorrhea due to
abeta apolipoprotenaemia.
Case report: A 28 year-old woman presented with secondary
amenorrhea in the last 11-month period. She had menarche on
the age of 13 with normal development of secondary female char-
acteristics. Her BMI was low. A progesterone challenge test was
performed and was positive. Her gonadotropin levels at baseline
were FSH = 26 mIU/mL and LH = 22 mIU/mL. Her lipidaemic prole
showed very low cholesterol values and non-detective levels of
apo-B. Her spinal Dexa scan showed a Z-score = 3.47. Furthermore,
she had vision disorders, especially on night vision and on colours
differentiation. These ndings suggested secondary amenorrhea
due to abeta apolipoprotenaemia.
Conclusion: Abeta apolipoprotenaemia is a very rare cause of
amenorrhea. Total cholesterol is used for steroid hormone synthe-
sis. Especially LDL is used for corpus luteum progesterone synthesis.
Lipoprotein disorders with low lipid production may impair ovar-
ian steroidogenesis.
http://dx.doi.org/10.1016/j.maturitas.2017.03.196
P097
Androgen excess in women A life long
problem
Johannes Bitzer , Aware
University Hospital of Basel, Obstetrics Gynecology,
Basel, Switzerland
Introduction: Hyperandrogenism in women leads to skin and
hair disorders, metabolic disturbances and can increase cardiovas-
cular and neoplastic risk. There are different treatment options
including local and endocrine treatment.
Objective: Dening the importance of the AEiW by summarizing
the prevalence of Hyperandrogenic Skin Disorders and PCO.
Perform a narrative review of studies about the efcacy, health
risks, tolerability, and possible health benets of different treat-
ment options.
Results:
Prevalence
Acne: 8095% in adolescents and 5% in women beyond 40
Hirsutism: 515% with regional differences