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  • Gene Expression of IL-10 in Relationship To TNF-Alpha, IL-1beta and IL-2 in The Rat Brain Following Middle Cerebral Artery Occlusion

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    Gene Expression of IL-10 Paper

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    Gene Expression of IL-10 in Relationship to TNF-Alpha, IL-1beta and IL-2 in the Rat Brain Following Middle Cerebral Artery Occlusion

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    Gene Expression of IL-10 Paper

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    9 views2 pages

    Gene Expression of IL-10 in Relationship To TNF-Alpha, IL-1beta and IL-2 in The Rat Brain Following Middle Cerebral Artery Occlusion

    Uploaded by

    Tarique
    Gene Expression of IL-10 Paper

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    4/5/2016 GeneexpressionofIL10inrelationshiptoTNFalpha,IL1betaandIL2intheratbrainfollowingmiddlecerebralarteryocclusion.

    PubMedNCBI

    PubMed

    Abstract Fulltextlinks

    JNeurolSci.1997Nov25152(2):11924.

    GeneexpressionofIL10inrelationshiptoTNFalpha,IL1betaandIL2
    intheratbrainfollowingmiddlecerebralarteryocclusion.
    ZhaiQH1,FutrellN,ChenFJ.

    Authorinformation

    Abstract
    Tosystematicallyelucidatethegeneexpressionofinflammatoryandimmunemodulatorsfollowing
    middlecerebralarteryocclusion(MCAO)intherat,westudiedinterleukin10(IL10)alongwith
    tumornecrosisfactoralpha(TNFalpha),interleukin1beta(IL1beta)andinterleukin2(IL2).
    GeneexpressionofthesecytokineswasstudiedipsilateralandcontralateraltotheMCAO,with
    mRNAexpressionlevelsevaluated2,4,6,8and12hfollowingpermanentMCAObyreverse
    transcriptasepolymerasechainreaction(RTPCR).IntheischemichemisphereTNFalphaandIL
    1betamRNAincreasedat2hfollowingMCAOandpeakedat6h,withIL10mRNAdetectedonly
    at6h.Contralaterally,bothTNFalphaandIL1betamRNAswereexpressedwithasimilarpattern
    tothatintheischemichemisphere,butatlowerlevels,withnocontralateralIL10expression.
    TherewasnodifferenceinIL2geneexpressionbetweencontrolandexperimentalanimalsin
    eitherhemisphere.TheseresultsdemonstratethatIL10andTNFalpha,IL1betagene
    expressionisinducedearlyfollowingMCAO.Thetemporalprofileofthesecytokinesissimilarto
    thatseeninsepsis,whereTNFalphainducesIL10subsequentlyIL10inhibitsTNFalpha
    expression.Thesimilarityofthetemporalprofileofcytokineexpressioninsepsisandcerebral
    ischemiasuggeststhatIL10shouldbestudiedasapotentialinhibitorofTNFalphaproductionin
    ischemicbraintissue.Thefactorsinducingcontralateralexpressionoftheinflammatorycytokines,
    TNFalphaandIL1beta,alongwiththepotentialclinicalsignificanceofthisremotecytokinegene
    expression,meritfurtherstudy.

    PMID:9415530[PubMedindexedforMEDLINE]

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    http://www.ncbi.nlm.nih.gov/pubmed/9415530 1/2
    4/5/2016 GeneexpressionofIL10inrelationshiptoTNFalpha,IL1betaandIL2intheratbrainfollowingmiddlecerebralarteryocclusion.PubMedNCBI

    http://www.ncbi.nlm.nih.gov/pubmed/9415530 2/2

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