INTEGRATIVE THERAPY FOR

DEGENERATIVE BRAIN DISEASES:

INTERMITTENT FASTING AND
INTERMITTENT HYPOXIA.

IX International Symposium
Actual Problem Bio-physic Medicine
12-14 May 2016
Kiev

Tamara Voronina
London
www.tvrejuvenation.com
info@tvrejuvenation.com
 Margaret Thatcher
13 October 1925 8 April 2013

President Ronald Reagan

February 6, 1911 June 5, 2004.

They had dementia

The best way to activate positive-
emotion circuits in the brain is
through generosity.

Neurosciences start to use the

same tools to study meditation,
empathy, kindness, generosity and
compassion.

Dadi Janki has celebrated a

100 birthday last 1 January,
2016 and she still is giving
her lectures.
Descartes, in Discourse on the Method, 1637:

I think, therefore I am
Prof Stephen Hawking has been celebrated a 70th
birthday (21 June 2015). He lives because he is thinking.
Scientists have established that the brain repairs itself

in circumstances
activation of the positive-emotion which circuits
in the brain through generosity.

in circumstances
which is promoted by intermittent challenges (mild stressors).

Generosity appears if we occasionally deprive ourselves of food,

air, a comfortable temperature or regularly meditate.
 DEGENERATIVE BRAIN DISEASES is
MITOCHONDRIAL METOBOLIC DISEASES,
not genetic,
same as diabetes type 2 and cancer.

Important to find a new approach to

manage these all disease.
My clinical practice experience of

Intermittent Therapeutic Fasting (IF),

Intermittent half-day fasting,
Intermittent Hypoxia Training (IHT),
Cold Water Dousing and
Acupuncture
Illustration of the fundamental concept that optimal health is
promoted by intermittent challenges (mild stressors).

Cells in the organ, in this case the brain, respond adaptively

by enhancing their ability to function and resist disease.
"Fasting is the greatest remedy -
the physician within. ~
Paracelsus
Prof. Yuri Nikolayev, Russia psychiatrist

His dissertation: Fasting therapy for

degenerative brain diseases, 1968.

He use fasting treatment for schizophrenia,

epilepsy, depression, Alzheimers and
Parkinson's patients.

Book: Fasting for health, 1969.

 Another interesting adaptation
suggested by studies of animal models,
is that cognitive function and stress
resistance improve in response to
intermittent fasting

(Wan et al., 2003; Ahmet et al., 2005;

Mattson, 2012a; Marosi and Mattson, 2014).
 Fasting therapy experience:
2000 patients over 12 years in the department of
endocrinology, Zaporozhe general hospital, Ukraine.

1978-1990

140 patients per year x 15 years

 Fasting therapy in general hospital
1975-1990
DISEASE PATIENTS DURATION OF FASTING

prostate adenoma 1 40 days fasting, the result - cure

severe candidiasis 1 fasting 13 daysthe result - cure
impotence 12 fasting 5-7- 30 days
hypertension >300 fasting 5-7-12 days
diabetes type 2 >300 fasting 5-7-12 days
obesity >400 fasting 5-7-12 days
Polycystic ovary 15 fasting 7-13 days
infertility 6 fasting 5-7 days
arrhythmia 2 fasting 3-5 days
asthma 12 fasting 5-7-10 days
depression 5 result - cure
hypothyroidism 20
My practice in London
1994 -2015
Half day of fasting, IHT and acupuncture
in London clinics 1993-2015.

DISEASE PATIENTS DURATION OF FASTING

diabetes type 2 >40
overweight >100
Polycystic ovary 3 fasting 7 days with acupuncture
infertility 2 fasting 5-7 day, have children
hypertension 10 fasting 5-7-12 days
arrhythmia 2 fasting 3-5 days
severe asthma, child 1 Half day fasting 17 days, the result cure
epilepsy 2 Half day fasting 17 days, the result - cure
lung abscess 1 Half day fasting 23 days, the result - cure
psoriasis with diabetes type 2
and hyperthyroidism 1 Half day fasting 4 months, the result cure
coronary artery calcification 1 decreases from 50% to 20% during 4 months treatment
depression 3 the result cure
ischemic strokes 2

Fasting with IHT and acupuncture 1996 -2014

Hashimoto's Thyroiditis 1 12 days fasting, the result - cure
Breast cancer 1 stage 1 Intermittent fasting 5, 13, 15 days normalisations p53
Obesity 1 fast 20 days, lost 15 kg
 Intermittent half-day Fasting
Patients fast for 17-18 hours per day.
That means no food, only tea and water.
They have an 6-hours daily feeding window
From 15.00 to 21.00,
in this time preferably have two meals.
Obesity accelerates age and
age related pathologies.
Influence of Obesity on Neurodegenerative Diseases
By Rana Awada , Avinash Parimisetty and Christian Lefebvre dHellencourt
"Neurodegenerative Diseases", book edited by Uday Kishore
In obese patients stress, depression and dementia affect the
whole body and the whole body influence on the brain.
Clinicians should have a lots of professional tricks
to make treatment pleasant and efficient.
How to build effective strategy for
prevention and treatment of
degenerative aging diseases?

What is the main focus

to deal with these
health problems?
 Mitochondria are working efficiently
and improve biogenesis
when they intake
low Glucose + low Oxygen

This way we can prevent metabolic diseases and

neurodegenerative disorder.
 There are two methods
that have strait effect on our
mitochondria:

Intermittent Fasting
and
Intermittent Hypoxia Training
Youth is flexibility.

Aging is rigidity.
Our purpose is to swing
the body chemistry
and coordinating
cell signalling

Intermittent type mild stress therapies fasting and

hypoxia initiate and challenge metabolism.

Its make the body flexible, adaptable more coherent and

coordinated with the signals between organs, cells and
molecules. These lead to neuroplasticity
.
 The integrated therapy at the morning

Meditation

+ + +

Cold Water Dousing at 8.00

Intermittent Hypoxia Training (IHT) with
Acupuncture and
Meditation during session IHT and acupuncture
Fasting before 14.00-16.00
 Treatment during the day:
IHT, Haft-day Fasting and Acupuncture
Insulin activity during the consumption of four meals
by Lean and Obese groups
 Insulin resistance could be decreased by changing
Insulin activity during the half day or more fasting
and only two meals in the evening.
Our genes developed so that our bodies could turn stressful
environmental circumstances
to their best advantage.

We have got to use stressors to mobilize beneficial

adaptive stress response.

We have genetic operating system whose function it is

constantly adapt to external conditions and needs.

Epigenetics proved:
Humans are self-upgradeable.
We are designed to upgrade on our own all the time.
EPIGENETICS CAN BE HARMFUL
Epigenetic events
occur as a response to food intake
Intermittent Fasting
Epigenetic response
 Epigenetic events
occur as a response
to food intake

Bile acids are necessary for

lipid digestion and
absorption, and more
recently have been identified
as signaling molecules.
Metabolic changes occurring in the fasted-to-fed cycle-Alteration of Bile
Acids quantity in Liver lead to longevity through sirtuin increase.
Nutrients 2010, 2(5), 551-571; Review. When Food Meets Man:
the Contribution of Epigenetics to Health Emma De Fabiani at al.
 Sirtiuns play a big role in life span
in yeast and worms.
The silent information regulator gene 2 (SIR2)
can increase life span when up-regulated and
decrease lifespan when down-regulated
(Kaeberlein, McVey, & Guarente, 1999).

The mammalian analog SIRT1 has many health

and longevity related effects, as shown in the
diagram below (Metoyer & Pruitt, 2008).
Recent progress in the biology and physiology of sirtuins

Toren Finkel, Chu-Xia Deng & Raul Mostoslavsky

Nature 460, 587-591(30 July 2009)
Nutrients 2010, 2(5), 551-571; Review
When Food Meets Man: the Contribution of Epigenetics to Health
Emma De Fabiani at al.

Abstract: Post-translational modifications of chromatin contribute to the

epigenetic control of gene transcription. The response to food intake and
individual nutrients also includes epigenetic events. Bile acids are necessary for
lipid digestion and absorption, and more recently have emerged (have been
identified) as signaling molecules.
Their synthesis is transcriptionally regulated also in relation to the fasted-to-fed
cycle, and interestingly, the underlying mechanisms include chromatin remodeling
at promoters of key genes involved in their metabolism.
Several compounds present in nutrients affect gene transcription through
epigenetic mechanisms and recent studies demonstrate that, beyond the well
known anti-cancer properties, they beneficially affect energy metabolism.
Obese subjects have high expression Leptin secretion
and low Adiponectine from adipose tissue.
Lean subjects and even fasting obese subjects have high Adipokine
expression and secretion by adipose tissue
IMPROVING INSULIN RECEPTORS

In diabetes type 2 the number of receptors to insulin on the

lymphocyte is half that of non-diabetics. Diabetics with obesity
are nearly one third of non-diabetics.

Healthy body about 7000

Diabetic patients 3680
Diabetics with obesity 2300

Balabolkin Mikhail., Diabetology.

(1983,1990)
 The main rule to use Glucose effectively is
to have less glucose and less insulin!
Low capacity of glucose/insulin - high affinity to glucose/insulin
High capacity of glucose/insulin low affinity to glucose/insulin
Too much food - cell signalling poor!

High capacity
less affinity (Less sensitivity to receptors).

Low capacity
high affinity (high sensitivity to receptors).

High oxygen - less affinity to oxygen

High Insulin - less affinity to Insulin
High glucose - less affinity to glucose
High calcium - less affinity to calcium
Many toys child has less motivation and interest
However
Fasting for 72 hours, 3 days, in diabetic patients,
results in receptors re-establishing themselves.

This effect lasts 2 to 3 days (approximately 80 hours), then

everything reduces to the previous number.

Balabolkin M. I., Diabetology (1983,1990)

My therapy shows positive results - that the patients with 4-6

years history of diabetes, had no diabetic symptoms for as
long as 10-12 years.
 Effective treatment of
diabetes type 2 with obesity.
 Intermittent Fasting (IF)
help to get rid of misfolded proteins and
removes of waste by autophagy
Cellular effects of protein misfolding lead
to ageing diseases
The main focus is misfolded protein:
Removal of waste by autophagy
Fasting appears to offer protective and
therapeutic benefits to the brain:
Fasting lead to Normoglyceamia and Increases Production of Ketones
Autophagy down-regulate wasteful processes, and repair themselves.

Increases Levels of Brain-Derived Neurotrophic Factor (BDNF)

Stroke, Brain Trauma, Cervical Spine Injury, Alzheimers disease, Huntingtons disease,
Age-Related Cognitive Decline, Depression.

Prolonged fasting reduced the enzyme PKA (Protein kinase A), which is linked to ageing
and a hormone which increases cancer risk and tumour growth,

Prolonged fasting eliminated p53 misfolded protein, normolise P53 gene protein,
improved telomerase (fasting 13 and 15 days)

Fasting for 72 hours also protected cancer patients against the toxic impact of
chemotherapy.
Neuroprotection
IF up-regulation of neurotropic factors like Glial cell-derived neurotropic factor
(GDNF) and brain- derived neurotropic factor (BDNF).
These both promote survival of neurons as well as the making of new connections.

Chaperone proteins like shock protein-70 (HSP-70) and glucose-regulated protein

78 (GRP-78) are also up-regulated, these can protect the cells from damage and death
from environmental conditions.

Cytoprotective activity with regard to seizures and epilepsy

IF has been shown to be more efficient that CR in the previously mentioned ketogenic
metabolic pathway.

This ketone body exhibits neuroprotectivity in models of Alzheimers and

Parkinsons disease (Kashiwaya et al., 2000). IF fed mice can develop a twofold
concentration of the -hydroxybutyrate ketone body compared to mice fed ad libidum
(Anson et al., 2003).
 Intermittent fasting (IF) induces the
expression of protein chaperones (e.g.,
heat-shock protein 70 and glucose-
regulated protein 78) and stimulates
autophagy in many cell types
(Duan and Mattson, 1999; Yu and Mattson, 1999; Alirezaei et al., 2010;
Arumugam et al., 2010; Lee and Notterpek, 2013).
In addition to being used as an energy source, ketone bodies can
modulate signaling pathways and gene expression by, for
example, inhibiting certain histone deacetylases
(Newman and Verdin, 2014).

Fasting can enhance the ability of cells to damaged proteins and

organelles, a process called autophagy (Jamart et al., 2013).

The latter actions of intermittent fasting (IF) enhance the

ability of cells to eliminate damaged proteins and organelles
such as mitochondria.
Animals that eat only every other day live up to
30% longer than those that eat every day
(Goodrick et al., 1983), and exhibit
resistance to neurodegenerative disease
(Duan et al., 2003; Halagappa et al., 2007;
Arumugam et al., 2010).
 During the fasting period, fatty acids are released from adipose
cells and enter the liver where they are converted to ketone
bodies (-hydroxybutyrate and acetoacetate) which provide a
robust energy source by for muscle cells and neurons
(Johnson et al., 2007; Maalouf et al., 2009).

Ketone bodies have beneficial effects on cells that can counteract

disease processes.

For example, ketones protect neurons against dysfunction and

degeneration in experimental models of epilepsy
(McNally and Hartman, 2012) and Alzheimers disease
(Kashiwaya et al., 2013).
Intermittent fasting (IF) can also increase
neurotrophic factor signaling in brain cells,
which may contribute to their abilities to
enhance hippocampal neurogenesis (Lee et al.,
2002) and protect neurons against oxidative
and metabolic stress in animal models of
Parkinsons disease (Duan and Mattson, 1999),
Huntingtons disease (Duan et al., 2003), Alzheimers
disease (Halagappa et al., 2007) and stroke (Yu and Mattson,
1999; Arumugam et al., 2010).
INTERMITTENT OXYGEN TRAINING (IHT)
The main purpose is to use O2 efficiently!
 High Oxygen consumption
speeds up aging!
Low Oxygen - slows down!
Life depends on how much oxygen we use
and distribute effectively. We are like rusting
metal or rotting fruit. Aging is oxidation.

The more oxygen we inhale, the sooner we

get burnt up or disintegrate; that is, the
more quickly we get older.
This is the law of life.
Oxygen is a danger!
 IHT session: 55 minutes, 6 cycles of 12% oxygen breathing
(which corresponds to an altitude of 4500m)

12% 12% 12% 12% 12% 12%

O2 O2 O2 O2 O2 O2
SpO2 SpO2 SpO2 SpO2 SpO2 SpO2
89% 88% 86% 85% 84% 84%

O2 O2 O2 O2 O2
21% 21% 21% 21% 21%
SpO2 SpO2 SpO2 SpO2 SpO2
95% 97% 95% 96% 98%

Time 5 10 15 20 25 30 35 40 45 50 55
 Mitophagy is renovater of mitochondria
leads to longevity
BOWHEAD WHALE
(Balaena mysticetus)
live 250.

The perfection of a
mitochondria
determines life span
IHT
High Altitude Training -
constant hypobaric hypoxia

Artificial Altitude Training

Normobaric Intermittent
Hypoxia Training
What we can observe
in 20-30 minutes of the IHT session:

more acute sight, color vision improvement

more free, feeling open lungs, and slowing breathing
slowing heart rate
decrease Blood Pressure
general relaxation
sleeping feeling or
feeling a lot of energy
pink cheeks, warming extremities
improvement mood

depression disappears
insomnia disappears
 COMPLEX PARTIAL SEIZURES
Neda (45years old, Kuweit)

Complex Partial seizure cure after one

treatment,
suffered 5 years.
I am Robin Maclear, 70 years old (24 Apr 2015)

In March 2010 I was diagnosed with Angina and

an angiogram revealed that one of my main
arteries in heart was 50% closed.
After IHT regularly for 4 months and on my
next examination the surgeon discovered that
the artery was now only 20% closed.
 Allergy reaction after tooth implant
Edema gone in one day after IHT

IHT bring in illumination Histamine, Lactic acid and water

retention where is acidosis.
The low pH becomes a regulator.
Patient L. M. 64 years old, London 2010

 High altitude and IHT decrease
lactic acid in tissue and organs

The mere presence of lactic acid can

make cells more vulnerable to the
transformation into cancer cells.
(Mothersill, et al., 1983.)

The implications of the increased resistance to

cancer at high altitude are obvious.


Clinical case resulting in the complete

eradication of asthma over 17 days.

Adam Lee, 12 years old, daily treatments, 24

July - 3 August 2001.
He had been under observation for 5,5 years.

He had been under observation for 15 years.

Before the treatment
Frequent Asthma attacks eradicated by daily administration of three puffs twice daily of Bricayl, total 3200
mg a day and three puffs twice daily of Pulmicort, total 1600mg a day. Lacks confidence because
overweight (weight 59.5 kg. height 114 cm), slow to react, craving sweet food, feeling heavy in stomach
after eating, indigestion and heartburn at times. Allergy to nuts, bananas and fish.

He had severe eczema at the age of one month, treated by diet only.
Asthma started from age six. On corticosteroid medications from age of 9.

Medication during the treatment Adam L.,12 years old

(17 days, 24 July - 13 August 2001).

Before the treatment Control pause- hold breath - 6 seconds

Bricayl dose a day before and during the treatment

(1600mg twice daily)
1st day 3200 mg Control pause 6
4th day 800 mg Control pause 17
9th day 400 mg Control pause 25
12th day 0 mg Control pause 40
IHT improves spermatogenesis
increases libido
 Epigenetic and
life in high altitude
 People living in mountains
live longer and are seldom obese,
have less aging diseases
and win marathons.
La Paz city, Bolivia, 3100m and 4100m
Citizen have a very low arterial oxygen tension
only PaO2* = 37 mmHg

People at sea level usually have

Normal PaO2 = 80-100 mmHg

*PaO2 assesses perfusion (gas exchange)

 IHT improves erythrocytes in 30 minutes
Blood test taken before and after 30 minutes of IHT. Patient
Mindy T. Picture taken 20/05/2006

During IHT haemoglobin binds with enzyme 2,3 - DPG

(2,3-diphosphoglycerate), which makes the release of oxygen
into tissue from haemoglobin significantly easier.
 IHT improves circulation
Chest and head Thermal Images taken before and after 30 minutes of IHT. Patient
Duncan taken 27/04/2006

Beneficial balancing of NO - leading to SMC (Smooth

muscle cells) relaxation and anti -inflammation
IHT triggers for build a new vessels
and neurons.
Thermal Images of head taken before and after 30 minutes of IHT.
Client Duncan H. taken 27/04/2006

It has been identified that hypoxia-induced growth factors

(as well as VEGF) involved in an angiogenesis as well as in
a neurogenesis.
Kunlin Jin, et al. Vascular endothelial growth factor (VEGF) stimulates
neurogenesis in vitro and in vivo. Neurobiology. June 18, 2002
 IHT improves circulation
because of NO production improving.
Head and chest Thermal Images taken before and after 30 minutes of IHT.
Patient D. H. taken 27/04/2006
 The role of nitric oxide (NO)
for effective treatment of microvascular complication
of diabetes, stroke and brain trauma.
Normoglyceamia is most important condition!
Hyperglycaemia impairs the activity of macrophages to
produce nitric oxide (NO), absence of NO leads to vasoconstriction.

Vasoconstriction cannot appear if is hyperglycaemia.

IHT cannot be enough effective if is hyperglycaemia.

Impairs the activity of NO resulting in endothelial dysfunction: causes

vasoconstriction, smooth muscle proliferation, platelet activation/aggregation,
and leukocyte adherence to the endothelium
(Adrie 1996; Cooke et al. 1997; Federici et al. 2002).

Hence need normoglyceamia (no breakfast!) before IHT treatment.

 Hyperglycemia no formation of NO
leads to proliferation of smooth muscle cells
 IHT against cellular aging

Hypoxia increases p53 protein levels in cells

Chandel NS, et,al.,Redox regulation of p53 during hypoxia. Department of Medicine, Gwen Knapp Center, Committee on Immunology
and the Howard Hughes Medical Institute, The University of Chicago, Illinois, USA. Oncogene 2000 Aug 10;19(34):3840-8

IHT increases stress-protein levels in cells

Meerson F. Z., Adaptive Medicine: mechanisms and protective effects of adaptation Monograph.
Moscow; 1993:254-257.

IHT stimulates nitric oxide (NO) production

IHT improved mitochondrial respiration by NO-
dependent reactions
Hypoxia up-regulates telomerase
Minamino T., et al. Hypoxia Extends the Life Span of Vascular Smooth Muscle Cells through Telomerase Activation. Molecular and
Cellular Biology, May 2001, p. 3336-3342, Vol. 21

Hypoxia increases Stem Cells production (by 15

times !)
 IHT in the treatment of Obesity
with Diabetes type 2
up-regulates glucose transport activity
through an increase of GLUT1 expression
Takagi H, King GL, Aiello LP Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells. Research Division, Joslin Diabetes Center,
Boston, Massachusetts, USA. Diabetes. 1998 Sep; 47(9):1480-8

triggers production of beta-cells in the pancreas Kolesnik Y. M., et al.,The new approaches to diabetes mellitus treatment.
Zaporozhye state medical university. Ukraine.1998

opens ATP-K channels in 20-25 minutes

ORP150 (oxygen-regulated protein ) plays an important role in insulin sensitivity.
Systemic expression of ORP150 improves insulin intolerance
Kentaro Ozawa1, et al., The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes. Diabetes 54:657-663, 2005

activates cytochrome P-450 in liver

Meerson F. Z., Adaptive Medicine: mechanisms and protective effects of adaptation Monograph. Moscow; 1993:190-194 .
Loss of appetite and weight are observed at high altitudes
hypoxia-induced growth factors (as well as VEGF) involved in an
angiogenesis as well as in a neurogenesis.
Kunlin Jin, et al. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Neurobiology.
June 18, 2002
 IHT for Parkinson's and Alzheimers
Disease.

Hypoxia triggers the production of HIF1--->

HIF1 stimulates Erythropoietin (EPO) in brain--->.
EPO --->
via increasing NO production --->
has protective and therapeutic effect in
survival of nigral dopaminergic neurons
and nitrate levels in substantia nigra and
striatum.
 .

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sirtiun
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SIRT1 Sirtuin FOXO, ,

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Our purpose to preventive diseases
and cure people
and provide treatments efficient,
safe and pleasant.

HUNGER can not be a problem.

How do to kill appetite?
How do to kill appetite?
cut out sweet food, since it creates after
hyperglycemia hypoglycemia and brings hunger pangs.

carry out gall bladder and liver cleansing, since overfull gallbladder increases gastric
juice and the appetite

carry out bowl cleansing, this decrease the appetite

regularly eat your first meal only when you feel hungry, gradually shifting the time
of your breakfast towards 11am-13pm, and start with raw green food or vegetable
juices

avoid foods that cause allergy, intolerance, as well food consist lectin - this helps to
eliminate inflammation

do special breathing exercise to release stomach juice

make yourself busy so that you dont think about food

massages, bath, swimming

 The approach
must be integrated.
Daily Mail
Oct. 1993

Free-drug
treatment for
over-weight and
obese people can
prevents
degenerative brain
diseases.
 Why does acupuncture kill appetite?
Acupuncture influence on stomach and pancreas secretion,
decrease insulin and increase glucagon.
It increase pleasure hormones.
 Acupuncture really kills appetite!
(by increase pleasure hormones and changing insulin/glucagon balance)
 The same acupuncture points
decrease appetite and improve memory!

The neuropeptides vasopressin, adrenocorticotropin (ACTH), and

beta-endorphin seem to have important effects on memory and
learning. ACTH and melanocyte-stimulating hormone (MSH) are
two peptides the primary behavioral effect of which seems to be
on attention or goal-motivated behavior rather than on memory
processes themselves.

Neurosurgery. 1985 Aug;17(2):355-69.

Neuropeptides in human memory and learning processes.
Zager EL, Black PM.
 Temperature
is one of the most important
environmental factors
affecting the physiology of humans.

Many cultures have adopted cold water dousing

and plunging for religious ceremonies to
maintain health.
 Ancient Spiritual cleansing
The ancient Russians took frequent plunges into ice cold rivers
for health and spiritual cleansing.
The Japanese practitioners of Shinto would stand under an icy
cold waterfall as part of a ritual known as misogi, which was
believed to cleanse the spirit.
 Medical research suggests the
following
benefits of regular cold showers:
Cold water adaptation increase in brown fat cells, which protect the body from
aging. Brown-fat cells have a large concentration of mitochondria to generate heat
without physical contraction or muscular movements.

One of the important pathogenic factors in cold therapy is the release of nitric oxide
(NO), leading to a rapid increase in skin blood flow. Hyperemia is largely (70%)
governed by the endothelial release of nitric oxide (NO).

Medical research has confirmed the effects of cold water treatment by dousing,
covering such areas as motor activity and physical efficiency, cardiovascular
response, lipid profile, haematology, hormonal screen, immunology and
inflammation. Some facts show that different type of intermittent cold procedure can
be an effective method of improving the immune system, preventing some diseases and
even curing severer diseases.
 The following benefits of regular cold showers:
- activation of the sympathetic nervous system (Shevchuk, 2008)
- increased blood level of beta-endorphin and noradrenaline and increased
synaptic release of noradrenaline in the brain as well (Shevchuk, 2008)
- electrical stimulation of peripheral nerve endings to the brain, which could have
an anti-depressive effect (Shevchuk, 2008)
- significant analgesic effect without noticeable side effects or causing dependence
(Shevchuk, 2008)
- reduction in muscle soreness after running a marathon (Liang et al, 2001)
- improved quality of sleep (Onen et al, 1994)
- decrease of uric acid level in blood plasma (Brenke et al, 1994)
- inhibition of purine metabolism (Brenke et al, 1994)
- long-term antioxidative adaptation (Brenke et al, 1994)
- improved tone of the skin and muscles (Mergeay et al, 1990)
- reduction in uremic pruritus (a major problem for patients
with end-stage renal disease) (Zucker et al, 2003)
 Epigenetic shows
we are designed to upgrade on our own.
We are self-upgradeable.
Oxygen, fasting, food, acupuncture and cold
exposure can act as a natural
regulators, restorers and rejuvenators.

.
Thank You!
Tamara Voronina MD
London

www.tvrejuvenation.com
info@tvrejuvenation.com