25/10/2017 Drug Interactions results - MICROMEDEX

Drug Interaction Results

Selected Drugs: Amitriptyline , Digoxin , Linezolid , Metoclopramide
Severity: All
Documentation: All
Interaction Type: All

Drug-Drug Interactions (4)

Drugs: Severity: Documentation: Summary:
AMITRIPTYLINE HYDROCHLORIDE -- LINEZOLID Good Concurrent use of
AMITRIPTYLINE and LINEZOLID
may result in increased risk of
Contraindicated serotonin syndrome
(hyperthermia, hyperreflexia,
myoclonus, mental status
changes).

AMITRIPTYLINE HYDROCHLORIDE -- METOCLOPRAMIDE Fair Concurrent use of

HYDROCHLORIDE METOCLOPRAMIDE and
TRICYCLIC
Contraindicated ANTIDEPRESSANTS may result
in an increased risk of
extrapyramidal reactions or
neuroleptic malignant syndrome.

DIGOXIN -- METOCLOPRAMIDE HYDROCHLORIDE Good Concurrent use of DIGOXIN and

Major METOCLOPRAMIDE may result
in decreased digoxin levels.

LINEZOLID -- METOCLOPRAMIDE HYDROCHLORIDE Good Concurrent use of LINEZOLID

Major and METOCLOPRAMIDE may
result in increased risk of
serotonin syndrome
(hyperthermia, hyperreflexia,
myoclonus, mental status
changes).

Ingredient Duplication (None found)

Drug-ALLERGY Interactions (None found)

Drug-FOOD Interactions (4)

Drugs: Severity: Documentation: Summary:
LINEZOLID Good Concurrent use of MONOAMINE
Major OXIDASE INHIBITORS and
AVOCADO may result in
hypertensive crisis (headache,
palpitation, neck stiffness).

LINEZOLID Fair Concurrent use of MONOAMINE

Major OXIDASE INHIBITORS and
BITTER ORANGE may result in
hypertensive crisis (headache,
hyperpyrexia, hypertension).

DIGOXIN Good Concurrent use of DIGOXIN and

Moderate FOOD may result in decreased
peak digoxin concentrations.

LINEZOLID Good Concurrent use of LINEZOLID

Moderate and TYRAMINE FOODS may
result in a significant pressor
response.

Drug-ETHANOL Interactions (2)

Drugs: Severity: Documentation: Summary:
AMITRIPTYLINE HYDROCHLORIDE Good Concurrent use of
Moderate AMITRIPTYLINE and ETHANOL
may result in enhanced CNS
depression and impairment of
motor skills.

METOCLOPRAMIDE HYDROCHLORIDE Fair Concurrent use of

Moderate METOCLOPRAMIDE and

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25/10/2017 Drug Interactions results - MICROMEDEX
ETHANOL may result in
increased sedation.

Drug-LAB Interactions (None found)

Drug-TOBACCO Interactions (1)

Drugs: Severity: Documentation: Summary:
AMITRIPTYLINE HYDROCHLORIDE Fair Concurrent use of CYP1A2
Major SUBSTRATES and TOBACCO
may result in decreased
exposure of CYP1A2 substrates.

Drug-PREGNANCY Interactions (4)

Drugs: Severity: Documentation: Summary:
AMITRIPTYLINE HYDROCHLORIDE Unknown Amitriptyline is rated as US FDA
Moderate Category C. Animal studies have
shown an adverse effect and
there are no adequate and well-
controlled studies in pregnant
women. (OR) No animal studies
have been conducted and there
are no adequate and well-
controlled studies in pregnant
women.

DIGOXIN Unknown Digoxin is rated as US FDA

Moderate Category C. Animal studies have
shown an adverse effect and
there are no adequate and well-
controlled studies in pregnant
women. (OR) No animal studies
have been conducted and there
are no adequate and well-
controlled studies in pregnant
women.

LINEZOLID Unknown Linezolid is rated as US FDA

Moderate Category C. Animal studies have
shown an adverse effect and
there are no adequate and well-
controlled studies in pregnant
women. (OR) No animal studies
have been conducted and there
are no adequate and well-
controlled studies in pregnant
women.

METOCLOPRAMIDE HYDROCHLORIDE Unknown Metoclopramide is rated as US

Moderate FDA Category B. Animal studies
have revealed no evidence of
harm to the fetus, however, there
are no adequate and well-
controlled studies in pregnant
women. (OR) Animal studies
have shown an adverse effect,
but adequate and well-controlled
studies in pregnant women have
failed to demonstrate a risk to the
fetus.

Drug-LACTATION Interactions (4)

Drugs: Severity: Documentation: Summary:
AMITRIPTYLINE HYDROCHLORIDE Unknown According to the American
Major Academy of Pediatrics,
Amitriptyline has unknown effects
and may be of concern during
breast-feeding.

LINEZOLID Unknown Infant risk cannot be ruled out:

Major Available evidence and/ or expert
consensus is inconclusive or is
inadequate for determining infant
risk when Linezolid is used during
breast-feeding. Weigh the
potential benefits of treatment
against potential risks before
prescribing Linezolid during
breast-feeding.

METOCLOPRAMIDE HYDROCHLORIDE Unknown According to the American

Major Academy of Pediatrics,
Metoclopramide has unknown

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25/10/2017 Drug Interactions results - MICROMEDEX
effects and may be of concern
during breast-feeding.

DIGOXIN Unknown According to the American

Minor Academy of Pediatrics, Digoxin is
compatible with breast-feeding.

Definitions
Severity:

The drugs are contraindicated for concurrent use.

Contraindicated

Major The interaction may be life-threatening and/or require medical

intervention to minimize or prevent serious adverse effects.

Moderate The interaction may result in exacerbation of the patient's condition

and/or require an alteration in therapy.
The interaction would have limited clinical effects. Manifestations may
Minor
include an increase in the frequency or severity of the side effects but
generally would not require a Major alteration in therapy.

Unknown Unknown.

Documentation:

Excellent Controlled studies have clearly established the existence of the

interaction.
Good Documentation strongly suggests the interaction exists,
but well-controlled studies are lacking.
Fair Available documentation is poor, but pharmacologic considerations lead
clinicians to suspect the interaction exists; or, documentation is good for a
pharmacologically similar drug.
Unknown Unknown.

Copyright 1974-2017 Truven Health Analytics LLC

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