Professional Documents
Culture Documents
Bayer CropScience
2 T.W. Alexander Drive
Research Triangle PK, NC 27709
USA
Appearance Off-white
Immediate Effects
Eye Do not get in eyes.
General Have the product container or label with you when calling a poison control center
or doctor or going for treatment.
Skin Call a poison control center or doctor for treatment advice. Remove
contaminated clothing and shoes. Wash off immediately with plenty of water for
at least 15 minutes.
Notes to Physician
Suitable Extinguishing Carbon dioxide (CO2), Dry powder, Foam, Sand, Water spray
Media
Fire Fighting Do not allow run-off from fire fighting to enter drains or water courses. Fight fire
Instructions from upwind position. Keep unnecessary people away, isolate hazard area and
deny entry. Firefighters should wear NIOSH/MSHA approved self-contained
breathing apparatus and full protective clothing. Cool closed containers exposed
to fire with water spray.
General and Disposal Use proper protective equipment to minimize personal exposure (see Section 8).
Wastes resulting from the use of this product may be disposed of on site or at an
approved waste disposal facility.
Land Spill or Leaks Dike area to prevent runoff. Do not allow material to enter streams, sewers, or
other waterways. Isolate area and keep unauthorized people away. Contain and
collect spillage with non-combustible absorbent material, (e.g. sand, earth,
diatomaceus earth, vermiculite) and place in container for disposal according to
local / national regulations (see section 13). Decontaminate tools and equipment
Page 2 of 8
Material Safety Data Sheet
MSDS Number: 000000002125
SCALA brand SC Fungicide MSDS Version 1.1
Handling Procedures Use proper protective equipment to minimize personal exposure (see Section 8).
Keep out of reach of children and domestic animals. Store in original container in
a secured, dry storage area.
Work/Hygienic Handle in accordance with good industrial hygiene and safety practice. Avoid
Procedures breathing spray mist.
Wash hands thoroughly with soap and water after handling and before eating,
drinking, chewing gum, using tobacco, or using the toilet.
Remove clothing immediately if pesticide gets inside. Then wash thoroughly and
put on clean clothing.
Engineering Controls Maintain exposure levels below the exposure limit through the use of general
and local exhaust ventilation.
When handlers used closed systems, enclosed cabs, or aircraft in a manner that
meets the requirements listed in the Worker Protection Standard (WPS) for
agricultural pesticides [(40 CFR 170.240(d) (4-6)], the handler PPE requirements
may be reduced or modified as specified in the WPS.
Hand Protection Chemical-resistant gloves made of waterproof material such as neoprene, butyl
rubber, barrier laminate or nitrile rubber.
Body Protection Wear long-sleeved shirt and long pants and shoes plus socks.
Respiratory Protection When respirators are required, select NIOSH/MSHA approved equipment based
on actual or potential airborne concentrations and in accordance with the
appropriate regulatory standards and/or Industry recommendations.
General Protection These recommendations provide general guidance for handling this product.
Because specific work environments and material handling practices vary, safety
procedures should be developed for each intended application. While developing
safe handling procedures, do not overlook the need to clean equipment and
piping systems for maintenance and repairs. Waste resulting from these
procedures should be handled in accordance with Section 13: Disposal
Page 3 of 8
Material Safety Data Sheet
MSDS Number: 000000002125
SCALA brand SC Fungicide MSDS Version 1.1
Considerations.
Do not apply this product in a way that will contact workers or other persons,
either directly or through drift. Wash hands thoroughly with soap and water after
handling and before eating, drinking, chewing gum, using tobacco, or using the
toilet.
Educate and train employees in safe use of the product. Eye wash facility and
safety shower should be available. In case of contact, immediately flush eyes or
skin with plenty of water for at least 15 minutes while removing contaminated
clothing and shoes.
Exposure Limits
1,2-Propylene glycol 57-55-6 WEEL TWA 50 ppm
Form of Exposure Total vapor and aerosol.
WEEL TWA 10 mg/m3
Form of Exposure Aerosol.
ACGIH TWA 3 mg/m3
Form of Exposure Respirable.
US CA OEL TWA PEL 5 mg/m3
Form of Exposure Respirable fraction.
US CA OEL TWA PEL 10 mg/m3
Form of Exposure Total dust.
US CA OEL TWA PEL 5 mg/m3
Form of Exposure Respirable fraction.
US CA OEL TWA PEL 5 mg/m3
Form of Exposure Respirable fraction.
US CA OEL TWA PEL 10 mg/m3
Form of Exposure Total dust.
US CA OEL TWA PEL 10 mg/m3
Form of Exposure Total dust.
ACGIH TWA 10 mg/m3
Form of Exposure Inhalable particulate.
Appearance Off-white
Page 4 of 8
Material Safety Data Sheet
MSDS Number: 000000002125
SCALA brand SC Fungicide MSDS Version 1.1
Only acute toxicity studies have been performed on this product as formulated. The non-acute information
pertains to the active ingredient, pyrimethanil technical.
Acute Inhalation Toxicity Male/Female Rat: LC50: 4-hr exposure to liquid aerosol: > 4.41 mg/l
(actual)
No deaths were observed. Maximum attainable vapor concentration.
Male/Female Rat: 1-hr exposure to liquid aerosol (extrapolated from 4-hr LC50):
> 17.64 mg/l
(actual)
Subchronic Toxicity In subacute and subchronic studies in mice, rats, and dogs, the major organs
affected from short-term exposure to pyrimethanil included the liver, kidney,
adrenal, urinary bladder and/or thyroid (secondary effect).
Chronic Toxicity The major organs affected from long-term exposure to pyrimethanil in studies in
mice, rats and dogs included the liver, urinary bladder and/or thyroid (secondary
effect).
Assessment Carcinogenicity
Pyrimethanil was not carcinogenic in a chronic feeding study in mice. In a chronic feeding study, high-dose
rats had increased incidence of benign thyroid tumors, secondary to disruption of thyroid-pituitary
homeostasis. EPA classified pyrimethanil as a Group C (possible human carcinogen) chemical based on
this well-known, threshold-mediated, non-genotoxic mechanism of carcinogenesis. The Agency used a
non-linear methodology approach for determining the Margin of Exposure (MOE) for the estimation of
human cancer risk because doses below this threshold did not result in thyroid tumors. Therefore, EPA
has a reasonable certainty that no harm will result from exposure to residues of pyrimethanil.
ACGIH
None
NTP
None
Page 5 of 8
Material Safety Data Sheet
MSDS Number: 000000002125
SCALA brand SC Fungicide MSDS Version 1.1
IARC
None
OSHA
None
Neurotoxicity Pyrimethanil was not neurotoxic in acute (oral gavage) and subchronic (diet)
neurotoxicity screening studies in rats. Transient neurobehavioral effects were
observed in the acute study with no correlating morphological changes in the
neural tissues.
Carp
LC50: 35.4 mg/l
Exposure Time: 48 h
Environmental Do not apply directly to water, to areas where surface water is present or to
Precautions intertidal areas below the mean high water mark. Do not contaminate surface or
ground water by cleaning equipment or disposal of wastes, including equipment
wash water. Drift and runoff from treated areas may be hazardous to fish/aquatic
organisms in adjacent sites.
Page 6 of 8
Material Safety Data Sheet
MSDS Number: 000000002125
SCALA brand SC Fungicide MSDS Version 1.1
General Disposal Pesticide Disposal: Pesticide wastes are acutely hazardous. Improper disposal
Guidance of excess pesticide, spray mixture, or rinsate is a violation of Federal Law. If
these wastes cannot be disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control Agency, or the Hazardous
Waste representative at the nearest EPA Regional Office for guidance.
DOT CLASSIFICATION:
Not regulated for Domestic Surface Transportation
FREIGHT CLASSIFICATION:
Insecticides or Fungicides N.O.I.; other than poison
US Federal Regulations
TSCA list
1,2-Propylene glycol 57-55-6
US. Toxic Substances Control Act (TSCA) Section 12(b) Export Notification (40 CFR 707, Subpt D)
None
SARA Title III - section 302 - notification and information
None
SARA Title III - section 313 - toxic chemical release reporting
None
US States Regulatory Reporting
CA Prop65
This product does not contain any substances known to the State of California to cause cancer.
This product does not contain any substances known to the State of California to cause reproductive
harm.
Canadian Regulations
Canadian Domestic Substance List
1,2-Propylene glycol 57-55-6
Environmental
CERCLA
Page 7 of 8
Material Safety Data Sheet
MSDS Number: 000000002125
SCALA brand SC Fungicide MSDS Version 1.1
None
Clean Water Section 307 Priority Pollutants
None
Safe Drinking Water Act Maximum Contaminant Levels
None
International Regulations
EU Classification
None
European Inventory of Existing Commercial Substances (EINECS)
1,2-Propylene glycol 57-55-6
Reason to Issue: Updated the following sections: 1 - Add EPA Reg. No.; 9 - User-defined text has been
removed from Solubility (in water) for pH and Solubility (in Solvent/Oil) for solvents; Removed Other Information;
16 - Updated NFPA Codes.
This information is provided in good faith but without express or implied warranty. Buyer assumes all
responsibility for safety and use not in accordance with label instructions. The product names are registered
trademarks of Bayer AG.:Bayer CropScience
Page 8 of 8