Professional Documents
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Institute
December 6, 2016 Volume 21, Issue 23
Lindvall recognized for innovative functional defects, says W. Nicholas a regulatory region appeared in
natural language processing research Haining, MD, of Dana-Farber/Boston exhausted T cells but not in their
Charlotta Lindvall, MD, PhD, of Adult Palliative Care, Childrens and the Broad Institute of functional counterparts, and vice versa.
is one of five winners of an Innovation Challenge issued by Harvard and MIT, the co-senior author This tells us the two types of cells
the National Quality Forum (NQF), which aims to introduce of the study with Nir Yosef of the use very different wiring diagrams to
novel methods to improving quality measurement in health University of California, Berkeley, and control their gene activity.
care. Lindvalls project, for which she is partnering with the Ragon Institute of Massachusetts The researchers then tested whether
surgeons at Brigham and Womens Hospital and researchers at General Hospital, Massachusetts removing a stretch of DNA that spurs
Massachusetts Institute of Technology, focuses on improving Institute of Technology, and Harvard the production of PD-1 protein would
Charlotta Lindvall University. They are paralyzed and drive down its expression. Using
care for palliative surgery patients using natural language
processing to mine the electronic medical record. Lindvall and the other winners will dont have the firepower to destroy CRISPR/Cas9 gene-editing technology,
be part of NQFs first Measure Incubator Learning Collaborative, which will connect cancer or virally-infected cells. In this they snipped out that region and PD-1
them with experts, resources, and data to implement their measures nationally. study, the question was, do exhausted expression indeed fell.
Our natural language processing method can access rich information in the patients cells represent a distinct type of T cell, The success of this approach may
charts that reflect what matters to them and their families, says Lindvall, who joined or are they merely a groggy version offer a key to improving CAR-T cell
Dana-Farbers Psychosocial Oncology and Palliative Care department in July. This is of functional T cells? Helping lead therapy. In this form of therapy, T cells
documented in the medical record, but patients with a serious illness like cancer have so the research were Debattama Sen of are removed from a patient, genetically
many notes that the patient experience often gets lost in manual chart review. Dana-Farber and James Kaminski of engineered to grow a protein sensor
Currently, providers need to search through hundreds of pages of notes to find the University of California, Berkeley. that directs them to tumor cells, and
information on symptoms, health care proxies, or end-of-life conversations and With chronically infected mice as then re-injected into the patient.
preferences. With Lindvalls method, she hopes to aggregate this information and their model, the researchers used a Although the resulting CAR-T cells
allow providers to access it as easily as they might find lab information. new technology called ATAC-seq are skilled at tracking down and
In her palliative surgery project, Lindvall is analyzing documentation of goals of care to map the regulatory regions of killing cancer cells, the attackers tend
prior to surgery. The typical quality measure for surgery is 30-day survival, but the goal the genome the sections of DNA to become exhausted over time. The
of palliative surgery is symptom improvement, not curing the disease. By assessing involved in switching genes on and study authors suggest that at the same
patients symptoms and goals of care, rather than survival, providers can get a better off in the animals exhausted and time the T cells are being engineered
sense of whether surgeries are successful. functional CD8+ T cells. (CD8+ T cells to produce the sensor, they could also
We are ensuring that patients voices have been heard and documented, and that help identify and eliminate cancerous be retooled to delete the genetic
conversations about their goals take place, says Lindvall. There is real data in the and infected cells.) wiring that causes them to express
conversations palliative care providers have with patients; we want to make this data We found the landscape of excessive levels of PD-1 and other
easily available to researchers so we can better understand patients experiences. regulatory regions to be fundamentally exhaustion genes. The newly persistent
While the project is focused on palliative surgery, she is working to expand her different in exhausted and functional CAR-T cells would be better at
methods throughout palliative care and medical oncology, and eventually across all T cells, Haining says. There stalking cancer and more aggressive
research areas at Dana-Farber, as the technology can be used to find any data in the were thousands of instances where in attacking it. RL
medical record. Lindvall will present an NQF webinar on her research in January, and
her team hopes to publish their first paper on natural language processing methods. SEW
Inside the Institute is published by the Dana-Farber Communications Senior Vice President for Communications Editor Editorial Contributors
Department for staff members and friends of Dana-Farber Cancer Institute. Steven R. Singer Naomi Funkhouser Christine Cleary, Andrea Kaufman, Robert Levy, Richard Saltus,
The next issue is scheduled for Tuesday, December 20. Shannon E. Watterson
Assistant Editor
Director, Content and Creative Services
Story ideas are welcome. Please contact Naomi Funkhouser at Jessica Cassidy
Michael Buller Photo and Design Contributors
617-632-5560 or Naomi_Funkhouser@dfci.harvard.edu. Designer John DiGianni, Kimberly Regensburg Ryan
Visit the Dana-Farber website at dana-farber.org or the Associate Director, Lee Whale
intranet at dfcionline.org. Content and Creative Services Inside the Institute is printed on 30% recycled post-industrial fiber.
Staff Photographer
Gillian Buckley
Sam Ogden
disconnect, but when providers are right here, its easier to
Dr. Matulonis and Cathy Earley, NP, are angels. They took communicate, says Jeffrey Meyerhardt, MD, MPH, clinical
director of the Gastrointestinal Cancer Treatment Center.
phenomenal care of my mother for 11 years. I am so glad to Meyerhardt and his group have teamed with Lida Nabati, MD, of
palliative care, who is on the floor every Wednesday afternoon,
see they continue to be the best and are able to help others.
Allison G.
Facebook f Logo CMYK / .eps Facebook f Logo CMYK / .eps
Staff ID
Patient care can be pretty dynamic, and having the
opportunity to check in face-to-face with other clinicians
has been helpful, she says.
Nabati tells providers that it is never too early to refer
Nina Scott, CMI a patient to palliative care; having a serious illness like
Department: Interpreter Services cancer can be reason enough to introduce it. She and her
Title: Supervisor of Interpreter Services colleagues including Doug Brandoff, MD, with the Center
Years at DFCI: 1 for Sarcoma and Bone Oncology, and John Halporn, MD, in
the Gynecologic Oncology Program, among others work
with not only oncologists, but also social workers and infusion
Describe your role here: Interpreter services are an important
nurses to identify appropriate patients for palliative care.
component of delivering safe, high-quality, and equal care.
My role is to preserve the primary relationship between
Dana-Farber provides medical interpreters at no charge to patients
the oncology team and the patient, Nabati explains. Patients
and their families who speak a language other than English. As
and I discuss symptom management and how theyre coping
supervisor of Interpreter Services, I oversee department operations
with their illness, and, if desired, we work with them and their
and support my staff of 50 medical interpreters to make sure that limited-English-proficiency
oncology team to define their goals and determine whats best
patients and providers can communicate. I also manage Dana-Farber relationships with third-party
for them in their treatment.
language services vendors and develop policies and procedures to ensure DFCI is compliant with
While palliative care has become more mainstream in
language access guidelines set by federal and state mandates, as well as other regulatory agencies
recent years, and the palliative care clinic even sees some
like the Joint Commission.
self-referrals, some education is still necessary about what
Where did you go to school? I earned my bachelors degree in international cultures and economics the specialty is and how it can help.
from Bentley University. I received my certificates in medical, legal, and community interpreting There are many parts to treating cancer, and people have
from Boston University. I also earned my masters degree in human services management from different perspectives on how to help a patient, Meyerhardt
UMass Boston. says. The understanding that cancer care is a collaborative
What brought you to Dana-Farber? Formerly, I worked at both McLean and Shriners hospitals, so I effort is much more accepted today.
was very attracted to the specialized hospital atmosphere and big-mission agenda of Dana-Farber. Nabati adds that by the time patients see her, the oncology
team has already dispelled most misconceptions patients may
What do you love about your work? I enjoy helping to bridge the cultural and linguistic gaps
have about palliative care.
between two people who need to communicate for a specific purpose.
This collaboration helps us better communicate with each
What is your biggest challenge? Educating providers and patients alike on the benefits of using qualified other and share our perspective of whats going on with each
medical interpreters and the dangers of using untrained interpreters such as family members, friends, or patient, Meyerhardt explains. The more we can provide
other bilingual persons. services like palliative care when patients are here for treatment,
What book are you reading? I like to alternate between reading something serious and something the more we enhance their care and experience.
fun. I recently finished The Girl on the Train, and now I am reading Is that a Fish in Your Ear?: Embedded palliative care clinicians currently work in
The Amazing Adventure of Translation. gastrointestinal, sarcoma, gynecologic, and head and neck clinics
If you didnt work in your current role, what job would you most like to do? Something involving
on certain days per week as part of a collaborative pilot project
language, culture, and helping others. These are very much part of who I am. involving oncologists, palliative care clinicians, and Quality and
Patient Safety. This is in addition to the ongoing Adult Palliative
What do you do for fun? I enjoy running, gathering with family and friends, and movie nights with Care Clinic on Yawkey 11. James Tulsky, MD, department chair
my husband and kids. ITI
and chief of palliative care, hopes to expand the program to more
treatment centers in the next several years. SEW