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Inside the

Institute
December 6, 2016 Volume 21, Issue 23

Lindvall is winner Annual luncheon Getting to know


of NQF Innovation
Challenge p. 2 highlights advances
in genetic testing p. 3 Nina Scott
p. 4
Large-scale Collaborative model between oncology
and palliative care benefits patients
cancer gene
profiling is
feasible
The success of the Profile program at
Dana-Farber/Brigham and Womens Cancer
Center and Boston Childrens Hospital shows
that genomic tumor profiling is technically
feasible in a broad population of adult and
pediatric patients with many different types of
cancer, according to a new study.
The Profile experience has also demonstrated
that some patients can benefit from tumor
analysis by having precision drugs targeted to
their cancers specific mutations or by enrolling
in clinical trials of experimental drugs.
Still, the researchers caution that challenges
remain in adopting the practice on a wide scale Jeffrey Meyerhardt and Lida Nabati are part of a team piloting a new model of care in which palliative care clinicians are
and integrating it into routine cancer care. embedded on treatment floors.
Tumor profiling uses DNA sequencing and A cancer care team includes nurses, radiation Cancer Treatment Center on Yawkey 7. In this new
other tools to analyze a patients tumor tissue for oncologists, social workers, psychiatrists, oncologists, model, palliative care clinicians see patients with
mutations and other abnormalities that drive the and others. While so many experts often improve their oncologist or one-on-one, or simply offer
cancers growth. This genomic fingerprint may patient outcomes, such a multidisciplinary team can guidance to providers. Having palliative care
help to refine the patients diagnosis, predict how sometimes make communication and coordination appointments readily available in the treatment
the cancer will behave, and enable doctors to difficult. Dana-Farbers Psychosocial Oncology and center streamlines the process for both providers
select the best drug treatment. Palliative Care department is working to change that. and patients, removing the need for time-consuming
The report, published online by the journal Since October, palliative care clinicians have referrals or extra trips to Dana-Farber.
JCI Insight, covers 3,727 patients whose samples been embedded on several treatment floors in the At times, sending patients up to the palliative
were analyzed during the first year of the Profile Yawkey Center, including the Gastrointestinal care clinic [on Yawkey 11] causes a bit of a

Gene profiling, page 4 Collaborative model, page 4

Research suggests way to boost staying power


of immunotherapy
In people with chronic infections or that controls the activity of genes.
cancer, disease-fighting T cells tend Scientists have known for years that the
to behave like an overwhelmed militia pattern of gene activity is different in
lethargic, ill-prepared, tentative exhausted than in robust T cells, but the
a state of exhaustion that allows actual extent of these differences has
disease to persist. In a recent paper in been uncertain.
Science, researchers at Dana-Farber/ One difference that is clear is
Boston Childrens Cancer and Blood that exhausted T cells express the
Disorders Center report that, in mouse programmed cell death protein-1
and human cells chronically infected by (PD-1), which commands them not
a virus, exhausted T cells are controlled to attack normal, healthy cells, but
by a fundamentally different set of can also prevent them from striking
molecular circuits than T cells engaged at cancerous or chronically infected
in battling disease. The finding suggests cells. Blocking PD-1 with checkpoint-
a way to increase the staying power inhibiting drugs thereby restoring
of CAR-T cells, a promising form of the cancer-killing zeal of T cells has
immunotherapy for cancer. become one of the most successful new
The study brings renewed focus approaches to cancer treatment in nearly
to the epigenetics of T cells the a decade. However, it has provided a
multilayered system of molecular benefit in only about a quarter of cases.
Pictured from left to right are Flavian Brown, W. Nicholas Haining, Debattama Sen, switches,accelerators, and throttles Exhausted T cells display a variety of
Hsiao-Wei Tsao, and Ulrike Gerdemann. Their studys findings may suggest a way to
increase the staying power of CAR-T cells. Immunotherapy, page 2

D i s c o v e r. C a r e . B e l i e v e . Visit the DFCI intranet at dfcionline.org


News of Note Immunotherapy, continued from page 1

Lindvall recognized for innovative functional defects, says W. Nicholas a regulatory region appeared in
natural language processing research Haining, MD, of Dana-Farber/Boston exhausted T cells but not in their
Charlotta Lindvall, MD, PhD, of Adult Palliative Care, Childrens and the Broad Institute of functional counterparts, and vice versa.
is one of five winners of an Innovation Challenge issued by Harvard and MIT, the co-senior author This tells us the two types of cells
the National Quality Forum (NQF), which aims to introduce of the study with Nir Yosef of the use very different wiring diagrams to
novel methods to improving quality measurement in health University of California, Berkeley, and control their gene activity.
care. Lindvalls project, for which she is partnering with the Ragon Institute of Massachusetts The researchers then tested whether
surgeons at Brigham and Womens Hospital and researchers at General Hospital, Massachusetts removing a stretch of DNA that spurs
Massachusetts Institute of Technology, focuses on improving Institute of Technology, and Harvard the production of PD-1 protein would
Charlotta Lindvall University. They are paralyzed and drive down its expression. Using
care for palliative surgery patients using natural language
processing to mine the electronic medical record. Lindvall and the other winners will dont have the firepower to destroy CRISPR/Cas9 gene-editing technology,
be part of NQFs first Measure Incubator Learning Collaborative, which will connect cancer or virally-infected cells. In this they snipped out that region and PD-1
them with experts, resources, and data to implement their measures nationally. study, the question was, do exhausted expression indeed fell.
Our natural language processing method can access rich information in the patients cells represent a distinct type of T cell, The success of this approach may
charts that reflect what matters to them and their families, says Lindvall, who joined or are they merely a groggy version offer a key to improving CAR-T cell
Dana-Farbers Psychosocial Oncology and Palliative Care department in July. This is of functional T cells? Helping lead therapy. In this form of therapy, T cells
documented in the medical record, but patients with a serious illness like cancer have so the research were Debattama Sen of are removed from a patient, genetically
many notes that the patient experience often gets lost in manual chart review. Dana-Farber and James Kaminski of engineered to grow a protein sensor
Currently, providers need to search through hundreds of pages of notes to find the University of California, Berkeley. that directs them to tumor cells, and
information on symptoms, health care proxies, or end-of-life conversations and With chronically infected mice as then re-injected into the patient.
preferences. With Lindvalls method, she hopes to aggregate this information and their model, the researchers used a Although the resulting CAR-T cells
allow providers to access it as easily as they might find lab information. new technology called ATAC-seq are skilled at tracking down and
In her palliative surgery project, Lindvall is analyzing documentation of goals of care to map the regulatory regions of killing cancer cells, the attackers tend
prior to surgery. The typical quality measure for surgery is 30-day survival, but the goal the genome the sections of DNA to become exhausted over time. The
of palliative surgery is symptom improvement, not curing the disease. By assessing involved in switching genes on and study authors suggest that at the same
patients symptoms and goals of care, rather than survival, providers can get a better off in the animals exhausted and time the T cells are being engineered
sense of whether surgeries are successful. functional CD8+ T cells. (CD8+ T cells to produce the sensor, they could also
We are ensuring that patients voices have been heard and documented, and that help identify and eliminate cancerous be retooled to delete the genetic
conversations about their goals take place, says Lindvall. There is real data in the and infected cells.) wiring that causes them to express
conversations palliative care providers have with patients; we want to make this data We found the landscape of excessive levels of PD-1 and other
easily available to researchers so we can better understand patients experiences. regulatory regions to be fundamentally exhaustion genes. The newly persistent
While the project is focused on palliative surgery, she is working to expand her different in exhausted and functional CAR-T cells would be better at
methods throughout palliative care and medical oncology, and eventually across all T cells, Haining says. There stalking cancer and more aggressive
research areas at Dana-Farber, as the technology can be used to find any data in the were thousands of instances where in attacking it. RL
medical record. Lindvall will present an NQF webinar on her research in January, and
her team hopes to publish their first paper on natural language processing methods. SEW

Newton-Wellesley oncologists join DF/BWCC Urgent need for platelet donors


Three oncologists from Newton-Wellesley Hospital
(NWH) joined Dana-Farber/Brigham and Womens An extreme shortage of necessary blood products is affecting the Kraft Family
Cancer Center on Oct. 1: Jeffrey Wisch, MD, in the Blood Donor Center, which provides life-saving platelets to patients at Dana-Farber
Gastrointestinal Cancer Treatment Center, and Caroline and Brigham and Womens Hospital. In particular, there is an urgent need for
Block, MD, and Susan Schumer, MD, in the Susan F. male platelet/plasma donors. The shortage of platelets is nationwide.
Smith Center for Womens Cancers. Platelets are the bodys internal bandages, have a shelf life of five days, and
We welcome Drs. Wisch, Block, and Schumer, says can be donated every seven days. The Kraft Family Blood Donor Center collects
Eric P. Winer, MD, chief strategy officer and director of Breast platelets seven days a week.
Oncology at the Susan F. Smith Center. We look forward to Email BloodDonor@partners.org, or call 617-632-3206 to make
Jeffrey Wisch
collaborating with them and are delighted that our patients an appointment.
can benefit from their extensive experience and skill. Kraft Family Blood Donor Center
Wisch cares for patients with gastrointestinal cancers at
DF/BWCC in the Longwood Medical Area and Dana-Farber
Cancer Institute at St. Elizabeths Medical Center, and
is a liaison to its broader network of community-based
satellites and practices. A graduate of Mount Sinai School at St. Elizabeths Medical Center and is also a liaison to its broader network of
of Medicine, he completed a residency at the University of community-based satellites and practices. She earned her medical degree from the
Pennsylvania and a fellowship in hematology and oncology University of Michigan, and after her residency at Beth Israel Deaconess Medical
Caroline Block at Brigham and Womens Hospital (BWH) and the Sidney Center, she completed a fellowship in medical oncology at Dana-Farber, a clinical
Farber Cancer Institute before it became Dana-Farber. He fellowship in hematology at BWH, and a Kellogg fellowship in Clinical Effectiveness,
has served at NWH since 1983 in various roles, including Epidemiology Program, at the Harvard T.H. Chan School of Public Health. She was on
division chief of Hematology/Oncology, clinical director staff at NWH from 1991 through 2016, where she was assistant chief of Hematology
of the Vernon Cancer Center, medical director of Inpatient and Medical Oncology, medical director of the Breast Clinic, director of Oncology
Oncology Unit, and president of New England Hematology Clinical Research, and director of the Anticoagulation Clinic.
Oncology Associates, PC. He oversaw the Tanger Infusion Schumer cares for breast oncology and gynecologic oncology patients. A graduate of
Center at NWH and was instrumental in the creation of the Tufts University School of Medicine, she completed her residency at New England
Vernon Cancer Center there. Medical Center and a fellowship at Beth Israel Deaconess Medical Center. She was a
Susan Schumer Block cares for breast cancer patients at DF/BWCC in the medical oncology attending physician there from 2003 to 2008, then served on staff at
Longwood Medical Area and Dana-Farber Cancer Institute NWH since 2009. CC

Inside the Institute is published by the Dana-Farber Communications Senior Vice President for Communications Editor Editorial Contributors
Department for staff members and friends of Dana-Farber Cancer Institute. Steven R. Singer Naomi Funkhouser Christine Cleary, Andrea Kaufman, Robert Levy, Richard Saltus,
The next issue is scheduled for Tuesday, December 20. Shannon E. Watterson
Assistant Editor
Director, Content and Creative Services
Story ideas are welcome. Please contact Naomi Funkhouser at Jessica Cassidy
Michael Buller Photo and Design Contributors
617-632-5560 or Naomi_Funkhouser@dfci.harvard.edu. Designer John DiGianni, Kimberly Regensburg Ryan
Visit the Dana-Farber website at dana-farber.org or the Associate Director, Lee Whale
intranet at dfcionline.org. Content and Creative Services Inside the Institute is printed on 30% recycled post-industrial fiber.
Staff Photographer
Gillian Buckley
Sam Ogden

2 Inside the Institute I December 6, 2016 dfcionline.org


Mobile art cart a welcome
diversion for patients
Calling all creative types: A traveling stressful moments so they can have
mobile art cart, sponsored by the a break and gain new coping skills,
Leonard P. Zakim Center for Integrative Woods says.
Therapies, now offers Dana-Farber The mobile art cart travels to waiting
patients an outlet to reduce stress and infusion areas to help patients pass
through expressive arts such as coloring, time before appointments. It is on floors
weaving, and card-making. The small six through eleven in the Yawkey Center
metal cart is lined with multi-colored every day.
drawers filled with adult coloring books, Its a non-threatening way for people
packs of colored pencils, high-quality art to explore themes that might be coming
Heather Woods (left) offers supplies from the art cart to patients waiting for their
paper, and more. up in their life, says Woods. next appointment.
Heather Woods, MT-BC, manager of The cart is an extension of the Open
Expressive Arts Therapies at the Zakim Arts Studio, a walk-in space in the Eleanor patients, families, friends, and staff. enhance quality of life. Woods says the
Center who runs the mobile art cart and Maxwell Blum Patient and Family Medical experts now view integrative mobile art cart does just that.
program, says the cart can help make Resource Center on the first floor of the therapies as an effective complement to Offering a way for patients to smile
the side effects of treatment a little Yawkey Center. The studio, open from traditional treatment. Studies show that and relax when they are going through
more manageable. 10 a.m. to 4 p.m., offers all kinds of arts expressive and other integrative therapies, tremendous challenges brings a lot of
Our goal is to bring more creative and crafts materials, including yarn, such as massage, acupuncture, and yoga, meaning to my work and my life,
opportunities directly to patients in these paints, fabrics, and canvases. It is open to help patients relieve stress, ease pain, and explains Woods. AK

Two lab scientists receive new NCI Research Specialist Awards


Last year, the National Cancer Institute (NCI) he loves being a part of in the Walensky lab at Dana-Farber. Shukla began as a non-tenure-track
created a new category of grants providing higher Dana-Farber. Walensky says, Greg has been scientist and is now a senior scientist.
salaries and long-term funding for laboratory research instrumental in generating thousands of novel The award is a good fit for what Im doing, says
scientists who have critical expertise but dont choose compounds for innumerable collaborative cancer Shukla. It supports scientists who have a track
to become principal investigators. research projects. We are just now beginning to see record of publishing and doing good research within
Dana-Farber research scientists Gregory Bird, PhD, the clinical impact of our decade of work together. a broad laboratory program. Shukla is applying his
and Sachet Shukla, PhD, have won two of these coveted I am thrilled that Gregs contributions are being bioinformatics expertise to two clinical trials led
R50 grants, known as Research Specialist Awards. recognized and supported as we continue to drive by Wu evaluating NeoVax, a personalized cancer
Bird, a former postdoc, is now a senior scientist our cancer research initiatives forward. vaccine, in patients with melanoma and glioblastoma.
in the laboratory of Loren Walensky, MD, PhD, In Wus laboratory, Shuklas specialty is analyzing Hes also involved in developing new bioinformatics
of Pediatric Oncology. Shukla is a computational large data sets in immunogenomics using genomic tools for analyzing trial data.
biologist and senior scientist in the laboratory of tools to study the complexity of the immune system Wu says, This award rightly recognizes the
Catherine Wu, MD, of Medical Oncology. and related diseases, including cancer. critical contributions of research staff scientists,
In announcing the new grants program, the NCI Originally trained as a chemical engineer in ensuring the continuation and stability of deep
noted that biomedical research is starting to rely more India, Shukla switched to molecular biology with knowledge and expertise in this instance, in
on staff scientific specialists within laboratories and a bioinformatics emphasis. He worked at a startup immunogenomics within our research unit, so
core facilities. company in Iowa and received his PhD from Iowa that we can continue to build our science in
Previously, research scientists like Bird and Shukla State University while a member of Wus lab at cutting-edge directions. RS
were dependent on grants held by their principal
investigators an unpredictable form of support
which, according to the NCI, lacks the recognition or
independent funding to attract the best scientists.
Beyond Boston Luncheon
With the launch of the R50 grants, research
scientists who receive the awards will be funded highlights advances in genetic testing
independently for five years with what the NCI calls The eighth annual Beyond
desirable salaries and greater career continuity. Boston Luncheon, held Nov. 15, is an
The grants are subject to renewal after five years, and educational forum and fundraising
if the research scientists move to other programs or event hosted by the Executive
institutions, they can take the funding with them. Council of the Susan F. Smith Center
These awards are not only impressive for Womens Cancers. The event
endorsements of Gregs and Sachets skills, but gave more than 280 attendees an
theyre also an external validation of Dana-Farbers inside look at how Dana-Farber
Scientist Program, a career track that weve devoted is advancing genetic testing for
a tremendous amount of time and effort to, says womens cancers.
Chief Scientific Officer Barrett Rollins, MD, PhD. [Genetic testing] is an area that Eric P. Winer speaks to attendees at the annual Beyond Boston Luncheon.
This is a wonderful confirmation of the value has exploded over the past few
scientists bring to Dana-Farbers mission. years, all to the benefit of patients is appropriate, and how it can affect of two chose to be proactive about
In Walenskys lab, Bird directs the Stapled around the world, remarked Eric treatment decisions. Rana, Stopfer, reducing her risk of breast and
Peptide Design Group. Walenskys lab has P. Winer, MD, director of Breast and Winer were three of 13 faculty ovarian cancers, and had her ovaries
pioneered the design and synthesis of stapled Oncology and chief of the division of members who participated in the event and fallopian tubes removed. Her
peptides compounds that can enter cells and act Womens Cancers, who moderated and shared insight with attendees. story highlights the importance of
as probes or switches to engage proteins. Theyre a panel featuring Huma Rana, MD, Katherine Saunders also took the being informed about genetic testing
being used as research tools and developed as new clinical director of the Center for stage at the Wellesley Country Club, and knowing your family history.
therapies, owing to their ability to modulate targets Cancer Genetics and Prevention, sharing her experience with genetic This years luncheon is close to
in cancer cells that cant be hit by conventional and Jill Stopfer, MS, LGC, associate testing and counseling at Dana-Farber. raising its goal of $250,000. Since
small-molecule drugs. Other potential uses are in director of Genetic Counseling. Rana When Saunders father tested positive 2002, the Executive Council has
treating diabetes and infections including HIV. and Stopfer provided an extensive for a BRCA mutation, the 37-year-old raised more than $11 million in
Bird says the five-year duration of the grant overview of the role genes play in decided to have testing and found support of research at the Susan F.
gives him recognition and job security, and that causing cancer, when genetic testing she, too, was a carrier. The mother Smith Center. ITI
he wont have to ponder alternatives to the work

Inside the Institute I December 6, 2016 3


Gene profiling, continued from page 1
research project, which launched in 2011. Laura of Profile analysis led to improved diagnoses and higher. Reasons for the high level of attrition
MacConaill, PhD, of Dana-Farber and Brigham and better outcomes. For example, a patient with blood included absence of effective drugs, timing of
Womens Hospital (BWH), the scientific director of cancer who received several diagnoses was found, genomic testing in the course of a patients disease,
the Profile program, is the corresponding author of through testing, to have an unusual form of acute less-than-optimal access to targeted drugs or
the publication; first author is Lynette M. Sholl, MD, myeloid leukemia that often responds to imatinib. clinical trials, and patient and provider preferences.
of BWH. He was treated with that drug and experienced a Identifying these barriers allows researchers to
To date, Profile researchers have analyzed more dramatic and sustained clinical response. develop and implement new solutions, with the goal
than 15,000 individual tumors. Unlike most other While determining the genetic makeup of a of improving the rate of use of the genomic results,
genomic testing programs, Profile tumor analysis is patients tumor is a critical tool for precision cancer the authors say.
offered to all patients, regardless of age, cancer type, medicine, the reports authors noted several challenges MacConaill notes that the results of Profile
or stage of the cancer. and unanswered questions about large-scale clinical genomic testing are being used to further research
According to the report, at least one actionable application of the methods. Just over half of patients within the institutions and are shared more widely
mutation one that could aid diagnosis or guide in the study who had tumor profiling ordered by a with initiatives like Project GENIE of the American
treatment was discovered in about two-thirds physician actually received results, due to a variety Association for Cancer Research, which will help
of patient samples. In 20 percent of cases, such of technical and logistical factors. For example, some advance the field of precision medicine.
mutations could enable doctors to match a patients patients cancer samples didnt have sufficient material The study wasnt designed to measure whether
tumor profile to a targeted drug or improve the for study or for DNA sequencing. tumor profiling made a difference in how patients
original diagnosis. In the remaining cases, the And in only a minority of cases about 10 percent fared, but it nonetheless lays the groundwork for
information could help patients be referred to across the cohort, the researchers estimated was more systematic study of the impact of genomics on
clinical trials of approved or investigational drugs. the test information used in caring for the patient, clinical practice and patient outcomes, according to
The authors listed several cases in which the results although in some cancer types the rate was much the report. RS

IN THEIR OWN WORDS Collaborative model, continued from page 1


disconnect, but when providers are right here, its easier to
Dr. Matulonis and Cathy Earley, NP, are angels. They took communicate, says Jeffrey Meyerhardt, MD, MPH, clinical
director of the Gastrointestinal Cancer Treatment Center.
phenomenal care of my mother for 11 years. I am so glad to Meyerhardt and his group have teamed with Lida Nabati, MD, of
palliative care, who is on the floor every Wednesday afternoon,
see they continue to be the best and are able to help others.
Allison G.
Facebook f Logo CMYK / .eps Facebook f Logo CMYK / .eps

as well as Andrea Enzinger, MD, a medical oncologist in the


center who also provides palliative care on Thursdays and
Fridays. Nabati often starts her afternoons with a visit to the
provider workroom, where she gets a report on patients from
nurse practitioners and provides advice on cases.

Staff ID
Patient care can be pretty dynamic, and having the
opportunity to check in face-to-face with other clinicians
has been helpful, she says.
Nabati tells providers that it is never too early to refer
Nina Scott, CMI a patient to palliative care; having a serious illness like
Department: Interpreter Services cancer can be reason enough to introduce it. She and her
Title: Supervisor of Interpreter Services colleagues including Doug Brandoff, MD, with the Center
Years at DFCI: 1 for Sarcoma and Bone Oncology, and John Halporn, MD, in
the Gynecologic Oncology Program, among others work
with not only oncologists, but also social workers and infusion
Describe your role here: Interpreter services are an important
nurses to identify appropriate patients for palliative care.
component of delivering safe, high-quality, and equal care.
My role is to preserve the primary relationship between
Dana-Farber provides medical interpreters at no charge to patients
the oncology team and the patient, Nabati explains. Patients
and their families who speak a language other than English. As
and I discuss symptom management and how theyre coping
supervisor of Interpreter Services, I oversee department operations
with their illness, and, if desired, we work with them and their
and support my staff of 50 medical interpreters to make sure that limited-English-proficiency
oncology team to define their goals and determine whats best
patients and providers can communicate. I also manage Dana-Farber relationships with third-party
for them in their treatment.
language services vendors and develop policies and procedures to ensure DFCI is compliant with
While palliative care has become more mainstream in
language access guidelines set by federal and state mandates, as well as other regulatory agencies
recent years, and the palliative care clinic even sees some
like the Joint Commission.
self-referrals, some education is still necessary about what
Where did you go to school? I earned my bachelors degree in international cultures and economics the specialty is and how it can help.
from Bentley University. I received my certificates in medical, legal, and community interpreting There are many parts to treating cancer, and people have
from Boston University. I also earned my masters degree in human services management from different perspectives on how to help a patient, Meyerhardt
UMass Boston. says. The understanding that cancer care is a collaborative
What brought you to Dana-Farber? Formerly, I worked at both McLean and Shriners hospitals, so I effort is much more accepted today.
was very attracted to the specialized hospital atmosphere and big-mission agenda of Dana-Farber. Nabati adds that by the time patients see her, the oncology
team has already dispelled most misconceptions patients may
What do you love about your work? I enjoy helping to bridge the cultural and linguistic gaps
have about palliative care.
between two people who need to communicate for a specific purpose.
This collaboration helps us better communicate with each
What is your biggest challenge? Educating providers and patients alike on the benefits of using qualified other and share our perspective of whats going on with each
medical interpreters and the dangers of using untrained interpreters such as family members, friends, or patient, Meyerhardt explains. The more we can provide
other bilingual persons. services like palliative care when patients are here for treatment,
What book are you reading? I like to alternate between reading something serious and something the more we enhance their care and experience.
fun. I recently finished The Girl on the Train, and now I am reading Is that a Fish in Your Ear?: Embedded palliative care clinicians currently work in
The Amazing Adventure of Translation. gastrointestinal, sarcoma, gynecologic, and head and neck clinics
If you didnt work in your current role, what job would you most like to do? Something involving
on certain days per week as part of a collaborative pilot project
language, culture, and helping others. These are very much part of who I am. involving oncologists, palliative care clinicians, and Quality and
Patient Safety. This is in addition to the ongoing Adult Palliative
What do you do for fun? I enjoy running, gathering with family and friends, and movie nights with Care Clinic on Yawkey 11. James Tulsky, MD, department chair
my husband and kids. ITI
and chief of palliative care, hopes to expand the program to more
treatment centers in the next several years. SEW

4 Inside the Institute I December 6, 2016

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