Professional Documents
Culture Documents
Learning Objectives
Select acute & preventative treatment for adult patients with
asthma, COPD & conditions requiring anticoagulation.
Classify a patient according to asthma severity class, and
assess his/her control, according to NHLBI guidelines.
Di
Discuss iindications
di i ffor warfarin
f i and
d goall INR ffor specific
ifi
patients, and adjust therapy according to INR, other clinical
findings and/or patient factors.
Design a treatment plan for a patient receiving warfarin who
needs to undergo an invasive procedure
Determine appropriate immunizations for an adult.
1
Ambulatory Topics Covered
Asthma
COPD
Anticoagulation
Adult Immunizations
ASTHMA
Page 190
Patient Case 1
Page 191
2
Classifying Asthma Severity > age 12 Page 190
Patient Case 1
A. Intermittent
B. Mild persistent
C. Moderate persistent
D. Severe persistent
Page 224
Patient Case 2
3
Page 190
Classifying Asthma Severity > age 12
Mild Moderate Severe
Intermittent
Persistent Persistent Persistent
Impairment
2 days / >2 days / wk Throughout the
Symptoms Daily
week but not daily day
Night >once / week Often
2 x / month 3-4 x / month
Awakenings but not nightly 7 x / week
-agonist Use 2 days / wk > 2 days / Several times per
Daily
f Symptoms
for S t weekk d
day
Interference
None Minor Some Extreme
with Activity
FEV1 60-80% FEV1<60%
Lung Function Normal Normal
FEV1/FVC 5% FEV1/FVC >5%
Risk
Systemic
<2 x / yr 2 / yr 2 / yr 2 / yr
Steroids
Therapy Step 6
Step 5
Step 4
Step 3
Step 2
Step 1
Preferred SABA prn Low Dose Low Dose Medium High
Hi hDDose High Dose
ICS ICS + Dose ICS + ICS +
LABA OR ICS + LABA LABA +
medium- LABA AND OCS
dose ICS Consider AND
omalizumab Consider
for patients omalizumab
Alternative Low-dose with for patients
LTRA or ICS + Medium- allergies with
theophylline LTRA, dose ICS + allergies
theophylline LTRA,
or zileuton theophylline
or zileuton
Page 192
Cromolyn&nedocromil: were alternatives for Step 2 but have been D/Ced by manufacturers
Patient Case 2
4
Patient Case 3
Therapy Step 6
Step 5
Step 4
Step 3
Step 2
Step 1
Preferred SABA prn Low Dose Low Dose Medium High
Hi hDDose High Dose
ICS ICS + Dose ICS + ICS +
LABA OR ICS + LABA LABA +
medium- LABA AND OCS
dose ICS Consider AND
omalizumab Consider
for patients omalizumab
Alternative Low-dose with for patients
LTRA or ICS + Medium- allergies with
theophylline LTRA, dose ICS + allergies
theophylline LTRA,
or zileuton theophylline
or zileuton
Page 192
5
ICS Comparative Daily Doses >12 y/o Page 197
Beclomethasone MDI 80 240 mcg >240 480 mcg > 480 mcg
(QVAR 40, 80)
Mometasone DPI 220 mcg 440 mcg > 440 mcg
(Asmanex 110, 220)
Ciclesonide MDI 160 mcg 320 mcg 640 mcg
(Alvesco 80, 160)
Patient Case 3
Patient Case 4
BW returns one month later. No longer awakening at
night. Uses albuterol MDI 2 puffs once per week to
treat symptoms. She also uses albuterol MDI 2 puffs 5
days per week prior to working out at the gym; she does
not have symptoms while working out. Which of the
f ll i is
following i correct??
A. No medication change needed
B. Increase fluticasone to 110mcg 2 puffs BID
C. Add formoterol inhalation BID
D. Add montelukast 10 mg/d
Page 192
6
Assessing Control in Adults
Not Well Very Poorly
Well Controlled Controlled Controlled
Symptoms
2 days/week >2 days/week Throughout the day
Nighttime
2 x/month 1-3x/week 4 days/week
Awakenings
Interference Some Limitation Extremely Limited
Impairment with activity None
Patient Case 4
BW returns one month later. No longer awakening at
night. Uses albuterol MDI 2 puffs once per week to
treat symptoms. She also uses albuterol MDI 2 puffs 5
days per week prior to working out at the gym; she does
not have symptoms while working out. Which of the
f ll i is
following i correct??
A. No medication change needed
B. Increase fluticasone to 110mcg 2 puffs BID
C. Add formoterol inhalation BID
D. Add montelukast 10 mg/d
Page 224
Patient Case 5
D.B is a 16 year old boy with asthma symptoms 1-
2 x/week. He is awakened twice weekly at night
with coughing and trouble breathing. What is his
asthma severity classification?
A. Intermittent
B. Mild persistent
C. Moderate persistent
D. Severe persistent
Page 196
7
Page 190
Classifying Asthma Severity> age 12
Mild Moderate Severe
Intermittent
Persistent Persistent Persistent
Impairment
2 days / >2 days / wk Throughout the
Symptoms Daily
week but not daily day
Night >once / week Often
2 x / month 3-4 x / month
Awakenings but not nightly 7 x / week
2 days / wk > 2 days / Several times per
-agonist
g Use Daily
y
weekk d
day
Interference
None Minor Some Extreme
with activity
FEV1 60-80% FEV1<60%
Lung Function Normal Normal
FEV1/FVC 5% FEV1/FVC >5%
Risk
Systemic
<2 x / yr 2 / yr 2 / yr 2 / yr
Steroids
Patient Case 5
D.B. is a 16 year old boy with asthma symptoms 1-
2x/week. He is awakened twice per week at night
with coughing and trouble breathing. What is his
asthma severity classification?
A. Intermittent
B. Mild persistent
C. Moderate persistent
D. Severe persistent
Page 224
Patient Case 6
8
Classifying Asthma Severity > age 12 Page 190
Therapy Step 6
Step 5
Step 4
Step 3
Step 2
Step 1
Preferred SABA prn Low Dose Low Dose Medium High
Hi hDDose High Dose
ICS ICS + Dose ICS + ICS +
LABA OR ICS + LABA LABA +
medium- LABA AND OCS
dose ICS Consider AND
omalizumab Consider
for patients omalizumab
Alternative Low-dose with for patients
LTRA or ICS + Medium- allergies with
theophylline LTRA, dose ICS + allergies
theophylline LTRA,
or zileuton theophylline
or zileuton
Page 192
Beclomethasone MDI 80 240 mcg >240 480 mcg > 480 mcg
(QVAR 40, 80)
Mometasone DPI 220 mcg 440 mcg > 440 mcg
(Asmanex 110, 220)
Ciclesonide MDI 160 mcg 320 mcg 640 mcg
(Alvesco 80, 160)
9
Patient Case 6
Page 196
10
Anticholinergic (Tiotropium) for
Chronic Asthma
RESULTS:
Adding tiotropium group: significantly greater
improvements in PEF & FEV1, better symptom control
& more asthma control daysy than doublingg ICS dose
Tiotropium non-inferior to adding LABA for all
outcomes; and it increased pre-bronchodilator FEV1
more than LABA (p=0.003)
Additional studies needed before using routinely in
clinical practice
Page 196
Pages 197-198
11
Asthma Action Plan (Adults):
Green Zone
Doing well, no symptoms
Take controller drug only
Use 2 puffs of SABA 55-15
15 min before exercise
if exercise-induced asthma
May use SABA as needed for periodic mild
symptoms
Page 197
Green Zone
Choice B is correct
Page 224
Patient Case 8
What are J.H.syellow zone instructions?
12
Asthma Action Plan (Adults):
Yellow Zone
Getting worse; some symptoms of wheezing and
dyspnea
Use SABA 2-6
2 6 puffs by MDI or 1 neb treatment;
may repeat in 20 minutes if needed
Use fewer puffs if mild exacerbation (e.g., 2 puffs)
Page 197
Incomplete R
Repeatt SABA;
SABA add dd OCS burst
b t
Response Contact clinician that day
X X
13
Patient Case 9
What are J.H.sred zone instructions?
14
Asthma Action Plan: Adults
Red Zone
ProAir 6 puffs,
puffs repeat in 20 min
min. then reassess
Prednisone 50mg once daily for 5 days
X
X X
X
Patient Case 10
R.D. is a 25 y/o male presenting to the ED with SOB at
rest. He is having trouble with conversation. He used 4
puffs of his albuterol MDI at home but it didnt seem to
help completely. FEV1 is checked and it is 38%
predicted.
di t d WhWhatt is
i his
hi severity
it off asthma
th exacerbation?
b ti ?
A.Mild
B. Moderate
C. Severe
D. Life-threatening
Page 201
Page 199
15
Patient Case 10
R.D. is a 25 y/o male presenting to the ED with SOB at
rest. He is having trouble with conversation. He used 4
puffs of his albuterol MDI at home but it didnt seem to
help completely. FEV1 is checked and it is 38%
predicted.
di t d WhWhatt is
i his
hi severity
it off asthma
th exacerbation?
b ti ?
A. Mild
B. Moderate
C. Severe
D. Life-threatening
Page 224
Patient Case 11
What is the best initial therapy for R.D. in the ED, in
addition to oxygen?
16
Patient Case 11
What is the best initial therapy for R.D. in the ED, in
addition to oxygen?
COPD
Page 201
Diagnosis
Consider COPD and perform spirometry
if>40 years old with any of the following:
Dyspnea
Chronic cough
Chronic sputum production
17
Diagnosis
Symptoms FEV1/FVC < 70% FEV1/FVC < 70% FEV1/FVC < 70% FEV1/FVC < 70%
Risk factor FEV1 80% 50% < FEV1 < 80% 30% < FEV1 < 50% FEV1 < 30% or
exposure FEV1 < 50% predicted
Normal plus chronic respiratory
spirometry failure
18
Patient Case 13
Which of the following is the most appropriate
for S.H. to be started on, in addition to albuterol
MDI 2 puffs q 4-6 hr PRN?
Page 205
Symptoms FEV1/FVC < 70% FEV1/FVC < 70% FEV1/FVC < 70% FEV1/FVC < 70%
Risk factor FEV1 80% 50% < FEV1 < 80% 30% < FEV1 < 50% FEV1 < 30% or
exposure FEV1 < 50% predicted
Normal plus chronic respiratory
spirometry failure
Addlong-term
oxygen if chronic
respiratory failure
Consider surgical
Page 204 treatments
Patient Case 13
Which of the following is the most appropriate
for S.H. to be started on, in addition to albuterol
MDI 2 puffs q 4-6 hr PRN?
A.
A Albuteroll PRN iis sufficient
Alb ffi i
B. Formoterol inhale 1 cap BID
C. Salmeterol/fluticasone 50/500 1 puff BID
D. Salmeterol/fluticasone 50/500 1 puff BID plus
home oxygen
Page 225
19
Long-Acting Bronchodilators
Page 203
Long-Acting Bronchodilators
POET-COPD study
7376 patients with moderate-severe COPD and
1 exacerbation in past year; 1 year
randomized, double-blind, parallel-group trial
Tiotropium vs. salmeterol
Primary endpoint: Time to first exacerbation
Moderate exacerbation: treated with OCS, antibiotics
or both
Severe exacerbation: hospitalized
NEJM 2011;364:1093-103.
Long-Acting Bronchodilators
Results:
Tiotropium (vs. salmeterol) significantly:
Increased time to first exacerbation
187 days vs. 145 days (42 day difference)
B th moderate
Both d t andd severe exacerbations
b ti were significant
i ifi t
Reduced annual number of exacerbations
Rate of both moderate and severe exacerbations was significant
Benefit was consistent in all major subgroups and
independent of concomitant ICS
Benefit evident in 1 month and maintained over 1 year
Sig. fewer patients taking tiotropium withdrew early
20
Patient Case 14
K.R. is a 60 y/0 man with COPD. Smokes ppd.
Gradual worsening of SOB. FEV1/FVC: 55% ;
FEV1: 63%. Meds: tiotropium (Spiriva) QD and
albuterol HFA prn. Which is most appropriate?
Page 205
Symptoms FEV1/FVC < 70% FEV1/FVC < 70% FEV1/FVC < 70% FEV1/FVC < 70%
Risk factor FEV1 80% 50% < FEV1 < 80% 30% < FEV1 < 50% FEV1 < 30% or
exposure FEV1 < 50% predicted
Normal plus chronic respiratory
spirometry failure
Addlong-term
oxygen if chronic
respiratory failure
Consider surgical
Page 204 treatments
Patient Case 14
K.R. is a 60 y/o man with COPD. Smokes ppd.
Gradually worsening SOB. FEV1/FVC: 55% ;
FEV1: 63%. Meds: tiotropium (Spiriva) QD and
albuterol HFA prn. Which is most appropriate?
Page 225
21
Page 205
-blockers in COPD
New observational data suggests long-term
treatment with-blockers (mostly cardioselective)
reduces the risk of exacerbations and improves
survival, even in patients without overt CVD.
More than half of the patients had CV risk factors
or CAD
Too early to use beta-blockers in the treatment of
COPD, but do not withhold in patients who also
have CAD or CHF.
Rutten et al. Arch Intern Med 2010;170:880-7.
Patient Case 15
M.J. is a 56 y/o man with Stage II (moderate) COPD and
HTN who presents to clinic with worsening SOB, coughing
& production of purulent sputum (much more sputum than
usual). Pulse ox 95%. In addition to
nebulizedalbuterol/ipratropiumq
p p q 1-4 hours,, what else
should be added?
A. No additional therapy needed
B. Add oral prednisone 60 mg once daily for 10 days
C. Add TMP/SMX DS 1 tablet BID for 7 days
D. Add oral predisone 60 mg once daily for 10 days and
TMP/SMX DS 1 tablet BID for 7 days.
Page 207
Managing Exacerbations
22
Managing Exacerbations
o Patients experiencing COPD exacerbations with
clinical signs of airway infection may benefit
from antibiotic treatment (Evidence B).
o Cardinal Symptoms:
o Increased sputum purulence
o Increased sputum volume
o Increased dyspnea
Page 206
Managing Exacerbations
o Antibiotics should be given if:
o COPD exacerbation with allTHREE cardinal
symptoms (Evidence B)
o COPD exacerbation with TWO cardinal
symptoms, if one is increased sputum
purluence (Evidence C)
o Severe COPD exacerbation requiring
mechanical ventilation (Evidence B)
Page 206
Managing Exacerbations
Page 207
23
Exacerbation Preferred Oral Alternative Oral Page 207
Group Antibiotics Antibiotics
Group A Doxycycline, Amoxicillin/clavulanate,
Mild trimethoprim/sulfam azithromycin, clarithromycin,
No risk factors ethoxazole second- or third-generation
for poor cephalosporin
outcome
Group B Amoxicillin/clavulan Levofloxacin, moxifloxacin
Moderate ate
Risk factors for
poor outcome
Group C Ciprofloxacin or
Severe Levofloxacin (at
Risk factorsfor least 750mg)
P. aeruginosa
Risk factors for poor outcome: comorbid diseases, severe COPD,> 3 exacerbations/year, antibiotic
use in past 3 months.
Risk factors for P. aeruginosa: Recent hospitalization, frequent antibiotics (4 courses in last year),
h/o severe COPD exacerbations, isolation of P. aeruginosan previous exacerbation
Patient Case 15
M.J. is a 56 y/o man with Stage II (moderate) COPD and
HTN who presents to clinic with worsening SOB, coughing
& production of purulent sputum (much more sputum than
usual). Pulse ox 95%. In addition to
nebulizedalbuterol/ipratropiumq 11-44 hours, what else
should be added?
A. No additional therapy needed
B. Add oral prednisone 60 mg once daily for 10 days
C. Add TMP/SMX DS 1 tablet BID for 7 days
D. Add oral predisone 60 mg once daily for 10 days and
TMP/SMX DS 1 tablet BID for 7 days. Page 225
ANTICOAGULATION
Page 208
24
Patient Case 16
J.J. is a 30 y/o woman receiving warfarin for a
proximal DVT. She was taking oral
contraceptives at the time her DVT was
diagnosed; they have since been discontinued.
Which of the follo
following
ing is correct with
ith regards to
recommended duration of warfarin?
A. 3 months
B. 6 months
C. 1 year
D. Indefinite
Page 212
Patient Case 16
J.J. is a 30 y/o woman receiving warfarin for a
proximal DVT. She was taking oral
contraceptives at the time her DVT was
diagnosed; they have since been discontinued.
Which of the following is correct with regards to
recommended duration of warfarin?
A. 3 months
B. 6 months
C. 1 year
D. Indefinite
Page 225
25
Patient Case 17
Page 213
Patient Case 17
Which of the following is the best way to deal
with B.D.s high INR?
A. Hold warfarinx 1 day then restart at lower dose (do
not check INR)
B. Hold warfarinx 2 days then restart at a lower dose (do
not check INR)
C. Hold warfarin, give po vitamin K 10 mg x 1 then
restart at lower dose when INR approaches 3
D. Hold warfarin, give po vitamin K 2.5 mg x 1 then
restart at lower dose when INR approaches 3
Page 213
26
Warfarin Drug Interactions
Pg 212
S - warfarin* (CYP 2C9) - inhibitors
e.g., Metronidazole, TMP/SMX, fluconazole,
INH, cimetidine, fluoxetine, sertraline, zafirlukast,
amiodarone, clopidogrel, lovastatin
R - warfarin (CYP 3A3/4/5) - inhibitors
e.g., Cimetidine, omeprazole, clarithromycin,
erythromycin, azole antifungals, nefazodone,
zafirlukast, fluoxetine, amiodarone, CYA, sertraline,
GF juice, ciprofloxacin, norfloxacin, protease
inhibitors, cyclosporine, diltiazem, verapamil, INH,
metronidazole, zafirlukast
Page 214
Warfarin Reversal Guidelines
Patient Case 17
Which of the following is the best way to deal
with B.D.s high INR?
A. Hold warfarinx 1 day then restart at lower dose (do
not check INR)
B. Hold warfarinx 2 days then restart at a lower dose (do
not check INR)
C. Hold warfarin, give po vitamin K 10 mg x 1 then
restart at lower dose when INR approaches 3
D. Hold warfarin, give po vitamin K 2.5 mg x 1 then
restart at lower dose when INR approaches 3
Page 225
27
Patient Case 18
Page 213
Page 210
Patient Case 18
Page 225
28
Patient Case 19
M.H. is a 63 y/o woman with mechanical mitral
valve replacement, HTN, dyslipidemia. Meds:
warfarin 8 mg/d, lisinopril 20 mg/d, atorvastatin
10 mg/d. What is M.H.s goal INR?
A. 1.5 2.5
B. 1.8 2.6
C. 23
D. 2.5 3.5
Page 213
Patient Case 19
M.H. is a 63 y/o woman with mechanical mitral
valve replacement, HTN, dyslipidemia. Meds:
warfarin 8 mg/d, lisinopril 20 mg/d, atorvastatin
10 mg/d. What is M.H.s goal INR?
A. 1.5 2.5
B. 1.8 2.6
C. 23
D. 2.5 3.5
Page 225
29
Patient Case 20
Page 213
Patient Case 20
Page 225
30
Patient Case 21
A 77 y/o man with atrial fibrillation, HTN,
diabetes, and h/o TIA 3 years ago. Having major
abdominal surgery in 1 week and will need to hold
his warfarin. Which of the following is the most
appropriate LMWH bridge therapy for him?
A. No bridge LMWH is needed; just hold warfarin
B. Enoxaparin 30 mg BID
C. Enoxaparin 1mg/kg BID
D. Either enoxaparin 30 mg BID or 1 mg/kg BID are
options
Page 213
Page 215-216
CHADS2 Score
Categorizes thromboembolic risk in atrial
fibrillation; assigns points for risk factors
CHF (any history) 1 point
HTN 1 point
Age > 75 1 point
Diabetes - 1 point
S2troke, TIA, systemic embolism - 2 points each
Pages 215-216
31
High Risk of Thromboembolism
Page 216
Page 216
High Risk of Thromboembolism
Stop warfarin 5 days before surgery
In 2 days, start therapeutic dose LMWH
Last dose the AM prior to surgery: half dose
Check INR day before surgery;
g give
g 1-2mgg vitamin
K if INR > 1.5
Post-op, commence LMWH (24 hr after surgery)
and warfarin (day of or day after surgery)
Continue LMWH until warfarin therapeutic
Page 216
32
Patient Case 21
A 77 y/o man with atrial fibrillation, HTN,
diabetes, and h/o TIA 3 years ago. Having
major abdominal surgery in 1 week and will need
to hold his warfarin. Which of the following is
the most appropriate LMWH bridge therapy for
him?
A. No bridge LMWH is needed; just hold warfarin
B. Enoxaparin 30 mg BID
C. Enoxaparin 1mg/kg BID
D. Either enoxaparin 30 mg BID or 1 mg/kg BID are
options Page 225
Low Risk:
No bridge OR bridge with low dose LMWH
Page 216
33
Home INR Monitoring/Management
NNT to prevent 1 thromboembolic event: 67
NNT to prevent one death: 36
LIMITATIONS:
If half of the trials, < 50% of the patients successfully
completed training and agreed to participate
Highly selected group of very motivated adults
Strength of evidence for mortality was low
Appears that benefit is mostly from PSM rather than PST
Withdrawal rates up to 25% despite improved QOL
Cost may be higher than usual care
New Anticoagulants
Dabigatran (Pradaxa)
Oral direct thrombin inhibitor
Indicated for the prevention of stroke/systemic
embolism in nonvalvularatrial fibrillation
Desirudin (Iprivask)
Specific inhibitor of human thrombin
Indicated for prophylaxis of DVT in patients
undergoing elective hip replacement surgery
Page 217
New Anticoagulants
Page 217
34
ADULT
IMMUNIZATIONS
Page 218
Patient Case 22
Patient Case 22
Page 222
35
Early pneumococcal vaccination
Pneumococcal vaccine is indicated prior to age 65 in:
Chronic lung disease (eg. COPD, asthma)
Chronic CV disease
Diabetes
Chronic liver disease,, cirrhosis
Chronic alcoholism
Functional or anatomic asplenia
Immunocompromising conditions
Smokers (age 19 64)
Cochlear implants, CSF leaks
Nursing home/LTCF patients Page 219
Page 219
Zoster Vaccine
Page 219
36
Recommended Adult Immunization Schedule
2011
Page 218
Patient Case 22
Page 225
Patient Case 23
S.C.: 20 y/o female going away to college; living in the
dorm. Smokes ppd; no other medical conditions.
She is up to date with all her routine childhood vaccines,
but no vaccines in the past 11 years. Not sexually active.
What vaccines should she receive today?
A. Td and HPV vaccines.
B. Tdap, meningococcal and HPV vaccines.
C. Meningococcal, pneumococcal polysaccharide, and
Td vaccines.
D. Meningococcal, pneumococcal polysaccharide, Tdap
and HPV vaccines Page 222
37
Meningococcal vaccine
First-year college students living in dormatories should
receive meningococcal vaccine
No revaccination after 5 years even if still living in on-
campus housing (other indications may require
revaccination)
Two types: MCV4 (Menactra)- now called quadrivalent- and
MPSV4 (Menomune)
Age < 55 should receive MCV4
Page 219
Pneumococcal vaccine:
Smoker age 19-64
HPV vaccine
For girls/women age 11-26
Ideally prior to sexual activity, but still administer to
sexually active girls/women
Still administer to women with a h/o HPV, genital warts,
abnormal pap
Two different HPV vaccines now available (HPV2-
Cervarix & HPV4-Gardasil); either can be used
May be administered to boys/men age 9-26 to reduce risk
of genital warts
Page 219
Page 221
38
Recommended Adult Immunization Schedule
2011
Page 218
Patient Case 23
Page 226
39