Course: B.

Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-1: Basic principles of medicinal chemistry

Long Essay
1. Write a note on Cytochrome p-450 and monoaminooxygenase with specific emphasis on
its constitution and their role in biotransformation.
2. Discuss how the solubility and partition co-efficient influence the biological activity and
write a note on logp value.
3. Define biotransformation. Differentiate between phase I and phase II biotransformation.
With suitable examples explain the role of glucuronic acid and glycine in drug
metabolism.
4. What are conjugation reactions? Explain the role of these reactions in drug metabolism
with any two examples.
5. What is phase I metabolism? Explain the following phase I biotransformation with
suitable example a) oxidative b) reductive c) hydrolytic.
6. Explain oxidative biotransformation in detail and enumerate the factors affecting
biotransformation.
7. Explain the role of hydrogen bonding, protein binding and chelation in drug action.
8. Define and classify receptors. Explain drug receptor interaction with suitable examples
9. Explain any four physicochemical properties affecting biological activity of drug
molecules.
10. Explain role of Cytochrome P-450 in biotransformation. Discuss phase II drug
metabolism

Short Answer

1. Define the terms “hit” and “lead” in drug design

2. Write the importance of glucuronic acid in metabolism
3. Define biotransformation. What is its importance
4. What is phase I biotransformation
5. What is phase II biotransformation
6. Write the significance of log P value
7. Write a note on protein binding in drug action
8. Write a note on partition co-effcient in drug action
9. Write a note on ionization and polar surface area
10. Write a note on hydrogen bonding in drug action

1
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-2: Central nervous system depressants

Long Essay

1. Define sedative and hypnotics. Explain the SAR of barbiturates. Write the synthesis of
barbital.
2. With examples, classify barbiturates giving structure of atleast one in each class. write
the synthesis of methobarbital
3. Define the terms sedative & hypnotics. Explain the SAR of benzodiazepine. Outline the
synthesis of diazepam.
4. Explain the SAR of phenothiazines. Outline the synthesis of haloperidol and
chlorpromazine
5. Define and classify convulsions. Classify anticonvulsant agents with suitable examples
giving one structure from each class.
6. Define and classify general anaesthetics. Explain the mode of action and enumerate the
synthesis of halothane.
7. Discuss the common structural features of anticonvulsant agents. Explain the synthesis of
phensuximide and phenytoin sodium.
8. Differentiate between the terms sedative, hypnotic and tranquiliser and write the
synthesis of any one drug from each class.
9. a) What are skeletal muscle relaxants? Explain their medicinal application. Outline the
synthesis of chlorphenesin.
b) Explain the SAR of benzodiazepines
10. Outline the synthesis of glutethimide, phenytoin and alprazolam. Enumerate to which
class of drug do they belong and write their specific medicinal uses.

Short Answer

1. What are inhalation anaesthetics? Give examples

2. Define spasticity. Mention any two antispastic drugs
3. What are ultra short acting barbiturates? Give examples
4. Give the structure and chemical name of diazepam
5. Give the structure and chemical name of phenobarbitone
6. What is preanaesthetic medication? Mention two examples used in preanaesthetic
medication
7. Give the structure and chemical name of halothane
8. Give the structure and chemical name of chlorpromazine
9. Give the structure and chemical name of clonazepam
10. Give the structure and chemical name of carbamazepine
11. Write the structure and uses of thiopental sodium and methohexital sodium
12. What are dissociative anaesthetics? Give examples
13. Give the structure and uses of baclofen and buspirone
14. Define tranquiliser. Give examples.

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 15. Write the structure and uses of valproic acid and chloral hydrate

Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-3: Adrenergic drugs

Short Essay

1. Outline the synthesis and uses of propranolol and clonidine

2. Outline the synthesis and uses of phenylephrine and isoproterenol
3. Write an account of β-adrenergic blocking agents and enumerate the synthesis of
propranolol.
4. Outline the biosynthesis and metabolism of adrenergic neurotransmitters.
5. Write a note on sympathomimetic agents and mention their specific uses
6. What are adrenergic agonists? Give the synthesis of clonidine
7. Write a note on adrenergic blocking agents
8. Classify adrenergic agents. Give the synthesis of terbutaline
9. Give the SAR of β–adrenergic blocking agents
10. Give the biosynthesis and metabolism of nor-adrenaline
11. Write a note on β–adrenergic blocking agents
12. Classify adrenergic blocking agent and outline the synthesis of phenoxybenzamine

Short Answer:
1. Outline the synthesis of isoproterenol
2. Discuss non-selective β-blocker
3. What are β-adrenergic agonists? Give examples
4. Give the structure and medicinal uses of methyl dopa and naphazoline
5. Outline the synthesis of prazosin
6. Write the structure and medicinal uses of propranolol
7. What are β1-adrenergic blockers? Give examples.
8. Write the structure and medicinal uses of phenylephrine and clonidine.
9. Classify adrenergic receptors.
10. Write the name and structure of any two β-adrenergic agonist
11. What are adrenergic neuro transmitters.
12. Write a note on α1–adrenergic blockers
13. Write a note on α2–adrenergic blockers

3
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-4: Cholinergic drugs and related agents

Short Essay

1. Give the structure and therapeutic significance of any two irreversible cholinesterase
inhibitors.
2. What are cholinergic neurotransmitters? Explain the biosynthesis of acetyl choline
3. Write a note on neuromuscular blocking agents.
4. Give the synthesis of dicyclomine and tropicamide
5. Classify cholinergic agonist and give the synthesis of neostigmine
6. Write a note on cholinesterase inhibitors.
7. Discuss the SAR of cholinergic agonist
8. Write a note on cholinergic blockers.
9. Write a note on ganglionic blocking agents
10. Classify cholinergic blockers. Outline the synthesis of dicyclomine
11. Give the biosynthesis, metabolism and functions of acetyl choline

Short Answer

1. Write the structure and uses of any two cholinergic blocking agents
2. Give the specific uses of atropine and neostigmine
3. Write the structures of any two cholinesterase inhibitors
4. Mention the types of cholinergic receptors
5. Outline the synthesis of neostigmine
6. Outline the synthesis of dicyclomine
7. Write the structure and uses of any two ganglionic blocking agents
8. Write the structure and uses of any two neuromuscular blocking agents
9. Write the structure and uses of any two irreversible cholinesterase inhibitors
10. Outline the synthesis of tropicamide
11. Outline the functions of acetylcholine
12. Write the structure and uses of any two postganglionic blocking agents
13. Write the structure and mode of action of tubocurarine
14. Write the structure and uses of trimethophan and mecamylamine
15. Write the structure and uses of scopolamine and atropine
16. Write the structure and uses of benztropine and tropicamide
17. Write the structure and uses of carbachol and methacholine
18. Differentiate reversible and irreversible cholinesterase inhibitors

4
Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-5: Local Anaesthetics

Short Essay

1. Define and classify local anaesthetic agents with examples. Outline the synthesis of
procaine
2. Explain the SAR of local anaesthetic agents with suitable example
3. Write the synthesis and uses of procaine and lidocaine
4. Classify local anaesthetic agents and explain their mechanism of action
5. Explain the mechanism of action of local anaesthetic agent and write the SAR of
lidocaine derivatives
6. Write the SAR of lidocaine derivatives and give the synthesis of procaine
7. Write the SAR of lidocaine derivatives and synthesis of lidocaine
8. Write the structure and uses of the following a) hexylcaine b) procainamide c)
Dimethisoquin d) prilocaine
9. Write the structure and uses of the following a) cyclomethicaine b) piperocaine c)
benzocaine d) dibucaine e) prilocaine
10. Define and classify local anaesthetic agent with examples. Outline the synthesis of
lidocaine

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Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-6: Histamine and antihistaminic agents

Short Essay

1. Explain in detail about histamine receptors.

2. Define antihistaminic agents. Classify them with examples
3. What are antihistaminic agents? Write the mechanism of action and synthesis of
chlorpheniramine
4. What are H2 receptor antagonists. Explain their mechanism of action and mention their
medicinal uses.
5. Explain gastric proton pump inhibitors and write their mechanism of action with labeled
diagram
6. Write the synthesis and uses of chlorpheniramine and promethazine
7. Outline the synthesis and uses of cetrizine and omeprazole
8. Outline the synthesis and uses of omeprazole and chlorpheniramine maleate
9. Outline the synthesis and uses of promethazine and citrizine
10. What are H1 receptor antagonists? Explain their mechanism of action and mention their
medicinal uses.
11. Outline the synthesis, mechanism of action and uses of omeprazole

Short Answer:
1. What are histamine receptor? Give examples
2. Write the structure and uses of any two aminoalkyl ether derivatives
3. Write the structure and uses of any two H2 antagonists
4. Write the structure and uses of tripelenamine and pheniramine
5. What are gastric proton pump inhibitors. Give examples
6. Write the synthesis of cetrizine
7. Write the synthesis of chlorpheniramine
8. Write the structure and uses of cyclizine and trimeprazine
9. Write the structure and uses of promethazine and meclizine
10. What are antihistamininc agents? Give examples
11. Write the structure of any two piperazine derivatives as antihistaminic agents
12. Write the structure of any two phenothiazine derivatives as antihistaminic agents
13. Write the structure of any two piperazine derivatives as antihistaminic agents
14. Write the structure of any two propylamine derivatives as antihistaminic agents
15. Write the structure of any two ethylamine derivatives as antihistaminic agents

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Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-7: Analgesic agents

Short Essay
1. What are narcotic analgesics? Write the structure and uses of any four drugs.
2. What are narcotic antagonist? Write the structure and uses of any four drugs.
3. Define and classify NSAID’s. Write the structure of one drug from each class
4. Write the synthesis and uses of methadone and dextromethorphan
5. Outline the synthesis and uses of mefenamic acid and ibuprofen
6. Ouline the synthesis and uses of piroxicam and naproxen
7. Discuss on narcotic analgesics? Give the synthesis of methadone
8. Write a note on narcotic analgesics. Outline the synthesis of dextromethorphan
9. Outline the synthesis and uses of nimesulide and acetaminophen
10. Write a note on steroidal anti-inflammatory agents. Explain their medicinal merits and
demerits.
11. What are non-steroidal anti-inflammatory agents? Explain their mechanism of action

Short Answer

1. What are narcotic antagonist?

2. Write the structure of aspirin. Give its various medicinal uses.
3. Give the structure and uses of codeine and dextromethorphan
4. Define and classify opioid receptors.
5. Write the medicinal uses of steroidal anti-inflammatory agents.
6. Give the use and mechanism of action of rofecoxib and valdecoxib
7. Define antipyretic. Write the structure and chemical name of paracetamol
8. Give the structure and chemical name of ibuprofen
9. Give the structure and chemical name of diclofenac
10. Give the structure and chemical name of mefenamic acid
11. Give the structure and chemical name of oxyphenbutazone
12. Give the structure and chemical name of phenylbutazone
13. Discuss the uses and mode of action of aspirin
14. What is analgesia? Compare and contrast narcotic and non-narcotic analgesics
15. What is inflammation? Mention any two anti-inflammatory agents
16. Write the structure and uses of tramadol and propoxyphen
17. What is the effect of acetyl group substitution in the analgesic activity of morphine
18. Write the structure and medicinal uses of indomethacin and phenacetin
19. Write the structure and medicinal uses of phenylbutazone and antipyrin
20. Write the structure and uses of triamcinolone and betamethasone
21. Write the structure and uses of loperamide and pentazocin
22. Write the structure and uses of levorphanol and fentanyl
23. What are anti-tussive agents? Give an example with structure

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Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-8: Structure and medical uses of important prostaglandins

Short Answer:
1. What are prostaglandins? Give examples
2. Write a note on the medicinal uses of prostaglandins
3. Write the structure and medicinal uses of any two prostaglandins
4. Give the structure and medicinal uses of PGE1 and PGE2
5. Give the structure and medicinal uses of prostaglandins PGF2A and PGE
6. Write the medicinal importance of prostaglandins
7. Give the name and structure of prostaglandins used in labour pain
8. What are thromboxanes? Give their medicinal uses
9. Classify prostaglandins with examples
10. Write the adverse effects of prostaglandins
11. What are prostaglandins? Name two examples used as abortefecents

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Course: B.Pharm
Class: 3 year
Subject: Medicinal Chemistry-I
Chapter-9: Natural Products

Short Essay

1. Enumerate the structural elucidation of ephedrine

2. Define and classify alkaloids giving the structure of one drug from each class.
3. What are purines? Write the structure and uses of caffeine, theophylline and theobromine
4. Explain the interrelationship between caffeine, theophylline and theobromine
5. Define and classify terpenoids giving the structure of one example from each class
6. Explain isoprene and special isoprene rule giving suitable examples.
7. Explain the interrelationship among monocyclic monoterpenoids
8. Define the following with two examples a) alkaloids b) purines c) terpenoids
9. Write the structure and uses of the following a) limonene b) terpenolene c) terpene
hydrate d) carvone e) cineone
10. Define and classify terpenoids and explain the isoprene and special isoprene rule