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_ Primary hemostasis
_ Formation of a platelet plug
_ Vasculature and platelets
_ Secondary hemostatis
$ _ Consolidation of the platelet plug by fibrin
_ cascade and inhibitors
_ Fibrinolysis
_ Cleanup
_ cascade and inhibitors
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$ Formation of a platelet plug - Vascular system and platelets
_ Activation in response to stimuli (Thromboplastin)
_ Damaged vessel releases
_ Epinephrine, collagen, thrombin, ADP, serotonin
_ Adherence to the margins of the lesion - platelets
_ Cell membrane receptors _ GpIIb/IIIa, GpIb
_ Release of granule content (caused by GpIIb/IIIa, GpIb)
_ Alpha granule _ Dense granule
_ Aggregation into a primary platelet plug
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Passed on from father to son, loss of this factor leads to
inability to clot.
essential for the formation of blood thromboplastin
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9 Formed in bone marrow
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_ Îegin as megakaryoblasts mature to megakaryocytes
_ 4-5 days maturation
_ Thrombocytes - _ In circulation 8-12 days
_ Normal range: 150,000-450,000 uL
_ 10-30 PLTs/þPF
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30. Factors II, VII, IX, & X are "blank" dependent 5 +
2. factors in this pathway are XII, XI, IX, VIII, X, V, II, & I
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9 measures platelet plug formation
_ small, whole blood sample (< 1 mL)
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_ challenges platelets under highshear flow conditions
_ hemodynamic conditions
_ sensitivity of 95% following ingestion of a single 325 mg
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_ Pain swelling, and discoloration in legs, and/or arms due to clotting
in the veins
_ Extreme difficulty breathing due to pulmonary clotting
" _ Severe headaches due to clotting in the brain
_ *There is no evidence showing that Factor V Leiden is associated
with clots in the heart because it has its effects in the veins and not
the arteries
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