Drug Study (MDH ER Jan. 29 – Feb. 1, 2018, Feb. 5 – Feb.

8, 2018)

Drug Mechanism of Action Classification Indications Contraindications Adverse Reactions / Side Nursing Management
Effects
Janumet combines two antidiabetic; adjunct to diet and Type 1 DM, severe anaphylaxis, angioedema, rash, - monitor for adverse
antidiabetic medications combination of exercise to improve renal impairment, urticaria, cutaneous vasculitis, reactions
with complementary sitagliptin and glycemic control in Hypersensitivity to and exfoliative skin conditions -monitor VS
mechanisms of action to metformin adults with type 2 metformin including Stevens-Johnson
improve glycemic control diabetes mellitus when hydrochloride syndrome, upper respiratory
in patients with type 2 treatment with both and/or sitagliptin or tract infection; hepatic enzyme
diabetes: sitagliptin, a sitagliptin and Janumet, Acute or elevations; acute pancreatitis,
dipeptidyl peptidase-4 metformin is chronic metabolic worsening renal function,
(DPP-4) inhibitor, and appropriate acidosis, including severe and disabling arthralgia,
metformin hydrochloride, diabetic bullous pemphigoid,
a member of the ketoacidosis constipation; vomiting;
biguanide class headache; myalgia; pain in
extremity; back pain; pruritus,
liver injury
Omeprazole Suppresses gastric acid Anti-secretory GERD, elimination of H. Pregnancy, Headache, dizziness, vertigo, - assess abdomen for
secretion by inhibiting drug pylori with amoxicillin lactation, rash, inflammation, pruritus, pain or swelling
gastric pump; block or metronidazole, hypersensitivity to dry skin, diarrhea, abdominal - monitor VS
hydrogen potassium Short term treatment of drug pain, nausea, vomiting, - monitor effects of
ATPase enzymes duodenal ulcer constipation, cough, epistaxis medication
- assess other
medications
Furosemide used to manage sulfonamide- hypertension Pregnancy, hypotension, dehydration, - monitor VS and
hypertension and edema type loop lactation, electrolyte imbalance fluids
associated with diuretic hypersensitivity to - monitor for adverse
congestive heart failure, drug effects
cirrhosis, and renal
disease, including the
nephrotic syndrome.
Losartan blocks the angiotensin II hypertension, NYHA hypersensitivity to cough, pruritus, rash, urticaria, - obtain drug
vasoconstrictor and receptor class II-IV heart failure, drug and hyperkalemia, hyponatremia, sensitivity to losartan
aldosterone-secreting antagonist, left ventricular systolic components hepatitis, angioedema, - monitor for adverse
effects of angiotensin II antihypertensive dysfunction neutropenia, leukopenia reactions
by selectively blocking - monitor VS
the binding of
angiotensin II to the AT1
receptor in many tissues,
such as vascular smooth
muscle and the adrenal
gland
 Pantoprazole Suppresses gastric acid Anti-secretory GERD, elimination of H. Pregnancy, Headache, dizziness, vertigo, - assess abdomen for
secretion by inhibiting drug pylori with amoxicillin lactation, rash, inflammation, pruritus, pain or swelling
gastric pump; block or metronidazole, hypersensitivity to dry skin, diarrhea, abdominal - monitor VS
hydrogen potassium Short term treatment of drug pain, nausea, vomiting, - monitor effects of
ATPase enzymes duodenal ulcer constipation, cough, epistaxis medication
- assess other
medications
Azithromycin prevents bacteria from antibiotic bacterial infections viral infections, diarrhea, nausea, abdominal - monitor for adverse
growing by interfering drug pain, and vomiting reactions
with their protein hypersensitivity, -monitor VS
synthesis. It binds to the pregnancy and
50S subunit of the lactation
bacterial ribosome, thus
inhibiting translation of
mRNA. Nucleic acid
synthesis is not affected
Metoclopramide inhibits gastric smooth dopamine D2 For the treatment of hypersensitivity to Drowsiness, dizziness, - monitor for adverse
muscle relaxation antagonist, gastroesophageal reflux drug tiredness, trouble sleeping, reactions
produced by dopamine, antiemetic disease (GERD). It is also agitation, headache, and -monitor VS
therefore increasing used in treating nausea diarrhea
cholinergic response of and vomiting, and to
the gastrointestinal increase gastric
smooth muscle. It emptying
accelerates intestinal
transit and gastric
emptying by preventing
relaxation of gastric body
and increasing the phasic
activity of antrum