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Although the immune system defends the host against infections and foreign antigens, immune
responses can themselves cause tissue injury and disease. Hypersensitivity is a reflection of
excessive or aberrant immune response to any type of stimulus (Abbas & Lichtman, 2008). It
usually does not occur with the first exposure to an allergen. Rather, the reaction follows a re-
exposure after sensitization, or build-up of antibodies, in a predisposed person. To promote
understanding of the immunopathogenesis of disease, hypersensitivity reactions have been
classified into four specific types of reactions. Most allergic reactions are either type I or type IV
hypersensitivity reactions.