OLFU College of Medicine Class 2015

Microbiology Platings 11: Complement

Dr. Bartolome August 24, 2012

1. Which among the following is true regarding the classical pathway of complement?
Initiated by
a. is part of adaptive immunity alone c. initiated by antigen-antibody complexes
antigen-antibody
b. formation of C3 convertase requires Factor B d. All of the above complexes
e. A and C only
2. Which among the following is true regarding the properdin pathway?
a. the first to act on re-exposure to an antigen c. stabilized by Factor D First to act on re-
b. major activator includes bacterial products exposure to
d. All of the above antigen
such as LPS
e. A and B only
3. Which among the following is ture regarding the lectin pathway?
a. Initiated by activation of C4 and C2 by MBL c. both Neither
b. Bypasses C1, C4, C2 d. neither
4. Which among the following is a pattern recognition receptor?
a. MBL c. MASP
MBL & L-ficolin
b. L-ficolin d. All of the above
e. A & B
5. Factor I cleaves fluid-phase or cell-bound C3b and C4b. This will affect formation of C3
convertase in which among the following pathways of complement?
a. Alternative c. Lectin Classical
b. Classical d. All of the above
e. B and C
6. A patient with deficiency of complement components C5-C8 and MBL will have a higher risk of
developing systemic infection with which among the following organisms?
Neisseria
a. Neisseria c. Measles
b. Syphilis d. Herpes
7. Which among the following is NOT an effect of complement activation?
Destruction of
a. destruction of virus-infected cells c. enhanced antibody production virus-infected cells
b. lysis of target cells d. enhanced phagocytosis
8. In hemolytic disease of the newborn, destruction of fetal red blood cells is due to activation of
which among the following complement pathways?
a. Alternative c. Lectin Classical
b. Classical d. A & B
e. B & C
9. Which among the following complement components from the classical pathway can enhance
phagocytosis by functioning as opsonins?
a. C1r c. C3a BONUS
b. C5a d. A & C
e. B & C
10. Recruitment of inflammatory cells is mediated by:
a. C3a c. C5a
C3a & C5a
b. C4a d. All of the above
e. A & C

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