Professional Documents
Culture Documents
Topics
Anatomy
Epidemiology
Etiology
Pathology
Immunohistochemistry
VIN
Treatment is recommended for all women with vulvar HSIL (VIN usual type).
Because of the potential for occult invasion, wide local excision should be performed if
cancer is suspected.
When occult invasion is not a concern, vulvar HSIL (VIN usual type) can be treated with
excision, laser ablation, or topical imiquimod .
Vaccinating girls with HPV vaccine before their initial sexual contact has been claimed to
reduce incidence of VIN
Presentation
Investigations
Prognosis
LN involvement – single most imp factor
-ve LN – 91% 5 yr survival
+ve LN – 52% 5 yr survival
Extent (number)
U/L vs B/L
Volume of tumor in involved nodes
Extracapsular extension
Level of metastatic disease in the nodal chain
<=2cm >1mm
>2cm any
Ability to protect skin outside the PTV Controversies about target delineation –
Groin,Skin bridge, Coverage of mons, Vaginal
Coverage
Protection of central pelvic bowel, Air gaps- issues with optimization
Concurrent boosts
Brachytherapy
Side effects of radiotherapy
Follow up
Chemotherapy
Melanoma of vulva
Pagets disease
Review of literature
Our data show that the risk of non-sentinel-node metastases increases with size of
sentinel-node metastasis. No size cutoff seems to exist below which chances of
non-sentinel-node metastases are close to zero. Therefore, all patients with
sentinel-node metastases should have additional groin treatment. The prognosis
for patients with sentinel-node metastasis larger than 2 mm is poor, and novel
treatment regimens should be explored for these patients.
Pre op RT
QUESTIONS???