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Learning Outcomes:
• Understanding basic concepts about metabolism and energy production in the
cell.
• Learning the main catabolic pathways that make up the -cellular respiration:
Glycolysis, Lactic acid fermentation, and Krebs cycle.
• Understanding the electron transport chain and the role of redox electron
carriers.
• Understanding the concepts of oxidative phosphorylation, chemiosmosis, and
electrochemical gradients.
• Calculating the amount of ATP produced in the different metabolic routes.
• Achieving an integrated view of the whole cellular respiration process and energy
use via respirometry experiments.
• Understanding the importance and good use of animal models in
experimentation.
2. Complete the following table which summarizes the details of cellular respiration.
(4 marks)
a. True / False: An advantage of using animal models for experiments in the lab
is the affordability.
b. True / False: Mice and rats are the most commonly used lab animals because
they are similar to humans and easy to maintain.
c. True / False: Respirometry measures oxygen consumption.
d. True / False: The two parameters in the respirometer that can be modified are
glucose usage and exercise intensity.
e. True / False: When the mouse starts running on the treadmill, oxygen
consumption will presumably decrease.
f. True / False: When the mouse first starts exercising, the main source of ATP is
lactic acid fermentation.
a. In order to test what happens under extreme exercise conditions, the test was
done at high speed and low oxygen availability.
b. The pain we feel after exercising at a very high intensity is a direct result of the
massive amount of lactic acid produced.
5. What chemical was used in the simulation to assess the importance of aerobic
respiration for energy production in our cells? Choose only one answer. (1 mark)
☐ Lactic acid
☐ Carbonyl cyanide m-chlorophenylhydrazone (CCCP)
☒ Potassium cyanide (KCN)
☐ ATP synthase
6. Why did the mouse die when the chemical from number 5 was injected into it?
Choose only one answer. (1 mark)
☐ It killed the mouse’s heart cells
☐ It further inhibited the mouse’s breathing
☐ The mouse died of exhaustion
☒ The mouse’s cells did not have enough energy to maintain its vital functions
8. Why would training at high altitudes benefit the football players? (2 marks)