A FIVE YEAR REVIEW OF CHILDREN WITH CHRONIC MYELOCYTIC LEUKEMIA AT Dr.

SARDJITO
GENERAL HOSPITAL, YOGYAKARTA, INDONESIA: 2012-2016

Authors : LARASATI Erlita, SIAGIAN Sondang Hazewinkel Suringa, SABRINA Dea Sella,
FITRIANI Ulfah, ARDIANTO Bambang, SUTARYO Sutaryo.
Departement of Child Health, Universitas Gadjah Mada/ Dr. Sardjito General Hospital.
Yogyakarta, Indonesia

Email : erlitalarasati@gmail.com

Background: Chronic myelocytic leukemia is a clonal disorder derived from pluripotent hematopoietic
stem cells involving the entire myeloid series and several lymphoid series with specific cytogenetic
markers of the Philadelphia chromosome. Chronic myelocytic leukemia is a very rare disease in children
with an incidence of 1: 1.000.000 per year. As a consequence of its rarity, only few studies have
specifically addressed pediatric features of CML at diagnosis and treatment.The purpose of this study
was to determine the biological, clinical, and laboratory characteristics of chronic myelocytic leukemia in
Dr. Sardjito general hospital.

Method: This is a retrospective descriptive study by taking data from pediatric patient's medical records
(0-18 years) with chronic myelocytic leukemia treated in Departement of pediatrics of Dr. Sardjito hospital
Yogyakarta from January 2012 through December 2016 and analyzed using SPSS 21 version.

Results: 26 patients (14 males and 12 females) were included in this study. The patient’s age between
one month and 17 years. Most of the patients came with abdominal enlargement (69.2%), pale (61.5%),
fever (57.7%), weight loss (57.7%), and discomfort or fullness in the abdomen (46.2%). Splenomegaly
was found in all patients. Laboratory results obtained median leukocyte count of 437.11x103/μL, median
Hb.71 g/dL, and median platelet counts of 576.5x103/μL. Eight (30.7%) of patients still alive, 8 (30.7%) of
patients died, and 10 (38.6%) of patients were lost to follow up.Overall survival in this study was 22.5%.

Conclusion: Most of children with chronic myelocytic leukemia of children aged between 10-14 years. All
patients had splenomegaly with the most common complaints were abdomen enlargement, pale, and
fever. The majority of children came with anemia, thrombocytosis, and leukocyte count >100x103/μL. The
overall 48-month survival in our study was 22.5%.