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BIOMEDICAL IMPORTANCE: amphibole TCA CYCLE 7 re nt Importance : 1. Citric actd — final common oxidatve pathway CHO: entering TCA cycle as PYrwate Acetyl CoA Fatty acid :- broken down into Acetyl Coh ~» Tea cycle Amine acid:- metabolized t Acetyl CoA or intermediates 2+ Excess Co are converted ty neutral fat b deposilect in Adipose ture. Glucose ~» Pyrvvate ~» Acetyl CoA > Fatty Aad 4. Source of precurser of biotynthese pathways, cing! CoA f atpartale from oxaloacetate. Eg: Heme is smy synthesized from su Hyper ammonemia C Ammonia intoxication ) excess armenia depletes glutamate Ketoghatwrate If ect conequenas yele. + deprive brain alls of + fo compensate. gletamate, a= in of aekeroghtarate depress TCA C\ a © | concentrates ¢ : eae coo Coo" ee ‘ ‘ ch Se ovh CHa CHa fn Cl é meas cvapend) OG ¢o0 ov coo Glutamate Pyruvate dehydrogenase Oleficiency * «deficiency In Es Gmplan Component of PDH complex. eresuits in an Inability te convert pyruvate —> actty| CoA Consequences: pyrvvate te ae shunted fe lactic acid VI4 Iactade dehydregenape to dhe brain ( or relies on TcA Probiem ee) Leigh syndrome C subacute necrotizing enceph alomye lopathy ) erare, progressive Neurslogical disorder + cause by + defects in rmbochondrial ATP production tame CRD complex) or (deren sonny) op ( Ate smthase )

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