Result and Calculation

Result:

i. Neutralization of ethanol

Initial volume of NaOH = 9.5 ml

Final volume of NaOH = 9.0 ml

Amount of NaOH used for neutralization = 0.5 ml

ii. Assay of mefenamic acid

Weight of the content of 5 capsules “X” = 1.415 g

Average weight of a capsule = 0.2831 g

Volume of NaOH added (ml) pH

0.00 6.27

0.1 6.96

1.2 6.76

2.2 7.21

3.2 7.38

4.2 7.50

5.2 7.65

6.2 7.75

7.4 8.13

8.4 8.50

9.4 9.60

9.5 9.83

9.6 10.06

9.7 10.73

9.8 11.10

9.9 11.81
 10.9 13.14

11.9 13.65

12.9 13.80

13.9 13.90

14.9 13.98

15.7 14.00
Table 1 Volume of NaOH added and pH value of mefenamic acid solution

Figure 1 Graph of pH against volume of NaOH added (ml)

Calculation:
Molarity of NaOH = 0.1 M
Volume of NaOH = 9.4 × 10−3 L
Volume of mefenamic acid = 0.1 L
MolarityNaOH × VolumeNaOH
Molarity of mefenamic acid (C15 H15 NO2 ) =
VolumeC15 H15 NO2

(0.1 M) × (9.4 × 10−3 L)

=
0.1 L
= 9.4 × 10−3 M
*Equilibrium has reached because of neutralization takes place.