CLINICOPATOLOGY PATIEN WITH GYNECOLOGICAL TROPOBLASTOMA NEOPLASMA IN RSUP

SANGLAH, BALI

ABSTRACT

Introduction: Gestational trophoblastic neoplasms (GTN) are malignant lesions that arise from placental
villous and extra-villous trophoblast. GTN occurs in 1:40,000 pregnancies and is more common in Asia than
in Europe or North America especially in Bali. Four clinicopathologic conditions make up this entity: 1)
invasive mole (IM) that follows either a complete (CHM) or partial hydatidiform mole (PHM), 2)
choriocarcinoma (CCA), 3) placental site trophoblastic tumor (PSTT) and 4) epithelioid trophoblastic tumor
(ETT). The purpose of this study aims to determine the characteristics and clinicopathology of patients with
GTN in Sanglah Hospital, Bali. Methods: This was a retrospective cross-sectional study by looking at
patient medical records. The subjects of the study were patients diagnosed with GTN at Sanglah Hospital.
The variables assessed were age, education, occupation, parity, FIGO stage, antecedent pregnancy, tumor
size, histopathology, treatment, and overall survival. Data obtained in the descriptive analysis with SPSS.
Result: The study subjects 40 patients with an average age of 38.5% ± 10,323. Obtained 82.5% already
have children and have a high school education (85%) but 57.5 % housewife. It was found that the most
common GTN in FIGO stage I was 70%, with antecedent pregnancy 50%, and histopathology was
choriocarcinoma. Therapy is often done with chemotherapy and surgery (42.5%), and overall survival is
21.55 ± 17.478. Conclusions: Patients with GTN at Sanglah Hospital were obtained more with
choriocarcinoma and on stage I which means having better overall survival.

KEY WORD: Gestational trophoblastic neoplasia (GTN), Clinicopathology, Sanglah Hospital, BALI