Healthy Aging

The Heart of the Matter

 The Heart of the Matter:
Therapeutic Nutrition Helps Reduce the Risk of Cardiovascular
Disease & Manages the Incidence of Associated Health Risks
including Improving Diabetic Health Status
 The Heart of the
Matter
Heart Disease is the Leading Cause of Death in the United States and
Associated with High Rates of Disease States Including Diabetes.
• Heart Diseases (including all cardiovascular conditions) are the leading cause of
death in America. 81% of these deaths are in people over the age of 60 years
(Am.Heart Assoc. 2010 Statistical Fact Sheet)

• 40% of people between 40 and 60 yrs have heart disease and by the time we reach
60 to 80yrs, more than 70% suffer from heart diseases. Of these numbers, 60%
suffer from 2 or more co-morbidities (AHA Heart Dis & Stroke, 2010)

• By age 60, nearly 60% of people have high blood cholesterol and fat (triglycerides)
levels. Increasing the risk of disease and death (Center for Disease Control, 2010
FastStats Heart Report) Elevated triglyceride levels leads to faster onset and
complications of diabetes and increases levels of inflammation of the body and
further increasing the risk of other compromised health conditions including a 40%
higher risk for cognitive impairment and Alzheimer’s.
 The Heart of the
Matter
These are Preventable Chronic Diseases that can be Managed with
Therapeutic Nutrition

•Diabetes and Obesity are two independent risk factors of/for heart disease with 15% of
those 55yr plus and 20% of those 65 yrs plus being diabetic – of these, 80% have heart
disease issues - 65% of diabetics die from some form of heart disease (Circulation 2010;121:e1-
e170; AHA Journals; MMWR 2010 Natl Vital Statistics)

•65% over age 55 are overweight & obese. Another 40% of those over 45 yrs are pre-
diabetic and not yet diagnosed. (Am.HeartAssoc. 2010 Statistical Fact Sheet).

•Heart Disease, Diabetes and Obesity (sometimes also described as the “metabolic
syndrome’) are chronic diseases with a basis in diet and inactivity. Therapeutic Nutrition &
Exercise is an important way to manage heart and diabetic health needs along with a
healthy body weight (NHANES, 2005-2006)
Body Composition

•The Number of Individuals Overweight and

Obese Increases with Age, reaching as high as
80% by 65 (vs.... 40% at age 40). This results in
Significantly Elevated levels of Fats in the blood
– including triglycerides and cholesterol – and
Leads to high incidence of Diabetes, (3X higher
than younger age groups)
•Muscle Mass decreases result in over a 100%
increase in Fat Mass by the time we reach
70yrs vs. 25yrs old.

•The aging shift of more Fat Mass vs... Muscle

contributes to elevated triglycerides found in
the blood and liver which leads to high
inflammation levels (c-Reactive Protein
average 8mg/dl) associated with heart disease
and diabetes risk factors .
(ABC Study 2007, Am J.Clin Nutr)
 Reducing the Risk

Three Important Variables to Help Reduce Health Risks associated

with Heart Disease and Diabetes

1) Maintain a Healthy Body Weight:

• While loss of muscle mass in aging decreases survival rates by 20%, Heart Disease
accelerates this rate by up to 30% more (Lancet, 1997; Obesity Research 2004)

• Maintaining lean muscle mass and function helps maintain ideal body weight with
less fat mass and BMI’s of between 23 and 29 (Obesity Res.2004;12:913; Obesity Res. 2004;
12:1995; JAGS,1999;48:1409)

• Active Nutrients like leucine work directly on lean mass and are more important
than calories in general to maintain body weight and are critical to a successful
weight control/reduction program (British Med J.2008;337:92-95)
 Reducing the Risk

Three Important Variables to Help Reduce Health Risks associated

with Heart Disease and Diabetes
2) Manage Triglyceride, Cholesterol and Blood Sugar levels

• Lowering triglycerides and cholesterol reduces the risk of heart disease and provides better
management of Diabetes (Science 2003;300:1140)

• Control of Post-Meal Glucose & Triglycerides decreases co-morbidities and mortality rates
(Eur.J.Clin.Nut 2004;Diab.Metab.2002;28:20

3) Maintain even light to moderate activity levels to support Muscle Mass

• Nearly 60% of those age 60yrs and above report little to no activity or exercise during
leisure time. This results in a decrease of lean muscle mass, an increase in fat mass and a
decrease in heart health with high risk of diabetes or complications of diabetes (AHA 2010
Statistical Fact Sheets Physical Inactivity and Diabetes; J.Geront A Biol Sci.MedSci, 2008)

• Moderate Activity combined with High Leucine Essential Amino Acid Supplement can help
increase and maintain muscle mass and avoid increase of fat mass thus maintaining energy
levels, supporting normal blood glucose and blood lipid levels (Clin. Nutrition,2008)
 Reducing the Risk

Maintaining Lean Muscle Mass with moderate activity and Nutritional Support is
a Critical Health Management Objective for Healthy Aging Outcomes

35
Protein Synthesis/Gram Supplement

30 Therapeutic Nutrition with active nutrients

25 including High leucine/essential amino acid
20 protein sources help manage and avoid the age-
15 associated risks of heart disease and diabetes and
10 can support lean muscle mass improvements
5 with/without exercise and thus minimizes a shift
to greater fat mass which leads to increased risk
Balanced
Amino Acids
Essential Essential Amino
Acids
factors for heart disease and diabetes
Amino Acids
With Activity (Clin Nutr, 2009; NHANES Report 2008-2009)
 Leucine Effects

Proprietary Blends of Protein with high levels of essential amino acids and
Leucine help manage the risks of heart disease and diabetes.
TG concentration at baseline (mg/dl)
50-99 100-149 >150

0 8 16
Week

16 weeks of intake of essential amino acid/high leucine intake resulted in up to a 50% reduction of
serum (left) and liver (right) triglyceride levels and thus reduces the complications of the risk of heart
disease and that of insulin resistance and poor blood glucose control in managing Diabetes
 Leucine and Muscle
Function

Increase Amounts of Luecine and Essential Amino Acids Improve Muscle

Function

Eight to 16 weeks of supplementation

with High Leucine Protein Blend results in
Significant improvement in Muscle
Functional tests of distance and time. On
average a 20% improvement is seen with
improved protein intake in 8 weeks of
consumption of BeneVia with ViaLeuPro

Specialized Protein blends high in Leucine and essential amino acids, overcome the
resistance of muscles to function and help improve daily activity levels as soon as 8
weeks of supplementation.
 Triglyceride and
Insulin

Elevated Triglycerides Leads to Insulin Resistance

Young Old

Elevated triglyceride levels in older subjects leads to insulin resistance as a result of higher fat
in the muscle, lower energy use by muscle cells and lower control of glucose metabolism
(Science 2003; 300:1186)
 Lower Triglycerides
A Protein Blend of Essential Amino Acids High in Leucine is Effective at Lowering Serum
and Liver triglycerides as Compared to Changes seen with Prescription Medication

Fig 1

Fig 2

New research findings reveal that the essential amino acid blends work as well as prescription medications (fenofibrate) in
lowering serum triglycerides (Fig 1) and is more effective at lowering liver triglyceride (Fig 2) levels. These results were found
in a group of 12 subjects with impaired glucose tolerance (average age – 67.5 yrs). Changes in liver enzymes were elevated
only in the fenofibrate group.

Decreasing fat levels also parallel a measured improvement in insulin sensitivity and improved glucose tolerance over an 8
week period of nutrient supplementation.
 Phytosterols

By Combining Natural Phytosterols with the High Leucine/Essential Amino Acid Protein Blend,
Significant reduction in total cholesterol and LDL is also observed over a 4 week period
(Am. J.Clin.Nut, 1999)

-8.3%
-8.3% -14.3%
 The Heart of the
Matter
Natural Phytosterols help increase HDL levels while decreasing LDL levels and ratio of LDL:HDL;
Small improvement in blood pressure was observed helping to reduce to overall risk and complications
of heart disease

3.6 g/d Phytrol reduces Total Cholesterol, Modest numerical decrease in systolic pressure;
LDL-Cholesterol, and LDL:HDL ratio negligible decrease in diastolic pressure.
while maintaining HDL
 Summary

• Elevated triglyceride and cholesterol levels not only complicate heart health but lead to
Diabetes and the need to manage insulin resistance and glucose

• By the time we reach 60 yrs and above, 20% will have Diabetes, 80% some type of heart
disease and 60% with elevated fat levels in the blood, liver and muscle.

• Specialized blends of High Leucine/Essential Amino Acid Proteins help lower serum
and liver triglyceride levels which helps control energy levels and glucose levels and thus
effectively helps manage heart health co-morbidities including Diabetes.

• Natural phytosterols in combination with the above will help lower total cholesterol and
LDL levels and reduce the risk of heart disease by up to 18%.

• 4 to 8 weeks of supplementation of these therapeutic nutrients will result in significant

improvement in glucose tolerance and a healthy body weight for improved control and
management of diabetes.
 gobenevia.com
Six Critical Scientific Studies and Peer Reviewed Publications Support The Need and Benefit of Superior
Protein Sources with Leucine & Essential Amino Acids
Study Type Findings Product Position Competitive
Difference
Role of Amino Acids in Human experimental 15-18g EAA as Proprietary blend and Smaller volume with
stimulation of protein Am J Clin Nutr 78:250-258, effective as 40g volume control greater effect; non-
Aug 2003.
synthesis intact protein milk
Response to 16wk Human Control Significant gains in Effective and Specific outcome
supplement of EAA Clin Nutr 27(2):189-195, functional convenient use of improvements
Apr 2008.
performance blend
Effect of Age on Human Experimental Specific needs and Age Specific Benefit Specialized blends for
Response to 7g EAA Controls response of aged and Effect target consumer
Am J Clin Nutr 82:00-00, vs... youth
1065-1073, Nov 2005

Comparisons of EAA’s Human experimental Dose and Optimal availability Superior stimulation
& Leucine vs... other J Clin Endocrinol Metabo combination use of protein synthesis
89:4351-4358, Sep 2004.
proteins and products
Relationship of Protein In Vivo and Human Omega-3 effect on Control of Protein and
Metabolism and experimental inflammation and inflammation Inflammatory control
Inflammatory Control J of Nutrition 2008; protein metabolism as synergistic benefit
138:954-963

Bed rest with EAA Human Control Supplementation Effective Specific Outcome
supplementation Clin Nutr 29:18-23, Feb ameliorates effect of supplementation stops improvements
2010
bed rest muscle loss
 Healthy Aging

Measuring Healthy Aging

•Overall ageing tools:

•Real age: http://www.realage.com
•Grow youthful: http://www.growyouthful.com/quiz.php
•Mental age tests:
•Mental age test: http://en.nienteansia.it/tests/mental-age-
test.html
•Heart age tests:
Heart age: http://www.heartagecalculator.com/
Cardiovascular risk calculator:
http://www.mayoclinic.com/health/heart-disease-
risk/HB00047
For Additional Information
Contact Us:

At our website: www.gobenevia.com

By email: Info@the-healthspan.com
By phone: 1-888-855-4442