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Anna Cassell, Duncan Edwards, Amelia Harshfield, Kirsty Rhodes, James Brimicombe,
Rupert Payne and Simon Griffin
Definition of multimorbidity
Hopkins University Adjusted Clinical Groups Patients with multimorbidity were defined
Case-Mix Systems (ACG) lists.4,12 The ACG as having two or more currently active
lists are complex and difficult to implement long-term conditions out of a list of 36
in research or clinical settings; the QOF lists conditions. The detailed definition for each
— although more practical to implement condition was developed by a group of
— fail to capture important, common researchers and GPs from the Primary Care
conditions, such as chronic pain, which can Unit, University of Cambridge. The overall
have a significant impact on patient care and taxonomy drew largely on the previous work
quality of life. Additionally, the diagnostic and by Barnett et al in Scotland;4 the authors
prescribing code lists used in these Scottish of the study presented here used Barnett
studies are not readily available, the methods et al ’s definition of morbidities, which
used to derive the codes are not well comprised those conditions:
described, and the association with service
utilisation beyond hospital admission has ‘… likely to be chronic (defined as having
not been examined. Furthermore, the data significant impact over at least the most
are now over 10 years old and considerable recent year) and with significant impact
changes in both disease prevalence and on patients in terms of need for chronic
health service use might be expected over treatment, reduced function, reduced quality
this time period. of life, and risk of future morbidity and
The study presented here aimed to provide mortality.’ 15
a comprehensive and more contemporary
description of the epidemiology of Information identifying whether patients
multimorbidity in England and its had current, active morbidities was extracted
association with health service utilisation, from patients’ primary care medical records
using a refined list of long-term conditions in the CPRD, using a list of both Read
based on the work by Barnett et al.4 codes (used by UK GPs to record coded
information in the EHR about diagnoses and
METHOD administrative activity) and product codes
Patient population and data acquisition (which are unique to the CPRD, and reflect
Data for this study were obtained from the all prescribed pharmacological and non-
Clinical Practice Research Datalink (CPRD). pharmacological products recorded in the
The CPRD provides researchers with EHR). A detailed description of how each
anonymised clinical information extracted individual condition was defined is available
from consenting general practice EHRs that from the authors on request.
are uploaded to the CPRD on a monthly In addition to the prevalence of
basis. The CPRD contains information from multimorbidity, the association between
approximately 6.9% of the UK population mental health morbidities and physical
and is representative of the UK general morbidities was also examined, with
population in terms of age, sex, and the authors specifically looking at the
ethnicity.13,14 To ensure records were up to coexistence of at least one mental morbidity
date, patients had to have up-to-standard (for example, depression/anxiety) with at
Statistically significant difference in percentage with multimorbidity ( P<0.001) within each variable group based on c2 test. SD = standard deviation.
b