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1. INTRODUCTION
2. REVIEW OF LITERATURE
6. CONCLUSION
7. REFERENCES
8. PUBLICATION/ POSTER PRESENTATION
1 Introduction (1page)
The dispersion of drug in an inert carrier is called Solid dispersions. Solid dispersion, a concept
firstly introduced by Sekiguchi and Obi. The drug can be dispersed molecularly, in amorphous
particles (clusters) or in crystalline particles. Poorly soluble drugs are associated with slow
drug absorption leading to inadequate or low bioavailability. Therefore, solid dispersion
technologies are particularly promising for improving the oral absorption and bioavailability of
BCS Class II drugs. Ketorolac Tromethamine is a non-steroidal anti-inflammatory drug. Due to
poor aqueous solubility Ketorolac have low dissolution rate. In this study, solvent evaporation,
fusion and kneading method is used to develop solid dispersion of drug. These methods have
advantage that in this technique porous and amorphous molecular dispersion is forms and this
will helps in the reduction of dose of the drug. Therefore, result in a higher dissolution rate and
increases the solubility of poorly water soluble drug. New optimized techniques are also useful
in the industries.
KTM-01
KTM-02
KTM-03
KTM-04
KTM-05
KTM-06
KTM-07
KTM-08
KTM-09
KTM-10
KTM-11
KTM-12
KTM-13
KTM-14
KTM-15
KTM-16
KTM-17
KTM-18
KTM-19
KTM-01
KTM-02
KTM-03
KTM-04
KTM-05
KTM-06
KTM-07
KTM-08
KTM-09
KTM-10
KTM-11
KTM-12
KTM-13
KTM-14
KTM-15
KTM-16
KTM-17
KTM-18
KTM-19
KTM-01
KTM-02
KTM-03
KTM-04
KTM-05
KTM-06
KTM-07
KTM-08
KTM-09
KTM-10
KTM-11
KTM-12
KTM-13
KTM-14
KTM-15
KTM-16
KTM-17
KTM-18
KTM-19
DSC analysis was done for pure Ketorolac tromethamine and its solid dispersions using carriers
(PEG-4000& soluplus) of different ratios. The DSC thermogram of pure Ketorolac
Tromethamine showed a sharp endothermic peak at 84.75ºC, which was ascribe to drug melting.
The DSC curves of kneading method were KTM- 01, KTM-07 and KTM-14 for PEG-4000 (1:4)
and Soluplus (1:6) respectively. These formulations showed the maximum amorphous character.
The DSC curves of solvent evaporation method were KTM- 01, KTM-07 and KTM-14 for PEG-
4000 respectively (figure 03)
6. Conclusion (1page)
Solid dispersion techniques were employed for improving the solubility of Ketorolac
Tromethamine. There are two processes kneading and solvent evaporation of solid dispersions
was used with different carriers like polymer Soluplus and PEG-4000. Incorporation of these
carriers solid dispersion significantly enhanced the dissolution rate of Ketorolac Tromethamine.
The enhancement of dissolution of drug from drug carrier systems can be ascribed to several
factors. The mechanism of dissolution rate improvement from solid dispersion is lack of
crystalinity and particle size reduction considered to be important factors for dissolution rate
enhancement. Mixing of drug with a hydrophilic carrier results in greater wetting and increase
surface available for dissolution by reducing interfacial tension between the hydrophilic drug and
dissolution media. It was noted that drug carrier system sink immediately, while pure drug keeps
floating on the surface for a longer time interval. The Solid dispersions formulated with the drug
carriers exhibited significant improvement in the dissolution of drug. The dissolution
enhancement with various binary systems was found to be in the order of KTM- 01, KTM-07
and KTM-14. The increase in the dissolution rate of the solid mixtures is due to size reduction
and increase in the wettability of the drug molecules in presence of the polymers and sugar
carriers.