10001 - TOXLINE

TI - Bimetallic AuPt nanochains: Synthesis and their application in

electrochemical immunosensor for the detection of carcinoembryonic
antigen.
AU - Cao X
AD - School of Biochemical and Pharmaceutical Sciences, Capital Medical
University, Beijing 100069, China.
AU - Wang N
AD - School of Biochemical and Pharmaceutical Sciences, Capital Medical
University, Beijing 100069, China.
AU - Jia S
AD - School of Biochemical and Pharmaceutical Sciences, Capital Medical
University, Beijing 100069, China.
AU - Guo L
AD - School of Biochemical and Pharmaceutical Sciences, Capital Medical
University, Beijing 100069, China.
AU - Li K
AD - School of Biochemical and Pharmaceutical Sciences, Capital Medical
University, Beijing 100069, China.
SO - Biosens Bioelectron. 2013, Jan 15; 39(1):226-30. [Biosensors &
bioelectronics]
AB - The recent development in the nanotechnology has paved the way for a large
number of alloyed nanomaterials and devices of desirable properties which
have useful functions for electrochemical sensor and biosensor
applications. In this paper, bimetallic AuPt nanochains were synthesized
through a mild chemical method, with which anti-horseradish
peroxidase-conjugated anti-carcinoembryonic antigen (HRP-anti-CEA-NCAuPt)
was developed for electrochemical detection of carcinoembryonic antigen
(CEA) in a sandwich-type immunoassay format. The alloyed nanocrystals
exhibit not only sound signal amplification effect of Au nanoparticles,
but also further new combination of interfacial, electrical and structural
properties arising from the disparate AuPt components. As a result, the
electrochemical signal was significantly amplified by using the
HRP-anti-CEA-NCAuPt as tracer and hydrogen peroxide as enzyme substrate.
The linear range of the developed immunosensor is 0.01-200ng/mL and the
detection limit is 0.11pg/mL of CEA, which makes the biometallic
nanochains promising candidates for the next-generation sandwich-type
electrochemical immunoassays.
RN - 49DFR088MY
RN - 7440-57-5
RN - EC 1.11.1.-
LA - eng
IS - 1873-4235 (Electronic)
PT - Evaluation Studies
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
TA - Biosens Bioelectron
YR - 2013
DATE- 20131121
CI - Copyright © 2012 Elsevier B.V. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Biosensors & bioelectronics
EDAT- 20120731
STAT- MEDLINE
DOCNO- medline/22921093