Professional Documents
Culture Documents
Corresponding Author:
Ari Fahrial Syam, MD., PhD. Division of Gastroenterology, Department of Internal Medicine, Faculty of
Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital. Jl. Diponegoro 71, Jakarta 10430, Indonesia.
email: ari_syam@hotmail.com.
ABSTRAK
Dispepsia merupakan salah satu dari berbagai keluhan umum yang dapat ditemui oleh dokter di berbagai
bidang, tidak terbatas hanya pada ahli saluran cerna saja dalam praktik kesehariannya. Pengertian mengenai
patofisiologi dispepsia terus berkembang sejak dimulainya investigasi secara ilmiah pada 1980-an sampai dengan
saat ini yang memandang infeksi Helicobacter pylori sebagai salah satu faktor kunci dalam menangani dispepsia,
baik terkait ulkus maupun non-ulkus. Penatalaksanaan dispepsia tidak bisa dilepaskan dari penatalaksaan infeksi
H.pylori, serta penambahan pengetahuan baru terkait definisi, patofisiologi, diagnosis dan penatalaksanaan
dispepsia dan infeksi H.pylori.
Konsensus penatalaksanaan dispepsia dan infeksi H.pylori di Indonesia ini dibuat berdasarkan evidence
based medicine, sehingga dapat digunakan sebagai rujukan para dokter dalam menangani kasus-kasus dispepsia
dan infeksi H.pylori di tempat praktik sehari-hari. Dengan adanya konsensus terbaru ini diharapkan para dokter
dapat lebih meningkatkan pelayanannya kepada pasien-pasien dispepsia dan infeksi H.pylori.
ABSTRACT
Dyspepsia is one of numerous general complaints, which is commonly encountered by doctors of
various disciplines. In daily practice, the complaint is not only limited for gastroenterologists. Knowledge
on pathophysiology of dyspepsia have been developing continuously since a scientific investigation has been
started in 1980’s, which considers Helicobacter pylori as one of key factor in managing dyspepsia, either it is
associated with ulcer or non-ulcer. The management of dyspepsia cannot be separated from the management
of H. pylori and there is an additional new knowledge associated with definition, pathophysiology, diagnosis
and treatment of both dyspepsia and H. pylori infection.
This consensus document on the management of dyspepsia and H. pylori infection in Indonesia has been
developed using the evidence-based medicine principles; therefore, it can be used as a reference for doctors
in dealing with dyspepsia and H. pylori infection cases in their daily practice. It is expected that with the new
consensus, doctors can provide greater service to their patients who have dyspepsia and H. pylori infection.
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emptying. It is also one of main mechanism in the a process of malignancy. Functional dyspepsia
pathophysiology of functional dyspepsia, which refers to the Rome III criteria, which has not
is associated with bloating after meal and it may been validated in Indonesia. The Asia-Pacific
be found in the form of abdominal distension, Consensus (2012) has decided to follow the
bloating and fullness.5,12 concept in the Rome III diagnosis criteria with
The Role of Visceral Hypersensitivity
some additional symptoms of bloating in the
Visceral hypersensitivity has an important role upper abdominal part, which is commonly found
in the pathophysiology of functional dyspepsia, as the symptom of functional dyspepsia.5
particularly in increasing the sensitivity of Dyspepsia according to the Rome III
peripheral and central sensory nerves against criteria is a disease with one or more symptoms
chemical and intraluminal receptor stimuli at associated with gastroduodenal abnormalities of:
the proximal part of the stomach. It can cause • Epigastric pain
or aggravate dyspepsia symptoms.5 • Epigastric burn sensation
• Fullness or discomfort after meal
The Role of Psychosocial Factors • Early satiety
Psychosocial disorder is one of inducers
The symptoms must occur at least in the last
that may have roles in functional dyspepsia. The
three months with an onset of symptoms in six
severity of psychosocial disorder is consistent
months before the diagnosis is established.
with the severity of dyspepsia. Various studies
The Rome III criteria categorize functional
show that depression and anxiety have roles in
dyspepsia into 2 subgroups, i.e. the epigatric pain
the development of functional dyspepsia.5,12
syndrome and postprandial distress syndrome.
The Role of Gastric Acid However, the most recent evidence demonstrates
Gastric acid may have a role in developing that there is an overlapping of diagnosis in two
symptoms of functional dyspepsia. It has also third of patients with dyspepsia.1
becomes an underlying reason for effective
treatment using anti-secretory agents as shown Uninvestigated dyspepsia
by some studies in patients with functional
dyspepsia. There is little data of studies on the Workups (consistent with indications)
- Blood test
gastric secretion and some reports in Asia are - Endoscopy
- Urea breath test
still controversial.5 - Abdominal USG
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Tests Sn Sp Notes
With endoscopy
-- Fast and inexpensive
Rapid urease test >98% 99% -- Reduced sensitivity following treatment
-- Specimens are obtained from antrum
-- Increased detection using special staining
Histology >95% >95% Warthin- Starry/ hematoxylin-eosin/ Giemsa)
-- Specimens are obtained from antrum and corpus
-- Very specific, poor sensitivity when transport medium is not
available
-- Requires experience
Culture
-- Expensive, often unavailable
-- Specimens are obtained from antrum and corpus
-- Using media such as Sparrow
-- Sensitive and specific
-- No standard
PCR
-- Specimens were obtained from antrum and corpus
-- Considered
Without endoscopy
-- Less accurate and does not demonstrate active infection
-- A reliable predictor of infection in developing countries with
ELISA serology 85-92% 79-83% high prevalencei
-- It is not recommended for a period after therapy
-- Inexpensive and available
-- It is recommended for establishing the diagnosis of Hp
infection before commencing therapy14
C urea breath test (UBT)
13
-- The test of choice for confirming eradication
such as: 13CO2 breath 95% 96%
-- Patient is not allowed having PPI and antibiotic treatment for
analyzer
2 weeks prior to the examination.15,16
-- Varied availability
Rarely used although it has high sensitivity and specificity,
Fecal antigen 95% 94%
before and after therapy
Finger-stick serology Very poor and can not match the ELISA serology
Urinary antibody: Urine- Right now, the urine test has not been available in Indonesia
73.2-82% 78.6-90.7%
baed Rapid Urine Test17-19
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who do not response to life style changes, When bismuth is not available:
2-4 weeks of treatment using single PPI and PPI* 2x1 7-14 days
ulcer, but have never been investigated. Second line: this class of drugs is used when there is a
failure with clarithromycin-based regimen
• Patients who will receive NSAID, particularly
PPI* 2x1 7-14 days
those with a history of gastroduodenal ulcer.
Bismuth
• Patients with unexplained iron deficiency subsalicylate
2x2 tablets
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lanzoprazole 2 x 30 mg and mucoprotectors such who have receivied 5-HT1 agonists compared to
as rebamipide 3 x 100 mg. placebo. On the other hand, the use of venlafaxin,
a serotonine and norepinephrin inhibitor, does
Functional Dyspepsia
not show better results compared to placebo.5
When there is no mucosal damage found
Psychological problems as well as sleep
after the investigation, the treatment can be given
disturbance and defects on central serotonin
in consistent with the presence of functional
sensitivity may become important factors in the
dyspepsia.
response of antidepressant therapy in patients
The use of prokinetics such as metoclopramide, with functional dyspepsia.5
domperidone, cisapride, itopride and others
can improve the symptoms of patients with Management of dyspepsia with Hp infection
functional dyspepsia. It may be associated with Hp eradication can provide long-term
slow gastric emptying as one of pathophysiology remission of dyspepsia symptoms.20 A cross-
in functional dyspepsia. Caution must always sectional study conducted in 21 patients at Cipto
be applied when using cisapride as it may have Mangunkusumo Hospital, Jakarta (2010) found
potency for cardiovascular complication.11 that the eradication therapy had improved the
Data about the use of antidepressants symptoms in a majority of dyspepsia patients
or antianxiolytic in patient siwht functional with a percentage of symptom improvement as
dyspepsia is still very limited. A recent study in much as 76% and 81% had negative Hp results
Japan has demonstrated a significant improved when they were evaluated using UBT.21
symptom in patients with functional dyspepsia
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