Cancer​ as a group of diseases characterized by → ​third-line therapy in the treatment of testicular

uncontrolled growth, and the spread of abnormal cancer

cells. Thiotepa
→ ​bladder cancer, ovarian cancer, and breast
Neoplasia ​is the uncontrolled growth of new cancer
tissue, product is a ​tumor Busulfan
→ ​treatment of chronic myelogenous leukemia
Malignant tumor​ has the capacity of invading (CML)​ and in high-dose therapy for refractory
surrounding tissues and moving to distant leukemia with bone marrow transplan
location in a process known as ​metastatis Cisplatin
→ ​most reactive and therefore the most effective
Chemotherapy​ refers to drugs that used to kill in platinating DNA
cells also known as antineoplastics Oxaliplatin
→​ colon cancer in combination with
Alkylating agents 5-fluorouracil/leucovori
→ ability to form covalent bonds with Carboplatin
biomolecules; DNA,RNA,Proteins Carmustine
→​brain tumors, Hodgkin’s and non-Hodgkin’s
Nitrogen Mustards disease, and multiple myeloma, treatment of
→compounds that are chemically similar to sulfur glioblastoma multiforme
mustard or mustard gas Lomustine
Streptozocin
Organoplatinum compounds Dacarbazine
→ ​organometallic compounds based on platinum Procarbazine HCl
that play a central role in many cancer treatment Altretamine

Nitrosoureas
→ identified N-methyl-N-nitroguanidine as having
activity against L1210 leukemia
Individual agents for Alkylating Agents
Mechlorethamine HCl (Mustargen)
→ treatment of Hodgkin’s lymphoma.
It is part of MOPP regimen (vincristine,
procarbazine, and prednisone)
→used topically in the treatment of mycosis
fungoide
Chlorambucil
→treatment of Hodgkin’s lymphoma, and chronic
lymphocytic leukemia in combination with
prednisone
Melphalan
Cyclophosphamide
→​ Wilms tumor; Coadministration of mesna is
recommended
Ifosfamide
Antimetabolites
→ ​useful drugs used in antimetabolite therapy are
purines, pyrimidines, folates, and related
compounds
→ enzyme inhibition at active, allosteric, or
related sites
5-Fluorouracil
→ ​breast cancer,colorectal cancer, stomach
cancer, pancreatic cancer, and topical use in
basal cell cancer of the skin
→ drug interaction with Leucovorin
Capecitabine
→ fluoropyrimidine carbamate prodrug form of
5-fluorouracil
→ treat breast cancer and colorectal cancer
Cytarabine
→treatment of acute myelogenous leukemia and
CML
→ ​Cryptothethya crypta
Floxuridine
→ treat metastatic GI adenocarcinoma
Gemcitabine
→ a potent radiosensitizer, and it increases the
cytotoxicity of cisplatin
→ treat bladder cancer, breast cancer, pancreatic
cancer, and NSCLC
Cladribine
Fludarabine
Mercaptopurine
→ treatment of lymphoblastic leukemia, acute
lymphocytic leukemia, and Crohn disease
→ use of xanthine oxidase inhibitors such as
allopurinol can enhance the potency of
mercaptopurine
Thioguanine
→ ​treat acute nonlymphocytic leukemia
Pentostatin
Methotrexate
→ ​inhibition of DHFR leading to a depletion of
critical reduced folates
→ breast cancer, bladder cancer, colorectal
cancer, and head and neck cancer
Pemetrexed
Trimetrexate
treat colorectal cancer, head and neck cancer as
well as NSCLC
Hydroxyurea
used to treat myelogenous leukemia, ovarian
cancer, and essential thrombocytosis
Antibiotics
Dactinomycin
→ ​ treatment of rhabdomyosarcoma and Wilms
tumor in children as well as in the treatment of
choriocarcinoma, Ewing sarcoma, Kaposi
sarcoma, and testicular carcinoma.
Epipodophyllotoxins ​are semisynthetic
derivatives of podophyllotoxin, which is isolated
from the​ mayapple (mandrake) root ​and
functions as an inhibitor of microtubule
Etoposide​ acts on ​topoisomerase II
Camptothecins​ are inhibitors of
topoisomerase I ​and isolated from
Camptotheca acuminata
Bleomycin ​is a glycopeptide antibiotic complex
isolated from​ ​Streptomyces verticillus
​ inca alkaloids​ ​are extracted from the leaves of
V
Catharanthus roseus (periwinkle)
Vinblastine
→​ part of the ABVD (adriamycin, bleomycin,
vinblastine, and dacarbazine) regimen used in the
treatment of Hodgkin’s lymphoma
Vincristine
→ multidrug regime for Hodgkin’s and
non-Hodgkin’s lymphoma
→ It has also been utilized in treating pediatric
cancer.
​Vinorelbine
→ is the most lipophilic of the vinca alkaloids
Taxanes
→ taxol (or paclitaxel) isolated from the bark of
the ​pacific yew tree
Paclitaxel
→major toxicity seen with paclitaxel is a
dose-limiting myelosuppression that normally
presents as ​neutropenia
Ixabepilone
→ is the semisynthetic amide analog of
epothilone B that is isolated from the
myxobacterium​ Sorangium cellulosum
Mitomycin C
→ ​was isolated from​ Streptomyces
caespitosus
Protein Kinase Inhibitor
Imatinib
→treatment of CML, gastrointestinal stromal
tumors (GIST) that express Kit and acute
lymphoplastic leukemia that is positive for the
Philadelphia chromosome.
Geftinib
→treatment of NSCLC for those patients who
have failed to respond to platinum-based
therapies
→inhibitor of the TK of EGF-R and possibly other
TK