Rechargeable Antibacterial and Antifungal Polymeric Silver Sulfadiazines ... http://jbc.sagepub.

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Department of Chemistry, South Dakota School of Mines and Technology 501 East St.
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Poly(methyl methacrylate) (PMMA)-based rechargeable antibacterial and antifungal polymeric silver Citing Articles

sulfadiazines were prepared by copolymerizing acryloyl sulfadiazine with methyl methacrylate and Citing Articles via Scopus
sequentially treating the copolymers with dilute silver nitrate aqueous solutions. The chemical
structures of the samples were characterized by FT-IR, 1H-NMR, XPS, and TGA analyses. On Google Scholar
contact, the PMMA-based polymeric silver sulfadiazines provided 100% inactivation of 108—109 Articles by Zhengbing Cao
CFU/mL of Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive
Articles by Hao Fong
bacteria) in 10 min, and Candida tropicalis (yeast) in 30 min. Kirby—Bauer test data indicated that the
antibacterial and antifungal effects were achieved through contact kill; no silver ions leached out of Social Bookmarking
the new copolymers. The antibacterial and antifungal functions were stable for at least 12 months
under normal storage conditions. Silver nitrate treatments regenerated any lost of antibacterial and
antifungal activity; this recharging can be repeated as needed to achieve long-term protection. These
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properties make the new PMMA-based polymeric silver sulfadiazines attractive candidates for a
broad range of medical (orthopedic), dental, and other related applications to reduce the risks of
bacterial and fungal contamination on high-touch/high-risk surfaces and foreign body-related infections.

Key Words: antibacterial • antifungal • contact kill • rechargeable activity • polymeric silver sulfadiazine • PMMA-based silver sulfadiazines.

Journal of Bioactive and Compatible Polymers, Vol. 24, No. 4, 350-367 (2009)
DOI: 10.1177/0883911509340198

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