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1. a full-length protein or
2. as a globular form.
•
CORRELATION BETWEEN ADIPONECTIN
AND INSULIN RESISTANCE
• Obesity and type 2 diabetes are associated with
decreased adiponectin levels
• Reduced plasma adiponectin is also seen in people
with conditions such as cardiovascular disease and
hypertension, diseases that are often associated with
insulin resistance.
• In a study conducted by Hotta et al., (2001), plasma
adiponectin levels dropped in parallel to the
observation of decreased insulin sensitivity in rhesus
monkeys. [6]
• Monkeys with decreased insulin sensitivity developed
type 2 diabetes.[6]
Contd..
• Adiponectin is inversely proportional to
obesity, diabetes, and other insulin-resistant
states.[7]
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with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes.
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lipoproteins: evidence for independent roles of age and sex. Diabetologia. 46: 459–469.
8.
12. . Dalamaga M, Diakopoulos KN, Mantzoros CS (2012) The
Role of Adiponectin in Cancer: A Review of Current
Evidence. Endocr Rev. (ADIPONECTIN RECEPTORS)
13. Narasimhan M.L. et al. (2005) Osmotin is a homolog of
mammalian adiponectin and controls apoptosis in yeast
through a homolog of mammalian adiponectin receptors.
Molecular Cell. 17(2): 171-180.