Breast Pathology

Q.1) A 30 year old woman presents with a rubbery movable mass. There was no lymph
node metastasis. The tumor is benign. Histology shows stromal cells with ductal epithlial
lined spaces. In her care they were pericanalicular and therefore there was compression.
What is the etiological factors?
A. increased estrogen
B. increased progesterone
C. increased testosterone
D. none of the above
E. all of the above

Q.2) A 22 year old woman presents with serous nipple discharge and nipple retraction.
There was no inflammation and a subareolar lump was palpated. Microscopically there are
branching papillae. What is a key microscopic feature?
A. double layer of epithelial cells
B. one layer of cuboidal cell
C. another layer of myoepithelial cell
D. only a
E. all of the above: a b and c

Q.3) A patient presents with peau d'orange like breast, she is diagnosed to have a cancer
that was originally intraductal carcinoma in situ. Microscopically, there are sheets of large
oval cells and little stroma. there is also lymphocytic infiltration. Which of the following has a
similar structure?
A. dysderminona of the ovary
B. seminoma of the testes
C. a and b
D. colloid carcinoma
E. lobular carcinoma

Q.4) A patient presents with a poorly defined induration of hardening of the breast, without
any mass. The carcinoma is derived from lobar insitu carcinoma. In the infiltrating kind, there
is an indian file microscopic appearance with a bulls-eye pattern of tumor cells around
normal acini and ducts. Which of the following cells are seen in the in-situ carcinoma?
A. oval non cohesive cells
B. large cells
C. hemosiderin laden macrophages
D. None of the above
E. all of the above
Q.5) A woman presents with a carcinoma a carcinoma that behave aggressively and mimics
an abscess, hot and tender. What is the most likely prognosis?
A. bad
B. good
C. unknown
D. all of the above
E. none of the above

Q.6) Clefts and slits seen microscopically are key features of ___________.
( 2 words or 1 word )
Possible correct answers:
 Phylloides tumor
 fibroadenoma
 intraductal papilloma

Q.7) A 32 year old female presents with a lumpy bumpy breast. It has a vague nodularity,
increases before menses, and no axillary lymph node metastasis. Which of the following is
indicative of cancer progression?
A. apocrine metaplasia
B. atypical hyperplasia
C. ductal papillomatosis
D. cribriform pattern
E. epithelial hyperplasia
Q.8) __________ and __________ mimic cancer clinically and produce ____________.
( 8 words )

Possible correct answers:

Traumatic fat necrosis and mammary duct ectasia; induration