Professional Documents
Culture Documents
Plasmodium Falciparum, P.malariae invade hepatocytes (then undergo exoerythrocytic schizogony) dvp
merozoite
P. vivax, ovale sporozoite hypnozoite(liver)merozoite (relapse)
Infective stage: sporozoite
Investigation
Giemsa stain ( thick –identifly, thin – differentiate species)
PCR amplification, ELISA
Drugs
Schizontocidal
Chloroquine/quinine
On pregnancy, quinine for chloroquine resistant falciparum
Mefloquine on later stage
If quinine fails, combine with tetracycline (but no in pregnant lady!)
Prophylaxis
chloroquine
Mefloquine/doxycycline in MDR area
Chloroquine + proguanil in MDR
Gametocidal
Primaquine
Tissue schizontocidal at exoerythrocytic stage
Primaquine (prevent relapse)
Complication
Cerebral malaria
Deformity of infected cell, adherence of cells to endothelium and to each other
Mechanical microcirculation obstruction
Hypoxia n ischemia
Edema, increase permeability in BBB